HK1041223A1 - Use of 3-hydroxy-3-methylglutaryl coenzym a reductase inhibitors for the manufacture of a medicamentfor the treatment of diabetic neuropathy - Google Patents

Use of 3-hydroxy-3-methylglutaryl coenzym a reductase inhibitors for the manufacture of a medicamentfor the treatment of diabetic neuropathy

Info

Publication number
HK1041223A1
HK1041223A1 HK02103012A HK02103012A HK1041223A1 HK 1041223 A1 HK1041223 A1 HK 1041223A1 HK 02103012 A HK02103012 A HK 02103012A HK 02103012 A HK02103012 A HK 02103012A HK 1041223 A1 HK1041223 A1 HK 1041223A1
Authority
HK
Hong Kong
Prior art keywords
medicamentfor
coenzym
methylglutaryl
hydroxy
manufacture
Prior art date
Application number
HK02103012A
Other languages
English (en)
Inventor
Norman E Cameron
Mary A Cotter
Original Assignee
Astrazeneca Ab
Univ Aberdeen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9902591.8A external-priority patent/GB9902591D0/en
Priority claimed from GBGB9902594.2A external-priority patent/GB9902594D0/en
Application filed by Astrazeneca Ab, Univ Aberdeen filed Critical Astrazeneca Ab
Publication of HK1041223A1 publication Critical patent/HK1041223A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK02103012A 1999-02-06 2002-04-22 Use of 3-hydroxy-3-methylglutaryl coenzym a reductase inhibitors for the manufacture of a medicamentfor the treatment of diabetic neuropathy HK1041223A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9902591.8A GB9902591D0 (en) 1999-02-06 1999-02-06 Pharmaceutical compositions
GBGB9902594.2A GB9902594D0 (en) 1999-02-06 1999-02-06 Pharmaceutical compositions
PCT/GB2000/000280 WO2000045818A1 (en) 1999-02-06 2000-02-01 Use of 3-hydroxy-3-methylglutaryl coenzym a reductase inhibitors for the manufacture of a medicament for the treatment of diabetic neuropathy

Publications (1)

Publication Number Publication Date
HK1041223A1 true HK1041223A1 (en) 2002-07-05

Family

ID=26315085

Family Applications (2)

Application Number Title Priority Date Filing Date
HK02103012A HK1041223A1 (en) 1999-02-06 2002-04-22 Use of 3-hydroxy-3-methylglutaryl coenzym a reductase inhibitors for the manufacture of a medicamentfor the treatment of diabetic neuropathy
HK08109378.5A HK1118209A1 (en) 1999-02-06 2008-08-21 Combined compositions comprising (e)-7-[4-(4-fluorophenyl)-6-isopropyl-2- [methyl(methylsulfonyl)amino]pyrimidin-5-yl](3r,5s)-3,5-dihydroxyhept-6- enoic acid

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK08109378.5A HK1118209A1 (en) 1999-02-06 2008-08-21 Combined compositions comprising (e)-7-[4-(4-fluorophenyl)-6-isopropyl-2- [methyl(methylsulfonyl)amino]pyrimidin-5-yl](3r,5s)-3,5-dihydroxyhept-6- enoic acid

Country Status (34)

Country Link
US (4) US6894058B1 (de)
EP (2) EP1897546B1 (de)
JP (3) JP2002536332A (de)
KR (1) KR100699757B1 (de)
CN (1) CN1196488C (de)
AR (1) AR025512A1 (de)
AT (2) ATE367162T1 (de)
AU (1) AU763970B2 (de)
BR (1) BR0007996A (de)
CA (1) CA2368186C (de)
CY (2) CY1106879T1 (de)
CZ (2) CZ302881B6 (de)
DE (2) DE60035575T2 (de)
DK (2) DK1897546T3 (de)
EE (2) EE05621B1 (de)
ES (2) ES2286995T3 (de)
GB (1) GB0001662D0 (de)
HK (2) HK1041223A1 (de)
HU (1) HU227642B1 (de)
IL (3) IL144730A0 (de)
IS (2) IS2793B (de)
MX (1) MXPA01007821A (de)
MY (1) MY138289A (de)
NO (1) NO330400B1 (de)
NZ (3) NZ513061A (de)
PL (1) PL198098B1 (de)
PT (2) PT1897546E (de)
RU (1) RU2239456C2 (de)
SI (2) SI1897546T1 (de)
SK (2) SK286854B6 (de)
TR (1) TR200102229T2 (de)
TW (1) TWI230067B (de)
WO (1) WO2000045818A1 (de)
ZA (1) ZA200105885B (de)

