ZA200006262B - Pharmaceutical composition for the treatment of diabetes. - Google Patents
Pharmaceutical composition for the treatment of diabetes. Download PDFInfo
- Publication number
- ZA200006262B ZA200006262B ZA200006262A ZA200006262A ZA200006262B ZA 200006262 B ZA200006262 B ZA 200006262B ZA 200006262 A ZA200006262 A ZA 200006262A ZA 200006262 A ZA200006262 A ZA 200006262A ZA 200006262 B ZA200006262 B ZA 200006262B
- Authority
- ZA
- South Africa
- Prior art keywords
- pharmaceutical composition
- anorectic
- composition according
- insulin sensitizer
- combination
- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 title claims description 34
- 206010012601 diabetes mellitus Diseases 0.000 title claims description 19
- -1 5-methyl-2-phenyloxazol-4- yl Chemical group 0.000 claims description 50
- 230000001539 anorectic effect Effects 0.000 claims description 31
- 206010061428 decreased appetite Diseases 0.000 claims description 31
- 229940122355 Insulin sensitizer Drugs 0.000 claims description 30
- 125000001931 aliphatic group Chemical group 0.000 claims description 12
- 150000001875 compounds Chemical class 0.000 claims description 12
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- 230000000694 effects Effects 0.000 claims description 10
- 150000003839 salts Chemical class 0.000 claims description 10
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 10
- YASAKCUCGLMORW-UHFFFAOYSA-N Rosiglitazone Chemical compound C=1C=CC=NC=1N(C)CCOC(C=C1)=CC=C1CC1SC(=O)NC1=O YASAKCUCGLMORW-UHFFFAOYSA-N 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 8
- GHUUBYQTCDQWRA-UHFFFAOYSA-N Pioglitazone hydrochloride Chemical group Cl.N1=CC(CC)=CC=C1CCOC(C=C1)=CC=C1CC1C(=O)NC(=O)S1 GHUUBYQTCDQWRA-UHFFFAOYSA-N 0.000 claims description 7
- 125000000623 heterocyclic group Chemical group 0.000 claims description 7
- 229960002827 pioglitazone hydrochloride Drugs 0.000 claims description 7
- 125000001183 hydrocarbyl group Chemical group 0.000 claims description 6
- 229960001641 troglitazone Drugs 0.000 claims description 6
- GXPHKUHSUJUWKP-UHFFFAOYSA-N troglitazone Chemical compound C1CC=2C(C)=C(O)C(C)=C(C)C=2OC1(C)COC(C=C1)=CC=C1CC1SC(=O)NC1=O GXPHKUHSUJUWKP-UHFFFAOYSA-N 0.000 claims description 6
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- 125000000217 alkyl group Chemical group 0.000 claims description 5
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- ZPXSCAKFGYXMGA-UHFFFAOYSA-N Mazindol Chemical compound N12CCN=C2C2=CC=CC=C2C1(O)C1=CC=C(Cl)C=C1 ZPXSCAKFGYXMGA-UHFFFAOYSA-N 0.000 claims description 4
- 229910052739 hydrogen Inorganic materials 0.000 claims description 4
- 239000001257 hydrogen Substances 0.000 claims description 4
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- 239000000126 substance Substances 0.000 claims description 4
- 125000001424 substituent group Chemical group 0.000 claims description 4
- 229910052717 sulfur Chemical group 0.000 claims description 4
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- 150000001467 thiazolidinediones Chemical class 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP18370098 | 1998-06-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200006262B true ZA200006262B (en) | 2001-11-02 |
Family
ID=16140426
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200006262A ZA200006262B (en) | 1998-06-30 | 2000-11-02 | Pharmaceutical composition for the treatment of diabetes. |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US6329403B1 (fr) |
