ZA200402812B - Imidazo (4,3-e)-1,2,4-triazolo(1,5-c) pyrimidines as adenosine A2a receptor antagonists. - Google Patents
Imidazo (4,3-e)-1,2,4-triazolo(1,5-c) pyrimidines as adenosine A2a receptor antagonists. Download PDFInfo
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- ZA200402812B ZA200402812B ZA200402812A ZA200402812A ZA200402812B ZA 200402812 B ZA200402812 B ZA 200402812B ZA 200402812 A ZA200402812 A ZA 200402812A ZA 200402812 A ZA200402812 A ZA 200402812A ZA 200402812 B ZA200402812 B ZA 200402812B
- Authority
- ZA
- South Africa
- Prior art keywords
- alkyl
- alkoxy
- compound
- phenyl
- group
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- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- Y02P20/50—Improvements relating to the production of bulk chemicals
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Landscapes
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Applications Claiming Priority (1)
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|---|---|---|---|---|
| ES2283625T3 (es) * | 2001-11-30 | 2007-11-01 | Schering Corporation | Antagonistas del receptopr a2a de adenosina de (1,2,4)-triazol biciclicos. |
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| DE3677445D1 (de) | 1985-09-30 | 1991-03-14 | Ciba Geigy Ag | 2-substituierte-e-kondensierte(1,5-c)-pyrimidine, pharmazeutische zubereitungen und ihre verwendung. |
| EP0263071B1 (en) * | 1986-09-30 | 1992-08-12 | Ciba-Geigy Ag | 2-Substituted-e-fused-[1,2,4]-triazolo[1,5-c] pyrimidines, pharmaceutical compositions, and uses thereof |
| IT1264901B1 (it) | 1993-06-29 | 1996-10-17 | Schering Plough S P A | Analoghi eterociclici di 1,2,4-triazolo(15-c)pirimidine ad attivita' antagonista per il recettore a2 dell'adenosina |
| ATE208199T1 (de) | 1993-07-27 | 2001-11-15 | Kyowa Hakko Kogyo Kk | Arzneimittel gegen parkinsonsche krankheit |
| IT1277392B1 (it) | 1995-07-28 | 1997-11-10 | Schering Plough S P A | Analoghi eterociclici di 1,2,4-triazolo(1,5-c]pirimidine ad attivita' antagonista per il recettore a2a dell'adenosina |
| IT1291372B1 (it) | 1997-05-21 | 1999-01-07 | Schering Plough S P A | Uso di analoghi eterociclici di 1,2,4-triazolo (1,5-c) pirimidine per la preparazione di medicamenti utili per il trattamento delle malattie |
| KR100513062B1 (ko) | 1998-04-03 | 2005-09-05 | 가부시키 가이샤 오오쯔카 세이야쿠 고우죠우 | 트리아조로푸린 유도체, 그 유도체를 함유하는 의약조성물, 아데노신 에이3 수용체 친화제 및 천식치료제 |
| CN1207298C (zh) | 1999-09-28 | 2005-06-22 | 株式会社大塚制药工厂 | 三唑并嘌呤衍生物、含有该衍生物的药物组合物和腺苷a3受体亲和剂 |
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| US6916811B2 (en) | 2001-11-30 | 2005-07-12 | Schering Corporation | Adenosine A2a receptor antagonists |
-
2002
- 2002-10-11 AR ARP020103834A patent/AR037243A1/es unknown
- 2002-10-11 WO PCT/US2002/032630 patent/WO2003032996A1/en not_active Ceased
- 2002-10-11 MY MYPI20023804A patent/MY124864A/en unknown
- 2002-10-11 CA CA002463598A patent/CA2463598C/en not_active Expired - Fee Related
- 2002-10-11 CN CNB028203283A patent/CN100421663C/zh not_active Expired - Fee Related
- 2002-10-11 NZ NZ531761A patent/NZ531761A/en unknown
- 2002-10-11 KR KR1020047005369A patent/KR100687954B1/ko not_active Expired - Fee Related
- 2002-10-11 JP JP2003535799A patent/JP4545437B2/ja not_active Expired - Fee Related
- 2002-10-11 EP EP02778530.2A patent/EP1435960B1/en not_active Expired - Lifetime
- 2002-10-11 AU AU2002340184A patent/AU2002340184B2/en not_active Ceased
- 2002-10-11 MX MXPA04003474A patent/MXPA04003474A/es active IP Right Grant
- 2002-10-11 US US10/269,754 patent/US6653315B2/en not_active Expired - Lifetime
- 2002-10-11 PE PE2002001009A patent/PE20030477A1/es not_active Application Discontinuation
- 2002-10-11 IL IL16087802A patent/IL160878A0/xx unknown
- 2002-10-11 HU HU0401777A patent/HUP0401777A3/hu unknown
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2004
- 2004-04-13 ZA ZA200402812A patent/ZA200402812B/en unknown
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- 2008-07-25 JP JP2008192667A patent/JP2008297312A/ja active Pending
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| AU2002340184B2 (en) | 2005-10-06 |
| HUP0401777A2 (hu) | 2004-12-28 |
| CA2463598A1 (en) | 2003-04-24 |
| PE20030477A1 (es) | 2003-06-06 |
| EP1435960A1 (en) | 2004-07-14 |
| US20030171381A1 (en) | 2003-09-11 |
| NZ531761A (en) | 2005-10-28 |
| KR100687954B1 (ko) | 2007-02-27 |
| US6653315B2 (en) | 2003-11-25 |
| CN1612736A (zh) | 2005-05-04 |
| JP2008297312A (ja) | 2008-12-11 |
| WO2003032996A1 (en) | 2003-04-24 |
| MXPA04003474A (es) | 2004-07-30 |
| IL160878A0 (en) | 2004-08-31 |
| JP4545437B2 (ja) | 2010-09-15 |
| KR20050035155A (ko) | 2005-04-15 |
| CA2463598C (en) | 2009-09-08 |
| JP2005506352A (ja) | 2005-03-03 |
| AR037243A1 (es) | 2004-11-03 |
| CN100421663C (zh) | 2008-10-01 |
| MY124864A (en) | 2006-07-31 |
| HUP0401777A3 (en) | 2008-06-30 |
| EP1435960B1 (en) | 2014-07-30 |
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