ZA200403002B - Allicin - Google Patents
Allicin Download PDFInfo
- Publication number
- ZA200403002B ZA200403002B ZA2004/03002A ZA200403002A ZA200403002B ZA 200403002 B ZA200403002 B ZA 200403002B ZA 2004/03002 A ZA2004/03002 A ZA 2004/03002A ZA 200403002 A ZA200403002 A ZA 200403002A ZA 200403002 B ZA200403002 B ZA 200403002B
- Authority
- ZA
- South Africa
- Prior art keywords
- allicin
- preparation
- resistant
- excipient
- mic
- Prior art date
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- JDLKFOPOAOFWQN-UHFFFAOYSA-N allicin Chemical compound C=CCSS(=O)CC=C JDLKFOPOAOFWQN-UHFFFAOYSA-N 0.000 title claims description 85
- JDLKFOPOAOFWQN-VIFPVBQESA-N Allicin Natural products C=CCS[S@](=O)CC=C JDLKFOPOAOFWQN-VIFPVBQESA-N 0.000 title claims description 81
- 235000010081 allicin Nutrition 0.000 title claims description 81
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- XUHLIQGRKRUKPH-ITZCMCNPSA-N 3-(Allylsulphinyl)-L-alanine Chemical compound OC(=O)[C@@H](N)CS(=O)CC=C XUHLIQGRKRUKPH-ITZCMCNPSA-N 0.000 description 1
- LMWHRTZSJLYLAJ-UHFFFAOYSA-N 3-ethenyldithiine Chemical compound C=CC1=CC=CSS1 LMWHRTZSJLYLAJ-UHFFFAOYSA-N 0.000 description 1
- 108010092760 Alliin lyase Proteins 0.000 description 1
- 241000234282 Allium Species 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
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- 108010038447 Chromogranin A Proteins 0.000 description 1
- 102100031186 Chromogranin-A Human genes 0.000 description 1
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- 235000019739 Dicalciumphosphate Nutrition 0.000 description 1
- JWCSIUVGFCSJCK-CAVRMKNVSA-N Disodium Moxalactam Chemical compound N([C@]1(OC)C(N2C(=C(CSC=3N(N=NN=3)C)CO[C@@H]21)C(O)=O)=O)C(=O)C(C(O)=O)C1=CC=C(O)C=C1 JWCSIUVGFCSJCK-CAVRMKNVSA-N 0.000 description 1
- 101100289061 Drosophila melanogaster lili gene Proteins 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 239000006000 Garlic extract Substances 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 241000186779 Listeria monocytogenes Species 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- RSPISYXLHRIGJD-UHFFFAOYSA-N OOOO Chemical compound OOOO RSPISYXLHRIGJD-UHFFFAOYSA-N 0.000 description 1
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- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 241000607720 Serratia Species 0.000 description 1
- 239000005864 Sulphur Substances 0.000 description 1
- 241000607447 Yersinia enterocolitica Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- IXELFRRANAOWSF-CYBMUJFWSA-N ajoene Natural products C=CCSSC=CC[S@](=O)CC=C IXELFRRANAOWSF-CYBMUJFWSA-N 0.000 description 1
- 238000009635 antibiotic susceptibility testing Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
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- 239000007795 chemical reaction product Substances 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
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- 238000004581 coalescence Methods 0.000 description 1
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- 150000001875 compounds Chemical class 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
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- 238000010924 continuous production Methods 0.000 description 1
- 239000007799 cork Substances 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
- 229940038472 dicalcium phosphate Drugs 0.000 description 1
- 229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
- 238000003113 dilution method Methods 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
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- 235000003599 food sweetener Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000020706 garlic extract Nutrition 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 150000002314 glycerols Chemical class 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 239000003676 hair preparation Substances 0.000 description 1
- 230000000774 hypoallergenic effect Effects 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
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- 239000008101 lactose Substances 0.000 description 1
- 229960001375 lactose Drugs 0.000 description 1
- 229960000433 latamoxef Drugs 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- CPTIBDHUFVHUJK-NZYDNVMFSA-N mitopodozide Chemical compound C1([C@@H]2C3=CC=4OCOC=4C=C3[C@H](O)[C@@H](CO)[C@@H]2C(=O)NNCC)=CC(OC)=C(OC)C(OC)=C1 CPTIBDHUFVHUJK-NZYDNVMFSA-N 0.000 description 1
- 239000002324 mouth wash Substances 0.000 description 1
- 229940051866 mouthwash Drugs 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 239000001508 potassium citrate Substances 0.000 description 1
- 229960002635 potassium citrate Drugs 0.000 description 1
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 1
- 235000011082 potassium citrates Nutrition 0.000 description 1
- 229940069328 povidone Drugs 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
