ZA200208168B - Stable pharmaceutical compositions containing 7-substituted-3,5-dihydroxyheptanoic acids or 7-substituted-3,5-dihydroxyheptenoic acids. - Google Patents
Stable pharmaceutical compositions containing 7-substituted-3,5-dihydroxyheptanoic acids or 7-substituted-3,5-dihydroxyheptenoic acids. Download PDFInfo
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- ZA200208168B ZA200208168B ZA200208168A ZA200208168A ZA200208168B ZA 200208168 B ZA200208168 B ZA 200208168B ZA 200208168 A ZA200208168 A ZA 200208168A ZA 200208168 A ZA200208168 A ZA 200208168A ZA 200208168 B ZA200208168 B ZA 200208168B
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- South Africa
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- composition
- containing polymeric
- group containing
- polymeric compound
- substituted
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- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 70
- -1 7-substituted-3,5-dihydroxyheptanoic acids Chemical class 0.000 title claims abstract description 41
- 229920000642 polymer Polymers 0.000 claims abstract description 98
- 125000003277 amino group Chemical group 0.000 claims abstract description 46
- 230000000087 stabilizing effect Effects 0.000 claims abstract description 42
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 26
- 239000002552 dosage form Substances 0.000 claims abstract description 15
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- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 13
- 239000000203 mixture Substances 0.000 claims description 109
- 125000003368 amide group Chemical group 0.000 claims description 57
- TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 claims description 41
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 29
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 29
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- XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 claims description 7
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- 229920001467 poly(styrenesulfonates) Polymers 0.000 description 1
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- ODGAOXROABLFNM-UHFFFAOYSA-N polynoxylin Polymers O=C.NC(N)=O ODGAOXROABLFNM-UHFFFAOYSA-N 0.000 description 1
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- 239000011591 potassium Substances 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- 239000001508 potassium citrate Substances 0.000 description 1
- 229960002635 potassium citrate Drugs 0.000 description 1
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 1
- 235000011082 potassium citrates Nutrition 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
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- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
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- 229940083542 sodium Drugs 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
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- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- WVLBCYQITXONBZ-UHFFFAOYSA-N trimethyl phosphate Chemical compound COP(=O)(OC)OC WVLBCYQITXONBZ-UHFFFAOYSA-N 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- UGZADUVQMDAIAO-UHFFFAOYSA-L zinc hydroxide Chemical compound [OH-].[OH-].[Zn+2] UGZADUVQMDAIAO-UHFFFAOYSA-L 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US19591600P | 2000-04-10 | 2000-04-10 |
Publications (1)
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ZA200208168B true ZA200208168B (en) | 2003-10-10 |
Family
ID=22723348
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200208168A ZA200208168B (en) | 2000-04-10 | 2002-10-10 | Stable pharmaceutical compositions containing 7-substituted-3,5-dihydroxyheptanoic acids or 7-substituted-3,5-dihydroxyheptenoic acids. |
Country Status (12)
Country | Link |
---|---|
US (2) | US6558659B2 (da) |
EP (2) | EP2382970B1 (da) |
AT (1) | ATE524163T1 (da) |
AU (2) | AU5328701A (da) |
CA (1) | CA2406574C (da) |
CY (1) | CY1112963T1 (da) |
DK (2) | DK2382970T3 (da) |
ES (2) | ES2401598T3 (da) |
IL (1) | IL152179A (da) |
PT (2) | PT1274401E (da) |
WO (1) | WO2001076566A1 (da) |
ZA (1) | ZA200208168B (da) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7411075B1 (en) * | 2000-11-16 | 2008-08-12 | Teva Pharmaceutical Industries Ltd. | Polymorphic form of atorvastatin calcium |
SI20848A (sl) | 2001-03-14 | 2002-10-31 | Lek, Tovarna Farmacevtskih In Kemijskih Izdelkov, D.D. | Farmacevtska formulacija, ki vsebuje atorvastatin kalcij |
JP2005500307A (ja) * | 2001-06-21 | 2005-01-06 | アンドルックス ファーマスーティカルズ インコーポレーテッド | プラバスタチンを含む安定な徐放性薬剤組成物 |
KR100514590B1 (ko) * | 2001-12-18 | 2005-09-14 | 주식회사 대웅 | 프라바스타틴나트륨 및 안정화제로서의 코폴리비돈을함유하는 약제 조성물 |
US20030162827A1 (en) * | 2002-01-30 | 2003-08-28 | Suresh Venkataram | HMG CoA reductase inhibiting composition, method of preparation thereof and method for competitively inhibiting HMG CoA reductase using such composition |
