ZA200105311B - Indole derivatives and their use as MCP-1 antagonists. - Google Patents
Indole derivatives and their use as MCP-1 antagonists. Download PDFInfo
- Publication number
- ZA200105311B ZA200105311B ZA200105311A ZA200105311A ZA200105311B ZA 200105311 B ZA200105311 B ZA 200105311B ZA 200105311 A ZA200105311 A ZA 200105311A ZA 200105311 A ZA200105311 A ZA 200105311A ZA 200105311 B ZA200105311 B ZA 200105311B
- Authority
- ZA
- South Africa
- Prior art keywords
- ethyl
- carboxylate
- mcp
- nmr
- compound
- Prior art date
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- 150000002475 indoles Chemical class 0.000 title description 3
- 229940123313 MCP-1 antagonist Drugs 0.000 title description 2
- 229940054051 antipsychotic indole derivative Drugs 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims description 89
- -1 carboxy, tetrazolyl Chemical group 0.000 claims description 63
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- 229940002612 prodrug Drugs 0.000 claims description 19
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 15
- 239000001257 hydrogen Substances 0.000 claims description 14
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- 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 claims description 7
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 7
- 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims description 5
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims description 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9902461.4A GB9902461D0 (en) | 1999-02-05 | 1999-02-05 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200105311B true ZA200105311B (en) | 2002-09-27 |
Family
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Family Applications (1)
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| ZA200105311A ZA200105311B (en) | 1999-02-05 | 2001-06-27 | Indole derivatives and their use as MCP-1 antagonists. |
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| EP (1) | EP1150952B1 (id) |
| JP (1) | JP2002536359A (id) |
| KR (1) | KR20010094755A (id) |
| CN (1) | CN1339025A (id) |
| AR (1) | AR022461A1 (id) |
| AT (1) | ATE280757T1 (id) |
| AU (1) | AU770856B2 (id) |
| BR (1) | BR0007984A (id) |
| CA (1) | CA2356898A1 (id) |
| CZ (1) | CZ20012807A3 (id) |
| DE (1) | DE60015296T2 (id) |
| EE (1) | EE200100403A (id) |
| GB (1) | GB9902461D0 (id) |
| HU (1) | HUP0105079A3 (id) |
| ID (1) | ID30401A (id) |
| IL (1) | IL144611A0 (id) |
| IS (1) | IS5980A (id) |
| MY (1) | MY133209A (id) |
| NO (1) | NO20013809L (id) |
| NZ (1) | NZ512680A (id) |
| PL (1) | PL350184A1 (id) |
| RU (1) | RU2235090C2 (id) |
| SK (1) | SK11152001A3 (id) |
| TR (1) | TR200102233T2 (id) |
| WO (1) | WO2000046196A1 (id) |
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| GB9716657D0 (en) | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
| GB9902461D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
| GB0000625D0 (en) * | 2000-01-13 | 2000-03-01 | Zeneca Ltd | Chemical compounds |
| GB0000626D0 (en) * | 2000-01-13 | 2000-03-01 | Zeneca Ltd | Chemical compounds |
