ZA200306434B - Topical composition comprising an antifungal. - Google Patents
Topical composition comprising an antifungal. Download PDFInfo
- Publication number
- ZA200306434B ZA200306434B ZA200306434A ZA200306434A ZA200306434B ZA 200306434 B ZA200306434 B ZA 200306434B ZA 200306434 A ZA200306434 A ZA 200306434A ZA 200306434 A ZA200306434 A ZA 200306434A ZA 200306434 B ZA200306434 B ZA 200306434B
- Authority
- ZA
- South Africa
- Prior art keywords
- diclofenac
- terbinafine
- topically acceptable
- antifungal
- drug
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims description 49
- 229940121375 antifungal agent Drugs 0.000 title claims description 34
- 230000000843 anti-fungal effect Effects 0.000 title claims description 30
- 230000000699 topical effect Effects 0.000 title description 22
- DOMXUEMWDBAQBQ-WEVVVXLNSA-N terbinafine Chemical compound C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 DOMXUEMWDBAQBQ-WEVVVXLNSA-N 0.000 claims description 59
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 claims description 50
- 229960002722 terbinafine Drugs 0.000 claims description 44
- 150000003839 salts Chemical class 0.000 claims description 42
- 229940079593 drug Drugs 0.000 claims description 34
- 239000003814 drug Substances 0.000 claims description 34
- 229960001259 diclofenac Drugs 0.000 claims description 28
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 claims description 28
- 229960000905 indomethacin Drugs 0.000 claims description 25
- 150000001875 compounds Chemical class 0.000 claims description 22
- 229960001193 diclofenac sodium Drugs 0.000 claims description 18
- JGMJQSFLQWGYMQ-UHFFFAOYSA-M sodium;2,6-dichloro-n-phenylaniline;acetate Chemical compound [Na+].CC([O-])=O.ClC1=CC=CC(Cl)=C1NC1=CC=CC=C1 JGMJQSFLQWGYMQ-UHFFFAOYSA-M 0.000 claims description 18
- 239000012071 phase Substances 0.000 claims description 17
- 239000000839 emulsion Substances 0.000 claims description 16
- -1 nattifine Chemical compound 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- 241001480043 Arthrodermataceae Species 0.000 claims description 12
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- 208000031888 Mycoses Diseases 0.000 claims description 11
- 229960004022 clotrimazole Drugs 0.000 claims description 11
- VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 claims description 11
- AFNXATANNDIXLG-SFHVURJKSA-N 1-[(2r)-2-[(4-chlorophenyl)methylsulfanyl]-2-(2,4-dichlorophenyl)ethyl]imidazole Chemical compound C1=CC(Cl)=CC=C1CS[C@H](C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 AFNXATANNDIXLG-SFHVURJKSA-N 0.000 claims description 9
- OCAPBUJLXMYKEJ-UHFFFAOYSA-N 1-[biphenyl-4-yl(phenyl)methyl]imidazole Chemical compound C1=NC=CN1C(C=1C=CC(=CC=1)C=1C=CC=CC=1)C1=CC=CC=C1 OCAPBUJLXMYKEJ-UHFFFAOYSA-N 0.000 claims description 9
- QXHHHPZILQDDPS-UHFFFAOYSA-N 1-{2-[(2-chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl}imidazole Chemical compound S1C=CC(COC(CN2C=NC=C2)C=2C(=CC(Cl)=CC=2)Cl)=C1Cl QXHHHPZILQDDPS-UHFFFAOYSA-N 0.000 claims description 9
- JLGKQTAYUIMGRK-UHFFFAOYSA-N 1-{2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}imidazole Chemical compound ClC1=CC(Cl)=CC=C1C(OCC=1C2=CC=CC(Cl)=C2SC=1)CN1C=NC=C1 JLGKQTAYUIMGRK-UHFFFAOYSA-N 0.000 claims description 9
- JZFPYUNJRRFVQU-UHFFFAOYSA-N Niflumic acid Chemical compound OC(=O)C1=CC=CN=C1NC1=CC=CC(C(F)(F)F)=C1 JZFPYUNJRRFVQU-UHFFFAOYSA-N 0.000 claims description 9
