AU772782C - Cyclic peptide derivatives as inhibitors of integrin alphavbeta6 - Google Patents

Cyclic peptide derivatives as inhibitors of integrin alphavbeta6

Info

Publication number
AU772782C
AU772782C AU58236/00A AU5823600A AU772782C AU 772782 C AU772782 C AU 772782C AU 58236/00 A AU58236/00 A AU 58236/00A AU 5823600 A AU5823600 A AU 5823600A AU 772782 C AU772782 C AU 772782C
Authority
AU
Australia
Prior art keywords
integrin
inhibitors
cyclic peptide
peptide derivatives
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU58236/00A
Other versions
AU772782B2 (en
AU5823600A (en
Inventor
Beate Diefenbach
Simon Goodman
Ulrich Groth
Alfred Jonczyk
Gunther Zischinsky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of AU5823600A publication Critical patent/AU5823600A/en
Publication of AU772782B2 publication Critical patent/AU772782B2/en
Application granted granted Critical
Publication of AU772782C publication Critical patent/AU772782C/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU58236/00A 1999-07-15 2000-07-03 Cyclic peptide derivatives as inhibitors of integrin alphavbeta6 Ceased AU772782C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19933173 1999-07-15
DE19933173A DE19933173A1 (en) 1999-07-15 1999-07-15 Cyclic peptide derivatives as inhibitors of the integrin alpha¶v¶beta¶6¶
PCT/EP2000/006188 WO2001005810A2 (en) 1999-07-15 2000-07-03 CYCLIC PEPTIDE DERIVATIVES AS INHIBITORS OF INTEGRIN αVβ¿6?

Publications (3)

Publication Number Publication Date
AU5823600A AU5823600A (en) 2001-02-05
AU772782B2 AU772782B2 (en) 2004-05-06
AU772782C true AU772782C (en) 2005-01-27

Family

ID=7914891

Family Applications (1)

Application Number Title Priority Date Filing Date
AU58236/00A Ceased AU772782C (en) 1999-07-15 2000-07-03 Cyclic peptide derivatives as inhibitors of integrin alphavbeta6

Country Status (23)

Country Link
EP (2) EP1754714A1 (en)
JP (1) JP2003505395A (en)
KR (1) KR20020010928A (en)
CN (1) CN1361792A (en)
AR (1) AR024742A1 (en)
AT (1) ATE340803T1 (en)
AU (1) AU772782C (en)
BR (1) BR0012418A (en)
CA (1) CA2379022A1 (en)
CZ (1) CZ200226A3 (en)
DE (2) DE19933173A1 (en)
DK (1) DK1196433T3 (en)
ES (1) ES2273703T3 (en)
HK (1) HK1048641A1 (en)
HU (1) HUP0201925A3 (en)
MX (1) MXPA02000465A (en)
NO (1) NO20020176D0 (en)
PL (1) PL354363A1 (en)
PT (1) PT1196433E (en)
SK (1) SK262002A3 (en)
TW (1) TWI226890B (en)
WO (1) WO2001005810A2 (en)
ZA (1) ZA200201275B (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002232176B2 (en) * 2001-02-19 2006-06-15 Takara Bio Inc. Cyclic peptide
DE10118550A1 (en) * 2001-04-14 2002-10-17 Merck Patent Gmbh New 3-ethanoylamino-3-phenyl-propionic acid derivatives, are integrin agonists or antagonists useful e.g. for treating angiogenic, cardiovascular, inflammatory, osteolytic or tumor diseases or infections
PL1667668T3 (en) * 2003-10-01 2008-10-31 Merck Patent Gmbh Alfavbeta3 and alfavbeta6 integrin antagonists as antifibrotic agents
ES2436170T3 (en) * 2003-12-03 2013-12-27 The Scripps Research Institute Antibodies and peptides specific for integrin alfa II beta3
WO2006041631A2 (en) 2004-10-06 2006-04-20 Amr Technology, Inc. Novel cyclosporin alkynes and their utility as pharmaceutical agents
GB0520068D0 (en) * 2005-10-03 2005-11-09 Cancer Res Technology av peptide ligand
US7696166B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7696165B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
WO2008112004A2 (en) 2006-08-03 2008-09-18 Astrazeneca Ab ANTIBODIES DIRECTED TO αVβ6 AND USES THEREOF
EP2784511A1 (en) 2013-03-27 2014-10-01 Universität Zürich Integrin alpha-v-beta6 for diagnosis/prognosis of colorectal carcinoma
ES2898844T3 (en) 2015-09-18 2022-03-09 Univ Muenchen Tech Ligands for alphavbeta6 integrin, synthesis and uses thereof
RU2769702C2 (en) 2017-02-28 2022-04-05 Морфик Терапьютик, Инк. Avb6 integrin inhibitors
EP3589285A4 (en) 2017-02-28 2020-08-12 Morphic Therapeutic, Inc. Inhibitors of (alpha-v)(beta-6) integrin
US11332498B2 (en) 2017-03-17 2022-05-17 Technische Universitat Munchen Ligands for integrin αVβ8, synthesis and uses thereof
GB201706472D0 (en) * 2017-04-24 2017-06-07 Cancer Res Tech Ltd Tumour-targeting peptide variants
EP3617206A1 (en) 2018-08-29 2020-03-04 Morphic Therapeutic, Inc. Integrin inhibitors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000037487A1 (en) * 1998-12-19 2000-06-29 Merck Patent Gmbh αvβ6 INTEGRIN INHIBITORS

