ZA200500047B - Tumor-lysing virus growing selectively in tumor cells - Google Patents
Tumor-lysing virus growing selectively in tumor cells Download PDFInfo
- Publication number
- ZA200500047B ZA200500047B ZA200500047A ZA200500047A ZA200500047B ZA 200500047 B ZA200500047 B ZA 200500047B ZA 200500047 A ZA200500047 A ZA 200500047A ZA 200500047 A ZA200500047 A ZA 200500047A ZA 200500047 B ZA200500047 B ZA 200500047B
- Authority
- ZA
- South Africa
- Prior art keywords
- cancer
- gene
- virus
- cells
- tumor
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title claims description 66
- 241000700605 Viruses Species 0.000 title claims description 55
- 210000004881 tumor cell Anatomy 0.000 title description 7
- 108090000623 proteins and genes Proteins 0.000 claims description 59
- 201000011510 cancer Diseases 0.000 claims description 46
- 108010017842 Telomerase Proteins 0.000 claims description 19
- 239000002246 antineoplastic agent Substances 0.000 claims description 17
- 241000701161 unidentified adenovirus Species 0.000 claims description 17
- 101150075174 E1B gene Proteins 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 14
- 101150029662 E1 gene Proteins 0.000 claims description 13
- 108091033319 polynucleotide Proteins 0.000 claims description 12
- 102000040430 polynucleotide Human genes 0.000 claims description 12
- 239000002157 polynucleotide Substances 0.000 claims description 12
- 201000003741 Gastrointestinal carcinoma Diseases 0.000 claims description 8
- 201000002313 intestinal cancer Diseases 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 6
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 5
- 201000005202 lung cancer Diseases 0.000 claims description 5
- 208000020816 lung neoplasm Diseases 0.000 claims description 5
- 239000004480 active ingredient Substances 0.000 claims description 4
- 210000000232 gallbladder Anatomy 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 201000008968 osteosarcoma Diseases 0.000 claims description 4
- 206010004593 Bile duct cancer Diseases 0.000 claims description 3
- 206010005003 Bladder cancer Diseases 0.000 claims description 3
- 208000003174 Brain Neoplasms Diseases 0.000 claims description 3
- 206010006187 Breast cancer Diseases 0.000 claims description 3
- 208000026310 Breast neoplasm Diseases 0.000 claims description 3
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims description 3
- 208000022072 Gallbladder Neoplasms Diseases 0.000 claims description 3
- 206010033128 Ovarian cancer Diseases 0.000 claims description 3
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 3
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 3
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 3
- 208000024770 Thyroid neoplasm Diseases 0.000 claims description 3
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 3
- 208000002495 Uterine Neoplasms Diseases 0.000 claims description 3
- 208000026900 bile duct neoplasm Diseases 0.000 claims description 3
- 208000006990 cholangiocarcinoma Diseases 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 3
- 201000004101 esophageal cancer Diseases 0.000 claims description 3
- 201000010175 gallbladder cancer Diseases 0.000 claims description 3
- 206010017758 gastric cancer Diseases 0.000 claims description 3
- 201000007270 liver cancer Diseases 0.000 claims description 3
- 208000014018 liver neoplasm Diseases 0.000 claims description 3
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 3
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 3
- 201000011549 stomach cancer Diseases 0.000 claims description 3
- 201000002510 thyroid cancer Diseases 0.000 claims description 3
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 3
- 206010046766 uterine cancer Diseases 0.000 claims description 3
- 239000003085 diluting agent Substances 0.000 claims description 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 210000004027 cell Anatomy 0.000 description 105
- 230000014509 gene expression Effects 0.000 description 16
- 230000000694 effects Effects 0.000 description 13
- 108091008146 restriction endonucleases Proteins 0.000 description 12
- 208000015181 infectious disease Diseases 0.000 description 11
