ZA200410011B - Carvedilol phosphate salts and/or solvates thereof, corresponding compositions, and/or methods of treatment - Google Patents

Carvedilol phosphate salts and/or solvates thereof, corresponding compositions, and/or methods of treatment

Info

Publication number
ZA200410011B
ZA200410011B ZA200410011A ZA200410011A ZA200410011B ZA 200410011 B ZA200410011 B ZA 200410011B ZA 200410011 A ZA200410011 A ZA 200410011A ZA 200410011 A ZA200410011 A ZA 200410011A ZA 200410011 B ZA200410011 B ZA 200410011B
Authority
ZA
South Africa
Prior art keywords
solvates
treatment
methods
phosphate salts
corresponding compositions
Prior art date
Application number
ZA200410011A
Other languages
English (en)
Inventor
Christopher S Brook
Wei Chen
Orco Philip C Dell
Lee M Katrincic
Ann M Diederich
Choon K Oh
Paul G Spoors
Christophe Werner
Original Assignee
Sb Pharmco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=30000823&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200410011(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sb Pharmco Inc filed Critical Sb Pharmco Inc
Publication of ZA200410011B publication Critical patent/ZA200410011B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56Ring systems containing three or more rings
    • C07D209/80[b, c]- or [b, d]-condensed
    • C07D209/82Carbazoles; Hydrogenated carbazoles
    • C07D209/88Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
ZA200410011A 2002-06-27 2004-12-10 Carvedilol phosphate salts and/or solvates thereof, corresponding compositions, and/or methods of treatment ZA200410011B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39217502P 2002-06-27 2002-06-27

Publications (1)

Publication Number Publication Date
ZA200410011B true ZA200410011B (en) 2006-07-26

Family

ID=30000823

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200410011A ZA200410011B (en) 2002-06-27 2004-12-10 Carvedilol phosphate salts and/or solvates thereof, corresponding compositions, and/or methods of treatment

Country Status (15)

