ZA200004899B - Process for purification of a cephalosporin derivative. - Google Patents

Process for purification of a cephalosporin derivative.

Info

Publication number
ZA200004899B
ZA200004899B ZA200004899A ZA200004899A ZA200004899B ZA 200004899 B ZA200004899 B ZA 200004899B ZA 200004899 A ZA200004899 A ZA 200004899A ZA 200004899 A ZA200004899 A ZA 200004899A ZA 200004899 B ZA200004899 B ZA 200004899B
Authority
ZA
South Africa
Prior art keywords
purification
cephalosporin derivative
cefixime
ceph
vwhich
Prior art date
Application number
ZA200004899A
Other languages
English (en)
Inventor
Martin Decristoforo
Johannes Ludescher
Hubert Sturm
Werner Veit
Original Assignee
Biochemie Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biochemie Gmbh filed Critical Biochemie Gmbh
Publication of ZA200004899B publication Critical patent/ZA200004899B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/70—Sulfur atoms
    • C07D277/74—Sulfur atoms substituted by carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
ZA200004899A 1998-04-02 2000-09-14 Process for purification of a cephalosporin derivative. ZA200004899B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0057598A AT406773B (de) 1998-04-02 1998-04-02 Neues salz von 7-(2-(aminothiazol-4yl)-2-

Publications (1)

Publication Number Publication Date
ZA200004899B true ZA200004899B (en) 2001-12-24

Family

ID=3494225

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200004899A ZA200004899B (en) 1998-04-02 2000-09-14 Process for purification of a cephalosporin derivative.

Country Status (16)

Country Link
US (1) US6825345B2 (fr)
EP (1) EP1068211B1 (fr)
JP (1) JP2002510694A (fr)
KR (1) KR20010034671A (fr)
CN (1) CN1134447C (fr)
AT (2) AT406773B (fr)
AU (1) AU3603599A (fr)
BR (1) BR9909898A (fr)
CA (1) CA2326441C (fr)
DE (1) DE69937143T2 (fr)
ES (1) ES2293720T3 (fr)
HK (1) HK1034078A1 (fr)
ID (1) ID26210A (fr)
TR (1) TR200002838T2 (fr)
WO (1) WO1999051607A2 (fr)
ZA (1) ZA200004899B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT404727B (de) * 1997-01-16 1999-02-25 Biochemie Gmbh Kristallines salz von cefixim und verfahren zu dessen herstellung
ITMI20012364A1 (it) * 2001-11-09 2003-05-09 Antibioticos Spa Processo di sintesi della cefixima via alchil-o arilsolfonati
US7244842B2 (en) * 2002-11-15 2007-07-17 Orchid Chemicals & Pharmaceuticals Ltd. Amorphous hydrate of a cephalosporin antibiotic
AU2003294161A1 (en) * 2003-03-20 2004-10-11 Orchid Chemicals And Pharmaceuticals Ltd An improved process for the preparation of cefoxitin
US8008478B2 (en) 2004-12-21 2011-08-30 Lupin Limited Process for the preparation of cefixime
ES2334685T3 (es) * 2005-03-29 2010-03-15 Hetero Drugs Limited Procedimiento mejorado de preparacion de cefixima.
CN1312158C (zh) * 2005-05-20 2007-04-25 天津市医药集团技术发展有限公司 一种头孢克肟的制备方法
CN101812075B (zh) * 2010-05-07 2012-06-13 郝志艳 一种头孢克肟化合物及其新制法
CN103265562A (zh) * 2013-05-29 2013-08-28 四川方向药业有限责任公司 头孢克肟的制备方法
CN103965216A (zh) * 2014-05-21 2014-08-06 广州白云山制药股份有限公司广州白云山化学制药厂 7-（噻唑羧甲氧亚氨基)- 3-三嗪环头孢化合物的制造方法
CN103965217A (zh) * 2014-05-21 2014-08-06 广州白云山制药股份有限公司广州白云山化学制药厂 3-三嗪环-7-（噻唑羧甲氧亚氨基）头孢烷酸的制备方法
WO2016142902A1 (fr) * 2015-03-11 2016-09-15 Lupin Limited Céfixime à aire de surface réduite et haute stabilité