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- LPEPZBJOKDYZAD-UHFFFAOYSA-N flufenamic acid Chemical compound OC(=O)C1=CC=CC=C1NC1=CC=CC(C(F)(F)F)=C1 LPEPZBJOKDYZAD-UHFFFAOYSA-N 0.000 claims description 9
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- BLSQLHNBWJLIBQ-OZXSUGGESA-N (2R,4S)-terconazole Chemical compound C1CN(C(C)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2N=CN=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 BLSQLHNBWJLIBQ-OZXSUGGESA-N 0.000 claims description 7
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- FRPZMMHWLSIFAZ-UHFFFAOYSA-N 10-undecenoic acid Chemical compound OC(=O)CCCCCCCCC=C FRPZMMHWLSIFAZ-UHFFFAOYSA-N 0.000 claims description 7
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- UETNIIAIRMUTSM-UHFFFAOYSA-N Jacareubin Natural products CC1(C)OC2=CC3Oc4c(O)c(O)ccc4C(=O)C3C(=C2C=C1)O UETNIIAIRMUTSM-UHFFFAOYSA-N 0.000 claims description 7
- BYBLEWFAAKGYCD-UHFFFAOYSA-N Miconazole Chemical compound ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 BYBLEWFAAKGYCD-UHFFFAOYSA-N 0.000 claims description 7
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- 229960004313 naftifine Drugs 0.000 claims description 7
- OZGNYLLQHRPOBR-DHZHZOJOSA-N naftifine Chemical compound C=1C=CC2=CC=CC=C2C=1CN(C)C\C=C\C1=CC=CC=C1 OZGNYLLQHRPOBR-DHZHZOJOSA-N 0.000 claims description 7
- 229960003483 oxiconazole Drugs 0.000 claims description 7
- QRJJEGAJXVEBNE-MOHJPFBDSA-N oxiconazole Chemical compound ClC1=CC(Cl)=CC=C1CO\N=C(C=1C(=CC(Cl)=CC=1)Cl)\CN1C=NC=C1 QRJJEGAJXVEBNE-MOHJPFBDSA-N 0.000 claims description 7
- 229960001940 sulfasalazine Drugs 0.000 claims description 7
- NCEXYHBECQHGNR-QZQOTICOSA-N sulfasalazine Chemical compound C1=C(O)C(C(=O)O)=CC(\N=N\C=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-QZQOTICOSA-N 0.000 claims description 7
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- LWZFANDGMFTDAV-BURFUSLBSA-N [(2r)-2-[(2r,3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O LWZFANDGMFTDAV-BURFUSLBSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000629 anti-dermatophyte Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 229940072107 ascorbate Drugs 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 210000001520 comb Anatomy 0.000 description 1
- 239000008139 complexing agent Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000008029 eradication Effects 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 210000002683 foot Anatomy 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 229940089474 lamisil Drugs 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229960003194 meglumine Drugs 0.000 description 1
- 239000004530 micro-emulsion Substances 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- FBUKVWPVBMHYJY-UHFFFAOYSA-N nonanoic acid Chemical class CCCCCCCCC(O)=O FBUKVWPVBMHYJY-UHFFFAOYSA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical class CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- QUANRIQJNFHVEU-UHFFFAOYSA-N oxirane;propane-1,2,3-triol Chemical compound C1CO1.OCC(O)CO QUANRIQJNFHVEU-UHFFFAOYSA-N 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 229940086539 peg-7 glyceryl cocoate Drugs 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229940068886 polyethylene glycol 300 Drugs 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229940068965 polysorbates Drugs 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 208000008742 seborrheic dermatitis Diseases 0.000 description 1
