ZA200402947B - Benzimidazoles useful as protein kinase inhibitors. - Google Patents
Benzimidazoles useful as protein kinase inhibitors. Download PDFInfo
- Publication number
- ZA200402947B ZA200402947B ZA200402947A ZA200402947A ZA200402947B ZA 200402947 B ZA200402947 B ZA 200402947B ZA 200402947 A ZA200402947 A ZA 200402947A ZA 200402947 A ZA200402947 A ZA 200402947A ZA 200402947 B ZA200402947 B ZA 200402947B
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- ZA
- South Africa
- Prior art keywords
- alkyl
- chosen
- compound according
- phenyl
- optionally substituted
- Prior art date
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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Landscapes
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| FR2851563B1 (fr) * | 2003-02-26 | 2005-04-22 | Sod Conseils Rech Applic | Nouveaux derives de benzimidazole et d'imidazo-pyridine et leur utilisation en tant que medicament |
| FR2862971B1 (fr) * | 2003-11-28 | 2006-03-24 | Sod Conseils Rech Applic | Nouveaux derives de benzimidazole et d'imidazo-pyridine et leur utilisation en tant que medicament |
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| US20050209284A1 (en) * | 2004-02-12 | 2005-09-22 | Boehringer Ingelheim Pharmaceuticals, Inc. | Tec kinase inhibitors |
| WO2006053342A2 (en) * | 2004-11-12 | 2006-05-18 | Osi Pharmaceuticals, Inc. | Integrin antagonists useful as anticancer agents |
| WO2006068105A1 (ja) * | 2004-12-20 | 2006-06-29 | Santen Pharmaceutical Co., Ltd. | 角結膜障害治療剤 |
| US7893267B2 (en) * | 2005-03-14 | 2011-02-22 | High Point Pharmaceuticals, Llc | Benzazole derivatives, compositions, and methods of use as β-secretase inhibitors |
| EP1879881A2 (en) * | 2005-04-14 | 2008-01-23 | Bristol-Myers Squibb Company | Inhibitors of 11-beta hydroxysteroid dehydrogenase type i |
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| EP1957491A2 (en) * | 2005-11-12 | 2008-08-20 | Boehringer Ingelheim International GmbH | Pyrrolo (2,3-b) pyridine derivatives useful as tec kinase inhibitors |
| US20110071130A1 (en) * | 2006-05-08 | 2011-03-24 | Pharmacopeia, Inc. | 2-aminobenzimidazoles for treating neurodegenerative diseases |
| US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
| MX358640B (es) | 2008-01-04 | 2018-08-29 | Intellikine Llc | Isoquinolin-1 (2h) -onas y tieno [2,3-d]pirimidin-4(3h) -onas substituidas, y metodos de uso de las mismas. |
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| US10517839B2 (en) * | 2008-06-09 | 2019-12-31 | Cornell University | Mast cell inhibition in diseases of the retina and vitreous |
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| EP2549874A4 (en) | 2010-03-23 | 2013-10-02 | High Point Pharmaceuticals Llc | SUBSTITUTED IMIDAZOLE [1,2-B] PYRIDAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS BETA-SECRETASE INHIBITORS |
| CN103168032A (zh) | 2010-08-05 | 2013-06-19 | 安美基公司 | 抑制间变性淋巴瘤激酶的苯并咪唑和氮杂苯并咪唑化合物 |
| TWI546305B (zh) | 2011-01-10 | 2016-08-21 | 英菲尼提製藥股份有限公司 | 製備異喹啉酮之方法及異喹啉酮之固體形式 |
