ZA200104620B - Benzoxazole derivatives and medicaments comprising said derivatives as active ingredient. - Google Patents
Benzoxazole derivatives and medicaments comprising said derivatives as active ingredient. Download PDFInfo
- Publication number
- ZA200104620B ZA200104620B ZA200104620A ZA200104620A ZA200104620B ZA 200104620 B ZA200104620 B ZA 200104620B ZA 200104620 A ZA200104620 A ZA 200104620A ZA 200104620 A ZA200104620 A ZA 200104620A ZA 200104620 B ZA200104620 B ZA 200104620B
- Authority
- ZA
- South Africa
- Prior art keywords
- group
- homopiperazinyl
- chloro
- lower alkyl
- alkyl group
- Prior art date
Links
- 239000003814 drug Substances 0.000 title claims description 25
- BCMCBBGGLRIHSE-UHFFFAOYSA-N 1,3-benzoxazole Chemical class C1=CC=C2OC=NC2=C1 BCMCBBGGLRIHSE-UHFFFAOYSA-N 0.000 title claims description 13
- 239000004480 active ingredient Substances 0.000 title claims description 10
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 claims description 74
- 150000001875 compounds Chemical class 0.000 claims description 67
- 125000000217 alkyl group Chemical group 0.000 claims description 36
- 150000003839 salts Chemical class 0.000 claims description 35
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 25
- 125000003277 amino group Chemical group 0.000 claims description 19
- 125000005843 halogen group Chemical group 0.000 claims description 18
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 14
- 230000003042 antagnostic effect Effects 0.000 claims description 13
- 208000002551 irritable bowel syndrome Diseases 0.000 claims description 12
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 12
- 125000006239 protecting group Chemical group 0.000 claims description 12
- 239000000126 substance Substances 0.000 claims description 12
- 125000001424 substituent group Chemical group 0.000 claims description 12
- 230000001225 therapeutic effect Effects 0.000 claims description 12
- 206010012735 Diarrhoea Diseases 0.000 claims description 11
- 210000001035 gastrointestinal tract Anatomy 0.000 claims description 11
- 239000012453 solvate Substances 0.000 claims description 11
- 230000003449 preventive effect Effects 0.000 claims description 10
- 229910052801 chlorine Inorganic materials 0.000 claims description 9
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 9
- 125000003342 alkenyl group Chemical group 0.000 claims description 8
- 125000003545 alkoxy group Chemical group 0.000 claims description 8
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- -1 acetamino group Chemical group 0.000 claims description 7
- 229940076279 serotonin Drugs 0.000 claims description 7
- 239000002111 antiemetic agent Substances 0.000 claims description 6
- 229940125683 antiemetic agent Drugs 0.000 claims description 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 6
- DTRMFUAUYNIOEZ-UHFFFAOYSA-N 5-chloro-2-(1,4-diazepan-1-yl)-6-methyl-1,3-benzoxazole Chemical compound N=1C=2C=C(Cl)C(C)=CC=2OC=1N1CCCNCC1 DTRMFUAUYNIOEZ-UHFFFAOYSA-N 0.000 claims description 4
- UNRCLDQBGKUOMP-UHFFFAOYSA-N 5-chloro-2-(1,4-diazepan-1-yl)-7-ethyl-1,3-benzoxazole Chemical compound O1C=2C(CC)=CC(Cl)=CC=2N=C1N1CCCNCC1 UNRCLDQBGKUOMP-UHFFFAOYSA-N 0.000 claims description 4
