HK1048641A1 - 作為整合蛋白αVβ6抑制劑的環肽衍生物 - Google Patents

作為整合蛋白αVβ6抑制劑的環肽衍生物

Info

Publication number
HK1048641A1
HK1048641A1 HK03100378.9A HK03100378A HK1048641A1 HK 1048641 A1 HK1048641 A1 HK 1048641A1 HK 03100378 A HK03100378 A HK 03100378A HK 1048641 A1 HK1048641 A1 HK 1048641A1
Authority
HK
Hong Kong
Prior art keywords
inhibitors
cyclic peptide
peptide derivatives
integrin αvβ6
αvβ6
Prior art date
Application number
HK03100378.9A
Other languages
English (en)
Inventor
Jonczyk Alfred
Diefenbach Beate
Goodman Simon
Groth Ulrich
Zischinsky Gunther
Original Assignee
默克專利股份公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 默克專利股份公司 filed Critical 默克專利股份公司
Publication of HK1048641A1 publication Critical patent/HK1048641A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK03100378.9A 1999-07-15 2003-01-15 作為整合蛋白αVβ6抑制劑的環肽衍生物 HK1048641A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19933173A DE19933173A1 (de) 1999-07-15 1999-07-15 Cyclische Peptidderivate als Inhibitoren des Integrins alpha¶v¶beta¶6¶
PCT/EP2000/006188 WO2001005810A2 (de) 1999-07-15 2000-07-03 CYCLISCHE PEPTIDDERIVATE ALS INHIBITOREN DES INTEGRINS αvβ¿6?

Publications (1)

Publication Number Publication Date
HK1048641A1 true HK1048641A1 (zh) 2003-04-11

Family

ID=7914891

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03100378.9A HK1048641A1 (zh) 1999-07-15 2003-01-15 作為整合蛋白αVβ6抑制劑的環肽衍生物

Country Status (23)

Country Link
EP (2) EP1754714A1 (zh)
JP (1) JP2003505395A (zh)
KR (1) KR20020010928A (zh)
CN (1) CN1361792A (zh)
AR (1) AR024742A1 (zh)
AT (1) ATE340803T1 (zh)
AU (1) AU772782C (zh)
BR (1) BR0012418A (zh)
CA (1) CA2379022A1 (zh)
CZ (1) CZ200226A3 (zh)
DE (2) DE19933173A1 (zh)
DK (1) DK1196433T3 (zh)
ES (1) ES2273703T3 (zh)
HK (1) HK1048641A1 (zh)
HU (1) HUP0201925A3 (zh)
MX (1) MXPA02000465A (zh)
NO (1) NO20020176D0 (zh)
PL (1) PL354363A1 (zh)
PT (1) PT1196433E (zh)
SK (1) SK262002A3 (zh)
TW (1) TWI226890B (zh)
WO (1) WO2001005810A2 (zh)
ZA (1) ZA200201275B (zh)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002232176B2 (en) * 2001-02-19 2006-06-15 Takara Bio Inc. Cyclic peptide
DE10118550A1 (de) * 2001-04-14 2002-10-17 Merck Patent Gmbh Liganden des Integrins alpha¶nu¶beta¶6¶
PL1667668T3 (pl) * 2003-10-01 2008-10-31 Merck Patent Gmbh Antagoniści integryny alfavbeta3 oraz alfavbeta6 jako czynniki przeciwzwłóknieniowe
ES2436170T3 (es) * 2003-12-03 2013-12-27 The Scripps Research Institute Anticuerpos y péptidos específicos de la integrina alfa II beta3
WO2006041631A2 (en) 2004-10-06 2006-04-20 Amr Technology, Inc. Novel cyclosporin alkynes and their utility as pharmaceutical agents
GB0520068D0 (en) * 2005-10-03 2005-11-09 Cancer Res Technology av peptide ligand
US7696166B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7696165B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
WO2008112004A2 (en) 2006-08-03 2008-09-18 Astrazeneca Ab ANTIBODIES DIRECTED TO αVβ6 AND USES THEREOF
EP2784511A1 (en) 2013-03-27 2014-10-01 Universität Zürich Integrin alpha-v-beta6 for diagnosis/prognosis of colorectal carcinoma
ES2898844T3 (es) 2015-09-18 2022-03-09 Univ Muenchen Tech Ligandos para integrina alphavbeta6, síntesis y usos de los mismos
RU2769702C2 (ru) 2017-02-28 2022-04-05 Морфик Терапьютик, Инк. Ингибиторы интегрина avb6
EP3589285A4 (en) 2017-02-28 2020-08-12 Morphic Therapeutic, Inc. INHIBITORS OF INTEGRIN (ALPHA-V) (BETA-6)
US11332498B2 (en) 2017-03-17 2022-05-17 Technische Universitat Munchen Ligands for integrin αVβ8, synthesis and uses thereof
GB201706472D0 (en) * 2017-04-24 2017-06-07 Cancer Res Tech Ltd Tumour-targeting peptide variants
EP3617206A1 (en) 2018-08-29 2020-03-04 Morphic Therapeutic, Inc. Integrin inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4472305A (en) 1983-05-17 1984-09-18 Sterling Drug Inc. Hexapeptide amides
DE4310643A1 (de) 1993-04-01 1994-10-06 Merck Patent Gmbh Cyclische Adhäsionsinhibitoren
DE19538741A1 (de) 1995-10-18 1997-04-24 Merck Patent Gmbh Cyclopeptidderivate
CA2355874A1 (en) * 1998-12-19 2000-06-29 Merck Patent Gesellschaft Mit Beschraenkter Haftung .alpha.v.beta.6 integrin inhibitors

Also Published As

Publication number Publication date
HUP0201925A2 (en) 2002-10-28
PT1196433E (pt) 2007-01-31
CN1361792A (zh) 2002-07-31
ZA200201275B (en) 2003-08-22
NO20020176L (no) 2002-01-14
ATE340803T1 (de) 2006-10-15
HUP0201925A3 (en) 2002-11-28
AR024742A1 (es) 2002-10-23
EP1754714A1 (de) 2007-02-21
SK262002A3 (en) 2002-07-02
EP1196433B1 (de) 2006-09-27
KR20020010928A (ko) 2002-02-06
DK1196433T3 (da) 2007-02-12
BR0012418A (pt) 2002-03-26
AU772782B2 (en) 2004-05-06
AU772782C (en) 2005-01-27
PL354363A1 (en) 2004-01-12
AU5823600A (en) 2001-02-05
MXPA02000465A (es) 2002-07-30
TWI226890B (en) 2005-01-21
ES2273703T3 (es) 2007-05-16
WO2001005810A3 (de) 2001-05-17
CA2379022A1 (en) 2001-01-25
JP2003505395A (ja) 2003-02-12
NO20020176D0 (no) 2002-01-14
DE50013525D1 (de) 2006-11-09
WO2001005810A2 (de) 2001-01-25
CZ200226A3 (cs) 2002-04-17
DE19933173A1 (de) 2001-01-18
EP1196433A2 (de) 2002-04-17

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