ZA200403903B - Method for detecting analyte(s) using magnetic collodial particles. - Google Patents
Method for detecting analyte(s) using magnetic collodial particles. Download PDFInfo
- Publication number
- ZA200403903B ZA200403903B ZA200403903A ZA200403903A ZA200403903B ZA 200403903 B ZA200403903 B ZA 200403903B ZA 200403903 A ZA200403903 A ZA 200403903A ZA 200403903 A ZA200403903 A ZA 200403903A ZA 200403903 B ZA200403903 B ZA 200403903B
- Authority
- ZA
- South Africa
- Prior art keywords
- analyte
- particles
- magnetic
- colloidal particles
- magnetic field
- Prior art date
Links
- 239000002245 particle Substances 0.000 title claims description 81
- 230000005291 magnetic effect Effects 0.000 title claims description 72
- 239000012491 analyte Substances 0.000 title claims description 53
- 238000000034 method Methods 0.000 title claims description 52
- 239000003446 ligand Substances 0.000 claims description 30
- 239000000427 antigen Substances 0.000 claims description 24
- 102000036639 antigens Human genes 0.000 claims description 24
- 108091007433 antigens Proteins 0.000 claims description 24
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 10
- 239000006249 magnetic particle Substances 0.000 claims description 10
- 239000011554 ferrofluid Substances 0.000 claims description 8
- 230000003993 interaction Effects 0.000 claims description 8
- 108010090804 Streptavidin Proteins 0.000 claims description 7
- 229960002685 biotin Drugs 0.000 claims description 7
- 239000011616 biotin Substances 0.000 claims description 7
- 239000003153 chemical reaction reagent Substances 0.000 claims description 7
- 235000020958 biotin Nutrition 0.000 claims description 6
- 238000012512 characterization method Methods 0.000 claims description 5
- 102000004169 proteins and genes Human genes 0.000 claims description 5
- 150000001720 carbohydrates Chemical class 0.000 claims description 4
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- 108090001008 Avidin Proteins 0.000 claims description 2
- 241000894006 Bacteria Species 0.000 claims description 2
- 108010039209 Blood Coagulation Factors Proteins 0.000 claims description 2
- 102000015081 Blood Coagulation Factors Human genes 0.000 claims description 2
- 108010017384 Blood Proteins Proteins 0.000 claims description 2
- 102000004506 Blood Proteins Human genes 0.000 claims description 2
- 102000003886 Glycoproteins Human genes 0.000 claims description 2
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- 206010028980 Neoplasm Diseases 0.000 claims description 2
- 241000700605 Viruses Species 0.000 claims description 2
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- 239000003114 blood coagulation factor Substances 0.000 claims description 2
- 235000014633 carbohydrates Nutrition 0.000 claims description 2
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- 239000007850 fluorescent dye Substances 0.000 claims description 2
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- 239000000243 solution Substances 0.000 description 17
- 238000001514 detection method Methods 0.000 description 15
- 238000003556 assay Methods 0.000 description 14
- 230000004520 agglutination Effects 0.000 description 13
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 9
- 238000007818 agglutination assay Methods 0.000 description 7
- 230000015572 biosynthetic process Effects 0.000 description 7
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- 238000001000 micrograph Methods 0.000 description 7
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- 241000894007 species Species 0.000 description 7
- LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide Chemical compound CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 description 6
- 239000000872 buffer Substances 0.000 description 5
- 235000013980 iron oxide Nutrition 0.000 description 5
- 239000000696 magnetic material Substances 0.000 description 5
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- 230000004523 agglutinating effect Effects 0.000 description 3
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- 238000006243 chemical reaction Methods 0.000 description 3
- 239000000084 colloidal system Substances 0.000 description 3
- 210000002381 plasma Anatomy 0.000 description 3