HUP0201083A2 (hu) * | 2002-03-28 | 2004-06-28 | Richter Gedeon Vegyészeti Gyár Rt. | Új atorvastatinsók és az azokat tartalmazó gyógyszerkészítmények |
CA2379887C (en) * | 2002-04-09 | 2004-01-20 | Bernard Charles Sherman | Stable tablets comprising simvastatin |
CA2385529A1 (en) * | 2002-05-21 | 2003-11-21 | Bernard Charles Sherman | Stable dosage forms comprising atorvastatin calcium |
SI21400A (sl) * | 2003-02-12 | 2004-08-31 | LEK farmacevtska družba d.d. | Stabilna farmacevtska oblika z inhibitorjem HMG-CoA reduktaze |
US7790197B2 (en) | 2003-06-09 | 2010-09-07 | Warner-Lambert Company Llc | Pharmaceutical compositions of atorvastatin |
US20050271717A1 (en) | 2003-06-12 | 2005-12-08 | Alfred Berchielli | Pharmaceutical compositions of atorvastatin |
CA2465565A1 (en) * | 2003-06-12 | 2004-12-12 | Warner-Lambert Company Llc | Pharmaceutical compositions of atorvastatin |
US20050031683A1 (en) * | 2003-08-04 | 2005-02-10 | Ashish Kapoor | Solid pharmaceutical composition |
US8163797B2 (en) * | 2003-12-31 | 2012-04-24 | Actavis Elizabeth Llc | Method of treating with stable pravastatin formulation |
US20090042979A1 (en) * | 2004-08-06 | 2009-02-12 | Transform Pharmaceuticals Inc. | Novel Statin Pharmaceutical Compositions and Related Methods of Treatment |
EP1786414A4 (en) * | 2004-08-06 | 2008-04-09 | Transform Pharmaceuticals Inc | NEW PHARMACEUTICAL STATIN COMPOSITIONS AND RELEVANT TREATMENT PROCEDURES |
CA2573316A1 (en) * | 2004-08-06 | 2006-02-16 | Transform Pharmaceuticals, Inc. | Novel fenofibrate formulations and related methods of treatment |
AU2005305460B2 (en) * | 2004-11-22 | 2011-04-21 | Dexcel Pharma Technologies Ltd. | Stable atorvastatin formulations |
KR20080079646A (ko) * | 2005-11-21 | 2008-09-01 | 테바 파마슈티컬 인더스트리즈 리미티드 | 아토르바스타틴 제제 |
GB0525461D0 (en) * | 2005-12-15 | 2006-01-25 | Archimedes Dev Ltd | Pharmaceutical compositions |
US7772273B2 (en) * | 2006-02-10 | 2010-08-10 | Lifecycle Pharma A/S | Stabilized atorvastatin |
MX2008010879A (es) * | 2006-02-24 | 2008-10-27 | Teva Pharma | Composiciones farmaceuticas de sodio de fluvastatina. |
US20080038332A1 (en) * | 2006-08-10 | 2008-02-14 | Cai Gu Huang | Stable pharmaceutical formulation comprising atorvastatin calcium |
EP1911441A3 (en) * | 2006-10-11 | 2008-08-06 | Lupin Limited | Controlled release color stable pharmaceutical dosage form of HMG-COA reductase inhibitors, free of alkalizing or buffering agents |
WO2008064259A2 (en) * | 2006-11-21 | 2008-05-29 | Biokey, Inc. | Solid dispersion composition comprising fluvastatin |
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-
2001
- 2001-04-09 DK DK11171296.4T patent/DK2382970T3/da active
- 2001-04-09 AU AU5328701A patent/AU5328701A/xx active Pending
- 2001-04-09 PT PT01926775T patent/PT1274401E/pt unknown
- 2001-04-09 AT AT01926775T patent/ATE524163T1/de active
- 2001-04-09 EP EP11171296A patent/EP2382970B1/en not_active Revoked
- 2001-04-09 PT PT111712964T patent/PT2382970E/pt unknown
- 2001-04-09 AU AU2001253287A patent/AU2001253287B2/en not_active Ceased
- 2001-04-09 EP EP01926775.6A patent/EP1274401B2/en not_active Expired - Lifetime
- 2001-04-09 ES ES11171296T patent/ES2401598T3/es not_active Expired - Lifetime
- 2001-04-09 CA CA002406574A patent/CA2406574C/en not_active Expired - Fee Related
- 2001-04-09 WO PCT/US2001/011514 patent/WO2001076566A1/en active IP Right Grant
- 2001-04-09 IL IL152179A patent/IL152179A/en not_active IP Right Cessation
- 2001-04-09 DK DK01926775.6T patent/DK1274401T4/da active
- 2001-04-09 US US09/829,026 patent/US6558659B2/en not_active Ceased
- 2001-04-09 ES ES01926775.6T patent/ES2372682T5/es not_active Expired - Lifetime
-
2002
- 2002-10-10 ZA ZA200208168A patent/ZA200208168B/en unknown
-
2005
- 2005-03-17 US US11/083,366 patent/USRE39502E1/en not_active Ceased
-
2011
- 2011-12-12 CY CY20111101231T patent/CY1112963T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
DK1274401T3 (da) | 2011-12-12 |
IL152179A0 (en) | 2003-05-29 |
CA2406574A1 (en) | 2001-10-18 |
ES2401598T3 (es) | 2013-04-22 |
EP2382970B1 (en) | 2013-01-09 |
EP1274401A4 (en) | 2009-07-22 |
USRE39502E1 (en) | 2007-03-06 |
US6558659B2 (en) | 2003-05-06 |
CY1112963T1 (el) | 2016-04-13 |
PT2382970E (pt) | 2013-02-18 |
DK2382970T3 (da) | 2013-03-25 |
WO2001076566A1 (en) | 2001-10-18 |
IL152179A (en) | 2009-06-15 |
EP1274401A1 (en) | 2003-01-15 |
EP1274401B2 (en) | 2014-08-13 |
EP2382970A1 (en) | 2011-11-02 |
AU5328701A (en) | 2001-10-23 |
PT1274401E (pt) | 2011-12-02 |
DK1274401T4 (da) | 2014-09-08 |
EP1274401B1 (en) | 2011-09-14 |
ES2372682T5 (es) | 2014-10-30 |
ATE524163T1 (de) | 2011-09-15 |
ES2372682T3 (es) | 2012-01-25 |
AU2001253287B2 (en) | 2005-04-28 |
US20020035142A1 (en) | 2002-03-21 |
CA2406574C (en) | 2006-12-05 |
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