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AR030379A1 (es) * 2000-08-22 2003-08-20 Novartis Ag Combinaciones
CN1230173C (zh) * 2000-10-12 2005-12-07 日产化学工业株式会社 糖尿病合并症预防及治疗剂
WO2002032411A2 (en) * 2000-10-18 2002-04-25 Pfizer Products Inc. Combination of statins and sorbitol dehydrogenase inhibitors
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US20030171407A1 (en) * 2002-03-07 2003-09-11 Upsher-Smith Laboratories, Inc. Composition for reducing blood glucose and cholesterol
WO2003077912A1 (en) * 2002-03-20 2003-09-25 The University Of Queensland Method of treatment and/or prophylaxis
PE20040291A1 (es) * 2002-03-22 2004-07-02 Novartis Ag COMBINACION QUE COMPRENDE UN INHIBIDOR DE HMG-CoA-REDUCTASA Y UN POTENCIADOR DE LA SECRECION DE INSULINA Y/O UN SENSIBILIZANTE DE INSULINA
JP4395633B2 (ja) * 2002-08-29 2010-01-13 学校法人鈴鹿医療科学大学 非神経細胞の神経細胞への分化成熟法、該組成物と該組成物探索法
US7179941B2 (en) 2003-01-23 2007-02-20 Sanofi-Aventis Deutschland Gmbh Carbonylamino-substituted acyl phenyl urea derivatives, process for their preparation and their use
DE10302452B4 (de) * 2003-01-23 2005-02-24 Aventis Pharma Deutschland Gmbh Carbonylamino-substituierte Acyl-phenyl-harnstoffderivate, Verfahren zu deren Herstellung und deren Verwendung
WO2004096278A1 (ja) * 2003-04-28 2004-11-11 Sankyo Company, Limited アディポネクチン産生増強剤
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EP1618893A4 (de) 2003-04-28 2009-08-12 Sankyo Co Mittel zur verstärkung der zuckeraufnahmefähigkeit
US20050014799A1 (en) * 2003-06-20 2005-01-20 Biostratum, Inc. Pyridoxamine for the treatment of diabetic kidney disease
US20090082407A1 (en) * 2004-06-18 2009-03-26 Biostratum, Inc. Pyridoxamine for the Treatment of Diabetic Kidney Disease
EP1510208A1 (de) * 2003-08-22 2005-03-02 Fournier Laboratories Ireland Limited Metformin-Statin-Kombination enthaltende pharmazeutische Zusammensetzungen
US20050054731A1 (en) * 2003-09-08 2005-03-10 Franco Folli Multi-system therapy for diabetes, the metabolic syndrome and obesity
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GB0322552D0 (en) * 2003-09-26 2003-10-29 Astrazeneca Uk Ltd Therapeutic treatment
AU2003272084A1 (en) * 2003-10-07 2005-04-21 Biocon Limited SALT OF 1,2,6,7,8,8A-HEXAHYDRO-Beta,Delta,6-TRIHYDROXY-2-METHYL-8-((2S)-2-METHYL-1-OXOBUTOXY)-, (BetaR,Delta R,1S,2S,6S,8S,8AR)- 1-NAPHTHALENEHEPTANOIC ACID WITH N,N-DIMETHYL-IMIDODICARBONIMIDIC DIAMIDE
KR100715114B1 (ko) * 2005-02-19 2007-05-10 한국유나이티드제약 주식회사 당뇨병 치료를 위한 약학적 조성물
CN101632673B (zh) * 2008-07-24 2011-08-10 鲁南制药集团股份有限公司 含有氯沙坦、吡格列酮和瑞舒伐他汀的药物组合物及其新用途
ES2639019T3 (es) 2008-09-06 2017-10-25 Bionevia Pharmaceuticals Inc. Nuevo cocristal de colina de epalrestat
EP2196476A1 (de) 2008-12-10 2010-06-16 Novartis Ag Antikörperformulierung
EP2779999A2 (de) 2011-11-15 2014-09-24 Dr. Reddy's Laboratories Ltd. Pharmazeutische formulierungen mit atorvastatin und glimepirid
WO2015053589A1 (ko) * 2013-10-11 2015-04-16 가톨릭대학교 산학협력단 메트포민 및 스타틴의 복합제를 이용한 자가면역질환의 예방 또는 치료용 조성물
KR101579656B1 (ko) * 2013-12-12 2015-12-22 가천대학교 산학협력단 프라바스타틴과 발사르탄을 포함하는 약학 조성물
CN110747206B (zh) * 2019-11-05 2021-11-23 昆明理工大学 3-羟基-3-甲基戊二酸单酰辅酶a还原酶基因rkhmgr及其应用

