ZA200304264B - Tetrahydropyridine derivatives, their preparation and their use as cell proliferation inhibitors. - Google Patents
Tetrahydropyridine derivatives, their preparation and their use as cell proliferation inhibitors. Download PDFInfo
- Publication number
- ZA200304264B ZA200304264B ZA200304264A ZA200304264A ZA200304264B ZA 200304264 B ZA200304264 B ZA 200304264B ZA 200304264 A ZA200304264 A ZA 200304264A ZA 200304264 A ZA200304264 A ZA 200304264A ZA 200304264 B ZA200304264 B ZA 200304264B
- Authority
- ZA
- South Africa
- Prior art keywords
- group
- alkyl
- octanoic acid
- formula
- dihydro
- Prior art date
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- 238000002360 preparation method Methods 0.000 title claims description 8
- 239000003112 inhibitor Substances 0.000 title claims description 6
- 230000004663 cell proliferation Effects 0.000 title claims description 4
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- 238000000034 method Methods 0.000 claims description 17
- 125000001424 substituent group Chemical group 0.000 claims description 17
- 150000003839 salts Chemical class 0.000 claims description 14
- 125000005843 halogen group Chemical group 0.000 claims description 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 10
- 125000003545 alkoxy group Chemical group 0.000 claims description 9
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- 125000004432 carbon atom Chemical group C* 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 8
- 125000006239 protecting group Chemical group 0.000 claims description 8
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00128487 | 2000-12-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200304264B true ZA200304264B (en) | 2004-08-30 |
Family
ID=8170814
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200304264A ZA200304264B (en) | 2000-12-23 | 2003-05-30 | Tetrahydropyridine derivatives, their preparation and their use as cell proliferation inhibitors. |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6800638B2 (xx) |
| EP (1) | EP1353921B1 (xx) |
| JP (1) | JP2004516325A (xx) |
| KR (1) | KR100836545B1 (xx) |
| CN (1) | CN1213046C (xx) |
| AR (1) | AR035513A1 (xx) |
| AT (1) | ATE323700T1 (xx) |
| AU (1) | AU2002226397B2 (xx) |
| BG (1) | BG107935A (xx) |
| BR (1) | BR0116402A (xx) |
| CA (1) | CA2431471A1 (xx) |
| CZ (1) | CZ20031940A3 (xx) |
| DE (1) | DE60118975T2 (xx) |
| EC (1) | ECSP034664A (xx) |
| ES (1) | ES2261519T3 (xx) |
| HU (1) | HUP0400554A2 (xx) |
| IL (1) | IL156131A0 (xx) |
| MA (1) | MA26976A1 (xx) |
| MX (1) | MXPA03005713A (xx) |
| NO (1) | NO20032830L (xx) |
| NZ (1) | NZ526189A (xx) |
| PL (1) | PL365531A1 (xx) |
| RU (1) | RU2276140C2 (xx) |
| SK (1) | SK9122003A3 (xx) |
| WO (1) | WO2002051842A1 (xx) |
| YU (1) | YU48803A (xx) |
| ZA (1) | ZA200304264B (xx) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6706686B2 (en) | 2001-09-27 | 2004-03-16 | The Regents Of The University Of Colorado | Inhibition of histone deacetylase as a treatment for cardiac hypertrophy |
| JP4638148B2 (ja) | 2001-10-16 | 2011-02-23 | スローン − ケタリング・インスティテュート・フォー・キャンサー・リサーチ | 神経変性疾患および脳の癌の処置 |
| AU2003218508A1 (en) | 2002-04-01 | 2003-10-13 | Ranko Rakanovic | Rubber elastic element |
| US7154002B1 (en) | 2002-10-08 | 2006-12-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US7250514B1 (en) | 2002-10-21 | 2007-07-31 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| AU2003900608A0 (en) * | 2003-02-11 | 2003-02-27 | Fujisawa Pharmaceutical Co., Ltd. | Hdac inhibitor |