Country Link
US (6) US7268156B2 (zh)
EP (1) EP1534270A4 (zh)
JP (3) JP2005533823A (zh)
KR (3) KR20110134952A (zh)
CN (6) CN103288714A (zh)
AU (1) AU2003248746B2 (zh)
BR (1) BR0312102A (zh)
CA (1) CA2492060C (zh)
EA (1) EA008384B1 (zh)
IL (1) IL165814A (zh)
MX (1) MXPA04012923A (zh)
NO (1) NO329710B1 (zh)
NZ (1) NZ537161A (zh)
WO (1) WO2004002419A2 (zh)
ZA (1) ZA200410011B (zh)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA02012795A (es) 2000-06-28 2004-07-30 Teva Pharma Carvedilol.
US8101209B2 (en) 2001-10-09 2012-01-24 Flamel Technologies Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
MXPA04006909A (es) 2002-01-15 2005-04-19 Teva Pharma Solidos cristalinos de carvedilol y procesos para su preparacion.
WO2003092622A2 (en) * 2002-04-30 2003-11-13 Sb Pharmco Puerto Rico Inc. Carvedilol monocitrate monohydrate
EA008384B1 (ru) * 2002-06-27 2007-04-27 Эс Би ФАРМКО ПУЭРТО РИКО ИНК. Фосфатные соли карведилола, их сольваты, композиции и способы лечения гипертензии, застойной сердечной недостаточности или стенокардии
WO2004002472A1 (en) 2002-06-27 2004-01-08 Sb Pharmco Puerto Rico Inc. Carvedilol hydrobromide
CN1694959B (zh) 2002-09-13 2013-09-18 雷普利瑟公司 非序列互补的抗病毒寡核苷酸
WO2005051383A1 (en) * 2003-11-25 2005-06-09 Sb Pharmco Puerto Rico Inc. Carvedilol salts, corresponding compositions, methods of delivery and/or treatment
JP2007512350A (ja) * 2003-11-25 2007-05-17 エスビー・ファルムコ・プエルト・リコ・インコーポレイテッド カルベジロール組成物の治療および送達方法
EP1691789B1 (en) * 2003-11-25 2017-12-20 SmithKline Beecham (Cork) Limited Carvedilol free base, salts, anhydrous forms or solvate thereof, corresponding pharmaceutical compositions, controlled release formulations, and treatment or delivery methods
WO2006135757A1 (en) * 2005-06-09 2006-12-21 Teva Pharmaceutical Industries Ltd. Crystalline forms of carvedilol and processes for their preparation
US8344159B2 (en) 2006-06-14 2013-01-01 Mylan Laboratories Limited Carvedilol phosphate sesquihydrate
EP1991527A2 (en) * 2006-06-28 2008-11-19 Teva Pharmaceutical Industries Ltd Polymorphous forms of carvedilol phosphate
US20080292695A1 (en) * 2006-12-01 2008-11-27 Kristin Arnold Carvedilol forms, compositions, and methods of preparation thereof
US20090028935A1 (en) * 2006-12-01 2009-01-29 Kristin Arnold Carvedilol forms, compositions, and methods of preparation thereof
WO2008084494A1 (en) * 2007-01-08 2008-07-17 Matrix Laboratories Limited Novel polymorphic forms of carvedilol dihydrogen phosphate and process for preparing the same
US20080207726A1 (en) * 2007-02-26 2008-08-28 Santiago Ini Process for the purification of carvedilol or its salts thereof
WO2008104990A1 (en) * 2007-02-27 2008-09-04 Lupin Limited Amorphous carvedilol dihydrogen phosphate
US20080249317A1 (en) * 2007-04-04 2008-10-09 Apotex Inc. Novel amorphous form of carvedilol phosphate and processes for the preparation thereof
WO2008142703A1 (en) * 2007-05-17 2008-11-27 Wanbury Limited A novel cost effective process for production of carvedilol phosphate
EP2014649A1 (en) * 2007-06-27 2009-01-14 Inke, S.A. Novel amorphous carvedilol dihydrogen phosphate
WO2009008009A1 (en) * 2007-07-11 2009-01-15 Lupin Limited Novel crystalline form b of carvedilol dihydrogen phosphate
US20100076047A1 (en) * 2007-08-20 2010-03-25 Sankar Reddy Budidet Amorphous 1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol phosphate salt
US8278461B2 (en) * 2007-08-21 2012-10-02 Lupin Limited Stable amorphous form of carvedilol dihydrogen phosphate with stabilizer
WO2009035535A2 (en) * 2007-09-07 2009-03-19 Scinopharm Taiwan Ltd. Method of crystallizing carvedilol phosphate and the product thereof
US20090111998A1 (en) * 2007-10-25 2009-04-30 Srinivas Reddy Gade Process for the preparation of carvedilol dihydrogen phosphate hemihydrate and pharmaceutical compositions thereof
WO2009122425A1 (en) * 2008-04-04 2009-10-08 Shodhana Laboratories Limited Novel crystalline form of carvedilol dihydrogen phosphate and related processes
US7763645B2 (en) * 2008-05-23 2010-07-27 Wanbury Limited Carvedilol dihydrogen phosphate monohydrate
CN101891671B (zh) * 2010-07-26 2012-06-27 天津大学 一种卡维地洛磷酸二氢盐的晶体及其制备方法
US8492426B1 (en) 2012-07-12 2013-07-23 Anis Ahmad Use of carvedilol for treatment of diabetes mellitus
CN106892858A (zh) * 2015-12-21 2017-06-27 上海科胜药物研发有限公司 一种卡维地洛磷酸二氢盐新晶型
US10357476B1 (en) 2018-10-30 2019-07-23 Anis Ahmad Method for treating coronary artery disease
CN110279662A (zh) * 2019-06-05 2019-09-27 合肥合源药业有限公司 一种难溶性药物卡维地洛的固体分散体及制备方法和应用
US10772869B1 (en) 2019-07-24 2020-09-15 ECI Pharmaceuticals, LLC Pharmaceutical compositions including carvedilol and methods of using the same

