ZA200404113B - Methods for treating cancer using a combination of a tumor-derived dendritic cell inhibitory factor antagonist and a toll-like receptor agonist - Google Patents
Methods for treating cancer using a combination of a tumor-derived dendritic cell inhibitory factor antagonist and a toll-like receptor agonistInfo
- Publication number
- ZA200404113B ZA200404113B ZA200404113A ZA200404113A ZA200404113B ZA 200404113 B ZA200404113 B ZA 200404113B ZA 200404113 A ZA200404113 A ZA 200404113A ZA 200404113 A ZA200404113 A ZA 200404113A ZA 200404113 B ZA200404113 B ZA 200404113B
- Authority
- ZA
- South Africa
- Prior art keywords
- toll
- tumor
- methods
- combination
- treating cancer
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Nanotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33343401P | 2001-11-27 | 2001-11-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200404113B true ZA200404113B (en) | 2006-03-29 |
Family
ID=23302758
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200404113A ZA200404113B (en) | 2001-11-27 | 2004-05-26 | Methods for treating cancer using a combination of a tumor-derived dendritic cell inhibitory factor antagonist and a toll-like receptor agonist |
Country Status (14)
Country | Link |
---|---|
US (2) | US20030138413A1 (ja) |
EP (1) | EP1450858A2 (ja) |
JP (3) | JP2006502080A (ja) |
CN (1) | CN1617742B (ja) |
AU (1) | AU2002359516B2 (ja) |
BR (1) | BR0214457A (ja) |
CA (1) | CA2468320A1 (ja) |
HU (1) | HUP0500999A2 (ja) |
MX (1) | MXPA04004998A (ja) |
NO (1) | NO20042697L (ja) |
NZ (1) | NZ565420A (ja) |
TW (1) | TW200303759A (ja) |
WO (1) | WO2003045431A2 (ja) |
ZA (1) | ZA200404113B (ja) |
Families Citing this family (76)
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US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
EP1733735B1 (en) | 1998-05-22 | 2017-03-22 | Ottawa Hospital Research Institute | Methods and products for inducing mucosal immunity |
US6977245B2 (en) | 1999-04-12 | 2005-12-20 | The United States Of America As Represented By The Department Of Health And Human Services | Oligodeoxynucleotide and its use to induce an immune response |
EP1311288A1 (en) * | 2000-01-20 | 2003-05-21 | Ottawa Health Research Institute | Immunostimulatory nucleic acids for inducing a th2 immune response |
US20040175355A1 (en) * | 2001-04-18 | 2004-09-09 | The Regents Of The University Of California | Methods of using secondary lymphoid organ chemokine to modulate physiological processes in mammals |
US7666674B2 (en) | 2001-07-27 | 2010-02-23 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of sterically stabilized cationic liposomes to efficiently deliver CPG oligonucleotides in vivo |
WO2003020884A2 (en) * | 2001-08-14 | 2003-03-13 | The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services | Method for rapid generation of mature dendritic cells |
CA2492826C (en) | 2001-09-14 | 2016-12-13 | Cytos Biotechnology Ag | Encapsulation of unmethylated cpg-containing oligonucleotides into virus-like particles: method of preparation and use |
US7615227B2 (en) * | 2001-12-20 | 2009-11-10 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of CpG oligodeoxynucleotides to induce angiogenesis |
US8466116B2 (en) | 2001-12-20 | 2013-06-18 | The Unites States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of CpG oligodeoxynucleotides to induce epithelial cell growth |
US8263091B2 (en) * | 2002-09-18 | 2012-09-11 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method of treating and preventing infections in immunocompromised subjects with immunostimulatory CpG oligonucleotides |
EP1578954A4 (en) | 2002-12-11 | 2010-08-11 | Coley Pharm Group Inc | 5'-CPG NUCLEIC ACIDS AND USE METHOD |
WO2004060319A2 (en) * | 2002-12-30 | 2004-07-22 | 3M Innovative Properties Company | Immunostimulatory combinations |
CA2516028C (en) * | 2003-02-14 | 2012-10-16 | University Of Southern California | Conjugates comprising a cancer targeting molecule linked to a liver-expressed chemokine |
US7537767B2 (en) | 2003-03-26 | 2009-05-26 | Cytis Biotechnology Ag | Melan-A- carrier conjugates |
EP1646427A1 (en) * | 2003-07-22 | 2006-04-19 | Cytos Biotechnology AG | Cpg-packaged liposomes |
CN107090034B (zh) * | 2004-01-07 | 2021-10-01 | 诺华疫苗和诊断公司 | M-csf特异性单克隆抗体及其应用 |
TW200533750A (en) * | 2004-02-19 | 2005-10-16 | Coley Pharm Group Inc | Immunostimulatory viral RNA oligonucleotides |
US7868158B2 (en) * | 2004-07-19 | 2011-01-11 | Baylor College Of Medicine | Modulation of cytokine signaling regulators and applications for immunotherapy |
US20060147456A1 (en) * | 2004-07-20 | 2006-07-06 | Serge Lebecque | Induction of apoptosis in toll-like receptor expressing tumor cells |
US20080274140A1 (en) * | 2004-11-19 | 2008-11-06 | David B Weiner | Vaccines and Methods for Using the Same |
WO2006077724A1 (ja) * | 2004-12-28 | 2006-07-27 | Immuno Frontier, Inc. | がんワクチン製剤 |
