ZA200201275B - Cyclic peptide derivatives as inhibitors of integrin alphavbeta6. - Google Patents

Cyclic peptide derivatives as inhibitors of integrin alphavbeta6.

Info

Publication number
ZA200201275B
ZA200201275B ZA200201275A ZA200201275A ZA200201275B ZA 200201275 B ZA200201275 B ZA 200201275B ZA 200201275 A ZA200201275 A ZA 200201275A ZA 200201275 A ZA200201275 A ZA 200201275A ZA 200201275 B ZA200201275 B ZA 200201275B
Authority
ZA
South Africa
Prior art keywords
integrin
inhibitors
cyclic peptide
peptide derivatives
derivatives
Prior art date
Application number
ZA200201275A
Other languages
English (en)
Inventor
Alfred Jonczyk
Simon Goodman
Gunther Zischinsky
Beate Diefenbach
Ulrich Groth
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of ZA200201275B publication Critical patent/ZA200201275B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biophysics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA200201275A 1999-07-15 2002-02-14 Cyclic peptide derivatives as inhibitors of integrin alphavbeta6. ZA200201275B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19933173A DE19933173A1 (de) 1999-07-15 1999-07-15 Cyclische Peptidderivate als Inhibitoren des Integrins alpha¶v¶beta¶6¶

Publications (1)

Publication Number Publication Date
ZA200201275B true ZA200201275B (en) 2003-08-22

Family

ID=7914891

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200201275A ZA200201275B (en) 1999-07-15 2002-02-14 Cyclic peptide derivatives as inhibitors of integrin alphavbeta6.

Country Status (23)

Country Link
EP (2) EP1754714A1 (da)
JP (1) JP2003505395A (da)
KR (1) KR20020010928A (da)
CN (1) CN1361792A (da)
AR (1) AR024742A1 (da)
AT (1) ATE340803T1 (da)
AU (1) AU772782C (da)
BR (1) BR0012418A (da)
CA (1) CA2379022A1 (da)
CZ (1) CZ200226A3 (da)
DE (2) DE19933173A1 (da)
DK (1) DK1196433T3 (da)
ES (1) ES2273703T3 (da)
HK (1) HK1048641A1 (da)
HU (1) HUP0201925A3 (da)
MX (1) MXPA02000465A (da)
NO (1) NO20020176D0 (da)
PL (1) PL354363A1 (da)
PT (1) PT1196433E (da)
SK (1) SK262002A3 (da)
TW (1) TWI226890B (da)
WO (1) WO2001005810A2 (da)
ZA (1) ZA200201275B (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2438663C (en) * 2001-02-19 2009-09-15 Takara Bio Inc. Cyclic peptide
DE10118550A1 (de) * 2001-04-14 2002-10-17 Merck Patent Gmbh Liganden des Integrins alpha¶nu¶beta¶6¶
JP4912881B2 (ja) * 2003-10-01 2012-04-11 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 抗線維症薬としてのαｖβ３及びαｖβ６インテグリンアンタゴニスト
AU2004297202B2 (en) * 2003-12-03 2011-08-25 The Scripps Research Institute Integrin alphaIIbbeta3 specific antibodies and peptides
JP2008515886A (ja) 2004-10-06 2008-05-15 エーエムアール テクノロジー インコーポレイテッド シクロスポリンアルキンおよびそれらの医用薬剤としての有用性
GB0520068D0 (en) * 2005-10-03 2005-11-09 Cancer Res Technology av peptide ligand
US7696165B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US7696166B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
RU2009107277A (ru) 2006-08-03 2010-09-10 Астразенека Аб (Se) АНТИТЕЛА, НАЦЕЛЕННЫЕ НА αVβ6, И ИХ ПРИМЕНЕНИЕ
EP2784511A1 (en) 2013-03-27 2014-10-01 Universität Zürich Integrin alpha-v-beta6 for diagnosis/prognosis of colorectal carcinoma
SI3350222T1 (sl) * 2015-09-18 2022-01-31 Technische Universitaet Muenchen Ligandi za integrin avbeta6, sinteza in uporaba le-teh
CA3054604A1 (en) 2017-02-28 2018-09-07 Morphic Therapeutic, Inc. Inhibitors of .alpha.v.beta.6 integrin
MA52117A (fr) 2017-02-28 2022-04-06 Morphic Therapeutic Inc Inhibiteurs de l'intégrine (alpha-v) (bêta-6)
US11332498B2 (en) 2017-03-17 2022-05-17 Technische Universitat Munchen Ligands for integrin αVβ8, synthesis and uses thereof
GB201706472D0 (en) * 2017-04-24 2017-06-07 Cancer Res Tech Ltd Tumour-targeting peptide variants
WO2020047239A1 (en) 2018-08-29 2020-03-05 Morphic Therapeutic, Inc. INHIBITING αV β6 INTEGRIN

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4472305A (en) 1983-05-17 1984-09-18 Sterling Drug Inc. Hexapeptide amides
DE4310643A1 (de) 1993-04-01 1994-10-06 Merck Patent Gmbh Cyclische Adhäsionsinhibitoren
DE19538741A1 (de) 1995-10-18 1997-04-24 Merck Patent Gmbh Cyclopeptidderivate
BR9916323A (pt) * 1998-12-19 2001-10-30 Merck Patent Gmbh Inibidores da integrina alfavbeta6

Also Published As

Publication number Publication date
HK1048641A1 (zh) 2003-04-11
CZ200226A3 (cs) 2002-04-17
EP1754714A1 (de) 2007-02-21
EP1196433B1 (de) 2006-09-27
AR024742A1 (es) 2002-10-23
ATE340803T1 (de) 2006-10-15
KR20020010928A (ko) 2002-02-06
WO2001005810A3 (de) 2001-05-17
HUP0201925A2 (en) 2002-10-28
ES2273703T3 (es) 2007-05-16
DE50013525D1 (de) 2006-11-09
DE19933173A1 (de) 2001-01-18
HUP0201925A3 (en) 2002-11-28
SK262002A3 (en) 2002-07-02
CA2379022A1 (en) 2001-01-25
AU5823600A (en) 2001-02-05
PL354363A1 (en) 2004-01-12
WO2001005810A2 (de) 2001-01-25
AU772782B2 (en) 2004-05-06
JP2003505395A (ja) 2003-02-12
NO20020176L (no) 2002-01-14
AU772782C (en) 2005-01-27
NO20020176D0 (no) 2002-01-14
PT1196433E (pt) 2007-01-31
MXPA02000465A (es) 2002-07-30
CN1361792A (zh) 2002-07-31
EP1196433A2 (de) 2002-04-17
TWI226890B (en) 2005-01-21
DK1196433T3 (da) 2007-02-12
BR0012418A (pt) 2002-03-26

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