ZA200205401B - Treatment of congestive heart failure by pretreated autologous blood. - Google Patents
Treatment of congestive heart failure by pretreated autologous blood. Download PDFInfo
- Publication number
- ZA200205401B ZA200205401B ZA200205401A ZA200205401A ZA200205401B ZA 200205401 B ZA200205401 B ZA 200205401B ZA 200205401 A ZA200205401 A ZA 200205401A ZA 200205401 A ZA200205401 A ZA 200205401A ZA 200205401 B ZA200205401 B ZA 200205401B
- Authority
- ZA
- South Africa
- Prior art keywords
- aliquot
- use according
- blood
- temperature
- treated
- Prior art date
Links
- 239000008280 blood Substances 0.000 title claims abstract description 88
- 210000004369 blood Anatomy 0.000 title claims abstract description 88
- 238000011282 treatment Methods 0.000 title claims abstract description 79
- 206010019280 Heart failures Diseases 0.000 title claims abstract description 49
- 206010007559 Cardiac failure congestive Diseases 0.000 title claims abstract description 47
- 230000001590 oxidative effect Effects 0.000 claims abstract description 11
- 230000036760 body temperature Effects 0.000 claims abstract description 8
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 claims description 20
- 102100040247 Tumor necrosis factor Human genes 0.000 claims description 20
- 239000007789 gas Substances 0.000 claims description 19
- 239000000203 mixture Substances 0.000 claims description 17
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 14
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 14
- 229910052760 oxygen Inorganic materials 0.000 claims description 14
- 239000001301 oxygen Substances 0.000 claims description 14
- 239000002981 blocking agent Substances 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 6
- 239000005541 ACE inhibitor Substances 0.000 claims description 5
- 239000002170 aldosterone antagonist Substances 0.000 claims description 5
- 229940083712 aldosterone antagonist Drugs 0.000 claims description 5
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 claims description 5
- 239000007800 oxidant agent Substances 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims description 4
- 239000002934 diuretic Substances 0.000 claims description 4
- 150000002823 nitrates Chemical class 0.000 claims description 4
- 241000208011 Digitalis Species 0.000 claims description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
- 229940030606 diuretics Drugs 0.000 claims description 3
- 239000012530 fluid Substances 0.000 claims description 3
- 239000003087 receptor blocking agent Substances 0.000 claims description 3
- 239000011734 sodium Substances 0.000 claims description 3
- 229910052708 sodium Inorganic materials 0.000 claims description 3
- UEJJHQNACJXSKW-UHFFFAOYSA-N 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C1CCC(=O)NC1=O UEJJHQNACJXSKW-UHFFFAOYSA-N 0.000 claims description 2
- -1 B-blockers Substances 0.000 claims description 2
- 239000002126 C01EB10 - Adenosine Substances 0.000 claims description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 2
- BYPFEZZEUUWMEJ-UHFFFAOYSA-N Pentoxifylline Chemical compound O=C1N(CCCCC(=O)C)C(=O)N(C)C2=C1N(C)C=N2 BYPFEZZEUUWMEJ-UHFFFAOYSA-N 0.000 claims description 2
- 229960005305 adenosine Drugs 0.000 claims description 2
- RNLQIBCLLYYYFJ-UHFFFAOYSA-N amrinone Chemical compound N1C(=O)C(N)=CC(C=2C=CN=CC=2)=C1 RNLQIBCLLYYYFJ-UHFFFAOYSA-N 0.000 claims description 2
- 229960002105 amrinone Drugs 0.000 claims description 2
- 239000011575 calcium Substances 0.000 claims description 2
- 229910052791 calcium Inorganic materials 0.000 claims description 2
- 230000005779 cell damage Effects 0.000 claims description 2
- 208000037887 cell injury Diseases 0.000 claims description 2
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims description 2
- 229960003957 dexamethasone Drugs 0.000 claims description 2
- 229960001476 pentoxifylline Drugs 0.000 claims description 2
- 229960003433 thalidomide Drugs 0.000 claims description 2
- 230000008646 thermal stress Effects 0.000 claims description 2