| JP2006520796A (ja) | 2003-03-17 | 2006-09-14 | タケダ サン ディエゴ インコーポレイテッド | ヒストンデアセチラーゼインヒビター |
| US20060235012A1 (en) * | 2003-06-16 | 2006-10-19 | Chroma Therapeutics Limited | Carboline and betacarboline derivatives for use as hdac enzyme inhibitors |
| US20090023718A1 (en) * | 2003-11-26 | 2009-01-22 | Aton Pharma, Inc. | Diamine and Iminodiacetic Acid Hydroxamic Acid Derivatives |
| WO2005065681A1 (en) * | 2003-12-19 | 2005-07-21 | Takeda San Diego, Inc. | N- hydroxy-3-(3-(1h-imidazol-2-yl)-phenyl)-acrylamide derivatives and related compounds as histone deacetylase (hdac) inhibitors for the treatment of cancer |
| US20050137234A1 (en) * | 2003-12-19 | 2005-06-23 | Syrrx, Inc. | Histone deacetylase inhibitors |
| WO2006066133A2 (en) | 2004-12-16 | 2006-06-22 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| EP1851219A1 (en) | 2005-02-14 | 2007-11-07 | Miikana Therapeutics, Inc. | Fused heterocyclic compounds useful as inhibitors of histone deacetylase |
| GB0509223D0 (en) | 2005-05-05 | 2005-06-15 | Chroma Therapeutics Ltd | Enzyme inhibitors |
| JP2008540574A (ja) | 2005-05-11 | 2008-11-20 | タケダ サン ディエゴ インコーポレイテッド | ヒストンデアセチラーゼ阻害剤 |
| CA2615105A1 (en) * | 2005-07-14 | 2007-01-25 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| EP2258357A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
| EP2275095A3 (en) | 2005-08-26 | 2011-08-17 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
| EP2377530A3 (en) | 2005-10-21 | 2012-06-20 | Braincells, Inc. | Modulation of neurogenesis by PDE inhibition |
| AU2006308889A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | GABA receptor mediated modulation of neurogenesis |
| EP1976835A2 (en) * | 2006-01-13 | 2008-10-08 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| EP2382975A3 (en) | 2006-05-09 | 2012-02-29 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| WO2007134077A2 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
| BRPI0716604A2 (pt) | 2006-09-08 | 2013-04-09 | Braincells Inc | combinaÇÕes contendo um derivado de 4-acilaminopiridina |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| TWI425945B (zh) * | 2007-05-28 | 2014-02-11 | Seldar Pharma Inc | 四氫異喹啉－１－酮衍生物或其鹽 |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| JP5838157B2 (ja) * | 2009-07-22 | 2015-12-24 | ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・イリノイＴｈｅ Ｂｏａｒｄ Ｏｆ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｉｌｌｉｎｏｉｓ | Ｈｄａｃ阻害剤およびそれを用いる治療法 |
| CN102153549B (zh) * | 2010-12-14 | 2012-11-14 | 华东理工大学 | γ咔啉化合物、制备方法和用途 |
| DK2991982T3 (en) | 2013-04-29 | 2018-12-10 | Chong Kun Dang Pharmaceutical Corp | PRESENT UNKNOWN RELATIONS TO SELECTIVE HISTONDEACETYLASE INHIBITORS AND PHARMACEUTICAL COMPOSITION, INCLUDING THESE |
| US10184933B2 (en) | 2013-10-01 | 2019-01-22 | The J. David Gladstone Industries | Compositions, systems and methods for gene expression noise drug screening and uses thereof |
| CN108084178B (zh) * | 2018-01-04 | 2020-09-01 | 济南大学 | 一类含有四氢-β-咔碄结构的异羟肟酸类化合物的用途 |
| CN108558653A (zh) * | 2018-05-14 | 2018-09-21 | 湖南华腾制药有限公司 | 赛乐西帕中间体及赛乐西帕的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990002119A1 (en) * | 1988-08-18 | 1990-03-08 | Banyu Pharmaceutical Co., Ltd. | 1,2,3,4-tetrahydroisoquinoline derivatives |
| US5369108A (en) | 1991-10-04 | 1994-11-29 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and methods of use thereof |
| WO1998007421A1 (fr) | 1996-08-16 | 1998-02-26 | Ishihara Sangyo Kaisha, Ltd. | Composition medicinale |