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Also Published As

Publication number Publication date
PL350312A1 (en) 2002-12-02
SI1150678T1 (sl) 2008-02-29
JP2012051898A (ja) 2012-03-15
EE201200015A (et) 2012-10-15
SK286854B6 (sk) 2009-06-05
CZ302881B6 (cs) 2012-01-04
ES2352803T3 (es) 2011-02-23
MY138289A (en) 2009-05-29
IL208330A0 (en) 2010-12-30
IS2793B (is) 2012-08-15
NO330400B1 (no) 2011-04-04
BR0007996A (pt) 2001-10-30
KR20010089635A (ko) 2001-10-06
ES2286995T3 (es) 2007-12-16
US20090186908A1 (en) 2009-07-23
PT1150678E (pt) 2007-09-14
EE200100405A (et) 2002-10-15
IS8978A (is) 2011-08-23
NZ536433A (en) 2006-08-31
EP1150678A1 (de) 2001-11-07
EE05556B1 (et) 2012-08-15
DK1897546T3 (da) 2011-01-17
EP1897546B1 (de) 2010-10-27
TR200102229T2 (tr) 2001-12-21
AU2304700A (en) 2000-08-25
US20120041010A1 (en) 2012-02-16
NO20013812L (no) 2001-10-02
JP2014065718A (ja) 2014-04-17
CN1338937A (zh) 2002-03-06
NO20013812D0 (no) 2001-08-03
RU2239456C2 (ru) 2004-11-10
IS6016A (is) 2001-07-20
CA2368186C (en) 2008-06-03
EE05621B1 (et) 2013-02-15
CY1110992T1 (el) 2015-06-11
EP1150678B1 (de) 2007-07-18
EP1897546A1 (de) 2008-03-12
SI1897546T1 (sl) 2011-02-28
DK1150678T3 (da) 2007-10-08
ZA200105885B (en) 2002-10-17
ATE485823T1 (de) 2010-11-15
NZ525419A (en) 2004-12-24
CA2368186A1 (en) 2000-08-10
DE60045168D1 (de) 2010-12-09
SK11102001A3 (sk) 2002-05-09
ATE367162T1 (de) 2007-08-15
CN1196488C (zh) 2005-04-13
HUP0105138A3 (en) 2002-11-28
IL144730A0 (en) 2002-06-30
DE60035575D1 (de) 2007-08-30
IS2820B (is) 2012-12-15
HU227642B1 (en) 2011-10-28
AU763970B2 (en) 2003-08-07
DE60035575T2 (de) 2008-04-03
GB0001662D0 (en) 2000-03-15
PL198098B1 (pl) 2008-05-30
CZ20012806A3 (cs) 2002-02-13
KR100699757B1 (ko) 2007-03-27
IL144730A (en) 2010-12-30
AR025512A1 (es) 2002-12-04
CZ302893B6 (cs) 2012-01-11
WO2000045818A1 (en) 2000-08-10
SK287792B6 (sk) 2011-10-04
HUP0105138A2 (hu) 2002-04-29
CY1106879T1 (el) 2012-05-23
HK1118209A1 (en) 2009-02-06
US6894058B1 (en) 2005-05-17
US20050209128A1 (en) 2005-09-22
NZ513061A (en) 2003-06-30
PT1897546E (pt) 2010-12-15
JP2002536332A (ja) 2002-10-29
TWI230067B (en) 2005-04-01
MXPA01007821A (es) 2004-08-19

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