ZA200105885B - Use of 3-hydroxy-3-methylglutaryl coenzym a reductase inhibitors for the manufacture of a medicament for the treatment of diabetic neuropathy. - Google Patents
Use of 3-hydroxy-3-methylglutaryl coenzym a reductase inhibitors for the manufacture of a medicament for the treatment of diabetic neuropathy. Download PDFInfo
- Publication number
- ZA200105885B ZA200105885B ZA200105885A ZA200105885A ZA200105885B ZA 200105885 B ZA200105885 B ZA 200105885B ZA 200105885 A ZA200105885 A ZA 200105885A ZA 200105885 A ZA200105885 A ZA 200105885A ZA 200105885 B ZA200105885 B ZA 200105885B
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- ZA
- South Africa
- Prior art keywords
- composition
- substance
- pharmaceutically acceptable
- treatment
- ethoxy
- Prior art date
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- 239000003814 drug Substances 0.000 title claims description 53
- 238000011282 treatment Methods 0.000 title claims description 36
- 208000032131 Diabetic Neuropathies Diseases 0.000 title claims description 24
- -1 3-hydroxy-3-methylglutaryl Chemical group 0.000 title claims description 9
- 238000004519 manufacturing process Methods 0.000 title claims description 4
- 239000003112 inhibitor Substances 0.000 title description 7
- 229940079593 drug Drugs 0.000 claims description 46
- 239000003795 chemical substances by application Substances 0.000 claims description 40
- 206010012601 diabetes mellitus Diseases 0.000 claims description 39
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims description 36
- 239000000203 mixture Substances 0.000 claims description 34
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- 239000005541 ACE inhibitor Substances 0.000 claims description 32
- 239000003288 aldose reductase inhibitor Substances 0.000 claims description 30
- 239000008194 pharmaceutical composition Substances 0.000 claims description 28
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- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 claims description 24
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9902591.8A GB9902591D0 (en) | 1999-02-06 | 1999-02-06 | Pharmaceutical compositions |
| GBGB9902594.2A GB9902594D0 (en) | 1999-02-06 | 1999-02-06 | Pharmaceutical compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200105885B true ZA200105885B (en) | 2002-10-17 |
Family
ID=26315085
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200105885A ZA200105885B (en) | 1999-02-06 | 2001-07-17 | Use of 3-hydroxy-3-methylglutaryl coenzym a reductase inhibitors for the manufacture of a medicament for the treatment of diabetic neuropathy. |
Country Status (34)
| Country | Link |
|---|---|
| US (4) | US6894058B1 (de) |
| EP (2) | EP1897546B1 (de) |
| JP (3) | JP2002536332A (de) |
| KR (1) | KR100699757B1 (de) |
| CN (1) | CN1196488C (de) |
| AR (1) | AR025512A1 (de) |
| AT (2) | ATE367162T1 (de) |
| AU (1) | AU763970B2 (de) |
| BR (1) | BR0007996A (de) |
| CA (1) | CA2368186C (de) |
| CY (2) | CY1106879T1 (de) |
| CZ (2) | CZ302881B6 (de) |