- 239000008177 pharmaceutical agent Substances 0.000 claims 2
- 239000002447 tumor necrosis factor alpha converting enzyme inhibitor Substances 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 24
- 238000011360 adjunctive therapy Methods 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 description 43
- 238000002347 injection Methods 0.000 description 32
- 239000007924 injection Substances 0.000 description 32
- 210000003734 kidney Anatomy 0.000 description 30
- 230000006907 apoptotic process Effects 0.000 description 20
- 238000002560 therapeutic procedure Methods 0.000 description 18
- 208000028867 ischemia Diseases 0.000 description 17
- 230000000302 ischemic effect Effects 0.000 description 15
- 206010003246 arthritis Diseases 0.000 description 14
- 230000000694 effects Effects 0.000 description 12
- 239000000523 sample Substances 0.000 description 12
- 230000008569 process Effects 0.000 description 11
- 102000004127 Cytokines Human genes 0.000 description 10
- 108090000695 Cytokines Proteins 0.000 description 10
- 230000010410 reperfusion Effects 0.000 description 10
- 241000700159 Rattus Species 0.000 description 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 9
- 239000011780 sodium chloride Substances 0.000 description 9
- 230000001413 cellular effect Effects 0.000 description 8
- 230000001419 dependent effect Effects 0.000 description 8
- 230000002107 myocardial effect Effects 0.000 description 8
- 206010048554 Endothelial dysfunction Diseases 0.000 description 7
- 210000004027 cell Anatomy 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 230000008694 endothelial dysfunction Effects 0.000 description 7
- 230000006872 improvement Effects 0.000 description 7
- 238000011084 recovery Methods 0.000 description 7
- 241000282472 Canis lupus familiaris Species 0.000 description 6
- 201000010099 disease Diseases 0.000 description 6
- 210000003470 mitochondria Anatomy 0.000 description 6
- 210000001700 mitochondrial membrane Anatomy 0.000 description 6
- 210000000107 myocyte Anatomy 0.000 description 6
- 239000000902 placebo Substances 0.000 description 6
- 229940068196 placebo Drugs 0.000 description 6
- 238000007634 remodeling Methods 0.000 description 6
- 239000001509 sodium citrate Substances 0.000 description 6
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 6
- 206010028851 Necrosis Diseases 0.000 description 5
- 230000004913 activation Effects 0.000 description 5
- 230000007423 decrease Effects 0.000 description 5
- 210000002683 foot Anatomy 0.000 description 5
- 230000006698 induction Effects 0.000 description 5
- 230000002757 inflammatory effect Effects 0.000 description 5
- 238000010255 intramuscular injection Methods 0.000 description 5
- 239000007927 intramuscular injection Substances 0.000 description 5
- 238000005259 measurement Methods 0.000 description 5
- 230000017074 necrotic cell death Effects 0.000 description 5
- 210000000056 organ Anatomy 0.000 description 5
- 230000009467 reduction Effects 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 102000004889 Interleukin-6 Human genes 0.000 description 4
- 108090001005 Interleukin-6 Proteins 0.000 description 4
- 208000027418 Wounds and injury Diseases 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 4
- 238000010171 animal model Methods 0.000 description 4
- 230000017531 blood circulation Effects 0.000 description 4
- 230000006378 damage Effects 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 230000008753 endothelial function Effects 0.000 description 4
- 238000013467 fragmentation Methods 0.000 description 4
- 238000006062 fragmentation reaction Methods 0.000 description 4
- 230000000977 initiatory effect Effects 0.000 description 4
- 210000000231 kidney cortex Anatomy 0.000 description 4
- 230000001991 pathophysiological effect Effects 0.000 description 4
- 230000007310 pathophysiology Effects 0.000 description 4
- 230000005855 radiation Effects 0.000 description 4
- 230000008326 skin blood flow Effects 0.000 description 4
- 230000035882 stress Effects 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 3