EP1712241A1 (en) | 2005-04-15 | 2006-10-18 | Centre National De La Recherche Scientifique (Cnrs) | Composition for treating cancer adapted for intra-tumoral administration and uses thereof |
US20100143899A1 (en) * | 2005-05-17 | 2010-06-10 | University Of Vermont And State Agricultural College | Methods and products for diagnosing cancer |
CN101501055B (zh) * | 2005-06-23 | 2016-05-11 | 贝勒医学院 | 负性免疫调节因子的调节和免疫疗法应用 |
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EP2316483A1 (en) * | 2005-12-01 | 2011-05-04 | The Provost Fellows And Scholars Of The College Of The Holy and Undivided Trinity Of Queen Elizabeth Near Dublin | Compositions and methods relating to the treatment of cancer and infectious diseases |
EP1973608A1 (en) | 2005-12-14 | 2008-10-01 | Cytos Biotechnology AG | Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity |
KR101552227B1 (ko) | 2006-06-12 | 2015-09-10 | 사이토스 바이오테크놀로지 아게 | 올리고뉴클레오티드를 rna 박테리오파지의 바이러스-유사 입자로 패키징하는 방법 |
DE102006035618A1 (de) * | 2006-07-31 | 2008-02-07 | Curevac Gmbh | Nukleinsäure der Formel (I): GlXmGn, insbesondere als immunstimulierendes Adjuvanz |
US20080124366A1 (en) * | 2006-08-06 | 2008-05-29 | Ohlfest John R | Methods and Compositions for Treating Tumors |
US20090074711A1 (en) * | 2006-09-07 | 2009-03-19 | University Of Southhampton | Human therapies using chimeric agonistic anti-human cd40 antibody |
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WO2008134020A1 (en) * | 2007-04-26 | 2008-11-06 | University Of Vermont And State Agricultural College | Ccl18 and ccl3 methods and compositions for detecting and treating cancer |
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BR112015027327B1 (pt) | 2013-04-29 | 2022-08-02 | Rutgers, The State University Of New Jersey | Composto, modulador de cgas, composição farmacêutica compreendendo o referido composto ou modulador |
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JP7420751B2 (ja) * | 2018-06-19 | 2024-01-23 | エイチ リー モフィット キャンサー センター アンド リサーチ インスティテュート インコーポレイテッド | I型インターフェロン及びcd40-配位子を用いる腫瘍溶解性ウイルス又は抗原提示細胞媒介性癌治療 |
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AUPM322393A0 (en) * | 1993-12-24 | 1994-01-27 | Austin Research Institute, The | Mucin carbohydrate compounds and their use in immunotherapy |
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ATE356630T1 (de) * | 1998-04-03 | 2007-04-15 | Univ Iowa Res Found | Verfahren und produkte zur stimulierung des immunsystems mittels immunotherapeutischer oligonukleotide und zytokine |
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EP1261366A4 (en) * | 2000-02-24 | 2003-06-18 | Univ Leland Stanford Junior | ADJUVANT TREATMENT BY ACTIVATING DENDRITIC CELLS IN VIVO |
CA2404365A1 (en) * | 2000-03-31 | 2001-10-11 | Idec Pharmaceutical Corporation | Combined use of anti-cytokine antibodies or antagonists and anti-cd20 for the treatment of b cell lymphoma |
-
2002
- 2002-11-25 TW TW091134176A patent/TW200303759A/zh unknown
- 2002-11-26 AU AU2002359516A patent/AU2002359516B2/en not_active Ceased
- 2002-11-26 HU HU0500999A patent/HUP0500999A2/hu unknown
- 2002-11-26 JP JP2003546932A patent/JP2006502080A/ja active Pending
- 2002-11-26 CN CN028275985A patent/CN1617742B/zh not_active Expired - Fee Related
- 2002-11-26 WO PCT/US2002/038098 patent/WO2003045431A2/en active IP Right Grant
- 2002-11-26 NZ NZ565420A patent/NZ565420A/en not_active IP Right Cessation
- 2002-11-26 MX MXPA04004998A patent/MXPA04004998A/es unknown
- 2002-11-26 CA CA002468320A patent/CA2468320A1/en not_active Abandoned
- 2002-11-26 US US10/304,616 patent/US20030138413A1/en not_active Abandoned
- 2002-11-26 BR BRPI0214457-3A patent/BR0214457A/pt not_active IP Right Cessation
- 2002-11-26 EP EP02794058A patent/EP1450858A2/en not_active Withdrawn
-
2004
- 2004-05-26 ZA ZA200404113A patent/ZA200404113B/xx unknown
- 2004-06-25 NO NO20042697A patent/NO20042697L/no not_active Application Discontinuation
-
2005
- 2005-11-18 JP JP2005334633A patent/JP2006131638A/ja active Pending
-
2008
- 2008-09-19 US US12/234,361 patent/US20090087440A1/en not_active Abandoned
-
2009
- 2009-12-01 JP JP2009274004A patent/JP2010053140A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
CA2468320A1 (en) | 2003-06-05 |
US20090087440A1 (en) | 2009-04-02 |
WO2003045431A2 (en) | 2003-06-05 |
HUP0500999A2 (en) | 2007-11-28 |
WO2003045431A3 (en) | 2004-01-22 |
CN1617742A (zh) | 2005-05-18 |
NO20042697L (no) | 2004-06-25 |
MXPA04004998A (es) | 2005-04-08 |
CN1617742B (zh) | 2010-10-27 |
JP2006502080A (ja) | 2006-01-19 |
JP2010053140A (ja) | 2010-03-11 |
AU2002359516A1 (en) | 2003-06-10 |
JP2006131638A (ja) | 2006-05-25 |
NZ565420A (en) | 2009-09-25 |
AU2002359516B2 (en) | 2006-02-02 |
US20030138413A1 (en) | 2003-07-24 |
BR0214457A (pt) | 2006-11-21 |
TW200303759A (en) | 2003-09-16 |
EP1450858A2 (en) | 2004-09-01 |
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