- YZVOXCBEYYKZNK-UHFFFAOYSA-N [5-chloro-2-(1,4-diazepan-1-yl)-1,3-benzoxazol-7-yl]methanol Chemical compound O1C=2C(CO)=CC(Cl)=CC=2N=C1N1CCCNCC1 YZVOXCBEYYKZNK-UHFFFAOYSA-N 0.000 claims description 4
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- 230000036961 partial effect Effects 0.000 claims description 4
- LOYJLGODJCVFLT-UHFFFAOYSA-N 5-chloro-2-(1,4-diazepan-1-yl)-1,3-benzoxazol-7-amine Chemical compound O1C=2C(N)=CC(Cl)=CC=2N=C1N1CCCNCC1 LOYJLGODJCVFLT-UHFFFAOYSA-N 0.000 claims description 3
- BBENGKGAKVSDCZ-UHFFFAOYSA-N 5-chloro-2-(1,4-diazepan-1-yl)-6,7-dimethyl-1,3-benzoxazole Chemical compound O1C2=C(C)C(C)=C(Cl)C=C2N=C1N1CCCNCC1 BBENGKGAKVSDCZ-UHFFFAOYSA-N 0.000 claims description 3
- ZCXNEHHRRBCEPK-UHFFFAOYSA-N 5-chloro-2-(1,4-diazepan-1-yl)-n-ethyl-1,3-benzoxazol-7-amine Chemical compound O1C=2C(NCC)=CC(Cl)=CC=2N=C1N1CCCNCC1 ZCXNEHHRRBCEPK-UHFFFAOYSA-N 0.000 claims description 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 3
- PBIFALKTLDJESI-UHFFFAOYSA-N n-[5-chloro-2-(1,4-diazepan-1-yl)-1,3-benzoxazol-7-yl]-2-methylpropanamide Chemical compound O1C=2C(NC(=O)C(C)C)=CC(Cl)=CC=2N=C1N1CCCNCC1 PBIFALKTLDJESI-UHFFFAOYSA-N 0.000 claims description 3
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- IWWLKUZVMOTTFP-UHFFFAOYSA-N tert-butyl n-[5-chloro-2-(1,4-diazepan-1-yl)-1,3-benzoxazol-7-yl]carbamate Chemical compound O1C=2C(NC(=O)OC(C)(C)C)=CC(Cl)=CC=2N=C1N1CCCNCC1 IWWLKUZVMOTTFP-UHFFFAOYSA-N 0.000 claims description 2
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- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP33127498 | 1998-11-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200104620B true ZA200104620B (en) | 2002-02-04 |
Family
ID=18241866
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200104620A ZA200104620B (en) | 1998-11-20 | 2001-06-06 | Benzoxazole derivatives and medicaments comprising said derivatives as active ingredient. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7045516B1 (de) |
| EP (1) | EP1134220B1 (de) |
| JP (1) | JP4557112B2 (de) |
| KR (1) | KR100675033B1 (de) |
| CN (1) | CN1333771A (de) |
| AT (1) | ATE273974T1 (de) |
| AU (1) | AU753797B2 (de) |
| BR (1) | BR9916793A (de) |
| CA (1) | CA2351446A1 (de) |
| CZ (1) | CZ20011700A3 (de) |
| DE (1) | DE69919575T2 (de) |
| ES (1) | ES2222763T3 (de) |
| HU (1) | HUP0104238A3 (de) |
| ID (1) | ID30143A (de) |
| IL (1) | IL143178A0 (de) |
| NO (1) | NO20012443L (de) |
| PL (1) | PL348426A1 (de) |
| RU (1) | RU2204558C2 (de) |
| SK (1) | SK6772001A3 (de) |
| TR (1) | TR200101945T2 (de) |
| TW (1) | TW520370B (de) |
| WO (1) | WO2000031073A1 (de) |
| ZA (1) | ZA200104620B (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6660858B2 (en) * | 2001-03-28 | 2003-12-09 | Lion Bioscience Ag | 2-aminobenzoxazole derivatives and combinatorial libraries thereof |
| GB0203061D0 (en) * | 2002-02-08 | 2002-03-27 | Novartis Ag | Organic compounds |
| AU2003252738A1 (en) * | 2002-08-09 | 2004-02-25 | Ajinomoto Co., Inc. | Remedy for intestinal diseases and visceral pain |
| WO2007005780A2 (en) * | 2005-07-01 | 2007-01-11 | Dynogen Pharmaceuticals, Inc. | Compositions and methods for treating gastrointestinal hypomotility and associated disorders |
| CN101410385B (zh) | 2006-03-28 | 2011-08-24 | 高点制药有限责任公司 | 具有组胺h3受体活性的苯并噻唑类 |
