YU91790A - Postopek za pripravo substituiranih aminoalkilfosfinskih kislin - Google Patents
Postopek za pripravo substituiranih aminoalkilfosfinskih kislinInfo
- Publication number
- YU91790A YU91790A YU91790A YU91790A YU91790A YU 91790 A YU91790 A YU 91790A YU 91790 A YU91790 A YU 91790A YU 91790 A YU91790 A YU 91790A YU 91790 A YU91790 A YU 91790A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- denotes
- hydrogen
- substituted
- acids
- halogen
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 150000007513 acids Chemical class 0.000 title abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 206010013754 Drug withdrawal syndrome Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 208000008238 Muscle Spasticity Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 206010008129 cerebral palsy Diseases 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 208000004296 neuralgia Diseases 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000018198 spasticity Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/36—Amides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
- Luminescent Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Detergent Compositions (AREA)
Abstract
POSTOPEK ZA PRIPRAVO SUBSTITUIRANIH AMINOALKILFOSFINSKIH KISLIN. P-substituirane aminoalkilfosfinske kisline s formulo kjer R označuje v danem primeru fluorirano metilno skupino, R1 označuje vodik, nižji alkil, nižji alkoksi, hidroksi, halogen ali fluorirano metilno skupino in R2 in R3 označujeta vodik, ali R2 označuje hidroksi, nižji alkoksi ali halogen in je R3 vodik, ali R2 in R3 skupaj predstavljata okso skupino, in njihove farmacevtsko sprejemljive soli, so učinkovite kot GABAb agonisti in se jih da uporabiti pri zdravljenju spinalne spastičnosti, multiple skleroze in cerebralne paralize, nevralgije trigeminusa, sindromov pri odvajanju od drog in/ali bolečinskih stanj. Da se jih pripraviti po samih po sebi znanih metodah in opisane so prikladne tovrstne metode.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SI9010917A SI9010917B (sl) | 1989-05-13 | 1990-05-10 | Postopek za pripravo substituiranih aminoalkilfosfinskih kislin |
| HRP-917/90A HRP940178A2 (en) | 1989-05-13 | 1994-03-18 | Substituted aminoalkylphosphonic acids |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898911017A GB8911017D0 (en) | 1989-05-13 | 1989-05-13 | Substituted aminoalkylphosphinic acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU91790A true YU91790A (sh) | 1992-07-20 |
Family
ID=10656689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU91790A YU91790A (sh) | 1989-05-13 | 1990-05-10 | Postopek za pripravo substituiranih aminoalkilfosfinskih kislin |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP0399949B1 (sh) |
| JP (1) | JP2930366B2 (sh) |
| KR (1) | KR0159501B1 (sh) |
| AT (1) | ATE121095T1 (sh) |
| AU (1) | AU629335B2 (sh) |
| CA (1) | CA2016631C (sh) |
| DD (1) | DD294265A5 (sh) |
| DE (1) | DE69018514T2 (sh) |
| DK (1) | DK0399949T3 (sh) |
| ES (1) | ES2070303T3 (sh) |
| FI (1) | FI94416C (sh) |
| GB (1) | GB8911017D0 (sh) |
| GR (1) | GR3015770T3 (sh) |
| HR (1) | HRP940178A2 (sh) |
| HU (1) | HU206885B (sh) |
| IE (1) | IE66165B1 (sh) |
| IL (1) | IL94317A (sh) |
| MX (1) | MX20639A (sh) |
