ZA200408768B - Fusions of cytokines and tumor targeting proteins - Google Patents
Fusions of cytokines and tumor targeting proteins Download PDFInfo
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- ZA200408768B ZA200408768B ZA200408768A ZA200408768A ZA200408768B ZA 200408768 B ZA200408768 B ZA 200408768B ZA 200408768 A ZA200408768 A ZA 200408768A ZA 200408768 A ZA200408768 A ZA 200408768A ZA 200408768 B ZA200408768 B ZA 200408768B
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Classifications
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/57—IFN-gamma
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
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- Biophysics (AREA)
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- Engineering & Computer Science (AREA)
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- Animal Behavior & Ethology (AREA)
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- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
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GBGB0209893.7A GB0209893D0 (en) | 2002-04-30 | 2002-04-30 | Conjugate |
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ZA200408768B true ZA200408768B (en) | 2007-03-28 |
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ZA200408768A ZA200408768B (en) | 2002-04-30 | 2004-10-29 | Fusions of cytokines and tumor targeting proteins |
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Country | Link |
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US (1) | US20050074426A1 (ru) |
EP (1) | EP1499362A1 (ru) |
JP (1) | JP2005525115A (ru) |
KR (1) | KR20050003400A (ru) |
CN (2) | CN100457189C (ru) |
AU (1) | AU2003236969A1 (ru) |
CA (1) | CA2484425A1 (ru) |
EA (2) | EA200800386A1 (ru) |
GB (1) | GB0209893D0 (ru) |
IL (1) | IL164897A0 (ru) |
NO (1) | NO20045236L (ru) |
WO (1) | WO2003092737A1 (ru) |
ZA (1) | ZA200408768B (ru) |
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EP2286843A3 (en) | 2000-06-02 | 2011-08-03 | Bracco Suisse SA | Compounds for targeting endothelial cells |
US8263739B2 (en) | 2000-06-02 | 2012-09-11 | Bracco Suisse Sa | Compounds for targeting endothelial cells, compositions containing the same and methods for their use |
WO2005094383A2 (en) * | 2004-03-31 | 2005-10-13 | Buck Institute | Hunter-killer peptides and methods of use |
EP2364995A1 (en) | 2004-12-23 | 2011-09-14 | Molmed SpA | Conjugation product |
AU2006227133A1 (en) * | 2005-03-22 | 2006-09-28 | Georgetown University | Delivery systems and methods for diagnosing and treating cardiovascular diseases |
CN102539734B (zh) * | 2005-05-12 | 2016-02-03 | 清华大学 | 核仁素辅助的癌症诊断与治疗方法 |
PL3263581T3 (pl) | 2005-05-17 | 2021-05-04 | University Of Connecticut | Kompozycje i sposoby immunomodulacji w organizmie |
GB0708864D0 (en) * | 2007-05-08 | 2007-06-13 | Molmed Spa | Cytokine Conjugate |
WO2008151819A2 (en) * | 2007-06-15 | 2008-12-18 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Treatment of tumors using specific anti-l1 antibody |
NZ599338A (en) | 2007-06-27 | 2013-11-29 | Marinepolymer Tech Inc | Complexes of il-15 and il-15ralpha and uses thereof |
GB0803076D0 (en) * | 2008-02-20 | 2008-03-26 | Univ Ghent | Mucosal Membrane Receptor and uses thereof |
AU2008201871A1 (en) * | 2008-04-16 | 2009-11-26 | Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts | Inhibition of angiogenesis and tumor metastasis |
CA2723823C (en) * | 2008-05-13 | 2012-10-16 | Molmed S.P.A. | Conjugates for the treatment of mesothelioma |
US20120107270A1 (en) * | 2009-06-30 | 2012-05-03 | Manuela Kaspar | Immunocytokines In Combination With Anti-ErbB Antibodies For The Treatment Of Cancer |
US9526251B2 (en) | 2010-02-25 | 2016-12-27 | Marrone Bio Innovations, Inc. | Use of Burkholderia formulations, compositions and compounds to modulate crop yield and/or corn rootworm infestation |
US8822193B2 (en) | 2010-02-25 | 2014-09-02 | Marrone Bio Innovations, Inc. | Isolated bacterial strain of the genus Burkholderia and pesticidal metabolites therefrom |
CN102260352B (zh) * | 2010-05-28 | 2013-11-20 | 山东先声麦得津生物制药有限公司 | 靶向性白细胞介素融合蛋白及其制备方法与应用 |
WO2013158962A1 (en) * | 2012-04-19 | 2013-10-24 | The Board Of Trustees Of The Leland Stanford Junior University | Imaging-aided gene therapy using mesenchymal stem cells as target-delivery vehicle |
US9119401B2 (en) | 2012-10-19 | 2015-09-01 | Marrone Bio Innovations, Inc. | Plant glutamine synthetase inhibitors and methods for their identification |
CN104177500B (zh) * | 2013-05-24 | 2018-05-25 | 江苏靶标生物医药研究所有限公司 | 一种肿瘤坏死因子相关凋亡配体融合蛋白及其制法和用途 |
CA2918363C (en) * | 2013-07-19 | 2021-12-14 | Centre Hospitalier Regional Universitaire De Montpellier | Targeted modified tnf family members |
KR102554634B1 (ko) | 2014-09-30 | 2023-07-11 | 도이체스크레브스포르슝스젠트룸스티프퉁데스외펜트리헨레크츠 | L1cam에 결합하는 신규한 결합 분자 특히 항체(cd171) |
GB201419184D0 (en) | 2014-10-28 | 2014-12-10 | Adc Biotechnology Ltd | Method of synthesising biomolecule-effector/reporter-conjugates using affinity resins |
CN104403004B (zh) * | 2014-11-24 | 2017-10-13 | 苏州丁孚靶点生物技术有限公司 | 抗体‑干扰素异二聚体的制备和用途 |
CN106380521B (zh) * | 2015-07-02 | 2020-12-29 | 博际生物医药科技(杭州)有限公司 | 用于肿瘤靶向治疗的白细胞介素-15融合蛋白 |
US11571480B2 (en) | 2015-08-11 | 2023-02-07 | Coherent Biopharma I, Limited | Multi-ligand drug conjugates and uses thereof |
CN105218682B (zh) * | 2015-10-26 | 2019-05-07 | 杨晶 | 经il-12/cd62l融合蛋白改造的肿瘤治疗剂及其制法和用途 |
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CN105585637B (zh) * | 2015-12-23 | 2020-04-03 | 杨晶 | 基于il-12稳定膜表达的肿瘤治疗剂及其制法和用途 |
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EP1499362A1 (en) | 2005-01-26 |
CA2484425A1 (en) | 2003-11-13 |
WO2003092737A1 (en) | 2003-11-13 |
AU2003236969A1 (en) | 2003-11-17 |
EA200401447A1 (ru) | 2005-08-25 |
GB0209893D0 (en) | 2002-06-05 |
NO20045236L (no) | 2005-01-31 |
EA009955B1 (ru) | 2008-04-28 |
CN1665543A (zh) | 2005-09-07 |
CN100457189C (zh) | 2009-02-04 |
US20050074426A1 (en) | 2005-04-07 |
IL164897A0 (en) | 2005-12-18 |
CN101433722A (zh) | 2009-05-20 |
JP2005525115A (ja) | 2005-08-25 |
KR20050003400A (ko) | 2005-01-10 |
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