| WO2010048514A1 (en) * | 2008-10-23 | 2010-04-29 | Albany Molecular Research, Inc. | Synthesis of 2-aminobenzoxazole compounds |
| KR101579688B1 (ko) | 2014-07-08 | 2015-12-24 | 재단법인 전남생물산업진흥원 | 좁쌀풀 추출물을 유효성분으로 함유하는 과민성 대장증후군에 의한 내장 통증 억제예방 또는 치료용 약학 조성물 |
| GEP20247674B (en) * | 2020-06-12 | 2024-09-25 | Hk Inno N Corp | Pharmaceutical composition comprising benzimidazole derivative compound |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3193560B2 (ja) * | 1993-04-16 | 2001-07-30 | 明治製菓株式会社 | 新規ベンゾオキサゾール誘導体 |
| JP3520177B2 (ja) * | 1996-05-09 | 2004-04-19 | 明治製菓株式会社 | セロトニン５−ｈｔ３受容体部分活性薬 |
-
1999
- 1999-11-18 TW TW088120112A patent/TW520370B/zh active
- 1999-11-19 HU HU0104238A patent/HUP0104238A3/hu unknown
- 1999-11-19 KR KR1020017006249A patent/KR100675033B1/ko not_active IP Right Cessation
- 1999-11-19 CN CN99815777A patent/CN1333771A/zh active Pending
- 1999-11-19 ID IDW00200101321A patent/ID30143A/id unknown
- 1999-11-19 DE DE69919575T patent/DE69919575T2/de not_active Expired - Lifetime
- 1999-11-19 AU AU11850/00A patent/AU753797B2/en not_active Ceased
- 1999-11-19 PL PL99348426A patent/PL348426A1/xx unknown
- 1999-11-19 SK SK677-2001A patent/SK6772001A3/sk unknown
- 1999-11-19 US US09/856,372 patent/US7045516B1/en not_active Expired - Fee Related
- 1999-11-19 JP JP2000583901A patent/JP4557112B2/ja not_active Expired - Fee Related
- 1999-11-19 RU RU2001116715/04A patent/RU2204558C2/ru not_active IP Right Cessation
- 1999-11-19 AT AT99972633T patent/ATE273974T1/de not_active IP Right Cessation
- 1999-11-19 TR TR2001/01945T patent/TR200101945T2/xx unknown
- 1999-11-19 CA CA002351446A patent/CA2351446A1/en not_active Abandoned
- 1999-11-19 IL IL14317899A patent/IL143178A0/xx unknown
- 1999-11-19 ES ES99972633T patent/ES2222763T3/es not_active Expired - Lifetime
- 1999-11-19 CZ CZ20011700A patent/CZ20011700A3/cs unknown
- 1999-11-19 BR BR9916793-0A patent/BR9916793A/pt not_active IP Right Cessation
- 1999-11-19 EP EP99972633A patent/EP1134220B1/de not_active Expired - Lifetime
- 1999-11-19 WO PCT/JP1999/006491 patent/WO2000031073A1/ja active IP Right Grant
-
2001
- 2001-05-18 NO NO20012443A patent/NO20012443L/no not_active Application Discontinuation
- 2001-06-06 ZA ZA200104620A patent/ZA200104620B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2204558C2 (ru) | 2003-05-20 |
| CA2351446A1 (en) | 2000-06-02 |
| HUP0104238A2 (en) | 2002-08-28 |
| CN1333771A (zh) | 2002-01-30 |
| NO20012443L (no) | 2001-07-12 |
| US7045516B1 (en) | 2006-05-16 |
| BR9916793A (pt) | 2001-11-13 |
| ATE273974T1 (de) | 2004-09-15 |
| WO2000031073A1 (fr) | 2000-06-02 |
| SK6772001A3 (en) | 2001-12-03 |
| AU1185000A (en) | 2000-06-13 |
| DE69919575T2 (de) | 2005-09-29 |
| HUP0104238A3 (en) | 2003-05-28 |
| JP4557112B2 (ja) | 2010-10-06 |
| ID30143A (id) | 2001-11-08 |
| NO20012443D0 (no) | 2001-05-18 |
| ES2222763T3 (es) | 2005-02-01 |
| DE69919575D1 (de) | 2004-09-23 |
| TW520370B (en) | 2003-02-11 |
| EP1134220A4 (de) | 2001-12-19 |
| IL143178A0 (en) | 2002-04-21 |
| KR100675033B1 (ko) | 2007-01-29 |
| KR20010086448A (ko) | 2001-09-12 |
| CZ20011700A3 (cs) | 2001-10-17 |
| AU753797B2 (en) | 2002-10-31 |
| PL348426A1 (en) | 2002-05-20 |
| EP1134220A1 (de) | 2001-09-19 |
| TR200101945T2 (tr) | 2001-11-21 |
| EP1134220B1 (de) | 2004-08-18 |
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