ZA200500831B - Parental formulations containing a rapamycin hydroxyester - Google Patents
Parental formulations containing a rapamycin hydroxyester Download PDFInfo
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- ZA200500831B ZA200500831B ZA200500831A ZA200500831A ZA200500831B ZA 200500831 B ZA200500831 B ZA 200500831B ZA 200500831 A ZA200500831 A ZA 200500831A ZA 200500831 A ZA200500831 A ZA 200500831A ZA 200500831 B ZA200500831 B ZA 200500831B
- Authority
- ZA
- South Africa
- Prior art keywords
- cci
- polyethylene glycol
- formulation
- diluent
- solvent
- Prior art date
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Landscapes
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EP (1) | EP1553940B1 (pt) |
JP (2) | JP2005537285A (pt) |
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CN (1) | CN100402031C (pt) |
AR (2) | AR040693A1 (pt) |
AT (1) | ATE385795T1 (pt) |
AU (2) | AU2003254168A1 (pt) |
BR (1) | BR0313024A (pt) |
CA (1) | CA2493878C (pt) |
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HK (1) | HK1076390A1 (pt) |
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PT (1) | PT1553940E (pt) |
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UA (1) | UA82328C2 (pt) |
WO (1) | WO2004011000A1 (pt) |
ZA (1) | ZA200500831B (pt) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR0313024A (pt) | 2002-07-30 | 2005-07-12 | Wyeth Corp | Formulações parenterais contendo um hidroxiéster de rapamicina |
CN100415233C (zh) * | 2002-09-17 | 2008-09-03 | 惠氏公司 | 口服制剂 |
PT1539157E (pt) * | 2002-09-18 | 2013-10-04 | Univ Pennsylvania | Rapamicina para utilização na inibição ou prevenção de neovascularização coroidal |
EP1648454A1 (en) * | 2003-07-25 | 2006-04-26 | Wyeth | Cci-779 lyophilized formulations |
AR046194A1 (es) * | 2003-11-04 | 2005-11-30 | Mayo Foundation | Metodo de tratamiento del linfoma de celulas del manto |
US8003122B2 (en) * | 2004-03-31 | 2011-08-23 | Cordis Corporation | Device for local and/or regional delivery employing liquid formulations of therapeutic agents |
US7846940B2 (en) * | 2004-03-31 | 2010-12-07 | Cordis Corporation | Solution formulations of sirolimus and its analogs for CAD treatment |
CA2562952A1 (en) | 2004-04-14 | 2005-11-10 | Wyeth | Regiospecific synthesis of rapamycin 42-ester derivatives |
JP2007532650A (ja) | 2004-04-14 | 2007-11-15 | ワイス | プロリンcci−779(2,2−ビス(ヒドロキシメチル)プロピオン酸とのプロリン−ラパマイシン42−エステル)ならびに細菌リパーゼを使用するプロリンcci−779およびcci−779の二段階酵素的合成 |
AU2005238493A1 (en) * | 2004-04-27 | 2005-11-10 | Wyeth | Labeling of rapamycin using rapamycin-specific methylases |
EP1804779A1 (en) | 2004-10-28 | 2007-07-11 | Wyeth | Use of an mtor inhibitor in treatment of uterine leiomyoma |
US8663639B2 (en) | 2005-02-09 | 2014-03-04 | Santen Pharmaceutical Co., Ltd. | Formulations for treating ocular diseases and conditions |
ES2564194T3 (es) | 2005-02-09 | 2016-03-18 | Santen Pharmaceutical Co., Ltd. | Formulaciones líquidas para el tratamiento de enfermedades o dolencias |
BRPI0607198A2 (pt) * | 2005-02-15 | 2016-11-01 | Wyeth Corp | composição, uso da composição método de tratamento doenças, e, embalagem farmacêutica |
PE20070763A1 (es) | 2005-11-04 | 2007-08-08 | Wyeth Corp | COMBINACIONES ANTINEOPLASICAS DE UN INHIBIDOR DE mTOR, TRASTUZUMAB Y/O HKI-272 |
US7538119B2 (en) * | 2005-11-04 | 2009-05-26 | Wyeth | 41-Methoxy isotope labeled rapamycin 42-ester |