| DE (2) | DE60035575T2 (de) |
| DK (2) | DK1897546T3 (de) |
| EE (2) | EE05621B1 (de) |
| ES (2) | ES2286995T3 (de) |
| GB (1) | GB0001662D0 (de) |
| HK (2) | HK1041223A1 (de) |
| HU (1) | HU227642B1 (de) |
| IL (3) | IL144730A0 (de) |
| IS (2) | IS2793B (de) |
| MX (1) | MXPA01007821A (de) |
| MY (1) | MY138289A (de) |
| NO (1) | NO330400B1 (de) |
| NZ (3) | NZ513061A (de) |
| PL (1) | PL198098B1 (de) |
| PT (2) | PT1897546E (de) |
| RU (1) | RU2239456C2 (de) |
| SI (2) | SI1897546T1 (de) |
| SK (2) | SK286854B6 (de) |
| TR (1) | TR200102229T2 (de) |
| TW (1) | TWI230067B (de) |
| WO (1) | WO2000045818A1 (de) |
| ZA (1) | ZA200105885B (de) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0001662D0 (en) * | 1999-02-06 | 2000-03-15 | Zeneca Ltd | Pharmaceutical compositions |
| US6555540B1 (en) * | 1999-06-30 | 2003-04-29 | Pfizer Inc | Combinations of aldose reductase inhibitors and selective cyclooxygenase-2 inhibitors |
| GB0001621D0 (en) * | 2000-01-26 | 2000-03-15 | Astrazeneca Ab | Pharmaceutical compositions |
| AU2001232244A1 (en) * | 2000-02-10 | 2001-08-20 | Takeda Chemical Industries Ltd. | Drug comprising combination |
| GB0003305D0 (en) * | 2000-02-15 | 2000-04-05 | Zeneca Ltd | Pyrimidine derivatives |
| DE10025308A1 (de) * | 2000-05-23 | 2001-11-29 | Bayer Ag | Kombination von Cerivastatin mit ACE Inhibitoren und ihre Verwendung in Arzneimitteln |
| US20060089389A1 (en) | 2000-08-22 | 2006-04-27 | Malcolm Allison | Combination |
| AR033390A1 (es) * | 2000-08-22 | 2003-12-17 | Novartis Ag | Una composicion farmaceutica que comprende un antagonista del receptor at1 y un potenciador de la secrecion de insulina, el uso de dicha composicion para la fabricacion de un medicamento y un kit de partes |
| AR030379A1 (es) * | 2000-08-22 | 2003-08-20 | Novartis Ag | Combinaciones |
| CN1230173C (zh) * | 2000-10-12 | 2005-12-07 | 日产化学工业株式会社 | 糖尿病合并症预防及治疗剂 |
| WO2002032411A2 (en) * | 2000-10-18 | 2002-04-25 | Pfizer Products Inc. | Combination of statins and sorbitol dehydrogenase inhibitors |
| MXPA03004871A (es) | 2000-11-30 | 2003-08-19 | Pfizer Prod Inc | Combinacion de agonistas de gaba e inhibidores de aldosa-reductasa. |
| US20030171407A1 (en) * | 2002-03-07 | 2003-09-11 | Upsher-Smith Laboratories, Inc. | Composition for reducing blood glucose and cholesterol |
| WO2003077912A1 (en) * | 2002-03-20 | 2003-09-25 | The University Of Queensland | Method of treatment and/or prophylaxis |
| PE20040291A1 (es) * | 2002-03-22 | 2004-07-02 | Novartis Ag | COMBINACION QUE COMPRENDE UN INHIBIDOR DE HMG-CoA-REDUCTASA Y UN POTENCIADOR DE LA SECRECION DE INSULINA Y/O UN SENSIBILIZANTE DE INSULINA |
| JP4395633B2 (ja) * | 2002-08-29 | 2010-01-13 | 学校法人鈴鹿医療科学大学 | 非神経細胞の神経細胞への分化成熟法、該組成物と該組成物探索法 |
| US7179941B2 (en) | 2003-01-23 | 2007-02-20 | Sanofi-Aventis Deutschland Gmbh | Carbonylamino-substituted acyl phenyl urea derivatives, process for their preparation and their use |
| DE10302452B4 (de) * | 2003-01-23 | 2005-02-24 | Aventis Pharma Deutschland Gmbh | Carbonylamino-substituierte Acyl-phenyl-harnstoffderivate, Verfahren zu deren Herstellung und deren Verwendung |
