ZA200402755B - Controlled release polymeric compositions of bone growth promoting compounds. - Google Patents
Controlled release polymeric compositions of bone growth promoting compounds. Download PDFInfo
- Publication number
- ZA200402755B ZA200402755B ZA200402755A ZA200402755A ZA200402755B ZA 200402755 B ZA200402755 B ZA 200402755B ZA 200402755 A ZA200402755 A ZA 200402755A ZA 200402755 A ZA200402755 A ZA 200402755A ZA 200402755 B ZA200402755 B ZA 200402755B
- Authority
- ZA
- South Africa
- Prior art keywords
- composition
- compound
- polymer
- amino
- phenoxy
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims description 140
- 239000000203 mixture Substances 0.000 title claims description 139
- 230000008468 bone growth Effects 0.000 title description 69
- 230000001737 promoting effect Effects 0.000 title description 68
- 238000013270 controlled release Methods 0.000 title description 14
- 229920000642 polymer Polymers 0.000 claims description 122
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical group CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims description 106
- 230000009969 flowable effect Effects 0.000 claims description 52
- 229920001577 copolymer Polymers 0.000 claims description 42
- 239000002904 solvent Substances 0.000 claims description 38
- 239000007943 implant Substances 0.000 claims description 37
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims description 31
- 229920001169 thermoplastic Polymers 0.000 claims description 31
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 26
- 159000000000 sodium salts Chemical class 0.000 claims description 25
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- 238000011065 in-situ storage Methods 0.000 claims description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 21
- 239000007787 solid Substances 0.000 claims description 19
- WOHRHWDYFNWPNG-UHFFFAOYSA-N evatanepag Chemical compound C1=CC(C(C)(C)C)=CC=C1CN(S(=O)(=O)C=1C=NC=CC=1)CC1=CC=CC(OCC(O)=O)=C1 WOHRHWDYFNWPNG-UHFFFAOYSA-N 0.000 claims description 17
- 239000003960 organic solvent Substances 0.000 claims description 16
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- 239000002253 acid Substances 0.000 claims description 9
- -1 3,5-dichloro-phenoxy Chemical group 0.000 claims description 7
- LMIHDKFZOCIOPZ-UHFFFAOYSA-N 7-[(4-butylphenyl)methyl-methylsulfonylamino]heptanoic acid Chemical compound CCCCC1=CC=C(CN(CCCCCCC(O)=O)S(C)(=O)=O)C=C1 LMIHDKFZOCIOPZ-UHFFFAOYSA-N 0.000 claims description 7
- 238000009792 diffusion process Methods 0.000 claims description 7
- 239000008194 pharmaceutical composition Substances 0.000 claims description 7
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 claims description 5
- DWLYPVVWVSFAEO-UHFFFAOYSA-N 7-[2-(3,5-dichlorophenoxy)ethyl-methylsulfonylamino]heptanoic acid Chemical compound OC(=O)CCCCCCN(S(=O)(=O)C)CCOC1=CC(Cl)=CC(Cl)=C1 DWLYPVVWVSFAEO-UHFFFAOYSA-N 0.000 claims description 5
- 229920000954 Polyglycolide Polymers 0.000 claims description 5
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- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims description 2
- 229920003177 water-insoluble biodegradable polymer Polymers 0.000 claims description 2
- 239000011159 matrix material Substances 0.000 description 31
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- SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 description 1
- XBBVURRQGJPTHH-UHFFFAOYSA-N 2-hydroxyacetic acid;2-hydroxypropanoic acid Chemical compound OCC(O)=O.CC(O)C(O)=O XBBVURRQGJPTHH-UHFFFAOYSA-N 0.000 description 1
- LCSKNASZPVZHEG-UHFFFAOYSA-N 3,6-dimethyl-1,4-dioxane-2,5-dione;1,4-dioxane-2,5-dione Chemical group O=C1COC(=O)CO1.CC1OC(=O)C(C)OC1=O LCSKNASZPVZHEG-UHFFFAOYSA-N 0.000 description 1
