YU64203A - Acilovani 6,7,8,9-tetrahidro-5h-benzocikloheptenil amini i njihova upotreba kao farmaceutskih sredstava - Google Patents
Acilovani 6,7,8,9-tetrahidro-5h-benzocikloheptenil amini i njihova upotreba kao farmaceutskih sredstavaInfo
- Publication number
- YU64203A YU64203A YU64203A YUP64203A YU64203A YU 64203 A YU64203 A YU 64203A YU 64203 A YU64203 A YU 64203A YU P64203 A YUP64203 A YU P64203A YU 64203 A YU64203 A YU 64203A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- hypertension
- alkyl
- description
- diabetes
- restricted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/54—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/74—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/12—One of the condensed rings being a six-membered aromatic ring the other ring being at least seven-membered
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Ovaj se pronalazak odnosi na jedinjenja prema opstom formuli (I) gde R1 do R4 imaju znacenja data u opisu, A je CH2, CHOH ili CH(C1-C3-alkil), B, C i D su nezavisno CH2 CH(C1-C3-alkil), a R5 je jedna arilna ili heteroarilna grupa, eventualno supstituisana supstituentima navedenim u opisu. Ova su jedinjenja korisna za izradu medikamenta za lecenje kardiovaskularnih oboljenja, stabilne ili nestabilne angine pektoris, koronarnog srcanog oboljenja, Princmetalove angine, akutnog koronarnog sindroma, otkaza srca, infarkta miokarda, mozdanog udara, tromboze, oboljenja zacepljenja periferne arterije, poremecene funkcije endotela, ateroskleroze, restenoze, ostecenja endotela posle PTCA (perkutana transluminalna koronarna angioplastija), hipertenzije, esencijalne hipertenzije, plucne hipertenzije, sekundarne hipertenzije, renovaskularne hipertenzije, hronicnog glomerulonefritisa, poremecaja funkcije erektivnog tkiva, aritmije srcane komore, dijabetesa, komplikacija od dijabetesa, nefropatije, retinopatije, angiogeneze, bronhijalne astme, hronicnog otkaza bubrega, ciroze jetre, osteoporoze, ogranicenog secanja ili ogranicene sposobnosti ucenja, ili za smanjenje kardiovaskularnog rizika za zene posle menopauze ili posle uzimanja kontraceptivnih sredstava.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01102853 | 2001-02-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
YU64203A true YU64203A (sh) | 2006-05-25 |
Family
ID=8176424
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU64203A YU64203A (sh) | 2001-02-13 | 2002-02-12 | Acilovani 6,7,8,9-tetrahidro-5h-benzocikloheptenil amini i njihova upotreba kao farmaceutskih sredstava |
Country Status (33)
Country | Link |
---|---|
US (2) | US6759412B2 (sh) |
EP (1) | EP1362027B1 (sh) |
JP (1) | JP4319836B2 (sh) |
KR (1) | KR100975781B1 (sh) |
CN (1) | CN1296346C (sh) |
AR (1) | AR035431A1 (sh) |
AT (1) | ATE396171T1 (sh) |
AU (1) | AU2002253012B2 (sh) |
BG (1) | BG108060A (sh) |
BR (1) | BR0207197A (sh) |
CA (1) | CA2438324C (sh) |
CZ (1) | CZ20032134A3 (sh) |
DE (1) | DE60226704D1 (sh) |
DK (1) | DK1362027T3 (sh) |
EE (1) | EE200300370A (sh) |
ES (1) | ES2304432T3 (sh) |
HK (1) | HK1061017A1 (sh) |
HR (1) | HRP20030645A2 (sh) |
HU (1) | HUP0303133A3 (sh) |
IL (2) | IL157211A0 (sh) |
MX (1) | MXPA03006893A (sh) |
MY (1) | MY136316A (sh) |
NO (1) | NO328767B1 (sh) |
NZ (1) | NZ527471A (sh) |
PE (1) | PE20020870A1 (sh) |
PL (1) | PL363639A1 (sh) |
PT (1) | PT1362027E (sh) |
RU (1) | RU2301797C2 (sh) |
SK (1) | SK10092003A3 (sh) |
UY (1) | UY27165A1 (sh) |
WO (1) | WO2002064546A2 (sh) |
YU (1) | YU64203A (sh) |
ZA (1) | ZA200305414B (sh) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020147198A1 (en) * | 2001-01-12 | 2002-10-10 | Guoqing Chen | Substituted arylamine derivatives and methods of use |
