ZA200401043B - Process for preparing pyridyl-alkylsulfonyl pyrazole derivatives. - Google Patents
Process for preparing pyridyl-alkylsulfonyl pyrazole derivatives. Download PDFInfo
- Publication number
- ZA200401043B ZA200401043B ZA200401043A ZA200401043A ZA200401043B ZA 200401043 B ZA200401043 B ZA 200401043B ZA 200401043 A ZA200401043 A ZA 200401043A ZA 200401043 A ZA200401043 A ZA 200401043A ZA 200401043 B ZA200401043 B ZA 200401043B
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- ZA
- South Africa
- Prior art keywords
- formula
- compound
- alkyl
- mixture
- compounds
- Prior art date
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- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 125000003107 substituted aryl group Chemical group 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 229960003329 sulfinpyrazone Drugs 0.000 description 1
- AUMHDRMJJNZTPB-UHFFFAOYSA-N sulfinpyrazone Chemical compound O=C1N(C=2C=CC=CC=2)N(C=2C=CC=CC=2)C(O)=C1CCS(=O)C1=CC=CC=C1 AUMHDRMJJNZTPB-UHFFFAOYSA-N 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- MLKXDPUZXIRXEP-MFOYZWKCSA-N sulindac Chemical compound CC1=C(CC(O)=O)C2=CC(F)=CC=C2\C1=C/C1=CC=C(S(C)=O)C=C1 MLKXDPUZXIRXEP-MFOYZWKCSA-N 0.000 description 1
- 229960000894 sulindac Drugs 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 229940036220 synvisc Drugs 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 229940000238 tasmar Drugs 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- 229940063683 taxotere Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- RZWIIPASKMUIAC-VQTJNVASSA-N thromboxane Chemical compound CCCCCCCC[C@H]1OCCC[C@@H]1CCCCCCC RZWIIPASKMUIAC-VQTJNVASSA-N 0.000 description 1
- 238000003354 tissue distribution assay Methods 0.000 description 1
- MIQPIUSUKVNLNT-UHFFFAOYSA-N tolcapone Chemical compound C1=CC(C)=CC=C1C(=O)C1=CC(O)=C(O)C([N+]([O-])=O)=C1 MIQPIUSUKVNLNT-UHFFFAOYSA-N 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 description 1
- 239000002447 tumor necrosis factor alpha converting enzyme inhibitor Substances 0.000 description 1
- 102000003298 tumor necrosis factor receptor Human genes 0.000 description 1
- 239000003383 uricosuric agent Substances 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 229960004528 vincristine Drugs 0.000 description 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
- 239000003064 xanthine oxidase inhibitor Substances 0.000 description 1
- PAPBSGBWRJIAAV-UHFFFAOYSA-N ε-Caprolactone Chemical compound O=C1CCCCCO1 PAPBSGBWRJIAAV-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32564701P | 2001-09-28 | 2001-09-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200401043B true ZA200401043B (en) | 2005-04-15 |
Family
ID=23268786
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200401043A ZA200401043B (en) | 2001-09-28 | 2004-02-09 | Process for preparing pyridyl-alkylsulfonyl pyrazole derivatives. |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US6646128B2 (cs) |
| EP (1) | EP1430046A1 (cs) |
| JP (1) | JP2005504127A (cs) |
| KR (1) | KR20040039424A (cs) |
| CN (1) | CN1561339A (cs) |
| AR (1) | AR036680A1 (cs) |
| BR (1) | BR0212860A (cs) |
| CA (1) | CA2457798A1 (cs) |
| CZ (1) | CZ2004414A3 (cs) |
| GT (1) | GT200200183A (cs) |
| HU (1) | HUP0401914A3 (cs) |
| IL (1) | IL160369A0 (cs) |
| MX (1) | MXPA04002879A (cs) |
| PA (1) | PA8555601A1 (cs) |
| PE (1) | PE20030532A1 (cs) |
| PL (1) | PL370110A1 (cs) |
| RU (1) | RU2004109148A (cs) |
| UY (1) | UY27453A1 (cs) |
| WO (1) | WO2003029244A1 (cs) |
| ZA (1) | ZA200401043B (cs) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008534505A (ja) * | 2005-03-25 | 2008-08-28 | メルク エンド カムパニー インコーポレーテッド | テストステロンサプリメントおよび５アルファ−レダクターゼインヒビターによる男性の治療方法 |
| EA028642B1 (ru) * | 2007-07-23 | 2017-12-29 | Те Чайниз Юниверсити Ов Гонгконг | Способ пренатальной диагностики фетальной хромосомной анэуплоидии |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH27357A (en) | 1989-09-22 | 1993-06-21 | Fujisawa Pharmaceutical Co | Pyrazole derivatives and pharmaceutical compositions comprising the same |
| IL104311A (en) | 1992-02-05 | 1997-07-13 | Fujisawa Pharmaceutical Co | Pyrazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same |
| US5474995A (en) | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
| US5434178A (en) | 1993-11-30 | 1995-07-18 | G.D. Searle & Co. | 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation |
| US5475018A (en) | 1993-11-30 | 1995-12-12 | G. D. Searle & Co. | 1,5-diphenyl pyrazole compounds for treatment of inflammation |