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- PIWKPBJCKXDKJR-UHFFFAOYSA-N Isoflurane Chemical compound FC(F)OC(Cl)C(F)(F)F PIWKPBJCKXDKJR-UHFFFAOYSA-N 0.000 description 1
- YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical compound C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 description 1
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- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
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- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
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- 229960003722 doxycycline Drugs 0.000 description 1
- HALQELOKLVRWRI-VDBOFHIQSA-N doxycycline hyclate Chemical compound O.[Cl-].[Cl-].CCO.O=C1C2=C(O)C=CC=C2[C@H](C)[C@@H]2C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H]([NH+](C)C)[C@@H]1[C@H]2O.O=C1C2=C(O)C=CC=C2[C@H](C)[C@@H]2C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H]([NH+](C)C)[C@@H]1[C@H]2O HALQELOKLVRWRI-VDBOFHIQSA-N 0.000 description 1
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- BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 1
- 229960001600 xylazine Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Rheumatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33725501P | 2001-11-30 | 2001-11-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200402755B true ZA200402755B (en) | 2005-04-08 |
Family
ID=23319774
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200402755A ZA200402755B (en) | 2001-11-30 | 2004-04-08 | Controlled release polymeric compositions of bone growth promoting compounds. |
Country Status (34)
| Country | Link |
|---|---|
| US (2) | US20030104031A1 (fr) |
| EP (1) | EP1448166A1 (fr) |
| JP (1) | JP4903985B2 (fr) |
| KR (1) | KR100629380B1 (fr) |
| CN (1) | CN1599598A (fr) |
| AP (1) | AP1781A (fr) |
| AR (1) | AR037462A1 (fr) |
| AU (2) | AU2002347502A1 (fr) |
| BR (1) | BR0214610A (fr) |
| CA (1) | CA2468703C (fr) |
| DO (1) | DOP2002000534A (fr) |
| EA (1) | EA011350B1 (fr) |
| EC (1) | ECSP045124A (fr) |
| GE (1) | GEP20063951B (fr) |
| GT (1) | GT200200242A (fr) |
| HR (1) | HRP20040486A2 (fr) |
| HU (1) | HUP0402135A3 (fr) |
| IL (1) | IL161835A0 (fr) |
| IS (1) | IS7217A (fr) |
| MA (1) | MA27084A1 (fr) |
| MX (1) | MXPA04003723A (fr) |
| NO (1) | NO20042273L (fr) |
| NZ (1) | NZ533115A (fr) |
| OA (1) | OA12731A (fr) |
| PA (1) | PA8559001A1 (fr) |
| PE (1) | PE20030581A1 (fr) |
| PL (1) | PL370085A1 (fr) |
| SV (1) | SV2004001421A (fr) |
| TN (1) | TNSN04096A1 (fr) |
| TW (1) | TW200300695A (fr) |
| UA (1) | UA76792C2 (fr) |
| WO (1) | WO2003045351A1 (fr) |
| YU (1) | YU35004A (fr) |
| ZA (1) | ZA200402755B (fr) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7074425B2 (en) * | 2002-09-26 | 2006-07-11 | Bonewax, Llc | Hemostatic compositions and methods |
| EP1596765A2 (fr) * | 2003-02-10 | 2005-11-23 | Smith & Nephew, Inc. | Dispositifs resorbables |
| GB0307011D0 (en) | 2003-03-27 | 2003-04-30 | Regentec Ltd | Porous matrix |
| WO2005034961A1 (fr) * | 2003-10-01 | 2005-04-21 | Optimer Pharmaceuticals, Inc. | Traitement d'un trouble chez un mammifere par administration d'une sucre amine et utilisations associees |
| GB0329654D0 (en) | 2003-12-23 | 2004-01-28 | Smith & Nephew | Tunable segmented polyacetal |
| US8123787B2 (en) | 2004-10-28 | 2012-02-28 | Ogilvie James W | Method of treating scoliosis using a biological implant |
| US8641738B1 (en) | 2004-10-28 | 2014-02-04 | James W. Ogilvie | Method of treating scoliosis using a biological implant |
| JP2009504929A (ja) * | 2005-08-18 | 2009-02-05 | スミス アンド ネフュー ピーエルシー | 高強度デバイス及び複合材料 |
| CN100443065C (zh) * | 2006-01-26 | 2008-12-17 | 上海交通大学 | 用于颌面骨缺损修复的复合体系植入体单元 |
| WO2008067531A2 (fr) | 2006-11-30 | 2008-06-05 | Smith & Nephew, Inc. | Matériau composite renforcé par des fibres |
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