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2815926A1 (de) * 1978-04-13 1979-10-18 Boehringer Mannheim Gmbh Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4053067A (en) * 1973-06-25 1977-10-11 Westinghouse Electric Corporation Fuel transfer system for a nuclear reactor
DE3319027A1 (de) * 1983-05-26 1984-11-29 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur herstellung von optisch aktiven carbazol-derivaten, neue r- und s-carbazol-derivate, sowie arzneimittel, die diese verbindungen enthalten
US4985464A (en) 1984-05-23 1991-01-15 Rudolf Happle Drug compositions for local treatment of alopecia areata
US5405863A (en) * 1992-12-01 1995-04-11 Smithkline Beecham Corporation Antioxidant cardioprotective use of, and method of treatment using, hydroxycarbazole compounds
US5308862A (en) * 1993-03-05 1994-05-03 Boehringer Mannheim Pharmaceuticals Corporation - Smithkline Beecham Corp., Ltd. Partnership No. 1 Use of, and method of treatment using, carbazolyl-(4)-oxypropanolamine compounds for inhibition of smooth muscle cell proliferation
US5393772A (en) * 1993-11-24 1995-02-28 Boehringer Mannheim Pharmaceuticals Corporation Use of, and method of treatment using, hydroxycarbazole compounds for inhibition of smooth muscle migration and proliferation
US5760069A (en) * 1995-02-08 1998-06-02 Boehringer Mannheim Pharmaceuticals Corporation-Smithkline Beecham Corporation Limited Partnership #1 Method of treatment for decreasing mortality resulting from congestive heart failure
US20010011099A1 (en) 1995-05-30 2001-08-02 Smithkline Beecham Corporation Antioxidant neuroprotective use of, and method of treatment using, hydroxycarbazole compounds
EP0910374A1 (de) 1996-07-13 1999-04-28 Roche Diagnostics GmbH Topisch einsetzbare pharmazeutische formulierungen enthaltend als wirkstoff ein carbazolyl-(4)-oxy-propanolamin-derivat
HUP9904243A3 (en) * 1996-08-23 2001-09-28 Boehringer Mannheim Pharm Corp Method for inhibiting the expression of fas
TR199900762T2 (xx) * 1996-10-09 1999-07-21 Boehringer Mannheim Pharmaceuticals Cor.Smithkline Beecham Stresle aktifle�tirilen protein kinazlar�n�n engellenme y�ntemi.
US6730326B2 (en) * 1997-07-22 2004-05-04 Roche Diagnostics Gmbh Thermodynamically stable modification of 1-(4-carbazolyl-oxy-3[2-(2-methoxyphenoxy)-ethylamino]-2-propanol process for its preparation and pharmaceutical compositions containing it
EP0893440A1 (en) * 1997-07-22 1999-01-27 Roche Diagnostics GmbH Thermodynamically stable modification of 1-(4-carbazolyloxy)-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanole, process for its preparation and pharmaceutical compositions containing it
GT199800126A (es) * 1997-08-29 2000-01-29 Terapia de combinacion.
ZA989365B (en) * 1997-10-15 1999-04-15 Boehringer Mannheim Pharm Corp Preparation for treating alzheimer's disease
US20020054911A1 (en) 2000-05-11 2002-05-09 Boehringer Mannheim Pharmaceutical Corporation-Sm Ithkline Beckman Corporation, Limited Partnershi Novel oral dosage form for carvedilol
US6541479B1 (en) * 1997-12-02 2003-04-01 Massachusetts College Of Pharmacy Calcium channel blockers
US6852337B2 (en) * 1998-04-09 2005-02-08 Roche Diagnostics Gmbh Carvedilol-galenics
AU3522399A (en) 1998-04-09 1999-11-01 Roche Diagnostics Gmbh Carvedilol-galenics
DE19833119A1 (de) 1998-07-23 2000-01-27 Roche Diagnostics Gmbh Spritzfertige Injektionslösungen enthaltend Carvedilol
US6664284B2 (en) * 1998-07-23 2003-12-16 Roche Diagnostics Gmbh Stabilized carvedilol injection solution
PE20001302A1 (es) 1998-11-27 2000-11-30 Hoffmann La Roche Preparaciones de una combinacion farmaceutica que contiene carvedilol e hidroclorotiazida
CA2392085A1 (en) * 1999-11-15 2001-05-25 Smithkline Beecham Corporation Carvedilol methanesulfonate
EP1106210A3 (en) * 1999-12-07 2003-12-03 Pfizer Products Inc. Combination of aldose reductase inhibitors and antihypertensive agents for the treatment of diabetic complications
US20010036959A1 (en) * 2000-04-03 2001-11-01 Gabel Rolf Dieter Carvedilol-hydrophilic solutions
JP2003528914A (ja) 2000-04-03 2003-09-30 エフ.ホフマン−ラ ロシュ アーゲー カルベジロールの濃縮溶液
AU5066101A (en) * 2000-04-13 2001-10-30 Synthon B.V. Modified release formulations containing a hypnotic agent
DK174645B1 (da) * 2000-05-18 2003-08-04 Gea Farmaceutisk Fabrik As Fremgangsmåde og mellemprodukter til fremstillingen af 1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxy-phenoxy)-ethylamino]-propan-2-ol, carvedilol og syreadditionssalte deraf
MXPA02012795A (es) * 2000-06-28 2004-07-30 Teva Pharma Carvedilol.
US20020099013A1 (en) * 2000-11-14 2002-07-25 Thomas Piccariello Active agent delivery systems and methods for protecting and administering active agents
JP2004525941A (ja) 2001-04-02 2004-08-26 スミスクライン・ビーチャム・コーポレイション 治療方法
IN191028B (zh) 2001-05-17 2003-09-13 Sun Pharmaceutical Ind Ltd
FI20011464A0 (fi) 2001-07-04 2001-07-04 Orion Corp Yhdistelmäterapia sydämen vajaatoiminnan hoitoon
US20050019399A1 (en) 2001-09-21 2005-01-27 Gina Fischer Controlled release solid dispersions
WO2003024429A1 (en) 2001-09-21 2003-03-27 Egalet A/S Polymer release system
DE60221683T2 (de) 2001-09-28 2008-04-30 F. Hoffmann-La Roche Ag Pseudopolymorphe formen von carvedilol
WO2003028718A1 (en) 2001-10-01 2003-04-10 Smithkline Beecham Corporation Novel formulations of carvedilol
WO2003028645A2 (en) 2001-10-01 2003-04-10 Smithkline Beecham Corporation Novel compositions of carvedilol
JP2005504815A (ja) 2001-10-02 2005-02-17 スミスクライン・ビーチャム・コーポレイション カルベジロールの新規組成物
US20040019096A1 (en) 2001-10-23 2004-01-29 Vlassios Andronis Novel formulations of carvedilol
MXPA04006909A (es) * 2002-01-15 2005-04-19 Teva Pharma Solidos cristalinos de carvedilol y procesos para su preparacion.
WO2003092622A2 (en) 2002-04-30 2003-11-13 Sb Pharmco Puerto Rico Inc. Carvedilol monocitrate monohydrate
EA008384B1 (ru) * 2002-06-27 2007-04-27 Эс Би ФАРМКО ПУЭРТО РИКО ИНК. Фосфатные соли карведилола, их сольваты, композиции и способы лечения гипертензии, застойной сердечной недостаточности или стенокардии
US20040152756A1 (en) 2002-07-15 2004-08-05 Wei Chen Carvedilol polymorph
JP2005533846A (ja) 2002-07-22 2005-11-10 ナノハイブリッド カンパニー リミテッド イトラコナゾール、シクロスポリン、またはカルベジロールと層状型珪酸塩との混成体及びその製造方法
ES2204303B2 (es) * 2002-08-07 2004-12-16 Laboratorios Vita, S.A. Procedimiento para la obtencion de un compuesto farmaceuticamente activo.
WO2004016249A1 (en) 2002-08-14 2004-02-26 Ranbaxy Laboratories Limited Extended release matrix tablets
WO2004041252A1 (en) 2002-11-08 2004-05-21 Egalet A/S Controlled release carvedilol compositions
WO2004056336A2 (en) 2002-12-20 2004-07-08 Ranbaxy Laboratories Limited Controlled release, multiple unit drug delivery systems
JP2007512350A (ja) 2003-11-25 2007-05-17 エスビー・ファルムコ・プエルト・リコ・インコーポレイテッド カルベジロール組成物の治療および送達方法
WO2005051383A1 (en) 2003-11-25 2005-06-09 Sb Pharmco Puerto Rico Inc. Carvedilol salts, corresponding compositions, methods of delivery and/or treatment
EP1691789B1 (en) 2003-11-25 2017-12-20 SmithKline Beecham (Cork) Limited Carvedilol free base, salts, anhydrous forms or solvate thereof, corresponding pharmaceutical compositions, controlled release formulations, and treatment or delivery methods