| EP (1) | EP1093370B1 (fr) |
| KR (1) | KR20010043455A (fr) |
| CN (1) | CN1305376A (fr) |
| AR (1) | AR019727A1 (fr) |
| AT (1) | ATE318138T1 (fr) |
| AU (1) | AU754740B2 (fr) |
| BR (1) | BR9911656A (fr) |
| CA (1) | CA2329004C (fr) |
| DE (1) | DE69929996T2 (fr) |
| DK (1) | DK1093370T3 (fr) |
| ES (1) | ES2255316T3 (fr) |
| ID (1) | ID27415A (fr) |
| NO (1) | NO20006630L (fr) |
| WO (1) | WO2000000195A1 (fr) |
| ZA (1) | ZA200006262B (fr) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6607751B1 (en) * | 1997-10-10 | 2003-08-19 | Intellipharamaceutics Corp. | Controlled release delivery device for pharmaceutical agents incorporating microbial polysaccharide gum |
| TWI249401B (en) * | 1999-04-14 | 2006-02-21 | Takeda Chemical Industries Ltd | Agent for improving ketosis |
| EP1849475A1 (fr) | 1999-06-21 | 2007-10-31 | Eli Lilly & Company | Utilisation synergique des thiazolidinediones avec peptide-1 comme glucagon et agonistes correspondants pour traiter les diabètes non dépendants de l'insuline |
| AT409081B (de) * | 2000-02-16 | 2002-05-27 | Gebro Pharma Gmbh | Stabile, nasal, oral oder sublingual anwendbare pharmazeutische zubereitung |
| CA2401356A1 (fr) * | 2000-02-24 | 2001-08-30 | Takeda Chemical Industries, Ltd. | Medicament combine |
| GB0021978D0 (en) * | 2000-09-07 | 2000-10-25 | Smithkline Beecham Plc | Novel pharmaceutical |
| JP2004331500A (ja) * | 2001-02-16 | 2004-11-25 | Dainippon Pharmaceut Co Ltd | 血中濃度制御製剤 |
| EP1385549A2 (fr) * | 2001-03-12 | 2004-02-04 | Novartis AG | Combinaison de composes organiques |
| KR200249057Y1 (ko) * | 2001-03-22 | 2001-10-19 | 김진환 | 뚜껑, 받침대에 합체된 하수역류. 악취방지 장치 |
| US20030008838A1 (en) * | 2001-04-03 | 2003-01-09 | Havel Peter J. | Method of increasing endogenous leptin production |
| US20070203225A1 (en) * | 2001-04-03 | 2007-08-30 | Havel Peter J | Method of increasing endogenous adiponectin production and leptin production |
| JP2002360666A (ja) * | 2001-06-11 | 2002-12-17 | Takeda Chem Ind Ltd | コバルト合金を用いた打錠用杵臼 |
| AU2002351752A1 (en) | 2001-12-29 | 2003-07-30 | Novo Nordisk A/S | Combined use of a glp-1 compound and another drug for treating dyslipidemia |
| US7105489B2 (en) * | 2002-01-22 | 2006-09-12 | Amylin Pharmaceuticals, Inc. | Methods and compositions for treating polycystic ovary syndrome |
| US7101845B2 (en) * | 2002-01-31 | 2006-09-05 | Joslin Diabetes Center, Inc. | Methods of modulating β cell function |
| AU2002356419A1 (en) | 2002-06-17 | 2003-12-31 | Themis Laboratories Private Limited | Multilayer tablets containing thiazolidinedione and biguanides and methods for producing them |
| EP1388352A1 (fr) * | 2002-08-08 | 2004-02-11 | Laboratoires Fournier S.A. | Utilisation d'un agoniste de PPAR-alpha pour traiter l'obesité associée au traitement avec un agonist de PPAR-gamma dans des patients |
| US8084058B2 (en) | 2002-09-20 | 2011-12-27 | Watson Pharmaceuticals, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
| US7785627B2 (en) * | 2002-09-20 | 2010-08-31 | Watson Pharmaceuticals, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
| US7959946B2 (en) | 2002-09-20 | 2011-06-14 | Watson Pharmaceuticals, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
| US9060941B2 (en) * | 2002-09-20 | 2015-06-23 | Actavis, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