| WO2013153539A1 (en) | 2012-04-13 | 2013-10-17 | Glenmark Pharmaceuticals S.A. | Tricyclic compounds as tec kinase inhibitors |
| US20150152083A1 (en) * | 2012-06-06 | 2015-06-04 | Irm Llc, A Delaware Limited Liability Company | Compounds and Compositions for Modulating EGFR Activity |
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| US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
| EP2890691B1 (en) * | 2012-08-31 | 2018-04-25 | Principia Biopharma Inc. | Benzimidazole derivatives as itk inhibitors |
| CN105102000B (zh) | 2012-11-01 | 2021-10-22 | 无限药品公司 | 使用pi3激酶亚型调节剂的癌症疗法 |
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| US10000469B2 (en) | 2014-03-25 | 2018-06-19 | Duke University | Heat shock protein 70 (hsp-70) receptor ligands |
| WO2015160975A2 (en) | 2014-04-16 | 2015-10-22 | Infinity Pharmaceuticals, Inc. | Combination therapies |
| KR101560338B1 (ko) | 2014-04-21 | 2015-10-19 | 건국대학교 산학협력단 | 야누스 키나아제 1의 활성을 선택적으로 저해하는 벤조이미다졸 유도체 |
| JP2019510802A (ja) * | 2016-04-07 | 2019-04-18 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | タンパク質調節物質として有用な複素環アミド |
| EP3474856B1 (en) | 2016-06-24 | 2022-09-14 | Infinity Pharmaceuticals, Inc. | Combination therapies |
| US11174245B2 (en) | 2018-02-21 | 2021-11-16 | Boehringer Ingelheim International Gmbh | Benzimidazole compounds and derivatives as EGFR inhibitors |
| JP7762957B2 (ja) * | 2019-04-05 | 2025-10-31 | ストーム・セラピューティクス・リミテッド | Ｍｅｔｔｌ３阻害化合物 |
| US20220380382A1 (en) | 2019-06-24 | 2022-12-01 | Boehringer Ingelheim International Gmbh | New macrocyclic compounds and derivatives as egfr inhibitors |
| CN114591333B (zh) * | 2020-12-04 | 2023-08-01 | 广州嘉越医药科技有限公司 | 一种吡咯并嘧啶类化合物的制备方法 |
| CN116444544A (zh) * | 2022-01-10 | 2023-07-18 | 中国科学院上海药物研究所 | 苯并咪唑类化合物及其医药用途 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3401171A (en) * | 1966-03-11 | 1968-09-10 | Smithkline Corp | 2-amidobenzimidazoles |
| CA1094061A (en) | 1976-03-19 | 1981-01-20 | Colin C. Beard | 5(6)-benzene ring substituted benzimidazole-2- carbamate derivatives having anthelmintic activity |
| US4139626A (en) | 1976-03-19 | 1979-02-13 | Syntex (U.S.A.) Inc. | Anthelmintic 5(6)-benzene ring substituted benzimidazole-2-carbamates |
| US4191764A (en) | 1976-03-19 | 1980-03-04 | Syntex (U.S.A.) Inc. | 5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity |
| US4312873A (en) | 1978-09-29 | 1982-01-26 | Syntex (U.S.A.) Inc. | 5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity |
| JP3380237B2 (ja) | 1988-09-12 | 2003-02-24 | ファルマシア・アンド・アップジョン・カンパニー | ２のｃｐｉサブユニットを有する新規ｃｃ―１０６５アナログ類 |
| JPH06759B2 (ja) | 1989-09-22 | 1994-01-05 | ファイザー製薬株式会社 | 新規なベンゾイミダゾール化合物 |
| GB9107398D0 (en) | 1991-04-09 | 1991-05-22 | British Bio Technology | Compounds |
| JP2729545B2 (ja) | 1991-06-05 | 1998-03-18 | 富士写真フイルム株式会社 | ハロゲン化銀カラー写真感光材料用の処理液及びそれを用いた処理方法 |
| WO1994001415A1 (fr) | 1992-07-03 | 1994-01-20 | Kumiai Chemical Industry Co., Ltd. | Derive heterocyclique condense et desherbant |
| CA2144763A1 (en) | 1992-10-14 | 1994-04-28 | George D. Hartman | Fibrinogen receptor antagonists |
