ZA200203627B - Method for the production of particles. - Google Patents
Method for the production of particles. Download PDFInfo
- Publication number
- ZA200203627B ZA200203627B ZA200203627A ZA200203627A ZA200203627B ZA 200203627 B ZA200203627 B ZA 200203627B ZA 200203627 A ZA200203627 A ZA 200203627A ZA 200203627 A ZA200203627 A ZA 200203627A ZA 200203627 B ZA200203627 B ZA 200203627B
- Authority
- ZA
- South Africa
- Prior art keywords
- solvent
- substance
- hydrofluorocarbon
- particles
- mixture
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 53
- 239000002245 particle Substances 0.000 title claims description 52
- 238000004519 manufacturing process Methods 0.000 title description 8
- 239000002904 solvent Substances 0.000 claims description 68
- 239000000126 substance Substances 0.000 claims description 59
- 239000000203 mixture Substances 0.000 claims description 53
- LVGUZGTVOIAKKC-UHFFFAOYSA-N 1,1,1,2-tetrafluoroethane Chemical compound FCC(F)(F)F LVGUZGTVOIAKKC-UHFFFAOYSA-N 0.000 claims description 33
- 238000009472 formulation Methods 0.000 claims description 27
- 238000000926 separation method Methods 0.000 claims description 14
- 239000006184 cosolvent Substances 0.000 claims description 13
- 239000007788 liquid Substances 0.000 claims description 9
- 239000003960 organic solvent Substances 0.000 claims description 9
- 239000003814 drug Substances 0.000 claims description 8
- 229930195733 hydrocarbon Natural products 0.000 claims description 7
- 239000004480 active ingredient Substances 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 6
- 238000001704 evaporation Methods 0.000 claims description 6
- 230000008020 evaporation Effects 0.000 claims description 6
- -1 hydrocarbon ethers Chemical class 0.000 claims description 6
- 150000002430 hydrocarbons Chemical class 0.000 claims description 6
- 239000004215 Carbon black (E152) Substances 0.000 claims description 4
- 238000009835 boiling Methods 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 4
- 239000000796 flavoring agent Substances 0.000 claims description 4
- 235000019634 flavors Nutrition 0.000 claims description 4
- 239000000049 pigment Substances 0.000 claims description 4
- 239000000975 dye Substances 0.000 claims description 3
- 239000003205 fragrance Substances 0.000 claims description 3
- 229920003023 plastic Polymers 0.000 claims description 3
- 239000004033 plastic Substances 0.000 claims description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 2
- 229910052799 carbon Inorganic materials 0.000 claims description 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 2
- 239000011737 fluorine Substances 0.000 claims description 2
- 229910052731 fluorine Inorganic materials 0.000 claims description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 2
- 239000000575 pesticide Substances 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 239000007921 spray Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 description 18
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 14
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 12
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 12
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 10
- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 description 10
- 239000013078 crystal Substances 0.000 description 9
- 239000007787 solid Substances 0.000 description 9
- 239000005639 Lauric acid Substances 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 239000001569 carbon dioxide Substances 0.000 description 6
- 229910002092 carbon dioxide Inorganic materials 0.000 description 6
- 239000003595 mist Substances 0.000 description 6
- 239000000843 powder Substances 0.000 description 6
- 238000002156 mixing Methods 0.000 description 5
- 229960003424 phenylacetic acid Drugs 0.000 description 5
- 239000003279 phenylacetic acid Substances 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- 239000007789 gas Substances 0.000 description 4
- 238000000227 grinding Methods 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 238000004064 recycling Methods 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 150000001335 aliphatic alkanes Chemical class 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 239000010419 fine particle Substances 0.000 description 3
- 150000002576 ketones Chemical class 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 239000011369 resultant mixture Substances 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 2