| WO2004096278A1 (ja) * | 2003-04-28 | 2004-11-11 | Sankyo Company, Limited | アディポネクチン産生増強剤 |
| JP2005232151A (ja) * | 2003-04-28 | 2005-09-02 | Iichiro Shimomura | 糖取り込み能増強剤 |
| EP1618893A4 (de) | 2003-04-28 | 2009-08-12 | Sankyo Co | Mittel zur verstärkung der zuckeraufnahmefähigkeit |
| US20050014799A1 (en) * | 2003-06-20 | 2005-01-20 | Biostratum, Inc. | Pyridoxamine for the treatment of diabetic kidney disease |
| US20090082407A1 (en) * | 2004-06-18 | 2009-03-26 | Biostratum, Inc. | Pyridoxamine for the Treatment of Diabetic Kidney Disease |
| EP1510208A1 (de) * | 2003-08-22 | 2005-03-02 | Fournier Laboratories Ireland Limited | Metformin-Statin-Kombination enthaltende pharmazeutische Zusammensetzungen |
| US20050054731A1 (en) * | 2003-09-08 | 2005-03-10 | Franco Folli | Multi-system therapy for diabetes, the metabolic syndrome and obesity |
| WO2005023766A1 (en) * | 2003-09-11 | 2005-03-17 | Biocon Limited | Salt of atorvastatin with metformin |
| GB0322552D0 (en) * | 2003-09-26 | 2003-10-29 | Astrazeneca Uk Ltd | Therapeutic treatment |
| AU2003272084A1 (en) * | 2003-10-07 | 2005-04-21 | Biocon Limited | SALT OF 1,2,6,7,8,8A-HEXAHYDRO-Beta,Delta,6-TRIHYDROXY-2-METHYL-8-((2S)-2-METHYL-1-OXOBUTOXY)-, (BetaR,Delta R,1S,2S,6S,8S,8AR)- 1-NAPHTHALENEHEPTANOIC ACID WITH N,N-DIMETHYL-IMIDODICARBONIMIDIC DIAMIDE |
| KR100715114B1 (ko) * | 2005-02-19 | 2007-05-10 | 한국유나이티드제약 주식회사 | 당뇨병 치료를 위한 약학적 조성물 |
| CN101632673B (zh) * | 2008-07-24 | 2011-08-10 | 鲁南制药集团股份有限公司 | 含有氯沙坦、吡格列酮和瑞舒伐他汀的药物组合物及其新用途 |
| ES2639019T3 (es) | 2008-09-06 | 2017-10-25 | Bionevia Pharmaceuticals Inc. | Nuevo cocristal de colina de epalrestat |
| EP2196476A1 (de) | 2008-12-10 | 2010-06-16 | Novartis Ag | Antikörperformulierung |
| EP2779999A2 (de) | 2011-11-15 | 2014-09-24 | Dr. Reddy's Laboratories Ltd. | Pharmazeutische formulierungen mit atorvastatin und glimepirid |
| WO2015053589A1 (ko) * | 2013-10-11 | 2015-04-16 | 가톨릭대학교 산학협력단 | 메트포민 및 스타틴의 복합제를 이용한 자가면역질환의 예방 또는 치료용 조성물 |
| KR101579656B1 (ko) * | 2013-12-12 | 2015-12-22 | 가천대학교 산학협력단 | 프라바스타틴과 발사르탄을 포함하는 약학 조성물 |
| CN110747206B (zh) * | 2019-11-05 | 2021-11-23 | 昆明理工大学 | 3-羟基-3-甲基戊二酸单酰辅酶a还原酶基因rkhmgr及其应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5196444A (en) * | 1990-04-27 | 1993-03-23 | Takeda Chemical Industries, Ltd. | 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof |
| CA2040865C (en) | 1990-05-15 | 2002-07-23 | James L. Bergey | Method for preventing, stabilizing or causing regression of atherosclerosis employing a combination of a cholesterol lowering drug and an ace inhibitor |
| US5298497A (en) | 1990-05-15 | 1994-03-29 | E. R. Squibb & Sons, Inc. | Method for preventing onset of hypertension employing a cholesterol lowering drug |
| US5140012A (en) | 1990-05-31 | 1992-08-18 | E. R. Squibb & Sons, Inc. | Method for preventing onset of restenosis after angioplasty employing pravastatin |
| US5622985A (en) | 1990-06-11 | 1997-04-22 | Bristol-Myers Squibb Company | Method for preventing a second heart attack employing an HMG CoA reductase inhibitor |