- 102100033902 Endothelin-1 Human genes 0.000 description 3
- 101800004490 Endothelin-1 Proteins 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 3
- 229960004373 acetylcholine Drugs 0.000 description 3
- 230000004075 alteration Effects 0.000 description 3
- 230000003110 anti-inflammatory effect Effects 0.000 description 3
- 239000003146 anticoagulant agent Substances 0.000 description 3
- 229940127219 anticoagulant drug Drugs 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 239000000480 calcium channel blocker Substances 0.000 description 3
- 230000003511 endothelial effect Effects 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 210000002216 heart Anatomy 0.000 description 3
- 230000028993 immune response Effects 0.000 description 3
- 239000003112 inhibitor Substances 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- 229920001684 low density polyethylene Polymers 0.000 description 3
- 239000004702 low-density polyethylene Substances 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 230000001404 mediated effect Effects 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 230000002438 mitochondrial effect Effects 0.000 description 3
- 230000036542 oxidative stress Effects 0.000 description 3
- 230000000750 progressive effect Effects 0.000 description 3
- 230000000770 proinflammatory effect Effects 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 239000005720 sucrose Substances 0.000 description 3
- 238000001356 surgical procedure Methods 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- GEVPIWPYWJZSPR-UHFFFAOYSA-N tcpo Chemical compound ClC1=CC(Cl)=CC(Cl)=C1OC(=O)C(=O)OC1=C(Cl)C=C(Cl)C=C1Cl GEVPIWPYWJZSPR-UHFFFAOYSA-N 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 description 2
- GKWLIQDHWRWNRS-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC(N)(CO)CO.OCCN1CCN(CCS(O)(=O)=O)CC1 GKWLIQDHWRWNRS-UHFFFAOYSA-N 0.000 description 2
- 201000001320 Atherosclerosis Diseases 0.000 description 2
- 229940127291 Calcium channel antagonist Drugs 0.000 description 2
- BMZRVOVNUMQTIN-UHFFFAOYSA-N Carbonyl Cyanide para-Trifluoromethoxyphenylhydrazone Chemical compound FC(F)(F)OC1=CC=C(NN=C(C#N)C#N)C=C1 BMZRVOVNUMQTIN-UHFFFAOYSA-N 0.000 description 2
- 208000009386 Experimental Arthritis Diseases 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 206010020772 Hypertension Diseases 0.000 description 2
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 2
- 102000004270 Peptidyl-Dipeptidase A Human genes 0.000 description 2
- 108090000882 Peptidyl-Dipeptidase A Proteins 0.000 description 2
- 208000018262 Peripheral vascular disease Diseases 0.000 description 2
- 230000005856 abnormality Effects 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 230000001640 apoptogenic effect Effects 0.000 description 2
- 230000003143 atherosclerotic effect Effects 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 230000004087 circulation Effects 0.000 description 2
- 230000001447 compensatory effect Effects 0.000 description 2
- 208000010247 contact dermatitis Diseases 0.000 description 2
- 230000004064 dysfunction Effects 0.000 description 2
- 210000003038 endothelium Anatomy 0.000 description 2
- 210000003414 extremity Anatomy 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 230000004179 hypothalamic–pituitary–adrenal axis Effects 0.000 description 2
- 230000005934 immune activation Effects 0.000 description 2
- 238000011694 lewis rat Methods 0.000 description 2
- 108020004999 messenger RNA Proteins 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000003387 muscular Effects 0.000 description 2
- 208000010125 myocardial infarction Diseases 0.000 description 2
- 210000004165 myocardium Anatomy 0.000 description 2
- 230000010412 perfusion Effects 0.000 description 2
- 238000005086 pumping Methods 0.000 description 2
- 210000002254 renal artery Anatomy 0.000 description 2
- 210000002796 renal vein Anatomy 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 230000001052 transient effect Effects 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- 230000000304 vasodilatating effect Effects 0.000 description 2
