ZA200402947B - Benzimidazoles useful as protein kinase inhibitors. - Google Patents
Benzimidazoles useful as protein kinase inhibitors. Download PDFInfo
- Publication number
- ZA200402947B ZA200402947B ZA200402947A ZA200402947A ZA200402947B ZA 200402947 B ZA200402947 B ZA 200402947B ZA 200402947 A ZA200402947 A ZA 200402947A ZA 200402947 A ZA200402947 A ZA 200402947A ZA 200402947 B ZA200402947 B ZA 200402947B
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- ZA
- South Africa
- Prior art keywords
- alkyl
- chosen
- compound according
- phenyl
- optionally substituted
- Prior art date
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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Landscapes
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| FR2833948B1 (fr) * | 2001-12-21 | 2004-02-06 | Sod Conseils Rech Applic | Nouveaux derives de benzimidazole et leur utilisation en tant que medicament |
| FR2851563B1 (fr) * | 2003-02-26 | 2005-04-22 | Sod Conseils Rech Applic | Nouveaux derives de benzimidazole et d'imidazo-pyridine et leur utilisation en tant que medicament |
| FR2862971B1 (fr) * | 2003-11-28 | 2006-03-24 | Sod Conseils Rech Applic | Nouveaux derives de benzimidazole et d'imidazo-pyridine et leur utilisation en tant que medicament |
| US20050176792A1 (en) * | 2004-01-14 | 2005-08-11 | Boehringer Ingelheim Pharmaceuticals, Inc. | Ketone substituted benzimidazole compounds |
| US20050209284A1 (en) * | 2004-02-12 | 2005-09-22 | Boehringer Ingelheim Pharmaceuticals, Inc. | Tec kinase inhibitors |
| EP1828144A2 (en) * | 2004-11-12 | 2007-09-05 | OSI Pharmaceuticals, Inc. | Integrin antagonists useful as anticancer agents |
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| EP2457901A1 (en) * | 2005-03-14 | 2012-05-30 | High Point Pharmaceuticals, LLC | Benzazole derivatives, compositions, and methods of use as B-secretase inhibitors |
| EP1879881A2 (en) * | 2005-04-14 | 2008-01-23 | Bristol-Myers Squibb Company | Inhibitors of 11-beta hydroxysteroid dehydrogenase type i |
| GB0515025D0 (en) * | 2005-07-21 | 2005-08-31 | Novartis Ag | Organic compounds |
| CA2629314A1 (en) * | 2005-11-12 | 2007-05-24 | Boehringer Ingelheim International Gmbh | Tec kinase inhibitors |
| WO2007133983A2 (en) * | 2006-05-08 | 2007-11-22 | Pharmacopeia, Inc. | 2-aminobenzimidazoles for treating neurodegenerative diseases |
| US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
| MX2010007418A (es) | 2008-01-04 | 2010-11-12 | Intellikine Inc | Ciertas entidades quimicas, composiciones y metodos. |
| ES2581386T3 (es) * | 2008-02-25 | 2016-09-05 | Merck Patent Gmbh | Activadores de la glucoquinasa |
| US10517839B2 (en) * | 2008-06-09 | 2019-12-31 | Cornell University | Mast cell inhibition in diseases of the retina and vitreous |
| EP2424533A4 (en) | 2009-04-27 | 2012-10-17 | High Point Pharmaceuticals Llc | SUBSTITUTED ISOQUINOLINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND THEIR METHODS OF USE AS-SECRETASE INHIBITORS |
| EP2549874A4 (en) | 2010-03-23 | 2013-10-02 | High Point Pharmaceuticals Llc | SUBSTITUTED IMIDAZOLE [1,2-B] PYRIDAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS BETA-SECRETASE INHIBITORS |