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- 238000003756 stirring Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 238000002965 ELISA Methods 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 229920001213 Polysorbate 20 Polymers 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
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- 238000005516 engineering process Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 2
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
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- 239000004094 surface-active agent Substances 0.000 description 2
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 241001415846 Procellariidae Species 0.000 description 1
- WGLPBDUCMAPZCE-UHFFFAOYSA-N Trioxochromium Chemical compound O=[Cr](=O)=O WGLPBDUCMAPZCE-UHFFFAOYSA-N 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 150000001615 biotins Chemical class 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 1
- 239000013626 chemical specie Substances 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 229910000423 chromium oxide Inorganic materials 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- IVMYJDGYRUAWML-UHFFFAOYSA-N cobalt(ii) oxide Chemical class [Co]=O IVMYJDGYRUAWML-UHFFFAOYSA-N 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001739 density measurement Methods 0.000 description 1
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- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 description 1
- 238000001502 gel electrophoresis Methods 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 230000036046 immunoreaction Effects 0.000 description 1
- VBMVTYDPPZVILR-UHFFFAOYSA-N iron(2+);oxygen(2-) Chemical class [O-2].[Fe+2] VBMVTYDPPZVILR-UHFFFAOYSA-N 0.000 description 1
- SZVJSHCCFOBDDC-UHFFFAOYSA-N iron(II,III) oxide Inorganic materials O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 238000007885 magnetic separation Methods 0.000 description 1
- 230000005415 magnetization Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 229910000480 nickel oxide Inorganic materials 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- GNRSAWUEBMWBQH-UHFFFAOYSA-N oxonickel Chemical compound [Ni]=O GNRSAWUEBMWBQH-UHFFFAOYSA-N 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
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- 229920001059 synthetic polymer Polymers 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 229910000859 α-Fe Inorganic materials 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
- G01N33/5434—Magnetic particles using magnetic particle immunoreagent carriers which constitute new materials per se
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54346—Nanoparticles
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Nanotechnology (AREA)
- Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0115011A FR2832507B1 (fr) | 2001-11-20 | 2001-11-20 | Methode de detection d'analyte(s) a l'aide de particules magnetiques colloidales |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200403903B true ZA200403903B (en) | 2005-06-23 |
Family
ID=8869592
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200403903A ZA200403903B (en) | 2001-11-20 | 2004-05-20 | Method for detecting analyte(s) using magnetic collodial particles. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7332353B2 (ko) |
| EP (1) | EP1446666B1 (ko) |
| JP (1) | JP2005517899A (ko) |
| KR (1) | KR20050044559A (ko) |
| CN (1) | CN100501403C (ko) |
| AT (1) | ATE431553T1 (ko) |
| AU (1) | AU2002361324A1 (ko) |
| BR (1) | BR0214233A (ko) |
| CA (1) | CA2467050A1 (ko) |
| DE (1) | DE60232353D1 (ko) |
| ES (1) | ES2325917T3 (ko) |
| FR (1) | FR2832507B1 (ko) |
| HU (1) | HU225636B1 (ko) |
| MX (1) | MXPA04004679A (ko) |
| NO (1) | NO20042579L (ko) |
| PL (1) | PL368690A1 (ko) |
| RU (1) | RU2004118490A (ko) |
| WO (1) | WO2003044532A1 (ko) |
| ZA (1) | ZA200403903B (ko) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2878960A1 (fr) * | 2004-12-08 | 2006-06-09 | Centre Nat Rech Scient | Procede pour mettre en oeuvre un test d'agglutination dans un microcanal |
| US9733315B2 (en) * | 2005-07-27 | 2017-08-15 | University Of Houston | Nanomagnetic detector array for biomolecular recognition |
| EP1932009B1 (en) | 2005-08-31 | 2014-02-12 | T2 Biosystems, Inc. | Nmr device for detection of analytes involving magnetic particles |
| US8586389B2 (en) * | 2005-09-28 | 2013-11-19 | Kent State University | Ligand concentrating, liquid crystal biosensor system |