- 208000014745 severe cutaneous adverse reaction Diseases 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 235000011067 sorbitan monolaureate Nutrition 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 150000004684 trihydrates Chemical class 0.000 description 1
- 239000002966 varnish Substances 0.000 description 1
- 229940063674 voltaren Drugs 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0108082.9A GB0108082D0 (en) | 2001-03-30 | 2001-03-30 | Topical composition |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200306434B true ZA200306434B (en) | 2004-04-29 |
Family
ID=9911965
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200306434A ZA200306434B (en) | 2001-03-30 | 2003-08-19 | Topical composition comprising an antifungal. |
Country Status (20)
Country | Link |
---|---|
US (1) | US20040101538A1 (de) |
EP (1) | EP1390031B1 (de) |
JP (1) | JP2004528317A (de) |
CN (1) | CN100366244C (de) |
AR (1) | AR033023A1 (de) |
AT (1) | ATE288752T1 (de) |
AU (1) | AU2002246119B2 (de) |
CA (1) | CA2437789A1 (de) |
CZ (1) | CZ295223B6 (de) |
DE (1) | DE60202946T2 (de) |
ES (1) | ES2236495T3 (de) |
GB (1) | GB0108082D0 (de) |
HK (1) | HK1063282A1 (de) |
HU (1) | HUP0303961A2 (de) |
IL (1) | IL157334A0 (de) |
NZ (1) | NZ528407A (de) |
PL (1) | PL362858A1 (de) |
PT (1) | PT1390031E (de) |
WO (1) | WO2002078648A2 (de) |
ZA (1) | ZA200306434B (de) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR041021A1 (es) | 2002-08-22 | 2005-04-27 | Novartis Consumer Health Sa | Composicion topica |
US8404751B2 (en) * | 2002-09-27 | 2013-03-26 | Hallux, Inc. | Subunguicide, and method for treating onychomycosis |
US20060165803A1 (en) * | 2002-12-18 | 2006-07-27 | Celia Palacin | Pharmaceutical compositions of sertaconazole for vaginal use |
US20040126343A1 (en) * | 2002-12-26 | 2004-07-01 | Garshowitz Solomon David | Nail drug delivery |
CA2538991A1 (en) | 2003-09-18 | 2005-03-31 | Children's Medical Center Corporation | Treatment of severe distal colitis |
US20050137262A1 (en) * | 2003-12-22 | 2005-06-23 | Hu Patrick C. | Highly concentrated pourable aqueous solutions of potassium ibuprofen, their preparation and their uses |
US20050238672A1 (en) * | 2004-04-27 | 2005-10-27 | Nimni Marcel E | Antifungal drug delivery |
US7740875B2 (en) * | 2004-10-08 | 2010-06-22 | Mediquest Therapeutics, Inc. | Organo-gel formulations for therapeutic applications |
US20060078580A1 (en) * | 2004-10-08 | 2006-04-13 | Mediquest Therapeutics, Inc. | Organo-gel formulations for therapeutic applications |
US20060142304A1 (en) * | 2004-12-27 | 2006-06-29 | Michael Southall | Method for treating or preventing pruritic and neurogenic skin disorders |
US20060251593A1 (en) * | 2005-04-07 | 2006-11-09 | Work By Docs, Inc. | Colored nail enamel treatment |
FR2892023B1 (fr) * | 2005-10-14 | 2009-09-25 | Galderma Sa | Composition pharmaceutique a base d'amorolfine et d'agent filmogene hydrosoluble pour application ungueale et peri-ungueale |
CN100364520C (zh) * | 2006-04-24 | 2008-01-30 | 魏锐 | 盐酸特比萘芬栓剂及其制备方法 |
PT2018164T (pt) | 2006-05-12 | 2017-06-12 | Christian Noe | Utilização de preparações combinadas que compreendem antimicóticos |
US20080317684A1 (en) * | 2006-09-06 | 2008-12-25 | Isw Group, Inc. | Topical Compositions |
EP2055298A1 (de) | 2007-10-30 | 2009-05-06 | Novartis AG | Topische Zusammensetzung |