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- 239000011734 sodium Substances 0.000 description 1
- 229920003109 sodium starch glycolate Polymers 0.000 description 1
- 229940079832 sodium starch glycolate Drugs 0.000 description 1
- 239000008109 sodium starch glycolate Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
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- -1 sulphur compound Chemical class 0.000 description 1
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- 239000000375 suspending agent Substances 0.000 description 1
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- 235000020679 tap water Nutrition 0.000 description 1
- 229940034610 toothpaste Drugs 0.000 description 1
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- 229940098232 yersinia enterocolitica Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0122793.3A GB0122793D0 (en) | 2001-09-21 | 2001-09-21 | Allicin |
| PCT/GB2002/004309 WO2003024437A1 (fr) | 2001-09-21 | 2002-09-23 | Allicine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200403002B true ZA200403002B (en) | 2005-06-29 |
Family
ID=9922476
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2004/03002A ZA200403002B (en) | 2001-09-21 | 2004-04-20 | Allicin |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1435928A1 (fr) |
| AU (1) | AU2002334074B2 (fr) |
| EA (2) | EA013519B1 (fr) |
| GB (1) | GB0122793D0 (fr) |
| WO (1) | WO2003024437A1 (fr) |
| ZA (1) | ZA200403002B (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003090537A2 (fr) * | 2002-04-25 | 2003-11-06 | Yeda Research And Development Co. Ltd | Utilisation de l'allicine en tant qu'insectifuge et insecticide dans des recoltes agricoles |
| EP1398034A1 (fr) * | 2002-09-13 | 2004-03-17 | Vicente Teofilo Roldan | Composition à application topique pour la prévention et le traitement de la pédiculose, procédé d'élaboration et ses utilisations |
| GB0307079D0 (en) * | 2003-03-27 | 2003-04-30 | Stone Island Holdings Ltd | Allicin |
| CN103328441B (zh) * | 2010-12-08 | 2016-08-31 | 丹麦技术大学 | 阿霍烯衍生物的制备方法 |
| US9145506B2 (en) * | 2013-07-01 | 2015-09-29 | Jr Co., Ltd. | Natural adhesive |
| FR3023716A1 (fr) * | 2014-07-18 | 2016-01-22 | Univ Aix Marseille | Compose et association de composes pour le traitement des poux |
| CN104434781A (zh) * | 2014-11-08 | 2015-03-25 | 新疆埃乐欣药业有限公司 | 大蒜辣素注射液作为制备治疗真菌/细菌引起感染性疾病药物的应用 |
| CN113209072A (zh) * | 2021-04-29 | 2021-08-06 | 广东省科学院微生物研究所(广东省微生物分析检测中心) | 二烯丙基三硫醚在制备抑制铜绿假单胞菌分泌系统制剂中的应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU177081B (en) * | 1978-12-12 | 1981-07-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing the occlusion complex of allicin with cyclodextrin |
| JPS57149226A (en) * | 1981-03-10 | 1982-09-14 | Riken Kagaku Kogyo Kk | Prevention of leucocytozoonosis |
| IL83715A0 (en) * | 1987-08-31 | 1988-01-31 | Yeda Res & Dev | Pharmaceutical anti-protozoal compositions |
| DE4012884A1 (de) * | 1990-04-23 | 1991-10-24 | Lichtwer Pharma Gmbh | Alliinhaltiger knoblauchtrockenextrakt und ein verfahren zu seiner herstellung |
| DE4024155C2 (de) * | 1990-07-30 | 1995-12-07 | Marcela Dipl Ing Holzhey | Verwendung eines "Allicin-Urotropin" Produktes für den Bereich der inneren Behandlung (oral, Injektionen und Dauertropfinfusionen) von Menschen und Tieren bei Pilzerkrankungen |
| US5705152A (en) * | 1990-10-26 | 1998-01-06 | Interprise Limited | Antimicrobial composition |
| FR2706307B1 (fr) * | 1993-06-18 | 1995-12-01 | Jacques Pelletier | Formule pour traitement du sida. |
| IL117934A0 (en) * | 1996-04-16 | 1996-08-04 | Yeda Res & Dev | Continuous production of allicin |
| DE19633444A1 (de) * | 1996-08-20 | 1997-05-22 | Holzhey Marcela Dipl Ing | Verwendung eines "Allicin-Urotropin" Produktes für den Bereich der inneren Behandlung (oral. Injektionen und Dauertropfinfusionen) von Menschen und Tieren bei Bakteriellerkrankungen |
| AUPP430698A0 (en) * | 1998-06-25 | 1998-07-16 | Middleton, John Stephen | Garlic pour-on cattle & sheep anthelmintic |
-
2001
- 2001-09-21 GB GBGB0122793.3A patent/GB0122793D0/en not_active Ceased
-
2002
- 2002-09-23 AU AU2002334074A patent/AU2002334074B2/en not_active Ceased
- 2002-09-23 EA EA200700663A patent/EA013519B1/ru not_active IP Right Cessation
- 2002-09-23 EA EA200400451A patent/EA009169B1/ru not_active IP Right Cessation
- 2002-09-23 EP EP02798782A patent/EP1435928A1/fr not_active Ceased
- 2002-09-23 WO PCT/GB2002/004309 patent/WO2003024437A1/fr active IP Right Grant
-
2004
- 2004-04-20 ZA ZA2004/03002A patent/ZA200403002B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EA200700663A1 (ru) | 2007-12-28 |
| AU2002334074B2 (en) | 2006-11-09 |
| EA013519B1 (ru) | 2010-06-30 |
| EA200400451A1 (ru) | 2004-12-30 |
| WO2003024437A1 (fr) | 2003-03-27 |
| GB0122793D0 (en) | 2001-11-14 |
| EP1435928A1 (fr) | 2004-07-14 |
| EA009169B1 (ru) | 2007-10-26 |
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