| WO2002030895A1 (en) | 2000-10-10 | 2002-04-18 | Smithkline Beecham Corporation | SUBSTITUTED INDOLES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH INDOLES AND THEIR USE AS PPAR-η BINDING AGENTS |
| CA2432908A1 (en) | 2000-12-20 | 2002-06-27 | Bristol-Myers Squibb Pharma Company | Diamines as modulators of chemokine receptor activity |
| AR035773A1 (es) | 2000-12-20 | 2004-07-14 | Bristol Myers Squibb Pharma Co | Compuestos diamino ciclico, composicion farmaceutica y su uso en la fabricacion de un medicamento util para modular la actividad de una quimioquina |
| US7842693B2 (en) | 2002-06-12 | 2010-11-30 | Chemocentryx, Inc. | Substituted piperazines |
| US7589199B2 (en) | 2002-06-12 | 2009-09-15 | Chemocentryx, Inc. | Substituted piperazines |
| JP4723242B2 (ja) | 2002-06-12 | 2011-07-13 | ケモセントリックス インコーポレーティッド | 炎症および免疫障害治療用ｃｃｒ１アンタゴニストとして使用するための１−アリール−４−置換ピペラジン誘導体 |
| TW200508224A (en) | 2003-02-12 | 2005-03-01 | Bristol Myers Squibb Co | Cyclic derivatives as modulators of chemokine receptor activity |
| TWI344955B (en) | 2003-03-14 | 2011-07-11 | Ono Pharmaceutical Co | Heterocyclic rinf having nitrogen atom derivatives and medicament containing the derivatives as active ingredient |
| US7498323B2 (en) | 2003-04-18 | 2009-03-03 | Ono Pharmaceuticals Co., Ltd. | Spiro-piperidine compounds and medicinal use thereof |
| US7230133B2 (en) | 2003-05-01 | 2007-06-12 | Bristol-Myers Squibb Company | Malonamides and malonamide derivatives as modulators of chemokine receptor activity |
| US7291615B2 (en) | 2003-05-01 | 2007-11-06 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
| US7732162B2 (en) | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
| US7288563B2 (en) | 2004-02-19 | 2007-10-30 | Bristol-Myers Squibb Company | Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity |
| US7479496B2 (en) | 2004-02-19 | 2009-01-20 | Bristol-Myers Squibb Company | Substituted spiro azabicyclics as modulators of chemokine receptor activity |
| US7230022B2 (en) | 2004-02-19 | 2007-06-12 | Bristol-Myers Squibb Company | Substituted fused bicyclic amines as modulators of chemokine receptor activity |
| US7381738B2 (en) | 2004-02-19 | 2008-06-03 | Bristol-Myers Squibb Company | Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity |
| CA2558211C (en) | 2004-03-03 | 2013-09-03 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
| US7435831B2 (en) | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
| US8481035B2 (en) | 2004-04-27 | 2013-07-09 | Northwestern University | Methods for treating chronic pelvic pain syndrome with antibodies that binds MCP-1 or MIP-1A |
| US20080187508A1 (en) * | 2004-09-08 | 2008-08-07 | Boys Town National Research Hospital | Treatment of Golmerular Basement Membrane Disease Involving Matrix Metalloproteinase-12 |
| TWI400232B (zh) | 2004-09-13 | 2013-07-01 | Ono Pharmaceutical Co | 含氮雜環衍生物及以該含氮雜環衍生物為有效成分之藥劑 |
| JPWO2006129679A1 (ja) | 2005-05-31 | 2009-01-08 | 小野薬品工業株式会社 | スピロピペリジン化合物およびその医薬用途 |
| FR2890071B1 (fr) | 2005-08-30 | 2007-11-09 | Fournier Sa Sa Lab | Nouveaux composes de l'indole |
| US8318931B2 (en) | 2005-10-28 | 2012-11-27 | Ono Pharmaceutical Co., Ltd. | Chemokine receptor antagonists and use thereof |
| JP5217438B2 (ja) | 2005-11-18 | 2013-06-19 | 小野薬品工業株式会社 | 塩基性基を含有する化合物およびその用途 |