- 239000013598 vector Substances 0.000 description 11
- 230000010076 replication Effects 0.000 description 10
- 102000004169 proteins and genes Human genes 0.000 description 7
- 238000011144 upstream manufacturing Methods 0.000 description 7
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 6
- 108020004414 DNA Proteins 0.000 description 6
- 230000034994 death Effects 0.000 description 6
- 238000001415 gene therapy Methods 0.000 description 6
- 230000000259 anti-tumor effect Effects 0.000 description 5
- 101150070966 eta gene Proteins 0.000 description 5
- 230000012010 growth Effects 0.000 description 5
- 108020004999 messenger RNA Proteins 0.000 description 5
- 230000003612 virological effect Effects 0.000 description 5
- 241000699660 Mus musculus Species 0.000 description 4
- 241001068263 Replication competent viruses Species 0.000 description 4
- 238000011580 nude mouse model Methods 0.000 description 4
- 241000701022 Cytomegalovirus Species 0.000 description 3
- 108020005202 Viral DNA Proteins 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 238000010367 cloning Methods 0.000 description 3
- 230000003013 cytotoxicity Effects 0.000 description 3
- 231100000135 cytotoxicity Toxicity 0.000 description 3
- 210000002950 fibroblast Anatomy 0.000 description 3
- 230000002458 infectious effect Effects 0.000 description 3
- 230000003362 replicative effect Effects 0.000 description 3
- 230000014616 translation Effects 0.000 description 3
- 230000004614 tumor growth Effects 0.000 description 3
- 230000029812 viral genome replication Effects 0.000 description 3
- 206010027476 Metastases Diseases 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- NKLPQNGYXWVELD-UHFFFAOYSA-M coomassie brilliant blue Chemical compound [Na+].C1=CC(OCC)=CC=C1NC1=CC=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C=CC(=CC=2)N(CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=C1 NKLPQNGYXWVELD-UHFFFAOYSA-M 0.000 description 2
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 238000010353 genetic engineering Methods 0.000 description 2
- 230000003834 intracellular effect Effects 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 230000009401 metastasis Effects 0.000 description 2
- 230000004660 morphological change Effects 0.000 description 2
- 239000002773 nucleotide Substances 0.000 description 2
- 125000003729 nucleotide group Chemical group 0.000 description 2
- 244000309459 oncolytic virus Species 0.000 description 2
- 239000002953 phosphate buffered saline Substances 0.000 description 2
- 239000013641 positive control Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 210000002307 prostate Anatomy 0.000 description 2
- 238000001243 protein synthesis Methods 0.000 description 2
- 238000010839 reverse transcription Methods 0.000 description 2
- 238000003757 reverse transcription PCR Methods 0.000 description 2
- 210000001082 somatic cell Anatomy 0.000 description 2
- 239000000829 suppository Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 230000014621 translational initiation Effects 0.000 description 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
- 238000001262 western blot Methods 0.000 description 2
- 108020004463 18S ribosomal RNA Proteins 0.000 description 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 229940123373 Adenovirus E1A gene Drugs 0.000 description 1
- 241000744472 Cinna Species 0.000 description 1
- 230000004543 DNA replication Effects 0.000 description 1
- 101150073211 ET gene Proteins 0.000 description 1
- 102100031181 Glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101000655352 Homo sapiens Telomerase reverse transcriptase Proteins 0.000 description 1
- 101150062031 L gene Proteins 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 101000702488 Rattus norvegicus High affinity cationic amino acid transporter 1 Proteins 0.000 description 1
- 108091023040 Transcription factor Proteins 0.000 description 1
- 102000040945 Transcription factor Human genes 0.000 description 1