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 125000001931 aliphatic group Chemical group 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 238000012377 drug delivery Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 125000001153 fluoro group Chemical group F* 0.000 description 2
- LELOWRISYMNNSU-UHFFFAOYSA-N hydrogen cyanide Chemical compound N#C LELOWRISYMNNSU-UHFFFAOYSA-N 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- NNPPMTNAJDCUHE-UHFFFAOYSA-N isobutane Chemical compound CC(C)C NNPPMTNAJDCUHE-UHFFFAOYSA-N 0.000 description 2
- 238000003801 milling Methods 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 238000007639 printing Methods 0.000 description 2
- 239000002002 slurry Substances 0.000 description 2
- 239000011343 solid material Substances 0.000 description 2
- 238000001694 spray drying Methods 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 230000003068 static effect Effects 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 1
- SCYULBFZEHDVBN-UHFFFAOYSA-N 1,1-Dichloroethane Chemical compound CC(Cl)Cl SCYULBFZEHDVBN-UHFFFAOYSA-N 0.000 description 1
- DKPFZGUDAPQIHT-UHFFFAOYSA-N Butyl acetate Natural products CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 description 1
- 235000002566 Capsicum Nutrition 0.000 description 1
- 240000008574 Capsicum frutescens Species 0.000 description 1
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 description 1
- XOBKSJJDNFUZPF-UHFFFAOYSA-N Methoxyethane Chemical compound CCOC XOBKSJJDNFUZPF-UHFFFAOYSA-N 0.000 description 1
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 description 1
- UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 description 1
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
- 208000010040 Sprains and Strains Diseases 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 239000005864 Sulphur Substances 0.000 description 1
- 150000001242 acetic acid derivatives Chemical class 0.000 description 1
- KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 125000002723 alicyclic group Chemical group 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 150000008064 anhydrides Chemical class 0.000 description 1
- 238000000889 atomisation Methods 0.000 description 1
- 239000001390 capsicum minimum Substances 0.000 description 1
- 235000013353 coffee beverage Nutrition 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 239000000599 controlled substance Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000011557 critical solution Substances 0.000 description 1
- 239000002178 crystalline material Substances 0.000 description 1
- 150000001924 cycloalkanes Chemical class 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000000779 depleting effect Effects 0.000 description 1
- 239000007933 dermal patch Substances 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 150000001983 dialkylethers Chemical class 0.000 description 1
- 239000013583 drug formulation Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000005357 flat glass Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 1
- 238000002657 hormone replacement therapy Methods 0.000 description 1
- 239000000976 ink Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 235000021539 instant coffee Nutrition 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 230000003387 muscular Effects 0.000 description 1
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 229960002715 nicotine Drugs 0.000 description 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 239000011236 particulate material Substances 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000002831 pharmacologic agent Substances 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 238000007614 solvation Methods 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000009834 vaporization Methods 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0018—Evaporation of components of the mixture to be separated
- B01D9/0027—Evaporation of components of the mixture to be separated by means of conveying fluid, e.g. spray-crystallisation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Extraction Or Liquid Replacement (AREA)
- Glanulating (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Pigments, Carbon Blacks, Or Wood Stains (AREA)