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4472305A (en) 1983-05-17 1984-09-18 Sterling Drug Inc. Hexapeptide amides
DE4310643A1 (en) 1993-04-01 1994-10-06 Merck Patent Gmbh Cyclic adhesion inhibitors
DE19538741A1 (en) 1995-10-18 1997-04-24 Merck Patent Gmbh Cyclopeptide derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000037487A1 (en) * 1998-12-19 2000-06-29 Merck Patent Gmbh αvβ6 INTEGRIN INHIBITORS

Also Published As

Publication number Publication date
HUP0201925A2 (en) 2002-10-28
PT1196433E (en) 2007-01-31
CN1361792A (en) 2002-07-31
ZA200201275B (en) 2003-08-22
NO20020176L (en) 2002-01-14
ATE340803T1 (en) 2006-10-15
HUP0201925A3 (en) 2002-11-28
AR024742A1 (en) 2002-10-23
EP1754714A1 (en) 2007-02-21
SK262002A3 (en) 2002-07-02
EP1196433B1 (en) 2006-09-27
KR20020010928A (en) 2002-02-06
DK1196433T3 (en) 2007-02-12
BR0012418A (en) 2002-03-26
AU772782B2 (en) 2004-05-06
PL354363A1 (en) 2004-01-12
AU5823600A (en) 2001-02-05
MXPA02000465A (en) 2002-07-30
TWI226890B (en) 2005-01-21
ES2273703T3 (en) 2007-05-16
HK1048641A1 (en) 2003-04-11
WO2001005810A3 (en) 2001-05-17
CA2379022A1 (en) 2001-01-25
JP2003505395A (en) 2003-02-12
NO20020176D0 (en) 2002-01-14
DE50013525D1 (en) 2006-11-09
WO2001005810A2 (en) 2001-01-25
CZ200226A3 (en) 2002-04-17
DE19933173A1 (en) 2001-01-18
EP1196433A2 (en) 2002-04-17

Similar Documents

Publication Publication Date Title
AU7830400A (en) Synthesis of insulin derivatives
AU5379900A (en) Thiophene integrin inhibitors
AU4796700A (en) Ureido-substituted cyclic amine derivatives and their use as drug
AU2001260455A1 (en) Cyclic amino acid derivatives useful as pharmaceutical agents
AU772782C (en) Cyclic peptide derivatives as inhibitors of integrin alphavbeta6
AU6111000A (en) Inhibitors of viral helcase
AU5991699A (en) Quinolizinones as integrin inhibitors
AU5619400A (en) Statine-derived tetrapeptide inhibitors of beta-secretase
AU4276599A (en) Phenylalanine derivatives as integrin inhibitors
AU2001243615A1 (en) Secure tracking of articles
AU2541000A (en) Beta-phenylalanine derivatives as integrin antagonists
AU5919900A (en) Cyclized amino acid derivatives
AU2001276027A1 (en) Heteroaryl-beta-alanine derivatives as alpha 4 integrin inhibitors
AU2001292122A1 (en) Heterocyclic derivatives useful as pharmaceutical agents
PL355811A1 (en) Novel branched substituted amino derivatives of 3-amino-1-phenyl-1h
AU6992500A (en) Alphavbeta3 integrin inhibitors
PL352409A1 (en) Derivatives of 1-trifluorometyl-4-hydroxy-7-piperidinyl-aminomethylochromane
AU8005100A (en) Inhibitors of neuraminidases
AUPQ180499A0 (en) Beta-amyloid peptide inhibitors
AU6071400A (en) Cyclized amide derivatives
AU5874800A (en) Antisense modulation of ets-2 expression
AU3595900A (en) Tyrosine alkoxyguanidines as integrin inhibitors
AU7608100A (en) 1-cyclohexene-1-carboxylic acid and 1-cyclohexene-1-carboxylates as neuraminidase inhibitors
AUPP182398A0 (en) Cyclic peptide inhibitors of pla2
AU7990000A (en) Neuraminidase inhibitors

Legal Events

Date Code Title Description
DA2 Applications for amendment section 104

Free format text: THE NATURE OF THE PROPOSED AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 20040615

FGA Letters patent sealed or granted (standard patent)