- 230000006499 vasodilator function Effects 0.000 description 2
- 230000002861 ventricular Effects 0.000 description 2
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
- 102000007469 Actins Human genes 0.000 description 1
- 108010085238 Actins Proteins 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 102000005862 Angiotensin II Human genes 0.000 description 1
- 101800000733 Angiotensin-2 Proteins 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 208000006029 Cardiomegaly Diseases 0.000 description 1
- 108091006146 Channels Proteins 0.000 description 1
- 102000029816 Collagenase Human genes 0.000 description 1
- 108060005980 Collagenase Proteins 0.000 description 1
- 108010008286 DNA nucleotidylexotransferase Proteins 0.000 description 1
- 102100033215 DNA nucleotidylexotransferase Human genes 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- 108010067770 Endopeptidase K Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 108010008165 Etanercept Proteins 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 239000007995 HEPES buffer Substances 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- 208000001953 Hypotension Diseases 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010022562 Intermittent claudication Diseases 0.000 description 1
- 102000000853 LDL receptors Human genes 0.000 description 1
- 108010001831 LDL receptors Proteins 0.000 description 1
- 206010049694 Left Ventricular Dysfunction Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 241000186359 Mycobacterium Species 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 108700020796 Oncogene Proteins 0.000 description 1
- 102000004316 Oxidoreductases Human genes 0.000 description 1
- 108090000854 Oxidoreductases Proteins 0.000 description 1
- 239000005662 Paraffin oil Substances 0.000 description 1
- 206010034464 Periarthritis Diseases 0.000 description 1
- 208000006735 Periostitis Diseases 0.000 description 1
- 208000003782 Raynaud disease Diseases 0.000 description 1
- 208000012322 Raynaud phenomenon Diseases 0.000 description 1
- 206010063897 Renal ischaemia Diseases 0.000 description 1
- 206010063837 Reperfusion injury Diseases 0.000 description 1
- 206010039710 Scleroderma Diseases 0.000 description 1
- 210000004241 Th2 cell Anatomy 0.000 description 1
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000003044 adaptive effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000011543 agarose gel Substances 0.000 description 1
- 238000000246 agarose gel electrophoresis Methods 0.000 description 1
- 239000000556 agonist Substances 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 238000001949 anaesthesia Methods 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 229950006323 angiotensin ii Drugs 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 239000002876 beta blocker Substances 0.000 description 1
- 229940030611 beta-adrenergic blocking agent Drugs 0.000 description 1
- 230000005587 bubbling Effects 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 210000004413 cardiac myocyte Anatomy 0.000 description 1
- 238000012754 cardiac puncture Methods 0.000 description 1
- 230000009084 cardiovascular function Effects 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- YTRQFSDWAXHJCC-UHFFFAOYSA-N chloroform;phenol Chemical compound ClC(Cl)Cl.OC1=CC=CC=C1 YTRQFSDWAXHJCC-UHFFFAOYSA-N 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 238000011278 co-treatment Methods 0.000 description 1
- 230000001112 coagulating effect Effects 0.000 description 1
- 229960002424 collagenase Drugs 0.000 description 1