- Seasonings (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9927011.8A GB9927011D0 (en) | 1999-11-16 | 1999-11-16 | Method for the production of particles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200203627B true ZA200203627B (en) | 2003-10-29 |
Family
ID=10864559
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200203627A ZA200203627B (en) | 1999-11-16 | 2002-05-07 | Method for the production of particles. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US7404828B1 (ru) |
| EP (1) | EP1232002B1 (ru) |
| JP (1) | JP4977841B2 (ru) |
| KR (1) | KR100709667B1 (ru) |
| CN (1) | CN1304098C (ru) |
| AT (1) | ATE340639T1 (ru) |
| AU (1) | AU783519B2 (ru) |
| BG (1) | BG106689A (ru) |
| BR (1) | BR0015596A (ru) |
| CA (1) | CA2391401C (ru) |
| DE (1) | DE60030999T2 (ru) |
| ES (1) | ES2272332T3 (ru) |
| GB (2) | GB9927011D0 (ru) |
| HU (1) | HUP0203940A2 (ru) |
| IL (1) | IL149508A0 (ru) |
| MX (1) | MXPA02004811A (ru) |
| PL (1) | PL204362B1 (ru) |
| RU (1) | RU2288030C2 (ru) |
| SK (1) | SK287374B6 (ru) |
| WO (1) | WO2001036078A1 (ru) |
| ZA (1) | ZA200203627B (ru) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT901786E (pt) | 1997-08-11 | 2007-08-07 | Pfizer Prod Inc | Disperções farmacêuticas sólidas com biodisponibilidade melhorada |
| US6869551B2 (en) * | 2001-03-30 | 2005-03-22 | Picoliter Inc. | Precipitation of solid particles from droplets formed using focused acoustic energy |
| GB0126716D0 (en) * | 2001-11-07 | 2002-01-02 | Advanced Phytonics Ltd | Method for the production of particles |
| US6922367B2 (en) * | 2003-07-09 | 2005-07-26 | Micron Technology, Inc. | Data strobe synchronization circuit and method for double data rate, multi-bit writes |
| GB0418447D0 (en) * | 2004-08-19 | 2004-09-22 | Advanced Phytonics Ltd | Process for preparing particles and apparatus |
| US8043645B2 (en) | 2008-07-09 | 2011-10-25 | Starbucks Corporation | Method of making beverages with enhanced flavors and aromas |
| EP3130396B1 (en) | 2009-03-27 | 2021-03-17 | Bend Research, Inc. | Spray-drying process |
| WO2012031129A2 (en) | 2010-09-03 | 2012-03-08 | Bend Research, Inc. | Spray-drying apparatus and methods of using the same |
| US9084944B2 (en) | 2010-09-03 | 2015-07-21 | Bend Research, Inc. | Spray-drying apparatus and methods of using the same |
| EP2618924A1 (en) | 2010-09-24 | 2013-07-31 | Bend Research, Inc. | High-temperature spray drying process and apparatus |
| CN103534282B (zh) * | 2011-05-18 | 2016-08-17 | 旭硝子株式会社 | 含氟共聚物及离子交换膜 |
| CN103534283B (zh) * | 2011-05-18 | 2016-10-12 | 旭硝子株式会社 | 含氟共聚物的制造方法 |
| SE536491C2 (sv) * | 2012-03-26 | 2013-12-27 | Bionicotine Ab | Påse innehållande nikotin och en tuggummikomposition |
| US9195156B2 (en) * | 2013-02-25 | 2015-11-24 | Ricoh Company, Ltd. | Particulate material production method, and particulate material production apparatus |
| PT3212169T (pt) | 2014-10-31 | 2021-05-06 | Bend Res Inc | Processo para formar domínios ativos dispersos numa matriz |
| EP3340982B1 (en) | 2015-08-26 | 2021-12-15 | Achillion Pharmaceuticals, Inc. | Compounds for treatment of immune and inflammatory disorders |
| AR106018A1 (es) | 2015-08-26 | 2017-12-06 | Achillion Pharmaceuticals Inc | Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos |
| AU2017290593A1 (en) | 2016-06-27 | 2019-01-03 | Achillion Pharmaceuticals, Inc. | Quinazoline and indole compounds to treat medical disorders |
| CN110639216A (zh) * | 2018-06-27 | 2020-01-03 | 南京绿环能源科技有限公司 | 耦合分步快速升温处理溶液的装置和方法 |
| US20230022157A1 (en) | 2018-08-20 | 2023-01-26 | Achillion Pharmaceuticals, Inc. | Pharmaceutical compounds for the treatment of complement factor d medical disorders |
| CN113365617A (zh) | 2018-10-16 | 2021-09-07 | 乔治亚州立大学研究基金会股份有限公司 | 用于医学疾病治疗的一氧化碳前药 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3932943A (en) * | 1970-08-14 | 1976-01-20 | E. I. Du Pont De Nemours And Company | Method of preparation of lyophilized biological products |
| GB1419958A (en) * | 1972-07-19 | 1975-12-31 | Brooke Bond Liebig Ltd | Extraction of flavour and fragrance components from plant material |
| DE3670216D1 (de) * | 1986-07-02 | 1990-05-17 | Chevron Res | Verfahren zur erzeugung von kugelfoermigen koerpern durch selektive agglomeration. |
| WO1994008599A1 (en) * | 1992-10-14 | 1994-04-28 | The Regents Of The University Of Colorado | Ion-pairing of drugs for improved efficacy and delivery |
| GB9313642D0 (en) * | 1993-07-01 | 1993-08-18 | Glaxo Group Ltd | Method and apparatus for the formation of particles |