US20030134836A1 (en) | 2001-01-12 | 2003-07-17 | Amgen Inc. | Substituted arylamine derivatives and methods of use |
MY136316A (en) * | 2001-02-13 | 2008-09-30 | Sanofi Aventis Deutschland | Acylated 6,7,8,9-tetrahydro-5h-benzocycloheptenyl amines and their use as pharmaceutical. |
TWI243164B (en) * | 2001-02-13 | 2005-11-11 | Aventis Pharma Gmbh | Acylated indanyl amines and their use as pharmaceuticals |
TWI241190B (en) * | 2001-02-13 | 2005-10-11 | Aventis Pharma Gmbh | 4-Fluoro-N-indan-2-yl benzamide and its use as pharmaceutical |
US7176310B1 (en) * | 2002-04-09 | 2007-02-13 | Ucb Sa | Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents |
EP1388342A1 (en) * | 2002-08-07 | 2004-02-11 | Aventis Pharma Deutschland GmbH | Acylated, heteroaryl-condensed cycloalkenylamines and their use as pharmaceuticals |
US7186735B2 (en) | 2002-08-07 | 2007-03-06 | Sanofi-Aventis Deutschland Gmbh | Acylated arylcycloalkylamines and their use as pharmaceuticals |
US7338956B2 (en) | 2002-08-07 | 2008-03-04 | Sanofi-Aventis Deutschland Gmbh | Acylamino-substituted heteroaromatic compounds and their use as pharmaceuticals |
US7105513B2 (en) * | 2002-08-07 | 2006-09-12 | Sanofi-Avertis Deutschland Gmbh | Acylated, heteroaryl-condensed cycloalkenylamines and their use as pharmaceuticals |
US7132536B2 (en) * | 2003-04-24 | 2006-11-07 | Sanofi-Aventis Deutschland Gmbh | Triaza- and tetraaza-anthracenedione derivatives, their preparation and their use as pharmaceuticals |
AU2004261250B2 (en) | 2003-07-29 | 2009-02-26 | Xenon Pharmaceuticals Inc. | Pyridyl derivatives and their use as therapeutic agents |
US8309608B2 (en) * | 2003-11-06 | 2012-11-13 | Sanofi-Aventis Deutschland Gmbh | Use of eNOS transcription enhancers in the cell therapy of ischemic heart diseases |
EP1529525A1 (en) * | 2003-11-06 | 2005-05-11 | Aventis Pharma Deutschland GmbH | ENOS transcription enhancers for use in the cell therapy of ischemic heart diseases |
EP1568698A1 (en) | 2004-02-27 | 2005-08-31 | Aventis Pharma Deutschland GmbH | Pyrrole-derivatives as factor Xa inhibitors |
JP2007277096A (ja) * | 2004-07-15 | 2007-10-25 | Astellas Pharma Inc | フェネチルニコチンアミド誘導体含有医薬 |
CA2586870A1 (en) * | 2004-11-10 | 2006-05-18 | Synta Pharmaceuticals Corp. | Il-12 modulatory compounds |
US7226942B2 (en) | 2004-11-15 | 2007-06-05 | Bristol-Myers Squibb Company | 2-amino-4-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors |
US7214704B2 (en) | 2004-11-15 | 2007-05-08 | Bristol-Myers Squibb Company | 2-Amino-1-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors |
US7223786B2 (en) | 2004-11-15 | 2007-05-29 | Bristol-Myers Squibb Company | 2-aminonaphthalene derivatives and related glycogen phosphorylase inhibitors |
US7365061B2 (en) | 2004-11-15 | 2008-04-29 | Bristol-Myers Squibb Company | 2-Amino-3-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors |
EP1741709A1 (en) | 2005-06-28 | 2007-01-10 | Sanofi-Aventis Deutschland GmbH | Heteroaryl-substituted amides comprising a saturated linker group, and their use as pharmaceuticals |
EP1741708A1 (en) | 2005-06-28 | 2007-01-10 | Sanofi-Aventis Deutschland GmbH | Heteroaryl-substituted amides comprising an unsaturated or cyclic linker group, and their use as pharmaceuticals |
KR20110007258A (ko) | 2006-03-22 | 2011-01-21 | 에프. 호프만-라 로슈 아게 | 11-베타-hsd-1로서의 피라졸 |
EP1905764A1 (en) | 2006-09-30 | 2008-04-02 | Sanofi-Aventis | Substituted 2-Phenyl-benzimidazoles and their use as pharmaceuticals |
EP1923062A1 (en) | 2006-11-16 | 2008-05-21 | sanofi-aventis | Imidazo[2,1-b]thiazoles and their use as pharmaceuticals |
EP1939180A1 (en) | 2006-12-20 | 2008-07-02 | sanofi-aventis | Heteroarylacrylamides and their use as pharmaceuticals for the stimulation of the expression of endothelial NO synthase |
