ZA200307242B - Dihydro-benzo[b][1,4]diazepin-2-one derivatives as mGluR2 antagonists I. - Google Patents
Dihydro-benzo[b][1,4]diazepin-2-one derivatives as mGluR2 antagonists I. Download PDFInfo
- Publication number
- ZA200307242B ZA200307242B ZA200307242A ZA200307242A ZA200307242B ZA 200307242 B ZA200307242 B ZA 200307242B ZA 200307242 A ZA200307242 A ZA 200307242A ZA 200307242 A ZA200307242 A ZA 200307242A ZA 200307242 B ZA200307242 B ZA 200307242B
- Authority
- ZA
- South Africa
- Prior art keywords
- phenyl
- dihydro
- benzo
- diazepin
- trifluoromethyl
- Prior art date
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- 108010038421 metabotropic glutamate receptor 2 Proteins 0.000 title 1
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- NJEDSZJNYRSQSF-UHFFFAOYSA-N tert-butyl n-[2-[[3-(3-cyanophenyl)-3-oxopropanoyl]amino]-5-methoxy-4-pyrrol-1-ylphenyl]carbamate Chemical compound C1=C(N2C=CC=C2)C(OC)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(C#N)=C1 NJEDSZJNYRSQSF-UHFFFAOYSA-N 0.000 description 1
- GCTLUKBVSGNCCY-UHFFFAOYSA-N tert-butyl n-[2-[[3-(3-imidazol-1-ylphenyl)-3-oxopropanoyl]amino]-5-methyl-4-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(C)=CC(NC(=O)OC(C)(C)C)=C1NC(=O)CC(=O)C1=CC=CC(N2C=NC=C2)=C1 GCTLUKBVSGNCCY-UHFFFAOYSA-N 0.000 description 1
- XUCFTALIKRJAME-UHFFFAOYSA-N tert-butyl n-[2-amino-5-(2-methoxyethoxy)-4-pyrrol-1-ylphenyl]carbamate Chemical compound COCCOC1=CC(NC(=O)OC(C)(C)C)=C(N)C=C1N1C=CC=C1 XUCFTALIKRJAME-UHFFFAOYSA-N 0.000 description 1
- YVLSWRDCRIHEOK-UHFFFAOYSA-N tert-butyl n-[2-amino-5-(cyanomethyl)-4-iodophenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC(CC#N)=C(I)C=C1N YVLSWRDCRIHEOK-UHFFFAOYSA-N 0.000 description 1
- YIIBSYFRWRSAFI-UHFFFAOYSA-N tert-butyl n-[2-amino-5-fluoro-4-(trifluoromethyl)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC(F)=C(C(F)(F)F)C=C1N YIIBSYFRWRSAFI-UHFFFAOYSA-N 0.000 description 1
- LXIKZPJLNNIMSY-UHFFFAOYSA-N tert-butyl n-[5-(cyanomethyl)-4-iodo-2-nitrophenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC(CC#N)=C(I)C=C1[N+]([O-])=O LXIKZPJLNNIMSY-UHFFFAOYSA-N 0.000 description 1
- NGJIIVWYRMAPRQ-UHFFFAOYSA-N tert-butyl n-[5-methoxy-2-nitro-4-(trifluoromethyl)phenyl]carbamate Chemical compound COC1=CC(NC(=O)OC(C)(C)C)=C([N+]([O-])=O)C=C1C(F)(F)F NGJIIVWYRMAPRQ-UHFFFAOYSA-N 0.000 description 1
- CRAJFVNFDNRPAS-UHFFFAOYSA-N tert-butyl-dimethyl-[3-(oxan-2-yloxy)prop-1-ynyl]silane Chemical compound CC(C)(C)[Si](C)(C)C#CCOC1CCCCO1 CRAJFVNFDNRPAS-UHFFFAOYSA-N 0.000 description 1
- FPGGTKZVZWFYPV-UHFFFAOYSA-M tetrabutylammonium fluoride Chemical compound [F-].CCCC[N+](CCCC)(CCCC)CCCC FPGGTKZVZWFYPV-UHFFFAOYSA-M 0.000 description 1
- 150000003536 tetrazoles Chemical class 0.000 description 1
- WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- VLLMWSRANPNYQX-UHFFFAOYSA-N thiadiazole Chemical compound C1=CSN=N1.C1=CSN=N1 VLLMWSRANPNYQX-UHFFFAOYSA-N 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- 229930192474 thiophene Natural products 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 229910052723 transition metal Inorganic materials 0.000 description 1
- 150000003624 transition metals Chemical class 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- VHKIEYIESYMHPT-UHFFFAOYSA-N triethyl(methoxycarbonylsulfamoyl)azanium;hydroxide Chemical compound [OH-].CC[N+](CC)(CC)S(=O)(=O)NC(=O)OC VHKIEYIESYMHPT-UHFFFAOYSA-N 0.000 description 1
