ZA200502183B - Enos mutants useful for gene therapy - Google Patents

Enos mutants useful for gene therapy Download PDF

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Publication number
ZA200502183B
ZA200502183B ZA200502183A ZA200502183A ZA200502183B ZA 200502183 B ZA200502183 B ZA 200502183B ZA 200502183 A ZA200502183 A ZA 200502183A ZA 200502183 A ZA200502183 A ZA 200502183A ZA 200502183 B ZA200502183 B ZA 200502183B
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ZA
South Africa
Prior art keywords
enos
polypeptide
amino acid
polypeptide mutant
activity
Prior art date
Application number
ZA200502183A
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English (en)
Inventor
Eric Blasko
John Parkinson
Katalin Kauser
Original Assignee
Schering Ag
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Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of ZA200502183B publication Critical patent/ZA200502183B/en

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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0012Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0071Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0073Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
    • C12N9/0075Nitric-oxide synthase (1.14.13.39)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P13/12Drugs for disorders of the urinary system of the kidneys
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    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
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    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
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    • C12YENZYMES
    • C12Y114/00Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/13Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen (1.14.13)
    • C12Y114/13039Nitric-oxide synthase (NADPH dependent) (1.14.13.39)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
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  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Wood Science & Technology (AREA)
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  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
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  • Pregnancy & Childbirth (AREA)
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  • Physics & Mathematics (AREA)
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ZA200502183A 2002-08-16 2005-03-15 Enos mutants useful for gene therapy ZA200502183B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40363802P 2002-08-16 2002-08-16

Publications (1)

Publication Number Publication Date
ZA200502183B true ZA200502183B (en) 2006-09-27

Family

ID=31888260

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200502183A ZA200502183B (en) 2002-08-16 2005-03-15 Enos mutants useful for gene therapy

Country Status (15)

Country Link
US (1) US20040096881A1 (ja)
EP (1) EP1553973A4 (ja)
JP (1) JP2005535345A (ja)
KR (1) KR20050042788A (ja)
CN (1) CN1691958A (ja)
AU (1) AU2003265461A1 (ja)
BR (1) BR0313511A (ja)
CA (1) CA2494847A1 (ja)
IL (1) IL166511A0 (ja)
MX (1) MXPA05001906A (ja)
NO (1) NO20051347L (ja)
PL (1) PL375219A1 (ja)
RU (1) RU2005107410A (ja)
WO (1) WO2004016764A2 (ja)
ZA (1) ZA200502183B (ja)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050074448A1 (en) * 2003-03-24 2005-04-07 The Curator Sof The University Of Missouri Method of treatment of endothelial dysfunction and engineered proteins for same
CA2545584C (en) 2003-11-17 2012-10-23 Biomarin Pharmaceutical Inc. Methods and compositions for the treatment of metabolic disorders
US8615368B2 (en) 2005-03-10 2013-12-24 Gen-Probe Incorporated Method for determining the amount of an analyte in a sample
EP1897016B1 (en) * 2005-06-22 2012-08-01 Gen-Probe Incorporated Method and algorithm for quantifying polynucleotides
US10550178B2 (en) * 2010-03-18 2020-02-04 Srikanth Vedamoorthy Antibodies for detecting redox modulated proteins
US9439978B2 (en) 2011-09-29 2016-09-13 University Of South Florida Multilayered magnetic micelle compositions and methods for their use
US9216178B2 (en) 2011-11-02 2015-12-22 Biomarin Pharmaceutical Inc. Dry blend formulation of tetrahydrobiopterin
US9782494B2 (en) 2012-02-23 2017-10-10 University Of South Florida Methods of using multilayer magnetic micelle compositions
WO2013154771A1 (en) * 2012-04-12 2013-10-17 Georgia Regents University Redox-resistant nitric oxide synthase
EP3163481B1 (en) * 2014-06-25 2019-05-01 Japan Science And Technology Agency Device, method and program for predicting mutant capable of thermally stabilizing membrane protein
CN107802826B (zh) * 2017-10-26 2020-02-18 首都医科大学宣武医院 eNOS突变体在促进血管生成中的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK14692001A3 (sk) * 1999-04-16 2002-09-10 Yale University Izolovaná molekula nukleovej kyseliny, izolovaný NOS polypeptid, spôsob stimulácie, spôsob liečby, spôsob identifikácie a nehumánne transgénne zviera
US6620616B1 (en) * 2000-09-13 2003-09-16 The Cleveland Clinic Foundation Nucleic acids encoding nitric oxide synthase variants

Also Published As

Publication number Publication date
WO2004016764A3 (en) 2005-05-19
BR0313511A (pt) 2006-06-13
NO20051347L (no) 2005-04-28
EP1553973A4 (en) 2006-03-01
KR20050042788A (ko) 2005-05-10
WO2004016764A2 (en) 2004-02-26
US20040096881A1 (en) 2004-05-20
CN1691958A (zh) 2005-11-02
RU2005107410A (ru) 2006-01-20
PL375219A1 (en) 2005-11-28
EP1553973A2 (en) 2005-07-20
CA2494847A1 (en) 2004-02-26
JP2005535345A (ja) 2005-11-24
AU2003265461A1 (en) 2004-03-03
MXPA05001906A (es) 2005-04-28
IL166511A0 (en) 2006-01-15

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