| WO2004078716A1 (fr) * | 2003-03-03 | 2004-09-16 | Merck & Co. Inc. | Derives de piperazine acyles utilises comme agonistes des recepteurs de la melanocortine 4 |
| US20050187266A1 (en) * | 2003-04-15 | 2005-08-25 | Pfizer Inc | Alpha substituted carboxylic acids |
| CA2529984C (fr) | 2003-06-26 | 2012-09-25 | Isa Odidi | Capsules contenant un inhibiteur de la pompe a protons comprenant des unites secondaires differemment structurees permettant une liberation retardee de l'ingredient actif |
| US7008957B2 (en) * | 2003-07-25 | 2006-03-07 | Sanofi-Aventis Deutschland Gmbh | Bicyclic cyanoheterocycles, process for their preparation and their use as medicaments |
| US7264813B2 (en) | 2003-09-24 | 2007-09-04 | Nikken Sohonsha Corporation | Therapeutic uses of Dunaliella powder |
| MXPA06005343A (es) * | 2003-11-14 | 2006-07-10 | Vertex Pharma | Tiazoles y oxazoles utiles como moduladores de transportadores con cassette de union a atp. |
| US20090111742A1 (en) * | 2004-01-26 | 2009-04-30 | Alexei Kharitonenkov | Use of fgf-21 and thiazolidinedione for treating type 2 diabetes |
| AR047541A1 (es) * | 2004-02-13 | 2006-01-25 | Sandoz Ag | Fosfato de 5-[[4-[2-metil-2-piridinil-amino-etoxi]fenil]metil]-2,4 tiazolidinadiona (rosiglitazona) y sus formas polimorficas |
| WO2005092040A2 (fr) * | 2004-03-22 | 2005-10-06 | The Regents Of The University Of California | Formulation pour ameliorer la production de leptine et d'adiponectine endogene |
| US8394409B2 (en) | 2004-07-01 | 2013-03-12 | Intellipharmaceutics Corp. | Controlled extended drug release technology |
| US20060024361A1 (en) * | 2004-07-28 | 2006-02-02 | Isa Odidi | Disintegrant assisted controlled release technology |
| US10624858B2 (en) * | 2004-08-23 | 2020-04-21 | Intellipharmaceutics Corp | Controlled release composition using transition coating, and method of preparing same |
| US7934562B2 (en) * | 2004-12-03 | 2011-05-03 | Vetco Gray Scandinavia As | Hybrid control system and method |
| KR100697982B1 (ko) * | 2005-07-08 | 2007-03-23 | 대봉엘에스 주식회사 | 로시글리타존의 제조방법 |
| KR100697983B1 (ko) * | 2005-07-08 | 2007-03-23 | 대봉엘에스 주식회사 | 신규 중간체 및 이를 이용한 피오글리타존의 제조방법 |
| US20070129444A1 (en) * | 2005-12-06 | 2007-06-07 | Mallinckrodt Inc. | Novel weight reduction composition and uses thereof |
| US10064828B1 (en) | 2005-12-23 | 2018-09-04 | Intellipharmaceutics Corp. | Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems |
| EP2007360B1 (fr) | 2006-04-03 | 2014-11-26 | Isa Odidi | Dispositif d'administration à libération commandée comprenant un enrobage organosol |
| US10960077B2 (en) * | 2006-05-12 | 2021-03-30 | Intellipharmaceutics Corp. | Abuse and alcohol resistant drug composition |
| WO2008091624A2 (fr) * | 2007-01-22 | 2008-07-31 | Teva Pharmaceutical Industries Ltd. | Formes polymorphes de bromhydrate de rosiglitazone et leurs procédés de préparation |
| EP2136801B1 (fr) * | 2007-03-30 | 2012-08-29 | Tioga Pharmaceuticals, Inc. | Agonistes du récepteur opiacé kappa pour le traitement du syndrome du côlon irritable avec alternance ou à diarrhée prédominante |
| US20090318520A1 (en) | 2008-06-20 | 2009-12-24 | Afecta Pharmaceuticals Drive | Use of isoindoles for the treatment of neurobehavioral disorders |
| JP5894174B2 (ja) * | 2010-11-03 | 2016-03-23 | アレコー リミテッド | グルカゴンを含む新規組成物 |
| CA3024640A1 (fr) * | 2012-11-06 | 2014-05-15 | Sigrid Therapeutics Ab | Matiere de silice poreuse utilisee en tant que principe actif pharmaceutique ou alimentaire |