- 108700005077 Viral Genes Proteins 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 239000011543 agarose gel Substances 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000003263 anti-adenoviral effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 210000000013 bile duct Anatomy 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 238000004520 electroporation Methods 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- ZMMJGEGLRURXTF-UHFFFAOYSA-N ethidium bromide Chemical compound [Br-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 ZMMJGEGLRURXTF-UHFFFAOYSA-N 0.000 description 1
- 229960005542 ethidium bromide Drugs 0.000 description 1
- 239000003889 eye drop Substances 0.000 description 1
- 229940012356 eye drops Drugs 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 210000004602 germ cell Anatomy 0.000 description 1
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000009036 growth inhibition Effects 0.000 description 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 description 1
- 230000008105 immune reaction Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 229960003444 immunosuppressant agent Drugs 0.000 description 1
- 230000001861 immunosuppressant effect Effects 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 230000002601 intratumoral effect Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 239000007951 isotonicity adjuster Substances 0.000 description 1
- 210000003292 kidney cell Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000003928 nasal cavity Anatomy 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 108700025694 p53 Genes Proteins 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000037425 regulation of transcription Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 210000003556 vascular endothelial cell Anatomy 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Virology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002198941A JP3867968B2 (ja) | 2002-07-08 | 2002-07-08 | 腫瘍細胞において選択的に増殖する腫瘍融解ウイルス |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200500047B true ZA200500047B (en) | 2006-05-31 |
Family
ID=30112441
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200500047A ZA200500047B (en) | 2002-07-08 | 2005-01-04 | Tumor-lysing virus growing selectively in tumor cells |
Country Status (15)
Country | Link |
---|---|
US (1) | US20060239967A1 (da) |
EP (1) | EP1553178B1 (da) |
JP (1) | JP3867968B2 (da) |
KR (2) | KR100947194B1 (da) |
CN (1) | CN100430476C (da) |
AU (1) | AU2003281310B2 (da) |
CA (1) | CA2491907C (da) |
DK (1) | DK1553178T3 (da) |
ES (1) | ES2455127T3 (da) |
HK (1) | HK1082958A1 (da) |
NZ (1) | NZ537631A (da) |
PL (1) | PL374644A1 (da) |
PT (1) | PT1553178E (da) |
WO (1) | WO2004005511A1 (da) |
ZA (1) | ZA200500047B (da) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7473418B2 (en) | 2004-03-25 | 2009-01-06 | Cell Genesys, Inc. | Pan cancer oncolytic vectors and methods of use thereof |
EP1745801A1 (en) * | 2004-05-13 | 2007-01-24 | Daiichi Pharmaceutical Co., Ltd. | Method of inhibiting telomerase activity and inhibitor |
CN100361710C (zh) * | 2004-06-07 | 2008-01-16 | 成都康弘生物科技有限公司 | 肿瘤细胞专一表达免疫调节因子gm-csf的溶瘤性腺病毒重组体的构建及其应用 |
US7943373B2 (en) * | 2004-09-29 | 2011-05-17 | Oncolys Biopharma, Inc. | Telomelysin/GFP-expressing recombinant virus |
WO2006085689A1 (ja) * | 2005-02-10 | 2006-08-17 | Oncolys Biopharma, Inc. | テロメライシン併用抗癌剤 |
JP5069871B2 (ja) * | 2006-05-30 | 2012-11-07 | シスメックス株式会社 | 新規な癌細胞検出試料調製用キット及びそれを用いた癌細胞検出用キット |
WO2008065726A1 (fr) * | 2006-11-29 | 2008-06-05 | Oncolys Biopharma Inc. | Agent contenant du télomelysin destiné à rompre la tolérance anti-tumorale |
WO2008136213A1 (ja) * | 2007-04-27 | 2008-11-13 | Oncolys Biopharma Inc. | 放射線増感増強剤 |
US20090181931A1 (en) * | 2008-01-16 | 2009-07-16 | Oncolys Biopharma, Inc. | Antiviral activity of cidofovir against oncolytic viruses |
CN102257156A (zh) | 2008-12-18 | 2011-11-23 | 希森美康株式会社 | 血样中癌细胞的检测方法 |
JP6323978B2 (ja) | 2010-12-24 | 2018-05-16 | アークレイ株式会社 | 癌細胞の検出方法 |
CN106591368A (zh) * | 2016-10-12 | 2017-04-26 | 郑州大学 | 携带il‑15r/il‑15融合基因的b亚群腺病毒11载体及其构建和用途 |
US11617765B2 (en) | 2017-10-10 | 2023-04-04 | Yamaguchi University | Enhancer for T-cells or B-cells having memory function, malignant tumor recurrence inhibitor, and inducer for inducing memory function in T-cells or B-cells |
JPWO2020230838A1 (da) * | 2019-05-14 | 2020-11-19 | ||