| WO2007085980A1 (en) | 2006-01-25 | 2007-08-02 | Koninklijke Philips Electronics N. V. | Device for analyzing fluids |
| KR100738496B1 (ko) * | 2006-07-27 | 2007-07-11 | 한양대학교 산학협력단 | 자성 미세입자 및 배향성 고정화 리간드를 이용한 항체단백질 분리방법 |
| US8368402B2 (en) * | 2006-11-08 | 2013-02-05 | T2 Biosystems, Inc. | NMR systems for in vivo detection of analytes |
| KR100823684B1 (ko) | 2006-12-06 | 2008-04-21 | 한국전자통신연구원 | 바코드 ｄｎａ를 이용한 생물학적 표적 물질의 검출 방법 |
| FR2919390B1 (fr) * | 2007-07-27 | 2009-10-30 | Bertin Technologies Soc Par Ac | Procede de dosage d'un analyte dans un milieu liquide |
| EP2217951A4 (en) | 2007-11-06 | 2011-05-18 | T2 Biosystems Inc | SMALL MAGNET AND RADIO FREQUENCY COIL FOR MAGNETIC RESONANCE RELAXOMETRY |
| WO2009072457A1 (ja) * | 2007-12-03 | 2009-06-11 | Tokyo Institute Of Technology | 被覆磁性微粒子を用いたバイオセンシング方法及び該方法に用いるバイオセンシング装置 |
| FR2928656B1 (fr) * | 2008-03-14 | 2011-08-26 | Biomerieux Sa | Procede de detection en temps reel de microorganismes dans un milieu de culture liquide par agglutination. |
| CA2741550C (en) | 2008-10-29 | 2018-12-04 | T2 Biosystems, Inc. | Nmr detection of coagulation time |
| US20120251392A1 (en) * | 2009-10-19 | 2012-10-04 | Tokyo Institute Of Technology | Biosensor Using Magnetic Microparticles |
| US9023607B2 (en) * | 2010-04-26 | 2015-05-05 | Intellectual Discovery Co., Ltd. | Method for early diagnosis of alzheimer'S disease using phototransistor |
| FR2959820B1 (fr) * | 2010-05-10 | 2013-03-15 | Bertin Technologies Sa | Procede de dosage d'un analyte dans un milieu liquide |
| US8409807B2 (en) | 2010-10-22 | 2013-04-02 | T2 Biosystems, Inc. | NMR systems and methods for the rapid detection of analytes |
| ES2576927T3 (es) | 2010-10-22 | 2016-07-12 | T2 Biosystems, Inc. | Sistemas de RMN y métodos para la detección rápida de analitos |
| US8563298B2 (en) | 2010-10-22 | 2013-10-22 | T2 Biosystems, Inc. | NMR systems and methods for the rapid detection of analytes |
| EP2541250A1 (en) | 2011-06-30 | 2013-01-02 | Koninklijke Philips Electronics N.V. | Molecular architecture on magnetic particles for affinity assays with low non-specific binding |
| EP3321373B1 (en) | 2011-07-13 | 2020-01-15 | T2 Biosystems, Inc. | Nmr methods for monitoring blood clot formation |
| WO2013043858A1 (en) | 2011-09-21 | 2013-03-28 | T2 Biosystems, Inc. | Nmr methods for endotoxin analysis |
| DE102011089798B4 (de) | 2011-12-23 | 2021-06-10 | Biophysical Tools GmbH | Massiv paralleler Test molekularer Wechselwirkungen basierend auf magnetischen Nano- und Mikropartikeln |
| FR2986617B1 (fr) * | 2012-02-02 | 2015-03-27 | Horiba Abx Sas | Dispositif et procede pour effectuer des mesures hematologiques et biochimiques a partir d'un echantillon biologique |
| US9562271B2 (en) | 2012-04-20 | 2017-02-07 | T2 Biosystems, Inc. | Compositions and methods for detection of Candida species |
| JP2016500443A (ja) | 2012-12-07 | 2016-01-12 | ティー２ バイオシステムズ，インコーポレーテッド | 強固な血餅形成をモニタリングするための方法 |
| CN108697141A (zh) * | 2015-12-29 | 2018-10-23 | N·V·努特里奇亚 | 含有不可消化寡糖和非复制型产乳酸细菌的营养配方物 |
| EP3405479A4 (en) | 2016-01-21 | 2019-08-21 | T2 Biosystems, Inc. | NMR METHOD AND SYSTEMS FOR THE FAST DETECTION OF BACTERIA |
| US11585882B2 (en) * | 2018-04-11 | 2023-02-21 | Mars Sciences Limited | Superparamagnetic particle imaging and its applications in quantitative multiplex stationary phase diagnostic assays |
| WO2019229276A1 (es) * | 2018-05-30 | 2019-12-05 | Pragmatic Diagnostics, S.L. | Método optomagnetoforético para la detección de sustancias biológicas y químicas |
| AU2019306640B2 (en) * | 2018-07-19 | 2022-09-22 | Beckman Coulter, Inc. | Magnetic particles |
| US20240182990A1 (en) | 2021-03-09 | 2024-06-06 | Etablissement Français Du Sang | Detection of infectious agent based on recombinase polymerase amplification combined with a magnetic field-enhanced agglutination |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK140815B (da) * | 1975-06-10 | 1979-11-19 | Weeke Bengt | Fremgangsmåde til påvisning eller bestemmelse af antistoffer i legemsvæsker ved hjælp af kendte antigener eller til bestemmelse af antigener ved hjælp af kendte antistoffer fra legemsvæsker samt et middel til anvendelse ved udøvelse af fremgangsmåden. |
| US4554088A (en) * | 1983-05-12 | 1985-11-19 | Advanced Magnetics Inc. | Magnetic particles for use in separations |