Also Published As

Publication number Publication date
KR101468827B1 (ko) 2014-12-03
KR20140006111A (ko) 2014-01-15
EP1534270A4 (en) 2006-05-17
CN101898995A (zh) 2010-12-01
NO20050427L (no) 2005-01-25
KR20110134952A (ko) 2011-12-15
JP2011088917A (ja) 2011-05-06
JP2005533823A (ja) 2005-11-10
CA2492060A1 (en) 2004-01-08
US20070244181A1 (en) 2007-10-18
CA2492060C (en) 2011-11-01
CN103288715A (zh) 2013-09-11
NO329710B1 (no) 2010-12-06
IL165814A0 (en) 2006-01-15
US20070259940A1 (en) 2007-11-08
US7893100B2 (en) 2011-02-22
JP5422545B2 (ja) 2014-02-19
US7759384B2 (en) 2010-07-20
EP1534270A2 (en) 2005-06-01
US7902378B2 (en) 2011-03-08
WO2004002419A2 (en) 2004-01-08
US20080262069A1 (en) 2008-10-23
CN103254114A (zh) 2013-08-21
CN103288714A (zh) 2013-09-11
US7626041B2 (en) 2009-12-01
BR0312102A (pt) 2007-05-29
EA200500091A1 (ru) 2005-10-27
EA008384B1 (ru) 2007-04-27
CN101898995B (zh) 2013-05-01
AU2003248746A1 (en) 2004-01-19
US20070244182A1 (en) 2007-10-18
NZ537161A (en) 2007-09-28
CN1678305A (zh) 2005-10-05
US7268156B2 (en) 2007-09-11
US20050240027A1 (en) 2005-10-27
MXPA04012923A (es) 2005-03-31
CN103333099A (zh) 2013-10-02
AU2003248746B2 (en) 2009-01-08
JP2013241450A (ja) 2013-12-05
US20070238774A1 (en) 2007-10-11
IL165814A (en) 2012-05-31
KR20130042047A (ko) 2013-04-25
WO2004002419A3 (en) 2004-06-03

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