TW200731967A (en) * | 2005-12-20 | 2007-09-01 | Wyeth Corp | Control of CCI-779 dosage form stability through control of drug substance impurities |
BRPI0707612B8 (pt) * | 2006-02-09 | 2021-05-25 | Macusight Inc | vaso lacrado e formulações líquidas contidas no mesmo |
AU2013200089B2 (en) * | 2006-02-09 | 2016-03-03 | Santen Pharmaceutical Co., Ltd | Stable formulations, and methods of their preparation and use |
US8222271B2 (en) | 2006-03-23 | 2012-07-17 | Santen Pharmaceutical Co., Ltd. | Formulations and methods for vascular permeability-related diseases or conditions |
US9700704B2 (en) | 2006-11-20 | 2017-07-11 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
US8414525B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US20080175887A1 (en) | 2006-11-20 | 2008-07-24 | Lixiao Wang | Treatment of Asthma and Chronic Obstructive Pulmonary Disease With Anti-proliferate and Anti-inflammatory Drugs |
US20080276935A1 (en) | 2006-11-20 | 2008-11-13 | Lixiao Wang | Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs |
US8425459B2 (en) | 2006-11-20 | 2013-04-23 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent |
US9737640B2 (en) | 2006-11-20 | 2017-08-22 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US8414910B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US8998846B2 (en) | 2006-11-20 | 2015-04-07 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
US8430055B2 (en) | 2008-08-29 | 2013-04-30 | Lutonix, Inc. | Methods and apparatuses for coating balloon catheters |
US8414526B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids |
TW200901989A (en) | 2007-04-10 | 2009-01-16 | Wyeth Corp | Anti-tumor activity of CCI-779 in papillary renal cell cancer |
US20110038899A1 (en) * | 2008-03-28 | 2011-02-17 | Garry Thomas Gwozdz | Pharmaceutical Solutions and Method for Solublilizing Therapeutic Agents |
US8420110B2 (en) | 2008-03-31 | 2013-04-16 | Cordis Corporation | Drug coated expandable devices |
US8409601B2 (en) * | 2008-03-31 | 2013-04-02 | Cordis Corporation | Rapamycin coated expandable devices |
PT3158991T (pt) | 2010-01-28 | 2021-06-23 | Eagle Pharmaceuticals Inc | Formulações de bendamustina |
JP2013527223A (ja) * | 2010-06-02 | 2013-06-27 | フレゼニウス・カビ・オンコロジー・リミテッド | ラパマイシンエステルの安定な医薬組成物 |
US20120252835A1 (en) * | 2011-04-01 | 2012-10-04 | Astron Research Limited | Stable temsirolimus composition and process of preparing same |
JP2014516075A (ja) | 2011-06-06 | 2014-07-07 | シェブロン フィリップス ケミカル カンパニー エルピー | 癌治療のためのメタロセン化合物の使用 |
CA2867295C (en) | 2012-03-20 | 2020-08-11 | Eagle Pharmaceuticals, Inc. | Formulations of bendamustine |
EP2827863B1 (en) | 2012-03-20 | 2019-01-16 | Eagle Pharmaceuticals, Inc. | Liquid composition for use in a method of treating bendamustine-responsive conditions in patients requiring reduced volumes for administration |
WO2014118696A2 (en) * | 2013-01-29 | 2014-08-07 | Gland Pharma Limited | Pharmacuetical compositions of rapamycin esters and its derivatives |
CN103989676B (zh) * | 2014-06-10 | 2016-06-22 | 福建省微生物研究所 | 可注射用的替西罗莫司组合物 |
EP3351245A4 (en) * | 2015-09-18 | 2019-05-22 | Nippon Kayaku Kabushiki Kaisha | PHARMACEUTICAL COMPOSITION COMPRISING RAPAMYCIN OR A DERIVATIVE THEREOF |
US10765665B2 (en) | 2015-11-24 | 2020-09-08 | Melin Jeffrey | Composition comprising combination of rapamycin and an activator of AMP kinase and use thereof for treating diseases |