ES2316312B1 (es) * | 2008-06-20 | 2010-02-08 | Ignacio Umbert Millet | Composicion farmaceutica dermatologica para el tratamiento de patologias de inflamacion de la piel, tales como por ejemplo dermatitis, dermatitis atopica, vitiligo, alopecia areata, acne, psoriasis y prurito,y combinaciones de las mismas. |
CA2731455A1 (en) | 2008-07-23 | 2010-01-28 | Gregor Cevc | Methods of administering topical antifungal formulations for the treatment of fungal infections |
EP2416759A2 (de) * | 2009-04-08 | 2012-02-15 | Cadila Healthcare Limited | Stabile pharmazeutische diclofenac-zusammensetzungen |
DE102009038512A1 (de) | 2009-07-30 | 2011-02-10 | Technische Universität Braunschweig | Arzneimittelformulierung zur Behandlung von Nagelerkrankungen |
CN102423293B (zh) * | 2011-01-28 | 2013-05-29 | 舒泰神(北京)生物制药股份有限公司 | 一种硝酸奥昔康唑的微乳凝胶制剂 |
WO2012126899A2 (en) * | 2011-03-18 | 2012-09-27 | Katholieke Universiteit Leuven Ku Leuven Research & Development | Inhibition and treatment of biofilms |
JP6339940B2 (ja) * | 2011-12-20 | 2018-06-06 | ビョーメ バイオサイエンシズ ピーブイティー.リミテッド | 真菌感染症の治療用の局所用オイル組成物 |
JP6189962B2 (ja) | 2012-10-09 | 2017-08-30 | ザ プロクター アンド ギャンブル カンパニー | 相乗作用する美容成分の組み合わせを特定する方法 |
WO2014059008A1 (en) | 2012-10-09 | 2014-04-17 | The Procter & Gamble Company | Method of identifying or evaluating beneficial actives and compositions containing the same |
US9433680B2 (en) | 2013-01-31 | 2016-09-06 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
US8778365B1 (en) | 2013-01-31 | 2014-07-15 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
US9452173B2 (en) | 2013-01-31 | 2016-09-27 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
US9446131B2 (en) | 2013-01-31 | 2016-09-20 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
US9144538B2 (en) | 2013-02-08 | 2015-09-29 | The Procter & Gamble Company | Cosmetic compositions containing substituted azole and methods for alleviating the signs of photoaged skin |
US9138393B2 (en) | 2013-02-08 | 2015-09-22 | The Procter & Gamble Company | Cosmetic compositions containing substituted azole and methods for improving the appearance of aging skin |
CA2904703A1 (en) | 2013-03-14 | 2014-10-02 | Hallux, Inc. | Method of treating infections, diseases or disorders of nail unit |
WO2014167554A2 (en) * | 2013-04-12 | 2014-10-16 | Vyome Biosciences Pvt. Ltd. | Composition and formulation of antimicrobial agents, processes thereof and methods for treating microbial infections |
RU2702898C2 (ru) | 2014-09-10 | 2019-10-14 | Гск Консьюмер Хелткер С.А. | Композиции диклофенака натрия для местного применения |
CN105193726B (zh) * | 2015-11-08 | 2018-01-26 | 长沙佰顺生物科技有限公司 | 一种治疗灰指甲的药物组合物 |
WO2017091168A1 (en) | 2015-11-28 | 2017-06-01 | Pharmacti̇ve İlaç San. Ve Ti̇c. A.Ş. | A topical spray comprising isoconazole nitrate and difluocortolone valerate |
ES2562985B1 (es) * | 2015-12-31 | 2016-09-14 | Enrique Blanxart Sena | Composición farmacéutica para el tratamiento de lesiones de la piel |
WO2017216722A2 (en) * | 2016-06-13 | 2017-12-21 | Vyome Biosciences Pvt. Ltd. | Synergistic antifungal compositions and methods thereof |
EP3468544A2 (de) * | 2016-06-13 | 2019-04-17 | Vyome Therapeutics Limited | Synergistische antifungale zusammensetzungen und verfahren dafür |
EP3482744A1 (de) * | 2017-11-14 | 2019-05-15 | ProFem GmbH | Emulsionen zur topischen behandlung urogenitaler und dermaler infektionen |
EP3482743A1 (de) * | 2017-11-14 | 2019-05-15 | ProFem GmbH | Emulsionen zur behandlung von scheideninfektionen |