- 238000011284 combination treatment Methods 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 230000001120 cytoprotective effect Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000001085 differential centrifugation Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 229910001882 dioxygen Inorganic materials 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 230000003828 downregulation Effects 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 210000001163 endosome Anatomy 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000007824 enzymatic assay Methods 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 229960000403 etanercept Drugs 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 239000008246 gaseous mixture Substances 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 230000004217 heart function Effects 0.000 description 1
- 230000000004 hemodynamic effect Effects 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 210000000548 hind-foot Anatomy 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 150000002432 hydroperoxides Chemical class 0.000 description 1
- 230000000260 hypercholesteremic effect Effects 0.000 description 1
- 230000036543 hypotension Effects 0.000 description 1
- 230000007954 hypoxia Effects 0.000 description 1
- 210000003090 iliac artery Anatomy 0.000 description 1
- 230000008105 immune reaction Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 208000021156 intermittent vascular claudication Diseases 0.000 description 1
- 238000001361 intraarterial administration Methods 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 238000012417 linear regression Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000001165 lymph node Anatomy 0.000 description 1
- 230000036244 malformation Effects 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 230000010060 microvascular dysfunction Effects 0.000 description 1
- 238000000329 molecular dynamics simulation Methods 0.000 description 1
- 230000004660 morphological change Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000002644 neurohormonal effect Effects 0.000 description 1
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 1
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 1
- 229960002748 norepinephrine Drugs 0.000 description 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- LCCNCVORNKJIRZ-UHFFFAOYSA-N parathion Chemical compound CCOP(=S)(OCC)OC1=CC=C([N+]([O-])=O)C=C1 LCCNCVORNKJIRZ-UHFFFAOYSA-N 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 229960001802 phenylephrine Drugs 0.000 description 1
- SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 210000000512 proximal kidney tubule Anatomy 0.000 description 1
- 239000013014 purified material Substances 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- TUFFYSFVSYUHPA-UHFFFAOYSA-M rhodamine 123 Chemical compound [Cl-].COC(=O)C1=CC=CC=C1C1=C(C=CC(N)=C2)C2=[O+]C2=C1C=CC(N)=C2 TUFFYSFVSYUHPA-UHFFFAOYSA-M 0.000 description 1
- 229940080817 rotenone Drugs 0.000 description 1
- JUVIOZPCNVVQFO-UHFFFAOYSA-N rotenone Natural products O1C2=C3CC(C(C)=C)OC3=CC=C2C(=O)C2C1COC1=C2C=C(OC)C(OC)=C1 JUVIOZPCNVVQFO-UHFFFAOYSA-N 0.000 description 1
- 238000011300 routine therapy Methods 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- 230000026799 smooth muscle cell apoptotic process Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000011699 spontaneously hypertensive rat Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000002889 sympathetic effect Effects 0.000 description 1
- 208000019270 symptomatic heart failure Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 230000006433 tumor necrosis factor production Effects 0.000 description 1
- 102000003298 tumor necrosis factor receptor Human genes 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
- 239000005526 vasoconstrictor agent Substances 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 230000001196 vasorelaxation Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000036642 wellbeing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0004—Homeopathy; Vitalisation; Resonance; Dynamisation, e.g. esoteric applications; Oxygenation of blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/10—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person