| DE4304650A1 (de) | 1993-02-16 | 1994-08-18 | Thomae Gmbh Dr K | Kondensierte 5-gliedrige Heterocyclen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| IL135176A0 (en) | 1997-11-10 | 2001-05-20 | Bristol Myers Squibb Co | Benzothiazole derivatives and pharmaceutical compositions containing the same |
| EP1214330A1 (en) | 1999-09-21 | 2002-06-19 | LION Bioscience AG | Benzimidazole derivatives and combinatorial libraries thereof |
| WO2001025238A2 (en) * | 1999-10-06 | 2001-04-12 | Boehringer Ingelheim Pharmaceuticals, Inc. | Heterocyclic compounds useful as inhibitors of tyrosine kinases |
| AU2001219185A1 (en) | 2000-03-17 | 2001-10-03 | Alcon, Inc. | 2-acylaminobenzimidazole derivatives for treating glaucoma |
| US6903126B2 (en) | 2001-07-09 | 2005-06-07 | Schering Ag | 1-Aryl-2-N-, S- or O-substituted benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives |
| ATE511840T1 (de) | 2001-10-09 | 2011-06-15 | Amgen Inc | Imidazolderivate als entzündungshemmende mittel |
-
2002
- 2002-11-05 BR BR0214019-5A patent/BR0214019A/pt not_active Application Discontinuation
- 2002-11-05 HR HR20040416A patent/HRP20040416A2/hr not_active Application Discontinuation
- 2002-11-05 WO PCT/US2002/035494 patent/WO2003041708A1/en not_active Ceased
- 2002-11-05 PL PL02369771A patent/PL369771A1/xx not_active Application Discontinuation
- 2002-11-05 IL IL16151602A patent/IL161516A0/xx unknown
- 2002-11-05 CA CA002464419A patent/CA2464419A1/en not_active Abandoned
- 2002-11-05 JP JP2003543595A patent/JP2005509003A/ja active Pending
- 2002-11-05 EP EP02789445A patent/EP1448199A1/en not_active Withdrawn
- 2002-11-05 CN CNA028270002A patent/CN1612733A/zh active Pending
- 2002-11-05 EA EA200400595A patent/EA200400595A1/ru unknown
- 2002-11-05 US US10/288,362 patent/US6825219B2/en not_active Expired - Lifetime
- 2002-11-05 NZ NZ533310A patent/NZ533310A/xx unknown
- 2002-11-05 YU YU37904A patent/YU37904A/sh unknown
- 2002-11-05 MX MXPA04004301A patent/MXPA04004301A/es unknown
- 2002-11-05 KR KR10-2004-7007023A patent/KR20040063144A/ko not_active Withdrawn
-
2004
- 2004-04-19 ZA ZA200402947A patent/ZA200402947B/en unknown
- 2004-05-07 NO NO20041887A patent/NO20041887L/no unknown
- 2004-06-01 CO CO04051014A patent/CO5580788A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CO5580788A2 (es) | 2005-11-30 |
| WO2003041708A1 (en) | 2003-05-22 |
| US20030144281A1 (en) | 2003-07-31 |
| CA2464419A1 (en) | 2003-05-22 |
| NZ533310A (en) | 2004-12-24 |
| IL161516A0 (en) | 2004-09-27 |
| JP2005509003A (ja) | 2005-04-07 |
| CN1612733A (zh) | 2005-05-04 |
| EA200400595A1 (ru) | 2004-10-28 |
| KR20040063144A (ko) | 2004-07-12 |
| MXPA04004301A (es) | 2004-08-11 |
| PL369771A1 (en) | 2005-05-02 |
| US6825219B2 (en) | 2004-11-30 |
| BR0214019A (pt) | 2004-10-13 |
| HRP20040416A2 (en) | 2005-04-30 |
| NO20041887L (no) | 2004-05-07 |
| EP1448199A1 (en) | 2004-08-25 |
| YU37904A (sh) | 2006-08-17 |
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