ZA200209757B - Methods of treating viral diseases with IL-18 combinations. - Google Patents

Methods of treating viral diseases with IL-18 combinations. Download PDF

Info

Publication number
ZA200209757B
ZA200209757B ZA200209757A ZA200209757A ZA200209757B ZA 200209757 B ZA200209757 B ZA 200209757B ZA 200209757 A ZA200209757 A ZA 200209757A ZA 200209757 A ZA200209757 A ZA 200209757A ZA 200209757 B ZA200209757 B ZA 200209757B
Authority
ZA
South Africa
Prior art keywords
polypeptide
virus
medicament
composition
manufacture
Prior art date
Application number
ZA200209757A
Other languages
English (en)
Inventor
Klaus M Esser
Martin Rosenberg
Ruth Tal-Singer
Gary Woodnutt
Francis V Chisari
Susan B Dillon
Original Assignee
Smithkline Beecham Corp
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp, Scripps Research Inst filed Critical Smithkline Beecham Corp
Publication of ZA200209757B publication Critical patent/ZA200209757B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0676Pancreatic cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/191Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/193Colony stimulating factors [CSF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/20Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/20Interleukins [IL]
    • A61K38/2013IL-2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/20Interleukins [IL]
    • A61K38/208IL-12
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/21Interferons [IFN]
    • A61K38/212IFN-alpha
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/21Interferons [IFN]
    • A61K38/215IFN-beta
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55522Cytokines; Lymphokines; Interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55522Cytokines; Lymphokines; Interferons
    • A61K2039/55527Interleukins
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Pulmonology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
ZA200209757A 2000-06-02 2002-12-02 Methods of treating viral diseases with IL-18 combinations. ZA200209757B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20886900P 2000-06-02 2000-06-02

Publications (1)

Publication Number Publication Date
ZA200209757B true ZA200209757B (en) 2004-10-04

Family

ID=22776366

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200209757A ZA200209757B (en) 2000-06-02 2002-12-02 Methods of treating viral diseases with IL-18 combinations.

Country Status (17)

Country Link
US (1) US20030113292A1 (de)
EP (1) EP1296707A4 (de)
JP (1) JP2004514652A (de)
KR (1) KR20030007840A (de)
CN (1) CN1457258A (de)
AU (2) AU2001275166B2 (de)
BR (1) BR0111393A (de)
CA (1) CA2411354A1 (de)
CZ (1) CZ20023921A3 (de)
HU (1) HUP0302233A3 (de)
IL (1) IL153201A0 (de)
MX (1) MXPA02011969A (de)
NO (1) NO20025722L (de)
NZ (1) NZ523123A (de)
PL (1) PL363166A1 (de)
WO (1) WO2001093898A1 (de)
ZA (1) ZA200209757B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060084627A1 (en) * 2002-06-27 2006-04-20 Medivir Ab Synergistic interaction of abacavir and alovudine
US20050079153A1 (en) * 2002-08-14 2005-04-14 Pfizer Inc. Methods for enhancing immune functions in neonatal mammals by administration of IL-18
AU2003295331A1 (en) * 2002-09-19 2004-04-23 Centocor, Inc. Method of inducing maturation of dendritic cells and uses therefor
DE602004031341D1 (de) 2003-07-21 2011-03-24 Transgene Sa Multifunktionelle cytokine
ES2359473T3 (es) 2003-07-21 2011-05-23 Transgene S.A. Citoquinas multifuncionales.
MX2007002134A (es) * 2004-08-20 2007-09-14 Smithkline Beecham Corp Metodos para curar heridas administrando interleucina-18 humana.
JP2010503680A (ja) * 2006-09-14 2010-02-04 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア ヒトil−18による調節t細胞のモジュレーション
ES2310129B1 (es) 2007-06-01 2009-10-02 Juan Carlos Garcia Saban Nueva superficie de implantes metalicos a base de titanio destinados a ser insertado en tejido oseo.
ES2315194B1 (es) 2007-09-10 2010-02-26 Francisco J. GARCIA SABAN Procedimiento para obtener una nueva superficie de un implante metalico a base de titanio destinado a ser insertado en tejido oseo.
CN104474534A (zh) * 2014-12-22 2015-04-01 哈德逊(天津)生物技术有限责任公司 白介素-18抗病毒口腔喷剂
US20190070262A1 (en) * 2017-09-06 2019-03-07 Yale University Interleukin-18 variants and methods of use
JP2023550545A (ja) 2020-11-02 2023-12-01 シムハ・アイエル-18・インコーポレイテッド インターロイキン-18バリアントおよび使用の方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW464656B (en) * 1994-11-15 2001-11-21 Hayashibara Biochem Lab Interferon-gamma production inducing polypeptide monoclonal antibody, and agent for interferon-gamma susceptive disease

