YU85790A - Postupak za izradu 8-/4(4-pirimidin-2-il-1-piperazinil)-butil/-8-azaspiro/4,5/dekan-7,9-diona/buspirona/ - Google Patents

Postupak za izradu 8-/4(4-pirimidin-2-il-1-piperazinil)-butil/-8-azaspiro/4,5/dekan-7,9-diona/buspirona/

Info

Publication number
YU85790A
YU85790A YU85790A YU85790A YU85790A YU 85790 A YU85790 A YU 85790A YU 85790 A YU85790 A YU 85790A YU 85790 A YU85790 A YU 85790A YU 85790 A YU85790 A YU 85790A
Authority
YU
Yugoslavia
Prior art keywords
azaspiro
dione
butyl
pyrimidin
piperazinyl
Prior art date
Application number
YU85790A
Other languages
English (en)
Inventor
F. Korodi
I. Koehegyi
Z. Cziaky
C. Simon
L. Frank
L. Nyiri
V. Galamb
J. Repasi
C. Jaszberenyi
F. Bene
S. Ondi
F. Barkanyi
F. Terebes
F. Flaskar
P. Baloghne Korik
M. Mocsar
S F. Tama
F. Fabian
F. Juhasz
F. Csuczor
F. Kovacs
Original Assignee
Alkaloida Vegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alkaloida Vegyeszeti Gyar filed Critical Alkaloida Vegyeszeti Gyar
Publication of YU85790A publication Critical patent/YU85790A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Pronalazak se odnosi na postupak za izradu 8-/4-(4-pirimidin-2-il-1-piperazinil)-butil/-8-azaspiro/4.5/dekan- 7,9-diona reakcijom 8-(4-piperazin-1-il-butil)-8-azaspiro /4.5/dekan-7,9-diona sa 2-hlor-pirimidinom. Za postupak je karakteristično, da derivat azaspiro(4,5/-dekan-7,9- diona reaguje u inertnom polarnom rastvaraču, prvenstveno hloroformu, etanolu, propanolu, butanolu ili dimetilformamidu, na temperaturi od 50-150 C, prvenstveno 80-120 C, u prisustvu sredstva koje vezuje kiselinu, ili pak na 0-80 C, prvenstveno 60-70 C, u prisustvu viška baznog reagensa, prvenstveno trietilamina ili piridina, sa hlorpirimidinom.
YU85790A 1989-04-28 1990-05-03 Postupak za izradu 8-/4(4-pirimidin-2-il-1-piperazinil)-butil/-8-azaspiro/4,5/dekan-7,9-diona/buspirona/ YU85790A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU203589A HU212301B (en) 1989-04-28 1989-04-28 Process for producing buspirone

Publications (1)

Publication Number Publication Date
YU85790A true YU85790A (sh) 1992-07-20

Family

ID=10957431

Family Applications (1)

Application Number Title Priority Date Filing Date
YU85790A YU85790A (sh) 1989-04-28 1990-05-03 Postupak za izradu 8-/4(4-pirimidin-2-il-1-piperazinil)-butil/-8-azaspiro/4,5/dekan-7,9-diona/buspirona/

Country Status (5)

Country Link
EP (1) EP0395192A3 (sh)
HU (1) HU212301B (sh)
PL (6) PL289815A1 (sh)
RU (1) RU1799381C (sh)
YU (1) YU85790A (sh)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
US4305944A (en) * 1980-09-08 1981-12-15 Mead Johnson & Company N-[(4-[3-cyano substituted pyridyl]piperazino)alkyl]-azaspirodecanediones
CA1172255A (en) * 1980-12-11 1984-08-07 Robert R. Covington Buspirone process

Also Published As

Publication number Publication date
EP0395192A3 (de) 1991-05-02
HUT53637A (en) 1990-11-28
PL289819A1 (en) 1991-10-07
HU212301B (en) 1996-05-28
PL289818A1 (en) 1991-10-07
PL284969A1 (en) 1991-08-12
PL289817A1 (en) 1991-10-07
PL289816A1 (en) 1991-10-07
RU1799381C (ru) 1993-02-28
PL289815A1 (en) 1991-10-07
EP0395192A2 (de) 1990-10-31

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