ZA200301047B - New macrolides with antibacterial activity. - Google Patents

New macrolides with antibacterial activity. Download PDF

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Publication number
ZA200301047B
ZA200301047B ZA200301047A ZA200301047A ZA200301047B ZA 200301047 B ZA200301047 B ZA 200301047B ZA 200301047 A ZA200301047 A ZA 200301047A ZA 200301047 A ZA200301047 A ZA 200301047A ZA 200301047 B ZA200301047 B ZA 200301047B
Authority
ZA
South Africa
Prior art keywords
compound
thio
compounds
formula
treatment
Prior art date
Application number
ZA200301047A
Other languages
English (en)
Inventor
Peter Angehrn
Pierre-Charles Wyss
Daniel Hunziker
Original Assignee
Basilea Pharmaceutica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basilea Pharmaceutica Ag filed Critical Basilea Pharmaceutica Ag
Publication of ZA200301047B publication Critical patent/ZA200301047B/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0031—Rectum, anus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
ZA200301047A 2000-08-22 2003-02-06 New macrolides with antibacterial activity. ZA200301047B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP00117971 2000-08-22

Publications (1)

Publication Number Publication Date
ZA200301047B true ZA200301047B (en) 2004-05-06

Family

ID=8169600

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200301047A ZA200301047B (en) 2000-08-22 2003-02-06 New macrolides with antibacterial activity.

Country Status (14)

Country Link
US (1) US6740642B2 (enExample)
EP (1) EP1313751B1 (enExample)
JP (1) JP4162992B2 (enExample)
KR (1) KR100502031B1 (enExample)
CN (1) CN1234718C (enExample)
AT (1) ATE408614T1 (enExample)
AU (1) AU2001282105A1 (enExample)
BR (1) BR0113472A (enExample)
CA (1) CA2419296C (enExample)
DE (1) DE60135859D1 (enExample)
ES (1) ES2313975T3 (enExample)
MX (1) MXPA03001607A (enExample)
WO (1) WO2002016380A1 (enExample)
ZA (1) ZA200301047B (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002217277B2 (en) * 2000-12-21 2005-06-16 Glaxo Group Limited Macrolide antibiotics
FR2826274B1 (fr) * 2001-06-21 2003-09-26 Aventis Pharma Sa Formulation pharmaceutique au gout masque et son procede de preparation
CA2460947A1 (en) 2001-09-17 2003-03-27 Ortho-Mcneil Pharmaceutical, Inc. 6-o-carbamate-11,12-lacto-ketolide antimicrobials
US6995143B2 (en) 2002-02-28 2006-02-07 Basilea Pharmaceutica Ag Macrolides with antibacterial activity
US6727229B2 (en) 2002-08-19 2004-04-27 Enanta Pharmaceuticals, Inc. 11,12-substituted lactone ketolide derivatives having antibacterial activity
US6720308B1 (en) 2002-11-07 2004-04-13 Enanta Pharmaceuticals, Inc. Anhydrolide derivatives having antibacterial activity
US20040254126A1 (en) * 2003-06-05 2004-12-16 Yao-Ling Qiu 11-12 Bicyclic erythromycin derivatives
US6716820B1 (en) 2003-06-05 2004-04-06 Enanta Pharmaceuticals, Inc. 6-O-substituted bicyclic macrolides
WO2004108745A2 (en) * 2003-06-05 2004-12-16 Enanta Pharmaceuticals, Inc. 11-12 bicyclic erythromycin derivatives
US6774115B1 (en) 2003-06-05 2004-08-10 Enanta Pharmaceuticals, Inc. 6-O-substituted bicyclic ketolides
US6765016B1 (en) 2003-06-05 2004-07-20 Enanta Pharmaceuticals, Inc. Bicyclic ketolide derivatives
US6790835B1 (en) 2003-06-05 2004-09-14 Enanta Pharmaceuticals, Inc. Bicyclic macrolide derivatives
WO2006065721A2 (en) * 2004-12-13 2006-06-22 Enanta Pharmaceuticals, Inc. 11, 12-lactone bicyclolides
CN101115764B (zh) * 2005-02-09 2012-09-26 巴斯利尔药物股份公司 大环内酯类化合物
ES2322775T3 (es) 2005-02-09 2009-06-26 Basilea Pharmaceutica Ag Nuevos macrolidos.
US7517859B2 (en) * 2005-05-04 2009-04-14 Enanta Pharmaceuticals, Inc. Spirocyclic bicyclolides
DK1934238T3 (en) 2005-08-24 2017-09-18 Melinta Therapeutics Inc TRIAZOL COMPOUNDS AND METHODS FOR THE PREPARATION AND USE OF THESE
PT2049556E (pt) * 2006-08-09 2013-08-22 Basilea Pharmaceutica Ag Novos macrólidos úteis contra doenças inflamatórias e alérgicas
CN101541331A (zh) * 2006-08-24 2009-09-23 沃克哈特研究中心 具有抗微生物活性的新颖大环内酯和酮内酯
KR101589960B1 (ko) 2008-02-08 2016-01-29 바실리어 파마슈티카 아게 Ｐｄｅ 억제를 통해 중재되는 질환의 치료를 위한 마크로라이드
KR101617897B1 (ko) * 2008-02-08 2016-05-03 바실리어 파마슈티카 아게 신규 마크로라이드 및 그의 용도
NZ596628A (en) 2009-05-27 2013-03-28 Ketolide compounds having antimicrobial activity
US8796474B1 (en) 2010-08-23 2014-08-05 Rutgers, The State University Of New Jersey Macrolide compounds and methods and intermediates useful for their preparation
CN102417530A (zh) * 2010-09-26 2012-04-18 中国医学科学院药物研究所 广谱抗菌素红霉素a大环酮内酯类衍生物的合成方法和用途
PT2673285T (pt) 2010-12-09 2017-10-19 Wockhardt Ltd Resumo
KR101567658B1 (ko) 2011-03-01 2015-11-09 욱크하르트 리미티드 케톨리드 중간체의 제조 방법
WO2014102315A1 (en) * 2012-12-31 2014-07-03 Basilea Pharmaceutica Ag Selected macrolides with pde4-inhibiting activity
CN108778255B (zh) 2016-01-12 2020-11-13 沃克哈特有限公司 药物组合物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2719587B1 (fr) * 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.

Also Published As

Publication number Publication date
US6740642B2 (en) 2004-05-25
JP2004506740A (ja) 2004-03-04
WO2002016380A1 (en) 2002-02-28
ES2313975T3 (es) 2009-03-16
ATE408614T1 (de) 2008-10-15
CA2419296A1 (en) 2002-02-28
KR100502031B1 (ko) 2005-07-25
CN1234718C (zh) 2006-01-04
EP1313751B1 (en) 2008-09-17
CN1464880A (zh) 2003-12-31
MXPA03001607A (es) 2003-06-04
US20030199459A1 (en) 2003-10-23
JP4162992B2 (ja) 2008-10-08
DE60135859D1 (de) 2008-10-30
AU2001282105A1 (en) 2002-03-04
EP1313751A1 (en) 2003-05-28
CA2419296C (en) 2008-12-09
BR0113472A (pt) 2003-07-01
KR20030029839A (ko) 2003-04-16

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