| US20170056352A1 (en) | 2015-08-25 | 2017-03-02 | Rgenix, Inc. | PHARMACEUTICALLY ACCEPTABLE SALTS OF beta-GUANIDINOPROPIONIC ACID WITH IMPROVED PROPERTIES AND USES THEREOF |
| WO2018160178A1 (fr) | 2017-03-01 | 2018-09-07 | Rgenix, Inc. | Sels pharmaceutiquement acceptables d'acide bêta-guanidinopropionique ayant des propriétés améliorées et utilisations de ceux-ci |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2030174C (fr) | 1990-01-10 | 1996-12-24 | Anthony H. Cincotta | Procede pour la reduction a long terme des reserves lipidiques, de l'insulinoresistance, de l'hyperinsulinemie et de l'hypoglycemie chez les vertebres |
| GB9111426D0 (en) | 1991-05-28 | 1991-07-17 | Ici Plc | Chemical compounds |
| WO1993003724A1 (fr) | 1991-08-26 | 1993-03-04 | The Upjohn Company | Composition pharmaceutique contenant de l'acide 3-guanidinopropionique ainsi que du glibenclamide ou glimepiride de pioglitazone |
| TW438587B (en) | 1995-06-20 | 2001-06-07 | Takeda Chemical Industries Ltd | A pharmaceutical composition for prophylaxis and treatment of diabetes |
| CA2244831A1 (fr) * | 1996-02-02 | 1997-08-07 | John T. Olson | Methode de traitement du diabete et d'etats pathologiques associes |
| GB9619757D0 (en) * | 1996-09-21 | 1996-11-06 | Knoll Ag | Chemical process |
-
1999
- 1999-06-29 CA CA002329004A patent/CA2329004C/fr not_active Expired - Fee Related
- 1999-06-29 AU AU42914/99A patent/AU754740B2/en not_active Ceased
- 1999-06-29 ES ES99957622T patent/ES2255316T3/es not_active Expired - Lifetime
- 1999-06-29 DE DE69929996T patent/DE69929996T2/de not_active Expired - Lifetime
- 1999-06-29 US US09/380,059 patent/US6329403B1/en not_active Expired - Fee Related
- 1999-06-29 DK DK99957622T patent/DK1093370T3/da active
- 1999-06-29 CN CN99807133A patent/CN1305376A/zh active Pending
- 1999-06-29 BR BR9911656-1A patent/BR9911656A/pt not_active IP Right Cessation
- 1999-06-29 AR ARP990103124A patent/AR019727A1/es unknown
- 1999-06-29 AT AT99957622T patent/ATE318138T1/de active
- 1999-06-29 KR KR1020007012502A patent/KR20010043455A/ko not_active Application Discontinuation
- 1999-06-29 EP EP99957622A patent/EP1093370B1/fr not_active Expired - Lifetime
- 1999-06-29 WO PCT/JP1999/003496 patent/WO2000000195A1/fr active IP Right Grant
- 1999-06-29 ID IDW20002745A patent/ID27415A/id unknown
-
2000
- 2000-11-02 ZA ZA200006262A patent/ZA200006262B/en unknown
- 2000-12-22 NO NO20006630A patent/NO20006630L/no not_active Application Discontinuation
-
2001
- 2001-12-29 US US10/036,208 patent/US20020086885A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000000195A1 (fr) | 2000-01-06 |
| US20020086885A1 (en) | 2002-07-04 |
| BR9911656A (pt) | 2001-03-20 |
| EP1093370B1 (fr) | 2006-02-22 |
| ATE318138T1 (de) | 2006-03-15 |
| DE69929996D1 (de) | 2006-04-27 |
| AU754740B2 (en) | 2002-11-21 |
| ID27415A (id) | 2001-04-05 |
| AU4291499A (en) | 2000-01-17 |
| KR20010043455A (ko) | 2001-05-25 |
| US6329403B1 (en) | 2001-12-11 |
| DE69929996T2 (de) | 2006-11-16 |
| AR019727A1 (es) | 2002-03-13 |
| ES2255316T3 (es) | 2006-06-16 |
| CN1305376A (zh) | 2001-07-25 |
| DK1093370T3 (da) | 2006-05-22 |
| NO20006630D0 (no) | 2000-12-22 |
| NO20006630L (no) | 2001-02-26 |
| CA2329004A1 (fr) | 2000-01-06 |
| EP1093370A1 (fr) | 2001-04-25 |
| CA2329004C (fr) | 2009-04-14 |
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