| US4622298A (en) * | 1984-08-09 | 1986-11-11 | Becton, Dickinson And Company | Detection and quantitation of microorganisms, leukocytes and squamous epithelial cells in urine |
| US5512332A (en) * | 1985-10-04 | 1996-04-30 | Immunivest Corporation | Process of making resuspendable coated magnetic particles |
| US5639620A (en) | 1990-10-31 | 1997-06-17 | Coulter Corporation | Polymeric particles having a biodegradable gelatin or aminodextran coating and process for making same |
| US5637469A (en) * | 1992-05-01 | 1997-06-10 | Trustees Of The University Of Pennsylvania | Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems |
| EP0665955B1 (en) * | 1992-10-15 | 2002-05-29 | Coulter International Corporation | Particles having gelatin-aminodextran coatings of and processes for making same |
| US5298741A (en) * | 1993-01-13 | 1994-03-29 | Trustees Of Tufts College | Thin film fiber optic sensor array and apparatus for concurrent viewing and chemical sensing of a sample |
| GB9524393D0 (en) * | 1995-11-29 | 1996-01-31 | Mini Agriculture & Fisheries | Extraction and labelling of materials |
| EP0933989A1 (en) * | 1996-10-15 | 1999-08-11 | Bio-Tech Imaging, Inc. | Reagent system and kit for detecting hiv infected cells |
| US5817458A (en) | 1996-10-15 | 1998-10-06 | The Avriel Group, Amcas Division Inc. | Reagent system for detecting HIV-infected peripheral blood lymphocytes in whole blood |
| AU7685498A (en) * | 1997-05-14 | 1998-12-08 | Weixin Tang | Fully-coated, uniform-sized metallic particles |
| DE19822123C2 (de) * | 1997-11-21 | 2003-02-06 | Meinhard Knoll | Verfahren und Vorrichtung zum Nachweis von Analyten |
| EP1042061A1 (en) * | 1997-12-24 | 2000-10-11 | Cepheid | Integrated fluid manipulation cartridge |
| CA2318779C (en) * | 1998-01-22 | 2009-08-25 | Luminex Corporation | Microparticles with multiple fluorescent signals |
-
2001
- 2001-11-20 FR FR0115011A patent/FR2832507B1/fr not_active Expired - Fee Related
-
2002
- 2002-11-20 JP JP2003546110A patent/JP2005517899A/ja active Pending
- 2002-11-20 WO PCT/FR2002/003974 patent/WO2003044532A1/fr active Application Filing
- 2002-11-20 AT AT02796851T patent/ATE431553T1/de not_active IP Right Cessation
- 2002-11-20 CN CNB028230337A patent/CN100501403C/zh not_active Expired - Fee Related
- 2002-11-20 US US10/496,114 patent/US7332353B2/en not_active Expired - Fee Related
- 2002-11-20 ES ES02796851T patent/ES2325917T3/es not_active Expired - Lifetime
- 2002-11-20 KR KR1020047007733A patent/KR20050044559A/ko not_active Application Discontinuation
- 2002-11-20 DE DE60232353T patent/DE60232353D1/de not_active Expired - Lifetime
- 2002-11-20 PL PL02368690A patent/PL368690A1/xx not_active Application Discontinuation
- 2002-11-20 HU HU0402276A patent/HU225636B1/hu not_active IP Right Cessation
- 2002-11-20 AU AU2002361324A patent/AU2002361324A1/en not_active Abandoned
- 2002-11-20 BR BR0214233-3A patent/BR0214233A/pt not_active IP Right Cessation
- 2002-11-20 EP EP02796851A patent/EP1446666B1/fr not_active Expired - Lifetime
- 2002-11-20 RU RU2004118490/15A patent/RU2004118490A/ru not_active Application Discontinuation
- 2002-11-20 MX MXPA04004679A patent/MXPA04004679A/es not_active Application Discontinuation
- 2002-11-20 CA CA002467050A patent/CA2467050A1/fr not_active Abandoned
-
2004
- 2004-05-20 ZA ZA200403903A patent/ZA200403903B/en unknown
- 2004-06-18 NO NO20042579A patent/NO20042579L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HU225636B1 (en) | 2007-05-02 |
| DE60232353D1 (de) | 2009-06-25 |
| RU2004118490A (ru) | 2005-04-20 |
| JP2005517899A (ja) | 2005-06-16 |
| FR2832507A1 (fr) | 2003-05-23 |
| FR2832507B1 (fr) | 2004-02-20 |
| BR0214233A (pt) | 2004-09-21 |
| EP1446666B1 (fr) | 2009-05-13 |
| HUP0402276A3 (en) | 2005-11-28 |
| CN100501403C (zh) | 2009-06-17 |
| CN1589405A (zh) | 2005-03-02 |
| US7332353B2 (en) | 2008-02-19 |
| HUP0402276A2 (hu) | 2005-02-28 |
| PL368690A1 (en) | 2005-04-04 |
| US20050048673A1 (en) | 2005-03-03 |
| EP1446666A1 (fr) | 2004-08-18 |
| ES2325917T3 (es) | 2009-09-24 |
| KR20050044559A (ko) | 2005-05-12 |
| ATE431553T1 (de) | 2009-05-15 |
| AU2002361324A1 (en) | 2003-06-10 |
| WO2003044532A1 (fr) | 2003-05-30 |
| NO20042579L (no) | 2004-06-18 |
| CA2467050A1 (fr) | 2003-05-30 |
| MXPA04004679A (es) | 2005-05-17 |
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