| CN103168032A (zh) | 2010-08-05 | 2013-06-19 | 安美基公司 | 抑制间变性淋巴瘤激酶的苯并咪唑和氮杂苯并咪唑化合物 |
| EP2663309B1 (en) | 2011-01-10 | 2017-03-15 | Infinity Pharmaceuticals, Inc. | Processes for preparing isoquinolinones and solid forms of isoquinolinones |
| WO2013153539A1 (en) | 2012-04-13 | 2013-10-17 | Glenmark Pharmaceuticals S.A. | Tricyclic compounds as tec kinase inhibitors |
| JP2015518895A (ja) * | 2012-06-06 | 2015-07-06 | アイアールエム・リミテッド・ライアビリティ・カンパニーＩｒｍ，Ｌｌｃ | Ｅｇｆｒ活性を調節するための化合物および組成物 |
| JO3300B1 (ar) * | 2012-06-06 | 2018-09-16 | Novartis Ag | مركبات وتركيبات لتعديل نشاط egfr |
| US8828998B2 (en) * | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
| US9573958B2 (en) | 2012-08-31 | 2017-02-21 | Principia Biopharma, Inc. | Benzimidazole derivatives as ITK inhibitors |
| MX375194B (es) | 2012-11-01 | 2025-03-06 | Infinity Pharmaceuticals Inc | Tratamiento de cánceres utilizando moduladores de las isoformas de pi3 cinasa. |
| WO2015081463A1 (en) * | 2013-12-02 | 2015-06-11 | Novartis Ag | Egfr inhibitor forms |
| WO2015083059A1 (en) * | 2013-12-02 | 2015-06-11 | Novartis Ag | Forms of the egfr inhibitor |
| US10000469B2 (en) | 2014-03-25 | 2018-06-19 | Duke University | Heat shock protein 70 (hsp-70) receptor ligands |
| US20150320755A1 (en) | 2014-04-16 | 2015-11-12 | Infinity Pharmaceuticals, Inc. | Combination therapies |
| KR101560338B1 (ko) | 2014-04-21 | 2015-10-19 | 건국대학교 산학협력단 | 야누스 키나아제 1의 활성을 선택적으로 저해하는 벤조이미다졸 유도체 |
| BR112018070602A2 (pt) * | 2016-04-07 | 2019-02-05 | Glaxosmithkline Ip Dev Ltd | composto, composição farmacêutica, uso do composto, e, método para tratar uma doença ou distúrbio |
| CN109640999A (zh) | 2016-06-24 | 2019-04-16 | 无限药品股份有限公司 | 组合疗法 |
| CN111741954B (zh) | 2018-02-21 | 2024-04-02 | 勃林格殷格翰国际有限公司 | 用作egfr抑制剂的新型苯并咪唑化合物及衍生物 |
| EP3946618A1 (en) * | 2019-04-05 | 2022-02-09 | Storm Therapeutics Ltd | Mettl3 inhibitory compounds |
| US20220380382A1 (en) | 2019-06-24 | 2022-12-01 | Boehringer Ingelheim International Gmbh | New macrocyclic compounds and derivatives as egfr inhibitors |
| CN114591333B (zh) * | 2020-12-04 | 2023-08-01 | 广州嘉越医药科技有限公司 | 一种吡咯并嘧啶类化合物的制备方法 |
| CN116444544A (zh) * | 2022-01-10 | 2023-07-18 | 中国科学院上海药物研究所 | 苯并咪唑类化合物及其医药用途 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3401171A (en) * | 1966-03-11 | 1968-09-10 | Smithkline Corp | 2-amidobenzimidazoles |
| US4139626A (en) | 1976-03-19 | 1979-02-13 | Syntex (U.S.A.) Inc. | Anthelmintic 5(6)-benzene ring substituted benzimidazole-2-carbamates |
| CA1094061A (en) | 1976-03-19 | 1981-01-20 | Colin C. Beard | 5(6)-benzene ring substituted benzimidazole-2- carbamate derivatives having anthelmintic activity |
| US4191764A (en) | 1976-03-19 | 1980-03-04 | Syntex (U.S.A.) Inc. | 5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity |
| US4312873A (en) | 1978-09-29 | 1982-01-26 | Syntex (U.S.A.) Inc. | 5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity |
| KR0137959B1 (ko) | 1988-09-12 | 1998-05-15 | 로버트 에이. 아미테이지 | 2개의 cpi 소단위를 갖는 신규한 cc-1065 유사화합물 |
| JPH06759B2 (ja) | 1989-09-22 | 1994-01-05 | ファイザー製薬株式会社 | 新規なベンゾイミダゾール化合物 |
| GB9107398D0 (en) | 1991-04-09 | 1991-05-22 | British Bio Technology | Compounds |
| JP2729545B2 (ja) | 1991-06-05 | 1998-03-18 | 富士写真フイルム株式会社 | ハロゲン化銀カラー写真感光材料用の処理液及びそれを用いた処理方法 |