EP1942104A1 (en) | 2006-12-20 | 2008-07-09 | sanofi-aventis | Heteroarylcyclopropanecarboxamides and their use as pharmaceuticals |
EP1939181A1 (en) | 2006-12-27 | 2008-07-02 | sanofi-aventis | Heteroaryl-substituted carboxamides and use thereof for the stimulation of the expression of NO synthase |
EP1964840A1 (en) | 2007-02-28 | 2008-09-03 | sanofi-aventis | Imidazo[1,2-a]pyridines and their use as pharmaceuticals |
EP1964841A1 (en) | 2007-02-28 | 2008-09-03 | sanofi-aventis | Imidazo[1,2-a]azine and their use as pharmaceuticals |
WO2011115804A1 (en) | 2010-03-17 | 2011-09-22 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
US8247436B2 (en) | 2010-03-19 | 2012-08-21 | Novartis Ag | Pyridine and pyrazine derivative for the treatment of CF |
CA2803292C (en) | 2010-06-30 | 2016-06-14 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
NZ609955A (en) | 2010-11-09 | 2015-05-29 | Ironwood Pharmaceuticals Inc | Sgc stimulators |
US20120309796A1 (en) * | 2011-06-06 | 2012-12-06 | Fariborz Firooznia | Benzocycloheptene acetic acids |
EP3112363A1 (en) | 2011-12-27 | 2017-01-04 | Ironwood Pharmaceuticals, Inc. | 2-[1-[(2-fluorophenyl)methyl]-5-(3-isoxazolyl)-1h-pyrazol-3-yl]-pyrimidine derivatives and related compounds as soluble guanylate cyclase (sgc) stimulators for the treatment of pulmonary hypertension |
US9309235B2 (en) | 2012-09-18 | 2016-04-12 | Ironwood Pharmaceuticals, Inc. | SGC stimulators |
CA2885645A1 (en) | 2012-09-19 | 2014-03-27 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
CN110016020B (zh) | 2013-03-15 | 2022-07-26 | 赛克里翁治疗有限公司 | 化合物或其药学上可接受的盐及其应用和药物组合物 |
JP6814630B2 (ja) * | 2013-06-03 | 2021-01-20 | マーヴィン サックナー | 受動模擬型ジョギングデバイス |
US20160311826A1 (en) | 2013-12-11 | 2016-10-27 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
WO2015106268A1 (en) | 2014-01-13 | 2015-07-16 | Ironwood Pharmaceuticals, Inc. | USE OF sGC STIMULATORS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS |
WO2016044447A1 (en) | 2014-09-17 | 2016-03-24 | Ironwood Pharmaceuticals, Inc. | Pyrazole derivatives as sgc stimulators |
WO2016044445A2 (en) | 2014-09-17 | 2016-03-24 | Ironwood Pharmaceuticals, Inc. | sGC STIMULATORS |
EP3194386A2 (en) | 2014-09-17 | 2017-07-26 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
IL263996B2 (en) | 2016-07-07 | 2024-03-01 | Ironwood Pharmaceuticals Inc | Solid configurations of the SGC promoter |
CN114736240A (zh) | 2016-07-07 | 2022-07-12 | 赛克里翁治疗有限公司 | sGC刺激剂的磷前药 |
WO2024091983A1 (en) * | 2022-10-25 | 2024-05-02 | Artus Therapeutics, Inc. | Therapeutic agents for enhancing epithelial and/or endothelial barrier function |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU8402275A (en) * | 1974-08-26 | 1977-02-17 | Takeda Chemical Industries Ltd | Benzocycloheptene derivatives |
DE3807813A1 (de) | 1988-03-10 | 1989-09-21 | Thomae Gmbh Dr K | Neue benzocycloheptenderivate, diese verbindungen enthaltende arzneimittel und verfahren zu deren herstellung |
CZ287969B6 (cs) | 1995-08-10 | 2001-03-14 | Astra Pharmaceuticals Limited | Amidinový derivát, způsob jeho přípravy, farmaceutický prostředek s jeho obsahem a použití |
US6180597B1 (en) | 1998-03-19 | 2001-01-30 | Brigham And Women's Hospital, Inc. | Upregulation of Type III endothelial cell nitric oxide synthase by rho GTPase function inhibitors |
WO2000003746A2 (en) * | 1998-07-14 | 2000-01-27 | The Brigham And Women's Hospital, Inc. | Upregulation of type iii endothelial cell nitric oxide synthase by agents that disrupt actin cytoskeletal organization |
AUPP891299A0 (en) | 1999-02-26 | 1999-03-25 | Fujisawa Pharmaceutical Co., Ltd. | New 6-membered cyclic compounds |
AUPQ309399A0 (en) | 1999-09-28 | 1999-10-21 | Fujisawa Pharmaceutical Co., Ltd. | Benzothiazoline derivatives |