Also Published As

Publication number Publication date
BR0111393A (pt) 2004-08-24
AU7516601A (en) 2001-12-17
NO20025722L (no) 2003-01-24
WO2001093898A1 (en) 2001-12-13
PL363166A1 (en) 2004-11-15
KR20030007840A (ko) 2003-01-23
US20030113292A1 (en) 2003-06-19
CA2411354A1 (en) 2001-12-13
EP1296707A1 (de) 2003-04-02
EP1296707A4 (de) 2004-03-17
NO20025722D0 (no) 2002-11-28
NZ523123A (en) 2005-12-23
JP2004514652A (ja) 2004-05-20
AU2001275166B2 (en) 2005-07-28
IL153201A0 (en) 2003-07-06
CN1457258A (zh) 2003-11-19
HUP0302233A3 (en) 2006-11-28
MXPA02011969A (es) 2004-09-06
HUP0302233A2 (hu) 2003-10-28
CZ20023921A3 (cs) 2003-10-15

Similar Documents

Publication Publication Date Title
Jain et al. Vaccines for visceral leishmaniasis: A review
Barral-Netto et al. Transforming growth factor-β in leishmanial infection: a parasite escape mechanism
JP3246918B2 (ja) 感染症の治療のためのIL―12およびIFNαの使用
Palatnik-de-Sousa Vaccines for leishmaniasis in the fore coming 25 years
AU2001275166B2 (en) Methods of treating viral diseases with il-18 and il-18 combinations
AU2001275166A1 (en) Methods of treating viral diseases with IL-18 and IL-18 combinations
US20110150914A1 (en) Compositions and methods for dengue virus (dv) treatment and vaccination
KR20190117462A (ko) 대상포진 백신 조성물
KR20140122258A (ko) Rsv 감염의 예방 및 치료를 위한 혼합 항원 및 dna 백신
Ahmad et al. Prime-boost and recombinant protein vaccination strategies using Sm-p80 protects against Schistosoma mansoni infection in the mouse model to levels previously attainable only by the irradiated cercarial vaccine
EP3025730A1 (de) Viraler immuntherapie-arzneistoffkomplex sowie verwendungen davon
JPH11502533A (ja) インターロイキン−10を用いる、特定の抗原に対する抗体応答を増強するための方法
TW575427B (en) Pharmaceutical composition for prevention or amelioration of Varicella or Zoster
Stevceva et al. Utilizing IL-12, IL-15 and IL-7 as mucosal vaccine adjuvants
US20080193412A1 (en) Method of Enhancing the Immune Response to a Vaccine
ES2395923T3 (es) Uso de histonas específicas para el tratamiento de enfermedades parasitarias
US7550150B2 (en) Methods of treating or preventing a disease, disorder or condition associated with a viral infection
EP0521916B1 (de) Verwendung von il-4 zur verstärkung der immunantwort auf infektiöse antigen-herausforderungen
WO2006058243A2 (en) Leishmania antigens and related compositions and uses
US11517611B2 (en) Methods of treating viral infection with a composition comprising IL-18 and IL-22
CA2057157A1 (en) Use of interferon and a substance with an antimalarial activity for the treatment of malaria infections
CN114072170A (zh) 包含具有S、前S1和前S2蛋白的乙型肝炎抗原、磷酸铝和干扰素-α的改善的治疗性组合物及其用于治疗乙型肝炎的用途
KR20230115528A (ko) 톡소포자충의 항원 rop4를 포함하는 재조합 베큘로바이러스 백신
KR20220139705A (ko) Prrsv 유래 펩타이드를 포함하는 면역원성 조성물
Seng et al. Unresponsiveness to surface antigen 1 modifies cytokine profiles in acute Toxoplasma gondii infection