| CA2116863A1 (en) | 1992-07-03 | 1994-01-20 | Sumio Yokota | Condensed heterocyclic derivatives and herbicides |
| CA2144763A1 (en) | 1992-10-14 | 1994-04-28 | George D. Hartman | Fibrinogen receptor antagonists |
| DE4304650A1 (de) | 1993-02-16 | 1994-08-18 | Thomae Gmbh Dr K | Kondensierte 5-gliedrige Heterocyclen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| DE69833224T2 (de) * | 1997-11-10 | 2006-09-28 | Bristol-Myers Squibb Co. | Benzothiazole als protein tyrosin-kinase inhibitoren |
| WO2001021634A1 (en) | 1999-09-21 | 2001-03-29 | Lion Bioscience Ag | Benzimidazole derivatives and combinatorial libraries thereof |
| ES2225231T3 (es) | 1999-10-06 | 2005-03-16 | Boehringer Ingelheim Pharmaceuticals Inc. | Compuestos heterociclicos, utiles como inhibidores de tirosina quinasas. |
| US6660870B1 (en) | 2000-03-17 | 2003-12-09 | Alcon, Inc. | 2-acylaminobenzimidazole derivatives for treating glaucoma |
| US6903126B2 (en) | 2001-07-09 | 2005-06-07 | Schering Ag | 1-Aryl-2-N-, S- or O-substituted benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives |
| ATE511840T1 (de) | 2001-10-09 | 2011-06-15 | Amgen Inc | Imidazolderivate als entzündungshemmende mittel |
-
2002
- 2002-11-05 YU YU37904A patent/YU37904A/sh unknown
- 2002-11-05 HR HR20040416A patent/HRP20040416A2/hr not_active Application Discontinuation
- 2002-11-05 IL IL16151602A patent/IL161516A0/xx unknown
- 2002-11-05 JP JP2003543595A patent/JP2005509003A/ja active Pending
- 2002-11-05 US US10/288,362 patent/US6825219B2/en not_active Expired - Lifetime
- 2002-11-05 EP EP02789445A patent/EP1448199A1/en not_active Withdrawn
- 2002-11-05 MX MXPA04004301A patent/MXPA04004301A/es unknown
- 2002-11-05 WO PCT/US2002/035494 patent/WO2003041708A1/en not_active Ceased
- 2002-11-05 PL PL02369771A patent/PL369771A1/xx not_active Application Discontinuation
- 2002-11-05 NZ NZ533310A patent/NZ533310A/xx unknown
- 2002-11-05 BR BR0214019-5A patent/BR0214019A/pt not_active Application Discontinuation
- 2002-11-05 EA EA200400595A patent/EA200400595A1/ru unknown
- 2002-11-05 CA CA002464419A patent/CA2464419A1/en not_active Abandoned
- 2002-11-05 CN CNA028270002A patent/CN1612733A/zh active Pending
- 2002-11-05 KR KR10-2004-7007023A patent/KR20040063144A/ko not_active Withdrawn
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2004
- 2004-04-19 ZA ZA200402947A patent/ZA200402947B/en unknown
- 2004-05-07 NO NO20041887A patent/NO20041887L/no unknown
- 2004-06-01 CO CO04051014A patent/CO5580788A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US20030144281A1 (en) | 2003-07-31 |
| CN1612733A (zh) | 2005-05-04 |
| WO2003041708A1 (en) | 2003-05-22 |
| CA2464419A1 (en) | 2003-05-22 |
| JP2005509003A (ja) | 2005-04-07 |
| MXPA04004301A (es) | 2004-08-11 |
| EP1448199A1 (en) | 2004-08-25 |
| US6825219B2 (en) | 2004-11-30 |
| KR20040063144A (ko) | 2004-07-12 |
| HRP20040416A2 (en) | 2005-04-30 |
| BR0214019A (pt) | 2004-10-13 |
| CO5580788A2 (es) | 2005-11-30 |
| NO20041887L (no) | 2004-05-07 |
| PL369771A1 (en) | 2005-05-02 |
| NZ533310A (en) | 2004-12-24 |
| EA200400595A1 (ru) | 2004-10-28 |
| YU37904A (sh) | 2006-08-17 |
| IL161516A0 (en) | 2004-09-27 |
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