MX2020005056A (es) | 2017-11-14 | 2020-10-28 | Profem Gmbh | Emulsiones para el tratamiento tópico de infecciones dérmicas y de mucosas. |
CN111432802A (zh) | 2017-12-04 | 2020-07-17 | 强生消费者公司 | 含有非甾体抗炎药的局部用乳液组合物 |
EP3760231A4 (de) * | 2018-02-27 | 2022-01-19 | Hisamitsu Pharmaceutical Co., Inc. | Emulgierte gelzusammensetzung |
US20210077393A1 (en) * | 2018-02-27 | 2021-03-18 | Hisamitsu Pharmaceutical Co., Inc. | Diclofenac-containing emulsified gel composition |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH655656B (de) * | 1982-10-07 | 1986-05-15 | ||
IT1247529B (it) * | 1991-04-24 | 1994-12-17 | Poli Ind Chimica Spa | Composizioni farmaceutiche in forma di schiuma per somministrazione intravaginale, cutanea e orale |
HU223343B1 (hu) * | 1991-05-20 | 2004-06-28 | Novartis Ag. | Allil-amin-származékot tartalmazó gyógyászati készítmények és eljárás azok előállítására |
FR2722102B1 (fr) * | 1994-07-11 | 1996-08-23 | Cird Galderma | Utilisation de particules creuses deformables dans une composition cosmetique et/ou dermatologique, contenant des matieres grasses |
US6159977A (en) * | 1998-11-16 | 2000-12-12 | Astan, Inc. | Therapeutic anti-fungal nail preparation |
-
2001
- 2001-03-30 GB GBGB0108082.9A patent/GB0108082D0/en not_active Ceased
-
2002
- 2002-03-27 AR ARP020101137A patent/AR033023A1/es unknown
- 2002-03-28 PT PT02714197T patent/PT1390031E/pt unknown
- 2002-03-28 WO PCT/EP2002/003547 patent/WO2002078648A2/en active IP Right Grant
- 2002-03-28 DE DE60202946T patent/DE60202946T2/de not_active Expired - Fee Related
- 2002-03-28 ES ES02714197T patent/ES2236495T3/es not_active Expired - Lifetime
- 2002-03-28 CZ CZ20032599A patent/CZ295223B6/cs not_active IP Right Cessation
- 2002-03-28 IL IL15733402A patent/IL157334A0/xx unknown
- 2002-03-28 HU HU0303961A patent/HUP0303961A2/hu unknown
- 2002-03-28 CA CA002437789A patent/CA2437789A1/en not_active Abandoned
- 2002-03-28 JP JP2002576915A patent/JP2004528317A/ja active Pending
- 2002-03-28 PL PL02362858A patent/PL362858A1/xx unknown
- 2002-03-28 CN CNB028076079A patent/CN100366244C/zh not_active Expired - Fee Related
- 2002-03-28 AU AU2002246119A patent/AU2002246119B2/en not_active Ceased
- 2002-03-28 EP EP02714197A patent/EP1390031B1/de not_active Expired - Lifetime
- 2002-03-28 AT AT02714197T patent/ATE288752T1/de not_active IP Right Cessation
- 2002-03-28 NZ NZ528407A patent/NZ528407A/en unknown
- 2002-03-28 US US10/472,697 patent/US20040101538A1/en not_active Abandoned
-
2003
- 2003-08-19 ZA ZA200306434A patent/ZA200306434B/en unknown
-
2004
- 2004-07-15 HK HK04105221A patent/HK1063282A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
PT1390031E (pt) | 2005-05-31 |
CZ295223B6 (cs) | 2005-06-15 |
JP2004528317A (ja) | 2004-09-16 |
WO2002078648A2 (en) | 2002-10-10 |
EP1390031A2 (de) | 2004-02-25 |
EP1390031B1 (de) | 2005-02-09 |
NZ528407A (en) | 2006-04-28 |
DE60202946D1 (de) | 2005-03-17 |
PL362858A1 (en) | 2004-11-02 |
AR033023A1 (es) | 2003-12-03 |
HUP0303961A2 (hu) | 2004-03-29 |
ATE288752T1 (de) | 2005-02-15 |
US20040101538A1 (en) | 2004-05-27 |
IL157334A0 (en) | 2004-02-19 |
WO2002078648A3 (en) | 2003-12-11 |
CA2437789A1 (en) | 2002-10-10 |
ES2236495T3 (es) | 2005-07-16 |
CN100366244C (zh) | 2008-02-06 |
GB0108082D0 (en) | 2001-05-23 |
CN1531430A (zh) | 2004-09-22 |
AU2002246119B2 (en) | 2005-04-07 |
CZ20032599A3 (cs) | 2004-09-15 |
HK1063282A1 (en) | 2004-12-24 |
DE60202946T2 (de) | 2005-07-07 |
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