| US5481058A (en) * | 1994-01-07 | 1996-01-02 | Minnesota Mining And Manufacturing Company | Supercritical fluid extraction involving hydrofluoroalkanes |
| US5470442A (en) * | 1994-03-11 | 1995-11-28 | E. I. Du Pont De Nemours And Company | Separating and removing impurities from tetrafluoroethanes by using extractive distillation |
| GB9413202D0 (en) | 1994-06-30 | 1994-08-24 | Univ Bradford | Method and apparatus for the formation of particles |
| US5501318A (en) | 1994-07-06 | 1996-03-26 | Riverwood International Corporation | Overhead pusher lug assembly for packaging machines |
| ES2170853T3 (es) * | 1995-03-28 | 2002-08-16 | Fidia Advanced Biopolymers Srl | Nanosferas que comprenden un polisacarido biocompatible. |
| US5665798A (en) * | 1995-12-27 | 1997-09-09 | North Pacific Paper Corporation | Composite wood products from solvent extracted wood raw materials |
| DE69723294T2 (de) | 1996-12-06 | 2004-05-27 | Advanced Phytonics Ltd. | Materialien behandlung |
| AU8118298A (en) * | 1997-06-20 | 1999-01-04 | Smithkline Beecham Plc | Treatment of a substance with a dense fluid (e.g. with a supercritical fluid |
| IT1295225B1 (it) * | 1997-10-14 | 1999-05-04 | Magneti Marelli Spa | Metodo ed impianto per la produzione di grani di sale aventi dimensioni granulometriche prefissate. |
| GB9810559D0 (en) | 1998-05-15 | 1998-07-15 | Bradford Particle Design Ltd | Method and apparatus for particle formation |
| GB9915975D0 (en) | 1999-07-07 | 1999-09-08 | Bradford Particle Design Ltd | Method for the formation of particles |
-
1999
- 1999-11-16 GB GBGB9927011.8A patent/GB9927011D0/en not_active Ceased
-
2000
- 2000-11-15 GB GB0027880A patent/GB2356823B/en not_active Expired - Lifetime
- 2000-11-15 JP JP2001538061A patent/JP4977841B2/ja not_active Expired - Fee Related
- 2000-11-15 WO PCT/GB2000/004350 patent/WO2001036078A1/en active IP Right Grant
- 2000-11-15 SK SK658-2002A patent/SK287374B6/sk not_active IP Right Cessation
- 2000-11-15 ES ES00976138T patent/ES2272332T3/es not_active Expired - Lifetime
- 2000-11-15 AT AT00976138T patent/ATE340639T1/de not_active IP Right Cessation
- 2000-11-15 PL PL355377A patent/PL204362B1/pl not_active IP Right Cessation
- 2000-11-15 US US10/130,204 patent/US7404828B1/en not_active Expired - Fee Related
- 2000-11-15 AU AU14024/01A patent/AU783519B2/en not_active Ceased
- 2000-11-15 CA CA002391401A patent/CA2391401C/en not_active Expired - Fee Related
- 2000-11-15 KR KR1020027006256A patent/KR100709667B1/ko not_active IP Right Cessation
- 2000-11-15 BR BR0015596-9A patent/BR0015596A/pt not_active Application Discontinuation
- 2000-11-15 HU HU0203940A patent/HUP0203940A2/hu unknown
- 2000-11-15 MX MXPA02004811A patent/MXPA02004811A/es active IP Right Grant
- 2000-11-15 RU RU2002113561/12A patent/RU2288030C2/ru not_active IP Right Cessation
- 2000-11-15 DE DE60030999T patent/DE60030999T2/de not_active Expired - Lifetime
- 2000-11-15 IL IL14950800A patent/IL149508A0/xx not_active IP Right Cessation
- 2000-11-15 EP EP00976138A patent/EP1232002B1/en not_active Expired - Lifetime
- 2000-11-15 CN CNB008157677A patent/CN1304098C/zh not_active Expired - Fee Related
-
2002
- 2002-05-07 ZA ZA200203627A patent/ZA200203627B/en unknown
- 2002-05-11 BG BG106689A patent/BG106689A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2288030C2 (ru) | 2006-11-27 |
| WO2001036078A1 (en) | 2001-05-25 |
| ES2272332T3 (es) | 2007-05-01 |
| EP1232002B1 (en) | 2006-09-27 |
| GB9927011D0 (en) | 2000-01-12 |
| ATE340639T1 (de) | 2006-10-15 |
| RU2002113561A (ru) | 2004-02-20 |
| DE60030999D1 (de) | 2006-11-09 |
| GB2356823B (en) | 2004-03-24 |
| SK6582002A3 (en) | 2002-10-08 |
| KR20020070280A (ko) | 2002-09-05 |
| CN1390153A (zh) | 2003-01-08 |
| US7404828B1 (en) | 2008-07-29 |
| CN1304098C (zh) | 2007-03-14 |
| GB0027880D0 (en) | 2000-12-27 |
| JP2003514034A (ja) | 2003-04-15 |
| IL149508A0 (en) | 2002-11-10 |
| CA2391401C (en) | 2009-02-10 |
| BR0015596A (pt) | 2002-07-09 |
| BG106689A (en) | 2003-04-30 |
| JP4977841B2 (ja) | 2012-07-18 |
| HUP0203940A2 (en) | 2003-04-28 |
| SK287374B6 (sk) | 2010-08-09 |
| PL204362B1 (pl) | 2010-01-29 |
| DE60030999T2 (de) | 2007-05-03 |
| AU783519B2 (en) | 2005-11-03 |
| KR100709667B1 (ko) | 2007-04-20 |
| PL355377A1 (en) | 2004-04-19 |
| AU1402401A (en) | 2001-05-30 |
| MXPA02004811A (es) | 2003-01-28 |
| EP1232002A1 (en) | 2002-08-21 |
| GB2356823A (en) | 2001-06-06 |
| CA2391401A1 (en) | 2001-05-25 |
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