| DK0923933T3 (da) | 1993-11-30 | 2002-10-21 | Searle & Co | Substituerede pyrazolyl-benzensulfonamider til anvendelse ved behandling af inflammation |
| US5401765A (en) | 1993-11-30 | 1995-03-28 | G. D. Searle | 1,4,5-triphenyl pyrazolyl compounds for the treatment of inflammation and inflammation-related disorders |
| CA2195847A1 (en) | 1994-07-27 | 1996-02-08 | John J. Talley | Substituted thiazoles for the treatment of inflammation |
| US5620999A (en) | 1994-07-28 | 1997-04-15 | Weier; Richard M. | Benzenesulfonamide subtituted imidazolyl compounds for the treatment of inflammation |
| US5585504A (en) | 1994-09-16 | 1996-12-17 | Merck & Co., Inc. | Process of making cox-2 inhibitors having a lactone bridge |
| DE69529690T2 (de) | 1994-12-21 | 2003-11-13 | Merck Frosst Canada Inc | Diaryl-2(5h)-fuaranone als cox-2-inhibitoren |
| US5691374A (en) | 1995-05-18 | 1997-11-25 | Merck Frosst Canada Inc. | Diaryl-5-oxygenated-2-(5H) -furanones as COX-2 inhibitors |
| US5756529A (en) | 1995-09-29 | 1998-05-26 | G.D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides for use in veterinary therapies |
| GB9520584D0 (en) | 1995-10-09 | 1995-12-13 | Fujisawa Pharmaceutical Co | Pyrazole derivatives,processes for preparation thereof and pharmaceutical composition comprising the same |
| UA57002C2 (uk) | 1995-10-13 | 2003-06-16 | Мерк Фросст Кенада Енд Ко./Мерк Фросст Кенада Енд Сі. | Похідне (метилсульфоніл)феніл-2-(5н)-фуранону, фармацевтична композиція та спосіб лікування |
| EP0904269B1 (en) | 1995-10-30 | 2002-01-23 | Merck Frosst Canada & Co. | 3,4-diaryl-2-hydroxy-2,5-dihydrofurans as prodrugs to cox-2 inhibitors |
| IL149581A0 (en) | 1999-12-03 | 2002-11-10 | Pfizer Prod Inc | Heterocyclo-alkylsulfonyl pyrazole derivatives as anti-inflammatory/analgesic agents |
| TR200302047T4 (tr) | 1999-12-03 | 2004-01-21 | Pfizer Products Inc. | Anti-iltihabik / analjezik maddeler olarak heteroaril fenil pirazol bileşikleri. |
| DE60004001T2 (de) | 1999-12-03 | 2004-04-15 | Pfizer Products Inc., Groton | Acetylenderivate zur Verwendung als schmerzstillendes oder entzündungshemmendes Mittel |
-
2002
- 2002-09-12 GT GT200200183A patent/GT200200183A/es unknown
- 2002-09-19 WO PCT/IB2002/003908 patent/WO2003029244A1/en not_active Application Discontinuation
- 2002-09-19 IL IL16036902A patent/IL160369A0/xx unknown
- 2002-09-19 PL PL02370110A patent/PL370110A1/xx not_active Application Discontinuation
- 2002-09-19 MX MXPA04002879A patent/MXPA04002879A/es unknown
- 2002-09-19 RU RU2004109148/04A patent/RU2004109148A/ru not_active Application Discontinuation
- 2002-09-19 JP JP2003532493A patent/JP2005504127A/ja active Pending
- 2002-09-19 EP EP02760508A patent/EP1430046A1/en not_active Withdrawn
- 2002-09-19 CA CA002457798A patent/CA2457798A1/en not_active Abandoned
- 2002-09-19 HU HU0401914A patent/HUP0401914A3/hu unknown
- 2002-09-19 KR KR10-2004-7004437A patent/KR20040039424A/ko not_active Application Discontinuation
- 2002-09-19 BR BR0212860-8A patent/BR0212860A/pt not_active IP Right Cessation
- 2002-09-19 CZ CZ2004414A patent/CZ2004414A3/cs unknown
- 2002-09-19 CN CNA028191625A patent/CN1561339A/zh active Pending
- 2002-09-25 UY UY27453A patent/UY27453A1/es not_active Application Discontinuation
- 2002-09-26 PE PE2002000951A patent/PE20030532A1/es not_active Application Discontinuation
- 2002-09-26 AR ARP020103634A patent/AR036680A1/es unknown
- 2002-09-27 PA PA20028555601A patent/PA8555601A1/es unknown
- 2002-09-27 US US10/256,432 patent/US6646128B2/en not_active Expired - Fee Related
-
2003
- 2003-08-25 US US10/648,588 patent/US6846930B2/en not_active Expired - Fee Related
-
2004
- 2004-02-09 ZA ZA200401043A patent/ZA200401043B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA04002879A (es) | 2004-07-15 |
| HUP0401914A3 (en) | 2006-04-28 |
| PA8555601A1 (es) | 2003-09-17 |
| US6846930B2 (en) | 2005-01-25 |
| GT200200183A (es) | 2003-05-23 |
| PL370110A1 (en) | 2005-05-16 |
| US20030100765A1 (en) | 2003-05-29 |
| WO2003029244A8 (en) | 2003-09-04 |
| PE20030532A1 (es) | 2003-06-18 |
| WO2003029244A1 (en) | 2003-04-10 |
| US20040044042A1 (en) | 2004-03-04 |
| AR036680A1 (es) | 2004-09-29 |
| UY27453A1 (es) | 2003-04-30 |
| RU2004109148A (ru) | 2005-08-20 |
| EP1430046A1 (en) | 2004-06-23 |
| US6646128B2 (en) | 2003-11-11 |
| JP2005504127A (ja) | 2005-02-10 |
| CN1561339A (zh) | 2005-01-05 |
| CZ2004414A3 (cs) | 2004-12-15 |
| IL160369A0 (en) | 2004-07-25 |
| HUP0401914A2 (hu) | 2005-01-28 |
| CA2457798A1 (en) | 2003-04-10 |
| KR20040039424A (ko) | 2004-05-10 |
| BR0212860A (pt) | 2004-10-13 |
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