| EP1960401B1 (en) | 2005-12-09 | 2009-11-11 | F.Hoffmann-La Roche Ag | Tricyclic amide derivatives useful for treating obesity |
| EP1990335A4 (en) * | 2006-03-02 | 2009-11-11 | Astellas Pharma Inc | 17-BETA-HSD-type-5 INHIBITOR |
| AU2007225836A1 (en) | 2006-03-10 | 2007-09-20 | Ono Pharmaceutical Co., Ltd. | Nitrogenated heterocyclic derivative, and pharmaceutical agent comprising the derivative as active ingredient |
| JP5257068B2 (ja) | 2006-05-16 | 2013-08-07 | 小野薬品工業株式会社 | 保護されていてもよい酸性基を含有する化合物およびその用途 |
| DE102006033572A1 (de) | 2006-07-20 | 2008-01-24 | Bayer Cropscience Ag | N'-Cyano-N-halogenalkyl-imidamid Derivate |
| EP2055705A4 (en) | 2006-07-31 | 2014-08-20 | Ono Pharmaceutical Co | COMPOUND WITH A CYCLIC GROUP BOUND BY A SPIRO BINDING THEREOF AND APPLY THEREOF |
| US20080076120A1 (en) * | 2006-09-14 | 2008-03-27 | Millennium Pharmaceuticals, Inc. | Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders |
| WO2008055945A1 (en) | 2006-11-09 | 2008-05-15 | Probiodrug Ag | 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases |
| WO2008065141A1 (en) | 2006-11-30 | 2008-06-05 | Probiodrug Ag | Novel inhibitors of glutaminyl cyclase |
| EP2481408A3 (en) | 2007-03-01 | 2013-01-09 | Probiodrug AG | New use of glutaminyl cyclase inhibitors |
| EP2865670B1 (en) | 2007-04-18 | 2017-01-11 | Probiodrug AG | Thiourea derivatives as glutaminyl cyclase inhibitors |
| RU2503672C2 (ru) * | 2008-01-18 | 2014-01-10 | Оксаген Лимитед | Соединения, обладающие активностью антагонистов crth2 |
| WO2010043396A1 (en) * | 2008-10-16 | 2010-04-22 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors |
| WO2010129351A1 (en) | 2009-04-28 | 2010-11-11 | Schepens Eye Research Institute | Method to identify and treat age-related macular degeneration |
| US8486940B2 (en) | 2009-09-11 | 2013-07-16 | Probiodrug Ag | Inhibitors |
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| JP6026284B2 (ja) | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
| EP2545047B9 (en) | 2010-03-10 | 2015-06-10 | Probiodrug AG | Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5) |
| EP2560953B1 (en) | 2010-04-21 | 2016-01-06 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
| KR101350077B1 (ko) * | 2010-12-13 | 2014-01-14 | 한국화학연구원 | 신규한 3-인돌리논 유도체 및 이를 포함하는 조성물 |
| JP6050264B2 (ja) | 2011-03-16 | 2016-12-21 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体 |
| EP3551046B1 (en) | 2016-12-07 | 2023-07-19 | Biora Therapeutics, Inc. | Gastrointestinal tract detection methods, devices and systems |
| CA3045310A1 (en) | 2016-12-14 | 2018-06-21 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor |
| PL3461819T3 (pl) | 2017-09-29 | 2020-11-30 | Probiodrug Ag | Inhibitory cyklazy glutaminylowej |
| KR20210095165A (ko) | 2018-11-19 | 2021-07-30 | 프로제너티, 인크. | 바이오의약품으로 질환을 치료하기 위한 방법 및 디바이스 |
| CN115666704A (zh) | 2019-12-13 | 2023-01-31 | 比奥拉治疗股份有限公司 | 用于将治疗剂递送至胃肠道的可摄取装置 |
| EP4450494A1 (en) * | 2023-04-20 | 2024-10-23 | Consejo Superior De Investigaciones Científicas | Indole derivatives as histone deacetylase (hdac) inhibitors for the treatment of cancer |
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| GB9902461D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