| WO1998015525A1 (fr) | 1996-10-07 | 1998-04-16 | Sumitomo Pharmaceuticals Co., Ltd. | Acides hydroxamiques |
| AUPO721997A0 (en) * | 1997-06-06 | 1997-07-03 | Queensland Institute Of Medical Research, The | Anticancer compounds |
| CA2367963A1 (en) * | 1999-03-22 | 2000-09-28 | Darwin Discovery Limited | Hydroxamic and carboxylic acid derivatives |
-
2001
- 2001-12-06 AR ARP010105675A patent/AR035513A1/es not_active Application Discontinuation
- 2001-12-21 US US10/451,757 patent/US6800638B2/en not_active Expired - Fee Related
- 2001-12-21 CZ CZ20031940A patent/CZ20031940A3/cs unknown
- 2001-12-21 SK SK912-2003A patent/SK9122003A3/sk unknown
- 2001-12-21 ES ES01995721T patent/ES2261519T3/es not_active Expired - Lifetime
- 2001-12-21 EP EP01995721A patent/EP1353921B1/en not_active Expired - Lifetime
- 2001-12-21 AU AU2002226397A patent/AU2002226397B2/en not_active Ceased
- 2001-12-21 AT AT01995721T patent/ATE323700T1/de not_active IP Right Cessation
- 2001-12-21 IL IL15613101A patent/IL156131A0/xx unknown
- 2001-12-21 MX MXPA03005713A patent/MXPA03005713A/es active IP Right Grant
- 2001-12-21 HU HU0400554A patent/HUP0400554A2/hu unknown
- 2001-12-21 CN CNB018212050A patent/CN1213046C/zh not_active Expired - Fee Related
- 2001-12-21 RU RU2003122190/04A patent/RU2276140C2/ru active
- 2001-12-21 PL PL01365531A patent/PL365531A1/xx not_active Application Discontinuation
- 2001-12-21 JP JP2002552937A patent/JP2004516325A/ja not_active Ceased
- 2001-12-21 YU YU48803A patent/YU48803A/sh unknown
- 2001-12-21 KR KR1020037008028A patent/KR100836545B1/ko not_active IP Right Cessation
- 2001-12-21 WO PCT/EP2001/015390 patent/WO2002051842A1/en active IP Right Grant
- 2001-12-21 BR BR0116402-3A patent/BR0116402A/pt not_active IP Right Cessation
- 2001-12-21 NZ NZ526189A patent/NZ526189A/en unknown
- 2001-12-21 CA CA002431471A patent/CA2431471A1/en not_active Abandoned
- 2001-12-21 DE DE60118975T patent/DE60118975T2/de not_active Expired - Fee Related
-
2003
- 2003-05-30 ZA ZA200304264A patent/ZA200304264B/en unknown
- 2003-06-20 MA MA27207A patent/MA26976A1/fr unknown
- 2003-06-20 NO NO20032830A patent/NO20032830L/no not_active Application Discontinuation
- 2003-06-22 EC EC2003004664A patent/ECSP034664A/es unknown
- 2003-06-23 BG BG107935A patent/BG107935A/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR100836545B1 (ko) | 2008-06-10 |
| JP2004516325A (ja) | 2004-06-03 |
| AU2002226397B2 (en) | 2006-10-05 |
| US20040053960A1 (en) | 2004-03-18 |
| CZ20031940A3 (cs) | 2003-10-15 |
| NO20032830L (no) | 2003-08-04 |
| CN1213046C (zh) | 2005-08-03 |
| IL156131A0 (en) | 2003-12-23 |
| PL365531A1 (en) | 2005-01-10 |
| BR0116402A (pt) | 2003-11-11 |
| HUP0400554A2 (hu) | 2004-06-28 |
| RU2003122190A (ru) | 2005-02-27 |
| AR035513A1 (es) | 2004-06-02 |
| DE60118975D1 (de) | 2006-05-24 |
| YU48803A (sh) | 2006-05-25 |
| MXPA03005713A (es) | 2003-10-06 |
| WO2002051842A1 (en) | 2002-07-04 |
| EP1353921B1 (en) | 2006-04-19 |
| RU2276140C2 (ru) | 2006-05-10 |
| SK9122003A3 (en) | 2004-02-03 |
| US6800638B2 (en) | 2004-10-05 |
| MA26976A1 (fr) | 2004-12-20 |
| CN1483033A (zh) | 2004-03-17 |
| ATE323700T1 (de) | 2006-05-15 |
| KR20030063424A (ko) | 2003-07-28 |
| NZ526189A (en) | 2004-10-29 |
| NO20032830D0 (no) | 2003-06-20 |
| ES2261519T3 (es) | 2006-11-16 |
| CA2431471A1 (en) | 2002-07-04 |
| DE60118975T2 (de) | 2006-12-21 |
| EP1353921A1 (en) | 2003-10-22 |
| BG107935A (bg) | 2004-08-31 |
| ECSP034664A (es) | 2003-07-25 |
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