CN105640878A (zh) * | 2016-01-25 | 2016-06-08 | 宿州学院 | 一种坦西莫司注射用浓溶液及其制备方法 |
WO2017129772A1 (en) | 2016-01-29 | 2017-08-03 | Xellia Phamaceuticals Aps | Stable pharmaceutical compositions of temsirolimus |
CN105687132B (zh) * | 2016-03-17 | 2020-06-12 | 鲁南贝特制药有限公司 | 一种坦西莫司注射用浓溶液及其制备方法 |
CN107550852B (zh) * | 2016-06-30 | 2021-05-14 | 山东新时代药业有限公司 | 一种坦西莫司注射液注射用溶剂及其制备方法 |
CN107773539A (zh) * | 2016-08-27 | 2018-03-09 | 鲁南制药集团股份有限公司 | 一种注射用坦西莫司及其制备方法 |
JP6989597B2 (ja) * | 2016-09-22 | 2022-01-05 | マーケイター メドシステムズ, インコーポレイテッド | テムシロリムスを使用する再狭窄の処置 |
CN110996687A (zh) | 2017-05-26 | 2020-04-10 | 墨卡托医疗系统公司 | 用于治疗再狭窄的联合疗法 |
US20200397763A1 (en) * | 2018-02-23 | 2020-12-24 | Biotronik Ag | Parenteral formulation materials and methods for 40-o-cyclic hydrocarbon esters and related structures |
WO2019178231A1 (en) | 2018-03-14 | 2019-09-19 | Mercator Medsystems, Inc. | Medical instrument and medical method for localized drug delivery |
CN114366715A (zh) * | 2022-01-28 | 2022-04-19 | 严鹏科 | 雷帕霉素自微乳注射剂及其制备方法及其应用 |
Family Cites Families (103)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA737247B (en) | 1972-09-29 | 1975-04-30 | Ayerst Mckenna & Harrison | Rapamycin and process of preparation |
US3993749A (en) | 1974-04-12 | 1976-11-23 | Ayerst Mckenna And Harrison Ltd. | Rapamycin and process of preparation |
US5206018A (en) | 1978-11-03 | 1993-04-27 | Ayerst, Mckenna & Harrison, Inc. | Use of rapamycin in treatment of tumors |
US4885171A (en) | 1978-11-03 | 1989-12-05 | American Home Products Corporation | Use of rapamycin in treatment of certain tumors |
AU543727B2 (en) | 1980-06-02 | 1985-05-02 | Ayerst Mckenna & Harrison Inc. | Injectable composition of rapamycin |
US4316885A (en) | 1980-08-25 | 1982-02-23 | Ayerst, Mckenna And Harrison, Inc. | Acyl derivatives of rapamycin |
US4401653A (en) | 1981-03-09 | 1983-08-30 | Ayerst, Mckenna & Harrison Inc. | Combination of rapamycin and picibanil for the treatment of tumors |
US4650803A (en) | 1985-12-06 | 1987-03-17 | University Of Kansas | Prodrugs of rapamycin |
GB8803836D0 (en) | 1988-02-18 | 1988-03-16 | Glaxo Group Ltd | Compositions |
US5100899A (en) | 1989-06-06 | 1992-03-31 | Roy Calne | Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof |
US5023264A (en) | 1990-07-16 | 1991-06-11 | American Home Products Corporation | Rapamycin oximes |
US5023263A (en) | 1990-08-09 | 1991-06-11 | American Home Products Corporation | 42-oxorapamycin |
US5221670A (en) | 1990-09-19 | 1993-06-22 | American Home Products Corporation | Rapamycin esters |
US5233036A (en) | 1990-10-16 | 1993-08-03 | American Home Products Corporation | Rapamycin alkoxyesters |
GB9103430D0 (en) | 1991-02-19 | 1991-04-03 | Smithkline Beecham Plc | Novel compound |
US5080899A (en) | 1991-02-22 | 1992-01-14 | American Home Products Corporation | Method of treating pulmonary inflammation |
US5078999A (en) | 1991-02-22 | 1992-01-07 | American Home Products Corporation | Method of treating systemic lupus erythematosus |
US5120842A (en) | 1991-04-01 | 1992-06-09 | American Home Products Corporation | Silyl ethers of rapamycin |
US5321009A (en) | 1991-04-03 | 1994-06-14 | American Home Products Corporation | Method of treating diabetes |
US5100883A (en) | 1991-04-08 | 1992-03-31 | American Home Products Corporation | Fluorinated esters of rapamycin |
US5118678A (en) | 1991-04-17 | 1992-06-02 | American Home Products Corporation | Carbamates of rapamycin |