- IMNIMPAHZVJRPE-UHFFFAOYSA-N triethylenediamine Chemical compound C1CN2CCN1CC2 IMNIMPAHZVJRPE-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229910052720 vanadium Inorganic materials 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000011995 wilkinson's catalyst Substances 0.000 description 1
- UTODFRQBVUVYOB-UHFFFAOYSA-P wilkinson's catalyst Chemical compound [Cl-].C1=CC=CC=C1P(C=1C=CC=CC=1)(C=1C=CC=CC=1)[Rh+](P(C=1C=CC=CC=1)(C=1C=CC=CC=1)C=1C=CC=CC=1)P(C=1C=CC=CC=1)(C=1C=CC=CC=1)C1=CC=CC=C1 UTODFRQBVUVYOB-UHFFFAOYSA-P 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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EP01109126 | 2001-04-12 |
Publications (1)
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ZA200307242B true ZA200307242B (en) | 2004-12-16 |
Family
ID=8177127
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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ZA200307242A ZA200307242B (en) | 2001-04-12 | 2003-09-16 | Dihydro-benzo[b][1,4]diazepin-2-one derivatives as mGluR2 antagonists I. |
Country Status (38)
Country | Link |
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US (1) | US6548495B2 (xx) |
EP (1) | EP1379522B1 (xx) |
JP (1) | JP4043953B2 (xx) |
KR (1) | KR100566178B1 (xx) |
CN (1) | CN1268626C (xx) |
AR (1) | AR035456A1 (xx) |
AT (1) | ATE287883T1 (xx) |
AU (1) | AU2002310912B2 (xx) |
BG (1) | BG108253A (xx) |
BR (1) | BR0208887A (xx) |
CA (1) | CA2441771C (xx) |
CZ (1) | CZ20033002A3 (xx) |
DE (1) | DE60202761T2 (xx) |
DK (1) | DK1379522T3 (xx) |
EC (1) | ECSP034796A (xx) |
ES (1) | ES2235044T3 (xx) |
GT (1) | GT200200072A (xx) |
HK (1) | HK1068339A1 (xx) |
HR (1) | HRP20030791B1 (xx) |
HU (1) | HUP0400991A3 (xx) |
IL (2) | IL158021A0 (xx) |
JO (1) | JO2273B1 (xx) |
MA (1) | MA27011A1 (xx) |
MX (1) | MXPA03009317A (xx) |
MY (1) | MY130369A (xx) |
NO (1) | NO325300B1 (xx) |
NZ (1) | NZ528345A (xx) |
PA (1) | PA8543201A1 (xx) |
PE (1) | PE20021072A1 (xx) |
PL (1) | PL367086A1 (xx) |
PT (1) | PT1379522E (xx) |
RU (1) | RU2270197C2 (xx) |
SI (1) | SI1379522T1 (xx) |
SK (1) | SK13692003A3 (xx) |
UY (1) | UY27259A1 (xx) |
WO (1) | WO2002083665A1 (xx) |
YU (1) | YU79103A (xx) |
ZA (1) | ZA200307242B (xx) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT1224175E (pt) * | 1999-10-15 | 2004-07-30 | Hoffmann La Roche | Derivados de benzodiazepina como antagonistas do receptor de glutamato metabotropico |
EP1651234B1 (en) * | 2003-07-25 | 2007-09-26 | F. Hoffmann-La Roche Ag | Combination of mglur2 antagonist and ache inhibitor for treatment of acute and/or chronic neurological disorders |
US7459563B2 (en) | 2004-11-05 | 2008-12-02 | Hoffmann-La Roche Inc. | Process for the preparation of isonicotinic acid derivatives |
TWI417095B (zh) | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | 1,4-二取代之3-氰基-吡啶酮衍生物及其作為mGluR2-受體之正向異位性調節劑之用途 |
TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
WO2008128889A1 (en) * | 2007-04-19 | 2008-10-30 | F. Hoffmann-La Roche Ag | Dihydro-benzo[b][1,4]diazepin-2-one sulfonamide derivatives |
TW200922566A (en) | 2007-09-14 | 2009-06-01 | Ortho Mcneil Janssen Pharm | 1,3 disubstituted 4-(aryl-X-phenyl)-1H-pyridin-2-ones |
JP5433579B2 (ja) * | 2007-09-14 | 2014-03-05 | ジャンセン ファーマシューティカルズ, インコーポレイテッド. | 1,3−二置換−4−フェニル−1h−ピリジン−2−オン |