| NO (1) | NO176761C (sh) |
| NZ (1) | NZ233647A (sh) |
| PT (1) | PT94014B (sh) |
| SI (1) | SI9010917B (sh) |
| YU (1) | YU91790A (sh) |
| ZA (1) | ZA903611B (sh) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0767174A1 (de) * | 1991-11-21 | 1997-04-09 | Ciba-Geigy Ag | Neue Aminoalkanphosphinsäuren und ihre Salze |
| PL189872B1 (pl) | 1996-07-24 | 2005-10-31 | Warner Lambert Co | Zastosowanie izobutylogaby i jej pochodnych do wytwarzania leku do leczenia bólu |
| CN1309659A (zh) | 1998-07-15 | 2001-08-22 | 哈桑·朱马 | 有机磷化合物及其用途 |
| GB9906882D0 (en) * | 1999-03-25 | 1999-05-19 | Novartis Ag | Organic compounds |
| SE9904508D0 (sv) | 1999-12-09 | 1999-12-09 | Astra Ab | New compounds |
| US7319095B2 (en) | 1999-12-09 | 2008-01-15 | Astrazeneca Ab | Use of GABAB receptor agonists |
| SE9904507D0 (sv) * | 1999-12-09 | 1999-12-09 | Astra Ab | New compounds |
| AR033779A1 (es) | 2001-06-08 | 2004-01-07 | Astrazeneca Ab | Compuestos utiles en la enfermedad de reflujo |
| SE0102055D0 (sv) * | 2001-06-08 | 2001-06-08 | Astrazeneca Ab | New Compounds |
| PL1691811T3 (pl) | 2003-12-11 | 2014-12-31 | Sunovion Pharmaceuticals Inc | Skojarzenie leku uspokajającego i modulatora neuroprzekaźnikowego oraz sposoby poprawy jakości snu i leczenia depresji |
| SE0401653D0 (sv) | 2004-06-24 | 2004-06-24 | Astrazeneca Ab | New compounds |
| KR20080087852A (ko) | 2005-12-23 | 2008-10-01 | 아스트라제네카 아베 | Ｇａｂａ-ｂ 수용체 조절제 |
| JP2009521428A (ja) | 2005-12-23 | 2009-06-04 | アストラゼネカ・アクチエボラーグ | 胃腸疾患治療用のイミダゾール誘導体 |
| DE102008056228A1 (de) * | 2008-11-06 | 2010-05-12 | Clariant International Limited | Verfahren zur Herstellung von monoaminofunktionalisierten Dialkylphosphinsäuren, deren Salze und Ester und ihre Verwendung |
| DE102008056339A1 (de) * | 2008-11-07 | 2010-05-12 | Clariant International Limited | Verfahren zur Herstellung von mono-aminofunktionalisierten Dialkylphosphinsäuren, -estern und -salzen und ihre Verwendung |
| WO2011113904A1 (en) | 2010-03-17 | 2011-09-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Medicaments for the prevention and treatment of a disease associated with retinal ganglion cell degeneration |
| WO2012050907A2 (en) | 2010-09-28 | 2012-04-19 | The Regents Of The University Of California | Gaba agonists in the treatment of disorders associated with metabolic syndrome and gaba combinations in treatment or prophylaxis of type i diabetes |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3311475C1 (de) * | 1983-03-29 | 1984-08-16 | Siemens AG, 1000 Berlin und 8000 München | Mikroprogramm-Steuereinrichtung |
| DE3312165A1 (de) * | 1983-04-02 | 1984-10-04 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von phosphinothricin |
| GB8728483D0 (en) * | 1987-12-04 | 1988-01-13 | Ciba Geigy Ag | Chemical compounds |
| GB8820266D0 (en) * | 1988-08-26 | 1988-09-28 | Smith Kline French Lab | Compounds |
-
1989
- 1989-05-13 GB GB898911017A patent/GB8911017D0/en active Pending
-
1990
- 1990-05-07 AU AU54809/90A patent/AU629335B2/en not_active Ceased
- 1990-05-07 IL IL94317A patent/IL94317A/xx not_active IP Right Cessation
- 1990-05-08 ES ES90810346T patent/ES2070303T3/es not_active Expired - Lifetime
- 1990-05-08 AT AT90810346T patent/ATE121095T1/de not_active IP Right Cessation