US5118677A (en) | 1991-05-20 | 1992-06-02 | American Home Products Corporation | Amide esters of rapamycin |
DE69209183T2 (de) | 1991-06-18 | 1996-08-08 | American Home Prod | Verwendung von Rapamycin zur Behandlung von T-Zellen Lymphom/Leukämie bei Erwachsenen |
ZA924953B (en) | 1991-07-25 | 1993-04-28 | Univ Louisville Res Found | Method of treating ocular inflammation |
US5162333A (en) | 1991-09-11 | 1992-11-10 | American Home Products Corporation | Aminodiesters of rapamycin |
US5286731A (en) | 1991-09-17 | 1994-02-15 | American Home Products Corporation | Method of treating immunoinflammatory bowel disease |
US5286730A (en) | 1991-09-17 | 1994-02-15 | American Home Products Corporation | Method of treating immunoinflammatory disease |
US5516781A (en) | 1992-01-09 | 1996-05-14 | American Home Products Corporation | Method of treating restenosis with rapamycin |
US5177203A (en) | 1992-03-05 | 1993-01-05 | American Home Products Corporation | Rapamycin 42-sulfonates and 42-(N-carboalkoxy) sulfamates useful as immunosuppressive agents |
WO1993019763A1 (en) * | 1992-03-30 | 1993-10-14 | American Home Products Corporation | Rapamycin formulation for iv injection |
US5288711A (en) | 1992-04-28 | 1994-02-22 | American Home Products Corporation | Method of treating hyperproliferative vascular disease |
ZA935112B (en) | 1992-07-17 | 1994-02-08 | Smithkline Beecham Corp | Rapamycin derivatives |
US5256790A (en) | 1992-08-13 | 1993-10-26 | American Home Products Corporation | 27-hydroxyrapamycin and derivatives thereof |
GB9221220D0 (en) | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
US5411967A (en) | 1992-10-13 | 1995-05-02 | American Home Products Corporation | Carbamates of rapamycin |
US5489680A (en) | 1992-10-13 | 1996-02-06 | American Home Products Corporation | Carbamates of rapamycin |
US5480989A (en) | 1992-10-13 | 1996-01-02 | American Home Products Corporation | Carbamates of rapamycin |
US5434260A (en) | 1992-10-13 | 1995-07-18 | American Home Products Corporation | Carbamates of rapamycin |
US5302584A (en) | 1992-10-13 | 1994-04-12 | American Home Products Corporation | Carbamates of rapamycin |
US5480988A (en) | 1992-10-13 | 1996-01-02 | American Home Products Corporation | Carbamates of rapamycin |
US5262423A (en) | 1992-10-29 | 1993-11-16 | American Home Products Corporation | Rapamycin arylcarbonyl and alkoxycarbonyl carbamates as immunosuppressive and antifungal agents |
US5258389A (en) | 1992-11-09 | 1993-11-02 | Merck & Co., Inc. | O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives |
US5260300A (en) | 1992-11-19 | 1993-11-09 | American Home Products Corporation | Rapamycin carbonate esters as immuno-suppressant agents |
US5504091A (en) | 1993-04-23 | 1996-04-02 | American Home Products Corporation | Biotin esters of rapamycin |
CH686761A5 (de) * | 1993-05-27 | 1996-06-28 | Sandoz Ag | Galenische Formulierungen. |
IL111008A (en) * | 1993-09-30 | 1999-10-28 | American Home Prod | Rapamycin formulations for intravenous injection and their preparation |
IL111003A0 (en) * | 1993-09-30 | 1994-11-28 | American Home Prod | Multi-component oral rapamycin formulation |
IL111004A (en) * | 1993-09-30 | 1998-06-15 | American Home Prod | Oral formulations of rapamycin |
US5516770A (en) * | 1993-09-30 | 1996-05-14 | American Home Products Corporation | Rapamycin formulation for IV injection |