- A61K41/17—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person by ultraviolet [UV] or infrared [IR] light, X-rays or gamma rays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Developmental Biology & Embryology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Alternative & Traditional Medicine (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA 2296997 CA2296997A1 (en) | 2000-01-18 | 2000-01-18 | Treatment of congestive heart failure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200205401B true ZA200205401B (en) | 2003-07-07 |
Family
ID=4165156
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200205401A ZA200205401B (en) | 2000-01-18 | 2002-07-05 | Treatment of congestive heart failure by pretreated autologous blood. |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US6572895B2 (ko) |
| EP (1) | EP1267897B1 (ko) |
| JP (1) | JP2003520244A (ko) |
| KR (1) | KR100543413B1 (ko) |
| CN (1) | CN1173710C (ko) |
| AT (1) | ATE281839T1 (ko) |
| AU (1) | AU773118B2 (ko) |
| BR (1) | BR0107705A (ko) |
| CA (2) | CA2296997A1 (ko) |
| CZ (1) | CZ20022402A3 (ko) |
| DE (1) | DE60107065T2 (ko) |
| DK (1) | DK1267897T3 (ko) |
| EA (1) | EA005011B1 (ko) |
| ES (1) | ES2232632T3 (ko) |
| HK (1) | HK1050847B (ko) |
| IL (1) | IL150725A0 (ko) |
| MX (1) | MXPA02007032A (ko) |
| NO (1) | NO20023267L (ko) |
| NZ (1) | NZ520083A (ko) |
| PL (1) | PL357261A1 (ko) |
| PT (1) | PT1267897E (ko) |
| TR (1) | TR200201822T2 (ko) |
| WO (1) | WO2001052870A1 (ko) |
| ZA (1) | ZA200205401B (ko) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040199209A1 (en) * | 2003-04-07 | 2004-10-07 | Hill Michael R.S. | Method and system for delivery of vasoactive drugs to the heart prior to and during a medical procedure |
| US8036741B2 (en) | 1996-04-30 | 2011-10-11 | Medtronic, Inc. | Method and system for nerve stimulation and cardiac sensing prior to and during a medical procedure |
| US6628987B1 (en) * | 2000-09-26 | 2003-09-30 | Medtronic, Inc. | Method and system for sensing cardiac contractions during vagal stimulation-induced cardiopalegia |
| US6449507B1 (en) * | 1996-04-30 | 2002-09-10 | Medtronic, Inc. | Method and system for nerve stimulation prior to and during a medical procedure |
| US6904318B2 (en) * | 2000-09-26 | 2005-06-07 | Medtronic, Inc. | Method and system for monitoring and controlling systemic and pulmonary circulation during a medical procedure |
| US7269457B2 (en) * | 1996-04-30 | 2007-09-11 | Medtronic, Inc. | Method and system for vagal nerve stimulation with multi-site cardiac pacing |
| US6479523B1 (en) * | 1997-08-26 | 2002-11-12 | Emory University | Pharmacologic drug combination in vagal-induced asystole |
| CA2271190A1 (en) * | 1999-05-06 | 2000-11-06 | Vasogen Ireland Limited | Improved method for treating mammals with modified mammalian blood |
| EP1198271A4 (en) * | 1999-06-25 | 2009-01-21 | Univ Emory | DEVICES AND METHODS FOR STIMULATING THE VAGUSNERVS |
| CA2296997A1 (en) * | 2000-01-18 | 2001-07-18 | Vasogen Ireland Limited | Treatment of congestive heart failure |
| AU2001278844A1 (en) * | 2000-04-26 | 2001-11-07 | Herzel Laor | Configuring optical fibers in a multi-chip module |
| US6487446B1 (en) * | 2000-09-26 | 2002-11-26 | Medtronic, Inc. | Method and system for spinal cord stimulation prior to and during a medical procedure |
| CA2327631A1 (en) * | 2000-12-05 | 2002-06-05 | Vasogen Ireland Limited | Inflammatory cytokine secretion inhibition |
| AU2003218583A1 (en) * | 2002-04-10 | 2003-10-27 | Vasogen Ireland Ltd | Electrocardiographic aspects of chf treatment |
| US7255880B2 (en) * | 2003-04-03 | 2007-08-14 | Vasogen Ireland Limited | Treatment of endothelin-related disorders |
| US20100318014A1 (en) * | 2003-07-31 | 2010-12-16 | Latino Joseph S | Treatment of acute ischemic brain stroke with ozone |
| US20100316730A1 (en) * | 2003-07-31 | 2010-12-16 | Latino Joseph S | Treatment of cardiovascular diseases with ozone |
| US20100316727A1 (en) * | 2003-07-31 | 2010-12-16 | Latino Joseph S | Treatment of inflammatory disorders with ozone |
| US20060095102A1 (en) * | 2003-09-17 | 2006-05-04 | Thomas Perez | Method and apparatus for sublingual application of light to blood |