- 1990-05-08 DK DK90810346.8T patent/DK0399949T3/da active
- 1990-05-08 DE DE69018514T patent/DE69018514T2/de not_active Expired - Fee Related
- 1990-05-08 EP EP90810346A patent/EP0399949B1/en not_active Expired - Lifetime
- 1990-05-09 MX MX2063990A patent/MX20639A/es unknown
- 1990-05-10 SI SI9010917A patent/SI9010917B/sl unknown
- 1990-05-10 YU YU91790A patent/YU91790A/sh unknown
- 1990-05-11 NZ NZ233647A patent/NZ233647A/en unknown
- 1990-05-11 CA CA002016631A patent/CA2016631C/en not_active Expired - Lifetime
- 1990-05-11 ZA ZA903611A patent/ZA903611B/xx unknown
- 1990-05-11 PT PT94014A patent/PT94014B/pt not_active IP Right Cessation
- 1990-05-11 HU HU903012A patent/HU206885B/hu not_active IP Right Cessation
- 1990-05-11 FI FI902368A patent/FI94416C/fi not_active IP Right Cessation
- 1990-05-11 KR KR1019900006687A patent/KR0159501B1/ko not_active IP Right Cessation
- 1990-05-11 IE IE171690A patent/IE66165B1/en not_active IP Right Cessation
- 1990-05-11 DD DD90340576A patent/DD294265A5/de not_active IP Right Cessation
- 1990-05-11 NO NO902109A patent/NO176761C/no not_active IP Right Cessation
- 1990-05-14 JP JP2121395A patent/JP2930366B2/ja not_active Expired - Fee Related
-
1994
- 1994-03-18 HR HRP-917/90A patent/HRP940178A2/hr not_active Application Discontinuation
-
1995
- 1995-04-13 GR GR950400747T patent/GR3015770T3/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| YU91790A (sh) | Postopek za pripravo substituiranih aminoalkilfosfinskih kislin | |
| EP0747383A3 (en) | Polyamine salts of clavulanic acid | |
| PT89111A (pt) | Processo de preparacao de analogos de camptotecina hidrossoluveis, dos seus intermediarios e de composicoes que os contem | |
| ATE133667T1 (de) | Thiazolderivate, verfahren zur ihrer herstellung und pharmazeutische zusammensetzungen, die sie enthalten | |
| ATE150462T1 (de) | Pyrazolopyridinverbindungen und verfahren zu ihrer herstellung | |
| SE0104334D0 (sv) | Therapeutic agents | |
| DE3272792D1 (en) | Process for the preparation of 2-penem compounds | |
| DK164937C (da) | Analogifremgangsmaade til fremstilling af 1-alkyl-2-aminotetralinderivater eller farmaceutisk acceptable syreadditionssalte deraf samt 1-alkyl-2-aminotetralinderivater til anvendelse som udgangsmateriale i fremgangsmaaden | |
| DE3870801D1 (de) | Gallensaeure-derivate, verfahren zu ihrer herstellung und pharmazeutische praeparate, die sie enthalten. | |
| NO161620C (no) | Analogifremgangsm te for fremstilling av terapeutisk aktive 8-alkyltio-2-piperazino-pyrimido(5,4-d)pyrimidin-derivater. | |
| AU655869B2 (en) | An amphoteric tricyclic compound | |
| DE3782548D1 (de) | Ergolin-ester, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammenstellungen. | |
| HUT46214A (en) | Process for producing medical preparation suitable for treatment of peptic ulcer | |
| DE3381885D1 (de) | Piperidinderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate. | |
| EP0318166A3 (en) | Isoxazolo[4,5-c]azepine derivatives, process for their preparation and pharmaceutical compositions containing them | |
| TH1354A (th) | ออพติคัลลี่ แอคตีฟ 1-(6-เมทธอกซี-2-แนพซิล)-2-(อัลคอกซิคาร์บอนิล) อะมิโน-1-โพรพะโนน อนุพันธุ์ต่างๆ และพวกสารฮาโลของมัน และกรรมวิธีการผลิตสารเหล่านี้ |