AU5823600A - Cyclic peptide derivatives as inhibitors of integrin alphavbeta6 - Google Patents

Cyclic peptide derivatives as inhibitors of integrin alphavbeta6

Info

Publication number
AU5823600A
AU5823600A AU58236/00A AU5823600A AU5823600A AU 5823600 A AU5823600 A AU 5823600A AU 58236/00 A AU58236/00 A AU 58236/00A AU 5823600 A AU5823600 A AU 5823600A AU 5823600 A AU5823600 A AU 5823600A
Authority
AU
Australia
Prior art keywords
integrin
inhibitors
cyclic peptide
peptide derivatives
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU58236/00A
Other versions
AU772782C (en
AU772782B2 (en
Inventor
Beate Diefenbach
Simon Goodman
Ulrich Groth
Alfred Jonczyk
Gunther Zischinsky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of AU5823600A publication Critical patent/AU5823600A/en
Application granted granted Critical
Publication of AU772782B2 publication Critical patent/AU772782B2/en
Publication of AU772782C publication Critical patent/AU772782C/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
AU58236/00A 1999-07-15 2000-07-03 Cyclic peptide derivatives as inhibitors of integrin alphavbeta6 Ceased AU772782C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19933173A DE19933173A1 (en) 1999-07-15 1999-07-15 Cyclic peptide derivatives as inhibitors of the integrin alpha¶v¶beta¶6¶
DE19933173 1999-07-15
PCT/EP2000/006188 WO2001005810A2 (en) 1999-07-15 2000-07-03 CYCLIC PEPTIDE DERIVATIVES AS INHIBITORS OF INTEGRIN αVβ¿6?

Publications (3)

Publication Number Publication Date
AU5823600A true AU5823600A (en) 2001-02-05
AU772782B2 AU772782B2 (en) 2004-05-06
AU772782C AU772782C (en) 2005-01-27

Family

ID=7914891

Family Applications (1)

Application Number Title Priority Date Filing Date
AU58236/00A Ceased AU772782C (en) 1999-07-15 2000-07-03 Cyclic peptide derivatives as inhibitors of integrin alphavbeta6

Country Status (23)

Country Link
EP (2) EP1754714A1 (en)
JP (1) JP2003505395A (en)
KR (1) KR20020010928A (en)
CN (1) CN1361792A (en)
AR (1) AR024742A1 (en)
AT (1) ATE340803T1 (en)
AU (1) AU772782C (en)
BR (1) BR0012418A (en)
CA (1) CA2379022A1 (en)
CZ (1) CZ200226A3 (en)
DE (2) DE19933173A1 (en)
DK (1) DK1196433T3 (en)
ES (1) ES2273703T3 (en)
HK (1) HK1048641A1 (en)
HU (1) HUP0201925A3 (en)
MX (1) MXPA02000465A (en)
NO (1) NO20020176D0 (en)
PL (1) PL354363A1 (en)
PT (1) PT1196433E (en)
SK (1) SK262002A3 (en)
TW (1) TWI226890B (en)
WO (1) WO2001005810A2 (en)
ZA (1) ZA200201275B (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002066499A1 (en) * 2001-02-19 2002-08-29 Takara Bio Inc. Cyclic peptide
DE10118550A1 (en) * 2001-04-14 2002-10-17 Merck Patent Gmbh New 3-ethanoylamino-3-phenyl-propionic acid derivatives, are integrin agonists or antagonists useful e.g. for treating angiogenic, cardiovascular, inflammatory, osteolytic or tumor diseases or infections
CA2540730C (en) * 2003-10-01 2012-08-21 Merck Patent Gmbh Alfavbeta3 and alfavbeta6 integrin antagonists as antifibrotic agents
WO2005056575A2 (en) * 2003-12-03 2005-06-23 The Scripps Research Institute INTEGRIN αIIbβ3 SPECIFIC ANTIBODIES AND PEPTIDES
US7361636B2 (en) 2004-10-06 2008-04-22 Amr Technology, Inc. Cyclosporin alkynes and their utility as pharmaceutical agents
GB0520068D0 (en) * 2005-10-03 2005-11-09 Cancer Res Technology av peptide ligand
US7696166B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7696165B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
AU2007348941B2 (en) 2006-08-03 2011-08-04 Medimmune Limited Antibodies directed to alphaVbeta6 and uses thereof
EP2784511A1 (en) 2013-03-27 2014-10-01 Universität Zürich Integrin alpha-v-beta6 for diagnosis/prognosis of colorectal carcinoma
HRP20211776T8 (en) * 2015-09-18 2022-03-18 Technische Universität München Ligands for integrin avbeta6, synthesis and uses thereof
CN110573499B (en) 2017-02-28 2023-04-21 莫菲克医疗股份有限公司 Inhibitors of αvβ6 integrin
CA3054792A1 (en) 2017-02-28 2018-09-07 Morphic Therapeutic, Inc. Inhibitors of .alpha.v.beta.6 integrin
US11332498B2 (en) 2017-03-17 2022-05-17 Technische Universitat Munchen Ligands for integrin αVβ8, synthesis and uses thereof
GB201706472D0 (en) * 2017-04-24 2017-06-07 Cancer Res Tech Ltd Tumour-targeting peptide variants
PE20211640A1 (en) 2018-08-29 2021-08-24 Morphic Therapeutic Inc INHIBITION OF INTEGRIN xvß6

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4472305A (en) 1983-05-17 1984-09-18 Sterling Drug Inc. Hexapeptide amides
DE4310643A1 (en) 1993-04-01 1994-10-06 Merck Patent Gmbh Cyclic adhesion inhibitors
DE19538741A1 (en) 1995-10-18 1997-04-24 Merck Patent Gmbh Cyclopeptide derivatives
JP2002533064A (en) * 1998-12-19 2002-10-08 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング Integrin αvβ6 inhibitor

Also Published As

Publication number Publication date
HUP0201925A3 (en) 2002-11-28
WO2001005810A3 (en) 2001-05-17
TWI226890B (en) 2005-01-21
EP1196433A2 (en) 2002-04-17
PL354363A1 (en) 2004-01-12
CA2379022A1 (en) 2001-01-25
CN1361792A (en) 2002-07-31
JP2003505395A (en) 2003-02-12
AR024742A1 (en) 2002-10-23
WO2001005810A2 (en) 2001-01-25
ATE340803T1 (en) 2006-10-15
NO20020176L (en) 2002-01-14
HUP0201925A2 (en) 2002-10-28
SK262002A3 (en) 2002-07-02
AU772782C (en) 2005-01-27
DE19933173A1 (en) 2001-01-18
ZA200201275B (en) 2003-08-22
DK1196433T3 (en) 2007-02-12
AU772782B2 (en) 2004-05-06
DE50013525D1 (en) 2006-11-09
EP1754714A1 (en) 2007-02-21
EP1196433B1 (en) 2006-09-27
BR0012418A (en) 2002-03-26
MXPA02000465A (en) 2002-07-30
KR20020010928A (en) 2002-02-06
HK1048641A1 (en) 2003-04-11
ES2273703T3 (en) 2007-05-16
CZ200226A3 (en) 2002-04-17
NO20020176D0 (en) 2002-01-14
PT1196433E (en) 2007-01-31

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Legal Events

Date Code Title Description
DA2 Applications for amendment section 104

Free format text: THE NATURE OF THE PROPOSED AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 20040615

FGA Letters patent sealed or granted (standard patent)