US5616588A (en) * | 1993-09-30 | 1997-04-01 | American Home Products Corporation | Rapamycin formulation for IV injection |
US5536729A (en) * | 1993-09-30 | 1996-07-16 | American Home Products Corporation | Rapamycin formulations for oral administration |
US5373014A (en) | 1993-10-08 | 1994-12-13 | American Home Products Corporation | Rapamycin oximes |
US5378836A (en) | 1993-10-08 | 1995-01-03 | American Home Products Corporation | Rapamycin oximes and hydrazones |
US5391730A (en) | 1993-10-08 | 1995-02-21 | American Home Products Corporation | Phosphorylcarbamates of rapamycin and oxime derivatives thereof |
US6022852A (en) | 1993-10-22 | 2000-02-08 | Hexal Ag | Pharmaceutical composition containing cyclosporin A |
US5385908A (en) | 1993-11-22 | 1995-01-31 | American Home Products Corporation | Hindered esters of rapamycin |
US5385909A (en) | 1993-11-22 | 1995-01-31 | American Home Products Corporation | Heterocyclic esters of rapamycin |
US5385910A (en) | 1993-11-22 | 1995-01-31 | American Home Products Corporation | Gem-distributed esters of rapamycin |
US5447936A (en) | 1993-12-22 | 1995-09-05 | Bionumerik Pharmaceuticals, Inc. | Lactone stable formulation of 10-hydroxy 7-ethyl camptothecin and methods for uses thereof |
US5389639A (en) | 1993-12-29 | 1995-02-14 | American Home Products Company | Amino alkanoic esters of rapamycin |
US5362718A (en) | 1994-04-18 | 1994-11-08 | American Home Products Corporation | Rapamycin hydroxyesters |
GB9409778D0 (en) | 1994-05-16 | 1994-07-06 | Dumex Ltd As | Compositions |
US5463048A (en) | 1994-06-14 | 1995-10-31 | American Home Products Corporation | Rapamycin amidino carbamates |
MY129435A (en) | 1994-10-26 | 2007-04-30 | Novartis Ag | Pharmaceutical microemulsion preconcentrates |
GB2327611B (en) | 1994-10-26 | 1999-06-02 | Novartis Ag | Macrolide compositions |
US5491231A (en) | 1994-11-28 | 1996-02-13 | American Home Products Corporation | Hindered N-oxide esters of rapamycin |
US5563145A (en) | 1994-12-07 | 1996-10-08 | American Home Products Corporation | Rapamycin 42-oximes and hydroxylamines |
US5561138A (en) | 1994-12-13 | 1996-10-01 | American Home Products Corporation | Method of treating anemia |
US5496832A (en) | 1995-03-09 | 1996-03-05 | American Home Products Corporation | Method of treating cardiac inflammatory disease |
NZ280689A (en) | 1995-12-15 | 1997-08-22 | Bernard Charles Sherma Sherman | Pharmaceutical composition comprising a cyclosporipharmaceutical composition comprising a cyclosporin; a tocol, tocopherol or tocotrienol; and propylen; a tocol, tocopherol or tocotrienol; and propylene carbonate or polyethylene glycol ne carbonate or polyethylene glycol |
US5780462A (en) | 1995-12-27 | 1998-07-14 | American Home Products Corporation | Water soluble rapamycin esters |
US6458373B1 (en) * | 1997-01-07 | 2002-10-01 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
IL131217A0 (en) * | 1998-03-10 | 2001-01-28 | Napro Biotherapeutics Inc | Novel methods and compositions for delivery of taxanes |
AU3843999A (en) | 1998-05-07 | 1999-11-23 | Elan Corporation, Plc | Solvent/cosolvent free microemulsion and emulsion preconcentrate drug delivery systems |
GB9826882D0 (en) | 1998-12-07 | 1999-01-27 | Novartis Ag | Organic compounds |
AU2002318972B8 (en) | 2001-07-18 | 2007-08-09 | Bionomics Limited | Mutations in ion channels |