| US5130333A (en) * | 1990-10-19 | 1992-07-14 | E. R. Squibb & Sons, Inc. | Method for treating type II diabetes employing a cholesterol lowering drug |
| US5190970A (en) | 1990-10-19 | 1993-03-02 | E. R. Squibb & Sons, Inc. | Method for preventing onset of or treating Type II diabetes employing a cholesterol lowering drug alone or in combination with an ace inhibitor |
| CA2052014A1 (en) | 1990-10-19 | 1992-04-20 | Henry Y. Pan | Method for preventing diabetic complications employing a cholesterol lowering drug alone or in combination with an ace inhibitor |
| JP2648897B2 (ja) * | 1991-07-01 | 1997-09-03 | 塩野義製薬株式会社 | ピリミジン誘導体 |
| HUT71331A (en) | 1992-04-13 | 1995-11-28 | Zeneca Ltd | Angiotensin ii antagonists against disorders associated with impaired neuronal conduction velocity, especially diabetic neuropathy |
| GB9208116D0 (en) * | 1992-04-13 | 1992-05-27 | Ici Plc | Therapeutic agents |
| WO1995013063A1 (en) | 1993-11-09 | 1995-05-18 | Merck & Co., Inc. | HMG-CoA REDUCTASE INHIBITORS IN THE NORMALIZATION OF VASCULAR ENDOTHELIAL DYSFUNCTION |
| WO1995026188A1 (en) | 1994-03-29 | 1995-10-05 | Merck & Co., Inc. | Treatment of atherosclerosis with angiotensin ii receptor blocking imidazoles |
| TW438587B (en) | 1995-06-20 | 2001-06-07 | Takeda Chemical Industries Ltd | A pharmaceutical composition for prophylaxis and treatment of diabetes |
| KR20050047560A (ko) | 1996-04-05 | 2005-05-20 | 다께다 케미칼 인더스트리즈,리미티드 | 안지오텐신 ⅱ 및 길항 활성을 갖는 화합물을 함유하는약제학적 조합물 |
| GB9714274D0 (en) * | 1997-07-08 | 1997-09-10 | Zeneca Ltd | Pharmaceutical composition |
| GT199800126A (es) | 1997-08-29 | 2000-01-29 | Terapia de combinacion. | |
| GB0001662D0 (en) * | 1999-02-06 | 2000-03-15 | Zeneca Ltd | Pharmaceutical compositions |
| US6262076B1 (en) * | 2000-01-28 | 2001-07-17 | Ajinomoto Co., Inc. | Pharmaceutical composition for use in the treatment of diabetic neuropathy |
| GB0322552D0 (en) * | 2003-09-26 | 2003-10-29 | Astrazeneca Uk Ltd | Therapeutic treatment |
-
2000
- 2000-01-26 GB GBGB0001662.6A patent/GB0001662D0/en not_active Ceased
- 2000-01-31 AR ARP000100409A patent/AR025512A1/es unknown
- 2000-02-01 NZ NZ513061A patent/NZ513061A/xx not_active IP Right Cessation
- 2000-02-01 EE EEP201200015A patent/EE05621B1/xx unknown
- 2000-02-01 US US09/889,409 patent/US6894058B1/en not_active Expired - Lifetime
- 2000-02-01 SI SI200031063T patent/SI1897546T1/sl unknown
- 2000-02-01 PL PL350312A patent/PL198098B1/pl unknown
- 2000-02-01 DK DK07008956.0T patent/DK1897546T3/da active
- 2000-02-01 DE DE60035575T patent/DE60035575T2/de not_active Expired - Lifetime
- 2000-02-01 MX MXPA01007821A patent/MXPA01007821A/es not_active IP Right Cessation
- 2000-02-01 CA CA002368186A patent/CA2368186C/en not_active Expired - Fee Related
- 2000-02-01 PT PT07008956T patent/PT1897546E/pt unknown
- 2000-02-01 SK SK1110-2001A patent/SK286854B6/sk not_active IP Right Cessation
- 2000-02-01 WO PCT/GB2000/000280 patent/WO2000045818A1/en active Application Filing