BR112022007952A2 (pt) | 2019-10-28 | 2022-10-04 | Noile Immune Biotech Inc | Medicamento para tratar câncer, medicamento de combinação, composição de medicamento, célula imunorresponsiva, veículo de entrega de ácido nucleico e produto |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999020108A1 (en) * | 1997-10-23 | 1999-04-29 | Uab Research Foundation | Human papillomavirus vectors for the episomal transduction of host cells and method of making same |
CA2362367C (en) * | 1999-02-04 | 2004-08-03 | Geron Corporation | Telomerase reverse transcriptase transcriptional regulatory sequences |
US6692736B2 (en) * | 2000-03-24 | 2004-02-17 | Cell Genesys, Inc. | Cell-specific adenovirus vectors comprising an internal ribosome entry site |
ATE412058T1 (de) | 2000-03-24 | 2008-11-15 | Cell Genesys Inc | Interne ribosomenzugangsstelle-enthaltende zell- spezifische adenovirale vektoren |
IL152420A0 (en) * | 2001-02-23 | 2003-05-29 | Novartis Ag | Novel oncolytic adenoviral vectors |
CN1177042C (zh) * | 2001-04-12 | 2004-11-24 | 上海华康生物技术有限公司 | 共表达人p53基因和人细胞因子基因的重组腺病毒及其制法和用途 |
CN1195056C (zh) * | 2001-07-12 | 2005-03-30 | 钱其军 | 一种在肿瘤细胞中特异性增殖及高效表达抗癌基因的重组病毒及其构建方法 |
-
2002
- 2002-07-08 JP JP2002198941A patent/JP3867968B2/ja not_active Expired - Lifetime
-
2003
- 2003-07-07 KR KR1020097005916A patent/KR100947194B1/ko active IP Right Grant
- 2003-07-07 AU AU2003281310A patent/AU2003281310B2/en not_active Expired
- 2003-07-07 WO PCT/JP2003/008573 patent/WO2004005511A1/ja active Application Filing
- 2003-07-07 US US10/520,901 patent/US20060239967A1/en not_active Abandoned
- 2003-07-07 CN CNB038160641A patent/CN100430476C/zh not_active Expired - Lifetime
- 2003-07-07 CA CA2491907A patent/CA2491907C/en not_active Expired - Lifetime
- 2003-07-07 EP EP03741222.8A patent/EP1553178B1/en not_active Expired - Lifetime
- 2003-07-07 KR KR1020057000306A patent/KR20050075867A/ko not_active Application Discontinuation
- 2003-07-07 ES ES03741222.8T patent/ES2455127T3/es not_active Expired - Lifetime
- 2003-07-07 DK DK03741222.8T patent/DK1553178T3/da active
- 2003-07-07 NZ NZ537631A patent/NZ537631A/en not_active IP Right Cessation
- 2003-07-07 PT PT37412228T patent/PT1553178E/pt unknown
- 2003-07-07 PL PL03374644A patent/PL374644A1/xx not_active Application Discontinuation
-
2005
- 2005-01-04 ZA ZA200500047A patent/ZA200500047B/en unknown
-
2006
- 2006-03-03 HK HK06102821.5A patent/HK1082958A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2491907A1 (en) | 2004-01-15 |
DK1553178T3 (da) | 2014-05-19 |
PL374644A1 (en) | 2005-10-31 |
KR100947194B1 (ko) | 2010-03-11 |
JP2004033186A (ja) | 2004-02-05 |
AU2003281310A1 (en) | 2004-01-23 |
KR20050075867A (ko) | 2005-07-22 |
WO2004005511A1 (ja) | 2004-01-15 |
JP3867968B2 (ja) | 2007-01-17 |
ES2455127T3 (es) | 2014-04-14 |
US20060239967A1 (en) | 2006-10-26 |
HK1082958A1 (en) | 2006-06-23 |
KR20090043589A (ko) | 2009-05-06 |
CN1665927A (zh) | 2005-09-07 |
EP1553178B1 (en) | 2014-03-05 |
PT1553178E (pt) | 2014-06-12 |
CN100430476C (zh) | 2008-11-05 |
AU2003281310B2 (en) | 2008-02-21 |
CA2491907C (en) | 2013-03-19 |
EP1553178A1 (en) | 2005-07-13 |
NZ537631A (en) | 2007-05-31 |
EP1553178A4 (en) | 2006-03-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20240100106A1 (en) | Isolated recombinant oncolytic adenoviruses, pharmaceutical compositions, and uses thereof for drugs for treatment of tumors and/or cancers | |
EP3029144B1 (en) | Tumor-selective adenovirus e1a and e1b mutants | |
AU2003281310B2 (en) | Tumor-lysing virus growing selectively in tumor cells | |
US8709812B2 (en) | Drug comprising as the active ingredient proliferative vector containing survivin promoter | |
KR20190098215A (ko) | 무장된 복제-가능 종양 분해 아데노바이러스 | |
EP1196616B1 (en) | Replication-competent anti-cancer vectors | |
WO2012161352A1 (ja) | Reic発現アデノウイルスベクター | |
JP4327844B2 (ja) | 改善された癌細胞特異性と活性を有する変形されたテロメア逆転写酵素のプロモーターおよびこれを含む組み換えベクター | |
US8163892B2 (en) | Oncolytic virus replicating selectively in tumor cells | |
JP7406263B2 (ja) | 改変アデノウイルス及びこれを含む医薬 | |
JP2016160249A (ja) | 腫瘍溶解改変アデノウイルス、疾患治療用改変ウイルス及びこれらを含むウイルス製剤 | |
TW200533752A (en) | Pan cancer oncolytic vectors and methods of use thereof |