WO2001008678A1 (en) * | 1999-07-30 | 2001-02-08 | University Of Kentucky Research Foundation | Cis-2,6-disubstituted piperidines for the treatment of psychostimulant abuse and withdrawal, eating disorders, and central nervous system diseases and pathologies |
US6277983B1 (en) | 2000-09-27 | 2001-08-21 | American Home Products Corporation | Regioselective synthesis of rapamycin derivatives |
EP1244800B1 (en) | 1999-10-29 | 2007-03-14 | Kosan Biosciences, Inc. | Rapamycin analogs |
US20020013335A1 (en) | 2000-06-16 | 2002-01-31 | American Home Products Corporation | Method of treating cardiovascular disease |
US6670355B2 (en) | 2000-06-16 | 2003-12-30 | Wyeth | Method of treating cardiovascular disease |
JP2004509898A (ja) * | 2000-09-19 | 2004-04-02 | ワイス | 水溶性ラパマイシンエステル |
US6399626B1 (en) | 2000-10-02 | 2002-06-04 | Wyeth | Hydroxyesters of 7-desmethylrapamycin |
TWI286074B (en) * | 2000-11-15 | 2007-09-01 | Wyeth Corp | Pharmaceutical composition containing CCI-779 as an antineoplastic agent |
EP1419153A1 (en) | 2001-08-22 | 2004-05-19 | Wyeth | Rapamycin dialdehydes |
EP1419154B1 (en) | 2001-08-22 | 2005-10-05 | Wyeth | Rapamycin 29-enols |
US20030176455A1 (en) | 2002-03-13 | 2003-09-18 | Wyeth | Method of inhibiting cell death |
BR0313024A (pt) | 2002-07-30 | 2005-07-12 | Wyeth Corp | Formulações parenterais contendo um hidroxiéster de rapamicina |
EP2460889B1 (en) * | 2002-10-11 | 2013-11-20 | Erasmus Universiteit Rotterdam | Nucleic acid amplification primers for PCR-based clonality studies of BCL2-IGH rearrangements |
MXPA06000407A (es) | 2003-07-16 | 2006-03-17 | Wyeth Corp | Isomero c cci-779. |
EP1648454A1 (en) | 2003-07-25 | 2006-04-26 | Wyeth | Cci-779 lyophilized formulations |
DK1658295T3 (da) | 2003-08-07 | 2007-09-24 | Wyeth Corp | Regioselektiv syntese af CCI-779 |
AU2005238432A1 (en) | 2004-04-14 | 2005-11-10 | Wyeth | Process for preparing rapamycin 42-esters and FK-506 32-esters with dicarboxylic acid, precursors for rapamycin conjugates and antibodies |
CA2562952A1 (en) | 2004-04-14 | 2005-11-10 | Wyeth | Regiospecific synthesis of rapamycin 42-ester derivatives |
JP2007532650A (ja) | 2004-04-14 | 2007-11-15 | ワイス | プロリンcci−779(2,2−ビス(ヒドロキシメチル)プロピオン酸とのプロリン−ラパマイシン42−エステル)ならびに細菌リパーゼを使用するプロリンcci−779およびcci−779の二段階酵素的合成 |
PA8641501A1 (es) | 2004-08-10 | 2006-09-08 | Wyeth Corp | Derivados de cci-779 y metodo para su preparacion |
AR050374A1 (es) | 2004-08-20 | 2006-10-18 | Wyeth Corp | Forma polimorfica de rafampicina |
CN101084226A (zh) | 2004-12-20 | 2007-12-05 | 惠氏公司 | 雷帕霉素衍生物及其治疗神经紊乱的用途 |
ES2380779T3 (es) | 2004-12-20 | 2012-05-18 | Wyeth Llc | Análogos de rapamicina y usos de los mismos en el tratamiento de trastornos neurológicos, proliferativos e inflamatorios |
BRPI0607198A2 (pt) | 2005-02-15 | 2016-11-01 | Wyeth Corp | composição, uso da composição método de tratamento doenças, e, embalagem farmacêutica |
KR20070107087A (ko) | 2005-03-02 | 2007-11-06 | 와이어쓰 | 라파마이신의 정제 |
BRPI0619578A2 (pt) | 2005-12-07 | 2011-10-04 | Wyeth Corp | processo para preparar um 42-éster de rapamicina, composto, método para isolar o boronato do 42-éster de rapamicina bruto a partir do licor mãe, método para purificação de um boronato do 42-éster de rapamicina, e, boronato de cci-779 |
TW200731967A (en) | 2005-12-20 | 2007-09-01 | Wyeth Corp | Control of CCI-779 dosage form stability through control of drug substance impurities |
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