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA806977B (en) * 1979-11-19 1981-10-28 Fujisawa Pharmaceutical Co 7-acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
JPS58986A (ja) * 1981-05-07 1983-01-06 Fujisawa Pharmaceut Co Ltd セフェム化合物
JPS57192392A (en) * 1981-05-19 1982-11-26 Sankyo Co Ltd Production of 3-alkoxymethylcephalosporin
AU564150B2 (en) * 1982-04-30 1987-08-06 Takeda Chemical Industries Ltd. 1-sulfo-2-azetidinone derivatives
EP0096296B1 (fr) 1982-06-03 1987-07-29 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Dérivés de 1-sulfo-2-oxoazétidine
EP0096297B1 (fr) * 1982-06-03 1988-06-15 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Procédé de préparation de dérivés de 1-sulfo-2-oxoazétidine
JPS59163387A (ja) * 1983-03-07 1984-09-14 Sankyo Co Ltd ３−アルコキシメチルセフアロスポリンの製造方法
JPH0692416B2 (ja) * 1985-03-13 1994-11-16 三共株式会社 セフアロスポラン酸誘導体
EP0231845B1 (fr) * 1986-02-07 1992-06-17 F. Hoffmann-La Roche Ag Procédé de préparation d'amides d'acides carboxyliques
US5359057A (en) 1986-02-07 1994-10-25 Hoffmann-La Roche Inc. Acylation of amines
JPH01242589A (ja) * 1988-03-22 1989-09-27 Fujisawa Pharmaceut Co Ltd セフエム化合物
PT630380E (pt) * 1992-02-05 2002-02-28 Biochemie Gmbh Processo para a purificacao de um derivado do acido 3-cefem-4-carboxilico
DE69427312T2 (de) * 1993-11-17 2001-08-23 Biochemie Ges.M.B.H., Kundl Trennung von Cephalosporinisomeren
AT403049B (de) * 1995-08-14 1997-10-27 Biochemie Gmbh Abreicherung von 7-adca in 3-vinyl-aca
AT404251B (de) * 1996-08-14 1998-10-27 Biochemie Gmbh Neues kristallines salz von cefixim
EP0831093A1 (fr) * 1996-09-23 1998-03-25 F. Hoffmann-La Roche Ag Dérivés de 1-carba-(déthia)-céphalosporine
TW538045B (en) * 1997-01-16 2003-06-21 Biochemie Gmbh Process for purifying cefixime

Also Published As

Publication number Publication date
US6825345B2 (en) 2004-11-30
WO1999051607A2 (fr) 1999-10-14
TR200002838T2 (tr) 2001-02-21
US20030208065A1 (en) 2003-11-06
ATE373666T1 (de) 2007-10-15
HK1034078A1 (en) 2001-10-12
CA2326441C (fr) 2008-03-18
EP1068211B1 (fr) 2007-09-19
KR20010034671A (ko) 2001-04-25
EP1068211A2 (fr) 2001-01-17
ATA57598A (de) 2000-01-15
DE69937143D1 (de) 2007-10-31
CA2326441A1 (fr) 1999-10-14
AU3603599A (en) 1999-10-25
CN1295576A (zh) 2001-05-16
CN1134447C (zh) 2004-01-14
DE69937143T2 (de) 2008-06-12
WO1999051607A3 (fr) 2000-01-27
ID26210A (id) 2000-12-07
AT406773B (de) 2000-08-25
BR9909898A (pt) 2000-12-26
JP2002510694A (ja) 2002-04-09
ES2293720T3 (es) 2008-03-16

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