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-
1999
- 1999-02-05 GB GBGB9902461.4A patent/GB9902461D0/en not_active Ceased
-
2000
- 2000-01-31 AT AT00901259T patent/ATE280757T1/de not_active IP Right Cessation
- 2000-01-31 ID IDW00200101667A patent/ID30401A/id unknown
- 2000-01-31 EE EEP200100403A patent/EE200100403A/xx unknown
- 2000-01-31 WO PCT/GB2000/000265 patent/WO2000046196A1/en not_active Application Discontinuation
- 2000-01-31 AU AU21213/00A patent/AU770856B2/en not_active Ceased
- 2000-01-31 IL IL14461100A patent/IL144611A0/xx unknown
- 2000-01-31 US US09/889,599 patent/US6737435B1/en not_active Expired - Fee Related
- 2000-01-31 AR ARP000100407A patent/AR022461A1/es not_active Application Discontinuation
- 2000-01-31 HU HU0105079A patent/HUP0105079A3/hu unknown
- 2000-01-31 PL PL00350184A patent/PL350184A1/xx not_active Application Discontinuation
- 2000-01-31 NZ NZ512680A patent/NZ512680A/en unknown
- 2000-01-31 DE DE60015296T patent/DE60015296T2/de not_active Expired - Lifetime
- 2000-01-31 TR TR2001/02233T patent/TR200102233T2/xx unknown
- 2000-01-31 BR BR0007984-7A patent/BR0007984A/pt not_active IP Right Cessation
- 2000-01-31 JP JP2000597267A patent/JP2002536359A/ja active Pending
- 2000-01-31 SK SK1115-2001A patent/SK11152001A3/sk unknown
- 2000-01-31 EP EP20000901259 patent/EP1150952B1/en not_active Expired - Lifetime
- 2000-01-31 KR KR1020017009862A patent/KR20010094755A/ko not_active Application Discontinuation
- 2000-01-31 CZ CZ20012807A patent/CZ20012807A3/cs unknown
- 2000-01-31 CA CA002356898A patent/CA2356898A1/en not_active Abandoned
- 2000-01-31 RU RU2001124567/04A patent/RU2235090C2/ru not_active IP Right Cessation
- 2000-01-31 CN CN00803463A patent/CN1339025A/zh active Pending
- 2000-02-04 MY MYPI20000404A patent/MY133209A/en unknown
-
2001
- 2001-06-26 IS IS5980A patent/IS5980A/is unknown
- 2001-06-27 ZA ZA200105311A patent/ZA200105311B/en unknown
- 2001-08-03 NO NO20013809A patent/NO20013809L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2121300A (en) | 2000-08-25 |
| RU2001124567A (ru) | 2004-01-10 |
| ID30401A (id) | 2001-11-29 |
| NZ512680A (en) | 2003-11-28 |
| TR200102233T2 (tr) | 2001-12-21 |
| ATE280757T1 (de) | 2004-11-15 |
| WO2000046196A1 (en) | 2000-08-10 |
| MY133209A (en) | 2007-10-31 |
| NO20013809D0 (no) | 2001-08-03 |
| DE60015296T2 (de) | 2006-02-02 |
| BR0007984A (pt) | 2001-11-06 |
| EP1150952B1 (en) | 2004-10-27 |
| CZ20012807A3 (cs) | 2001-10-17 |
| CN1339025A (zh) | 2002-03-06 |
| AR022461A1 (es) | 2002-09-04 |
| GB9902461D0 (en) | 1999-03-24 |
| SK11152001A3 (sk) | 2001-12-03 |
| US6737435B1 (en) | 2004-05-18 |
| JP2002536359A (ja) | 2002-10-29 |
| HUP0105079A3 (en) | 2002-11-28 |
| IS5980A (is) | 2001-06-26 |
| DE60015296D1 (de) | 2004-12-02 |
| NO20013809L (no) | 2001-10-02 |
| EE200100403A (et) | 2002-10-15 |
| EP1150952A1 (en) | 2001-11-07 |
| HUP0105079A2 (hu) | 2002-04-29 |
| PL350184A1 (en) | 2002-11-18 |
| AU770856B2 (en) | 2004-03-04 |
| CA2356898A1 (en) | 2000-08-10 |
| KR20010094755A (ko) | 2001-11-01 |
| IL144611A0 (en) | 2002-05-23 |
| RU2235090C2 (ru) | 2004-08-27 |
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