| US20050100964A1 (en) * | 2003-11-11 | 2005-05-12 | George Jackowski | Diagnostic methods for congestive heart failure |
| WO2005097145A1 (en) * | 2004-04-12 | 2005-10-20 | Vasogen Ireland Limited | Myocarditis treatment |
| WO2008000067A1 (en) * | 2006-06-26 | 2008-01-03 | Vasogen Ireland Limited | Treatment of mild chronic heart failure in human patients |
| US20100158874A1 (en) * | 2007-02-26 | 2010-06-24 | Mount Sinai Hospital | Compositions and Methods for Treating Peripheral Vascular Diseases |
| US8200308B2 (en) * | 2007-07-18 | 2012-06-12 | Siemens Medical Solutions Usa, Inc. | Continuous measurement and mapping of physiological data |
| CA2765479A1 (en) * | 2009-06-19 | 2010-12-23 | Acquisci, Inc. | Treatment of inflammatory disorders, cardiovascular diseases and acute ischemic brain stroke with ozone |
| CN102802643A (zh) * | 2009-06-19 | 2012-11-28 | 阿奎赛公司 | 利用臭氧治疗炎性病症、心血管疾病和急性缺血性脑中风 |
| US8423134B2 (en) | 2010-04-29 | 2013-04-16 | Medtronic, Inc. | Therapy using perturbation and effect of physiological systems |
| US8639327B2 (en) | 2010-04-29 | 2014-01-28 | Medtronic, Inc. | Nerve signal differentiation in cardiac therapy |
| US8620425B2 (en) | 2010-04-29 | 2013-12-31 | Medtronic, Inc. | Nerve signal differentiation in cardiac therapy |
| CN101829372A (zh) * | 2010-05-11 | 2010-09-15 | 江苏中惠医疗科技股份有限公司 | 血细胞凋亡诱导系统 |
| CN101843931A (zh) * | 2010-05-19 | 2010-09-29 | 江苏中惠医疗科技股份有限公司 | 一种血细胞凋亡诱导方法 |
| US8706223B2 (en) | 2011-01-19 | 2014-04-22 | Medtronic, Inc. | Preventative vagal stimulation |
| US8725259B2 (en) | 2011-01-19 | 2014-05-13 | Medtronic, Inc. | Vagal stimulation |
| US8781582B2 (en) | 2011-01-19 | 2014-07-15 | Medtronic, Inc. | Vagal stimulation |
| US8781583B2 (en) | 2011-01-19 | 2014-07-15 | Medtronic, Inc. | Vagal stimulation |
| US8718763B2 (en) | 2011-01-19 | 2014-05-06 | Medtronic, Inc. | Vagal stimulation |
| ITMI20120338A1 (it) * | 2012-03-06 | 2013-09-07 | Dr Andrea Bignotti | Preparato terapeutico e procedimento di preparazione di detto preparato terapeutico |
| CN113057965B (zh) * | 2021-03-31 | 2023-07-04 | 河北康腾生物科技有限公司 | 一种活化焕颜美容液及其制备方法和应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5591457A (en) * | 1992-02-07 | 1997-01-07 | Vasogen Inc | Method of inhibiting the aggregation of blood platelets and stimulating the immune systems of a human |
| ES2280454T3 (es) * | 1992-02-07 | 2007-09-16 | Vasogen Ireland Limited | Metodo para aumentar la concentracion de oxido nitrico en la sangre. |
| US5980954A (en) * | 1992-02-07 | 1999-11-09 | Vasogen Ireland Limited | Treatment of autoimmune diseases |
| EA003232B1 (ru) | 1997-09-12 | 2003-02-27 | Вэсоджен Айрленд Лимитид | Лечение стресса и предварительное формирование условных рефлексов против стресса |
| US6136308A (en) * | 1997-09-12 | 2000-10-24 | Vasogen Ireland Limited | Treatment of stress and preconditioning against stress |
| US6037346A (en) * | 1997-10-28 | 2000-03-14 | Vivus, Inc. | Local administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction |
| US6422462B1 (en) * | 1998-03-30 | 2002-07-23 | Morris E. Cohen | Apparatus and methods for improved credit cards and credit card transactions |
| CA2271190A1 (en) | 1999-05-06 | 2000-11-06 | Vasogen Ireland Limited | Improved method for treating mammals with modified mammalian blood |
| CA2296997A1 (en) * | 2000-01-18 | 2001-07-18 | Vasogen Ireland Limited | Treatment of congestive heart failure |
| US7627531B2 (en) * | 2000-03-07 | 2009-12-01 | American Express Travel Related Services Company, Inc. | System for facilitating a transaction |
-
2000
- 2000-01-18 CA CA 2296997 patent/CA2296997A1/en not_active Abandoned
-
2001
- 2001-01-17 US US09/760,600 patent/US6572895B2/en not_active Expired - Fee Related
- 2001-01-18 DK DK01942557T patent/DK1267897T3/da active
- 2001-01-18 ES ES01942557T patent/ES2232632T3/es not_active Expired - Lifetime
- 2001-01-18 AT AT01942557T patent/ATE281839T1/de not_active IP Right Cessation
- 2001-01-18 BR BR0107705A patent/BR0107705A/pt not_active IP Right Cessation
- 2001-01-18 CA CA002400801A patent/CA2400801C/en not_active Expired - Fee Related