- 2000-02-01 HU HU0105138A patent/HU227642B1/hu not_active IP Right Cessation
- 2000-02-01 EP EP07008956A patent/EP1897546B1/de not_active Expired - Lifetime
- 2000-02-01 AU AU23047/00A patent/AU763970B2/en not_active Ceased
- 2000-02-01 DE DE60045168T patent/DE60045168D1/de not_active Expired - Lifetime
- 2000-02-01 RU RU2001124665/15A patent/RU2239456C2/ru active
- 2000-02-01 KR KR1020017009907A patent/KR100699757B1/ko not_active IP Right Cessation
- 2000-02-01 BR BR0007996-0A patent/BR0007996A/pt not_active Application Discontinuation
- 2000-02-01 IL IL14473000A patent/IL144730A0/xx unknown
- 2000-02-01 EE EEP200100405A patent/EE05556B1/xx not_active IP Right Cessation
- 2000-02-01 JP JP2000596938A patent/JP2002536332A/ja active Pending
- 2000-02-01 SI SI200030962T patent/SI1150678T1/sl unknown
- 2000-02-01 AT AT00901744T patent/ATE367162T1/de active
- 2000-02-01 SK SK5109-2008A patent/SK287792B6/sk not_active IP Right Cessation
- 2000-02-01 EP EP00901744A patent/EP1150678B1/de not_active Expired - Lifetime
- 2000-02-01 CZ CZ20012806A patent/CZ302881B6/cs not_active IP Right Cessation
- 2000-02-01 TR TR2001/02229T patent/TR200102229T2/xx unknown
- 2000-02-01 ES ES00901744T patent/ES2286995T3/es not_active Expired - Lifetime
- 2000-02-01 ES ES07008956T patent/ES2352803T3/es not_active Expired - Lifetime
- 2000-02-01 NZ NZ536433A patent/NZ536433A/en not_active IP Right Cessation
- 2000-02-01 DK DK00901744T patent/DK1150678T3/da active
- 2000-02-01 CN CNB008034974A patent/CN1196488C/zh not_active Expired - Lifetime
- 2000-02-01 NZ NZ52541900A patent/NZ525419A/xx not_active IP Right Cessation
- 2000-02-01 PT PT00901744T patent/PT1150678E/pt unknown
- 2000-02-01 AT AT07008956T patent/ATE485823T1/de active
- 2000-02-01 CZ CZ20110341A patent/CZ302893B6/cs not_active IP Right Cessation
- 2000-02-03 TW TW089101895A patent/TWI230067B/zh not_active IP Right Cessation
- 2000-02-04 MY MYPI20000412A patent/MY138289A/en unknown
-
2001
- 2001-07-17 ZA ZA200105885A patent/ZA200105885B/en unknown
- 2001-07-20 IS IS6016A patent/IS2793B/is unknown
- 2001-08-03 NO NO20013812A patent/NO330400B1/no not_active IP Right Cessation
- 2001-08-05 IL IL144730A patent/IL144730A/en not_active IP Right Cessation
-
2002
- 2002-04-22 HK HK02103012A patent/HK1041223A1/xx unknown
-
2004
- 2004-09-08 US US10/935,747 patent/US20050209128A1/en not_active Abandoned
-
2007
- 2007-09-19 CY CY20071101207T patent/CY1106879T1/el unknown
-
2008
- 2008-08-11 US US12/222,534 patent/US20090186908A1/en not_active Abandoned
- 2008-08-21 HK HK08109378.5A patent/HK1118209A1/xx unknown
-
2010
- 2010-09-21 IL IL208330A patent/IL208330A0/en unknown
- 2010-12-16 CY CY20101101157T patent/CY1110992T1/el unknown
-
2011
- 2011-03-15 US US13/048,377 patent/US20120041010A1/en not_active Abandoned
- 2011-08-23 IS IS8978A patent/IS2820B/is unknown
- 2011-09-29 JP JP2011213694A patent/JP2012051898A/ja active Pending
-
2013
- 2013-11-20 JP JP2013239770A patent/JP2014065718A/ja active Pending
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