ZA200006685B - A hepatocyte targeting polyethylene Glyco-grafted poly-l-lysine polymeric gene carrier. - Google Patents

A hepatocyte targeting polyethylene Glyco-grafted poly-l-lysine polymeric gene carrier.

Info

Publication number
ZA200006685B
ZA200006685B ZA200006685A ZA200006685A ZA200006685B ZA 200006685 B ZA200006685 B ZA 200006685B ZA 200006685 A ZA200006685 A ZA 200006685A ZA 200006685 A ZA200006685 A ZA 200006685A ZA 200006685 B ZA200006685 B ZA 200006685B
Authority
ZA
South Africa
Prior art keywords
pll
peg
targeting moiety
lysine
gene
Prior art date
Application number
ZA200006685A
Other languages
English (en)
Inventor
Jong Sang Park
Young-Hun Choi
Feng Liu
Original Assignee
Expression Genetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Expression Genetics Inc filed Critical Expression Genetics Inc
Publication of ZA200006685B publication Critical patent/ZA200006685B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Polyamides (AREA)
  • Polyethers (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
ZA200006685A 1998-05-20 2000-11-16 A hepatocyte targeting polyethylene Glyco-grafted poly-l-lysine polymeric gene carrier. ZA200006685B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8607298P 1998-05-20 1998-05-20

Publications (1)

Publication Number Publication Date
ZA200006685B true ZA200006685B (en) 2001-07-13

Family

ID=22196073

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200006685A ZA200006685B (en) 1998-05-20 2000-11-16 A hepatocyte targeting polyethylene Glyco-grafted poly-l-lysine polymeric gene carrier.

Country Status (17)

Country Link
US (1) US6177274B1 (zh)
EP (1) EP1083882B1 (zh)
JP (1) JP2002515418A (zh)
KR (1) KR20010071279A (zh)
CN (1) CN1333678A (zh)
AT (1) ATE411049T1 (zh)
AU (1) AU4193199A (zh)
BR (1) BR9911062A (zh)
CA (1) CA2329147A1 (zh)
DE (1) DE69939740D1 (zh)
FI (1) FI20002539A (zh)
IL (1) IL139761A0 (zh)
MX (1) MXPA00011312A (zh)
NO (1) NO20005809D0 (zh)
TR (1) TR200003441T2 (zh)
WO (1) WO1999059546A1 (zh)
ZA (1) ZA200006685B (zh)

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Also Published As

Publication number Publication date
TR200003441T2 (tr) 2001-04-20
BR9911062A (pt) 2001-02-06
AU4193199A (en) 1999-12-06
EP1083882A1 (en) 2001-03-21
CA2329147A1 (en) 1999-11-25
IL139761A0 (en) 2002-02-10
JP2002515418A (ja) 2002-05-28
FI20002539A (fi) 2001-01-19
MXPA00011312A (es) 2003-04-22
WO1999059546A1 (en) 1999-11-25
DE69939740D1 (de) 2008-11-27
KR20010071279A (ko) 2001-07-28
US6177274B1 (en) 2001-01-23
EP1083882A4 (en) 2004-08-18
NO20005809D0 (no) 2000-11-17
ATE411049T1 (de) 2008-10-15
EP1083882B1 (en) 2008-10-15
CN1333678A (zh) 2002-01-30

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