- 2001-01-18 CZ CZ20022402A patent/CZ20022402A3/cs unknown
- 2001-01-18 WO PCT/CA2001/000039 patent/WO2001052870A1/en active IP Right Grant
- 2001-01-18 JP JP2001552917A patent/JP2003520244A/ja active Pending
- 2001-01-18 IL IL15072501A patent/IL150725A0/xx unknown
- 2001-01-18 NZ NZ52008301A patent/NZ520083A/xx unknown
- 2001-01-18 AU AU28208/01A patent/AU773118B2/en not_active Ceased
- 2001-01-18 EA EA200200767A patent/EA005011B1/ru not_active IP Right Cessation
- 2001-01-18 EP EP01942557A patent/EP1267897B1/en not_active Expired - Lifetime
- 2001-01-18 PT PT01942557T patent/PT1267897E/pt unknown
- 2001-01-18 MX MXPA02007032A patent/MXPA02007032A/es active IP Right Grant
- 2001-01-18 DE DE2001607065 patent/DE60107065T2/de not_active Expired - Fee Related
- 2001-01-18 TR TR200201822T patent/TR200201822T2/xx unknown
- 2001-01-18 CN CNB018048463A patent/CN1173710C/zh not_active Expired - Fee Related
- 2001-01-18 KR KR1020027009206A patent/KR100543413B1/ko not_active IP Right Cessation
- 2001-01-18 PL PL01357261A patent/PL357261A1/xx not_active IP Right Cessation
-
2002
- 2002-07-05 NO NO20023267A patent/NO20023267L/no not_active Application Discontinuation
- 2002-07-05 ZA ZA200205401A patent/ZA200205401B/en unknown
- 2002-10-24 US US10/278,920 patent/US7153649B2/en not_active Expired - Fee Related
-
2003
- 2003-03-18 HK HK03101992.3A patent/HK1050847B/zh not_active IP Right Cessation
-
2005
- 2005-09-01 US US11/218,922 patent/US20060193835A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2400801C (en) | Treatment of congestive heart failure by pretreated autologous blood | |
| Fan et al. | Oxygen radicals trigger activation of NF-κB and AP-1 and upregulation of ICAM-1 in reperfused canine heart | |
| Tiscornia et al. | The inhibition of canine exocrine pancreatic secretion by intravenous ethanol | |
| Wilkinson et al. | Centrally acting vasopressin contributes to endotoxin tolerance | |
| Guillot et al. | Involvement of capsaicin-sensitive nerves in the regulation of glucose tolerance in diabetic rats | |
| De Tejada et al. | Design and evaluation of nitrosylated α-adrenergic receptor antagonists as potential agents for the treatment of impotence | |
| Jones et al. | Systematic studies invalidate the neonatally androgenized rat as a model for polycystic ovary disease | |
| Fingar et al. | Changes in tumor interstitial pressure induced by photodynamic therapy | |
| Zou et al. | Effects of diosmin on vascular leakage and inflammation in a mouse model of venous obstruction | |
| Cole et al. | Brown recluse spider envenomation of the eyelid: an animal model | |
| US6800300B1 (en) | Method for treating autoimmune and alloimmune diseases | |
| WO2019161707A1 (zh) | 一种猴睾酮缺乏模型的建立方法 | |
| US5854271A (en) | Effective method for the amelioration and prevention of tissue and cellular damage | |
| AU741181B2 (en) | Treatment of stress and preconditioning against stress | |
| US6696092B2 (en) | Endothelial lining effects and treatment of vasospastic disorders | |
| Kile et al. | Serotonergic and cholinergic interaction in the regulation of pituitary-adrenal function in rats | |
| Burns et al. | Effects of ecstasy on aldosterone secretion in the rat in vivo and in vitro. | |
| KONDO et al. | Induction of metastases by treatment with carcinostatic agents II. Depression of host resistance and antibody production | |
| Malone et al. | In vivo effects of nonsteroidal antiinflammatory drugs on rat skin and synovial mast cell–induced vasopermeability | |
| US20020150560A1 (en) | Treatment of Il-10 deficiencies | |
| Bonnet et al. | Extrarenal renin–angiotensin systems are unable to maintain blood pressure in sheep | |
| Solomon | Mechanisms of canine endotoxin shock: modification of the shock state by salicylates | |
| Jara et al. | Intracavernous methoxamine in the treatment of priapism | |
| Solomon | Mechanisms of canine endotoxin shock | |
| Penziner | Time-related alterations in compensatory renal function in obstructed vs. nephrectomized Sprague-Dawley rats |