RS51660B (en) | 2007-09-14 | 2011-10-31 | Ortho-Mcneil-Janssen Pharmaceuticals Inc. | 1`, 3`-DISUPSTITUATED-4-PHENYL-3,4,5,6-TETRAHYDRO-2H, 1`H- [1,4`] BIPYRIDINYL-2`-ONE |
CN101861316B (zh) | 2007-11-14 | 2013-08-21 | 奥梅-杨森制药有限公司 | 咪唑并[1,2-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途 |
RU2510396C2 (ru) | 2008-09-02 | 2014-03-27 | Янссен Фармасьютикалз, Инк. | 3-азабицикло[3.1.0]гексильные производные в качестве модуляторов метаботропных глутаматных рецепторов |
US8697689B2 (en) | 2008-10-16 | 2014-04-15 | Janssen Pharmaceuticals, Inc. | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors |
RU2512283C2 (ru) | 2008-11-28 | 2014-04-10 | Янссен Фармасьютикалз, Инк. | Производные индола и бензоксазина в качестве модуляторов метаботропных глутаматных рецепторов |
MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
ME01573B (me) | 2009-05-12 | 2014-09-20 | Addex Pharma Sa | DERIVATI 1,2,4-TRIAZOLO[4,3-a]PIRIDINA I NJIHOVA UPOTREBA U TRETMANU ILI PREVENCIJI NEUROLOŠKIH I PSIHIJATRIJSKIH POREMEĆAJA |
MY153912A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 1, 2, 4,-triazolo[4,3-a[pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
CN103261195B (zh) | 2010-11-08 | 2015-09-02 | 杨森制药公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途 |
WO2012062759A1 (en) | 2010-11-08 | 2012-05-18 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
CA2814996C (en) | 2010-11-08 | 2019-10-01 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
EP2602248A1 (en) | 2011-12-05 | 2013-06-12 | University Of Leicester | Novel pyrrole compounds |
RU2015116749A (ru) | 2012-10-23 | 2016-12-20 | Ф. Хоффманн-Ля Рош Аг | Антагонисты mglu2/3 для лечения аутических расстройств |
CA2901168C (en) * | 2013-02-28 | 2020-09-22 | Eisai R&D Management Co., Ltd. | Tetrahydroimidazo[1,5-d][1,4]oxazepine derivative |
JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
KR102502485B1 (ko) | 2014-01-21 | 2023-02-21 | 얀센 파마슈티카 엔.브이. | 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도 |
UA121965C2 (uk) | 2014-01-21 | 2020-08-25 | Янссен Фармацевтика Нв | Комбінації, які містять позитивні алостеричні модулятори або ортостеричні агоністи метаботропного глутаматергічного рецептора 2 підтипу, та їх застосування |
MX2016013711A (es) | 2014-04-23 | 2017-01-13 | Hoffmann La Roche | Antagonistas de receptores de glumato metabotropicos 2/3 (mglu2/3) para el tratamiento de varias discapacidades intelectuales. |
US9969726B2 (en) | 2014-06-10 | 2018-05-15 | Sanford-Burnham Medical Research Institute | Metabotropic glutamate receptor negative allosteric modulators (NAMS) and uses thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
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EP1210338A2 (en) * | 1999-08-05 | 2002-06-05 | IGT Pharma Inc. | 1,4-diazepine derivatives for the treatment of diseases related to the central nervous system |
PT1224175E (pt) * | 1999-10-15 | 2004-07-30 | Hoffmann La Roche | Derivados de benzodiazepina como antagonistas do receptor de glutamato metabotropico |
PT1224174E (pt) * | 1999-10-15 | 2004-01-30 | Hoffmann La Roche | Derivados de benzodiazepina como antagonistas do receptor metabotropico do glutamato |
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2002
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