PE20020856A1 (es) * | 2001-02-13 | 2002-11-11 | Aventis Pharma Gmbh | 1,2,3,4-tetrahidronaftil aminas aciladas |
MY136316A (en) * | 2001-02-13 | 2008-09-30 | Sanofi Aventis Deutschland | Acylated 6,7,8,9-tetrahydro-5h-benzocycloheptenyl amines and their use as pharmaceutical. |
TWI241190B (en) * | 2001-02-13 | 2005-10-11 | Aventis Pharma Gmbh | 4-Fluoro-N-indan-2-yl benzamide and its use as pharmaceutical |
TWI243164B (en) * | 2001-02-13 | 2005-11-11 | Aventis Pharma Gmbh | Acylated indanyl amines and their use as pharmaceuticals |
US7186735B2 (en) * | 2002-08-07 | 2007-03-06 | Sanofi-Aventis Deutschland Gmbh | Acylated arylcycloalkylamines and their use as pharmaceuticals |
US7338956B2 (en) * | 2002-08-07 | 2008-03-04 | Sanofi-Aventis Deutschland Gmbh | Acylamino-substituted heteroaromatic compounds and their use as pharmaceuticals |
US7105513B2 (en) * | 2002-08-07 | 2006-09-12 | Sanofi-Avertis Deutschland Gmbh | Acylated, heteroaryl-condensed cycloalkenylamines and their use as pharmaceuticals |
US8309608B2 (en) * | 2003-11-06 | 2012-11-13 | Sanofi-Aventis Deutschland Gmbh | Use of eNOS transcription enhancers in the cell therapy of ischemic heart diseases |
-
2002
- 2002-02-11 MY MYPI20020476A patent/MY136316A/en unknown
- 2002-02-11 PE PE2002000103A patent/PE20020870A1/es not_active Application Discontinuation
- 2002-02-11 AR ARP020100441A patent/AR035431A1/es active IP Right Grant
- 2002-02-12 CZ CZ20032134A patent/CZ20032134A3/cs unknown
- 2002-02-12 NZ NZ527471A patent/NZ527471A/en unknown
- 2002-02-12 JP JP2002564479A patent/JP4319836B2/ja not_active Expired - Fee Related
- 2002-02-12 HU HU0303133A patent/HUP0303133A3/hu unknown
- 2002-02-12 YU YU64203A patent/YU64203A/sh unknown
- 2002-02-12 ES ES02722069T patent/ES2304432T3/es not_active Expired - Lifetime
- 2002-02-12 KR KR1020037010680A patent/KR100975781B1/ko not_active IP Right Cessation
- 2002-02-12 WO PCT/EP2002/001449 patent/WO2002064546A2/en active IP Right Grant
- 2002-02-12 RU RU2003127723/04A patent/RU2301797C2/ru not_active IP Right Cessation
- 2002-02-12 CA CA002438324A patent/CA2438324C/en not_active Expired - Fee Related
- 2002-02-12 EE EEP200300370A patent/EE200300370A/xx unknown
- 2002-02-12 PL PL02363639A patent/PL363639A1/xx not_active Application Discontinuation
- 2002-02-12 IL IL15721102A patent/IL157211A0/xx unknown
- 2002-02-12 EP EP02722069A patent/EP1362027B1/en not_active Expired - Lifetime
- 2002-02-12 DK DK02722069T patent/DK1362027T3/da active
- 2002-02-12 PT PT02722069T patent/PT1362027E/pt unknown
- 2002-02-12 MX MXPA03006893A patent/MXPA03006893A/es active IP Right Grant
- 2002-02-12 SK SK1009-2003A patent/SK10092003A3/sk unknown
- 2002-02-12 DE DE60226704T patent/DE60226704D1/de not_active Expired - Lifetime
- 2002-02-12 CN CNB028048563A patent/CN1296346C/zh not_active Expired - Fee Related
- 2002-02-12 AT AT02722069T patent/ATE396171T1/de active
- 2002-02-12 BR BR0207197-5A patent/BR0207197A/pt not_active IP Right Cessation
- 2002-02-12 AU AU2002253012A patent/AU2002253012B2/en not_active Ceased
- 2002-02-13 US US10/073,203 patent/US6759412B2/en not_active Expired - Lifetime
- 2002-02-13 UY UY27165A patent/UY27165A1/es unknown
-
2003
- 2003-07-14 ZA ZA200305414A patent/ZA200305414B/en unknown
- 2003-08-03 IL IL157211A patent/IL157211A/en not_active IP Right Cessation
- 2003-08-05 BG BG108060A patent/BG108060A/bg unknown
- 2003-08-12 NO NO20033566A patent/NO328767B1/no not_active IP Right Cessation
- 2003-08-12 HR HR20030645A patent/HRP20030645A2/hr not_active Application Discontinuation
-
2004
- 2004-05-03 HK HK04103983A patent/HK1061017A1/xx not_active IP Right Cessation
- 2004-06-03 US US10/859,773 patent/US7709478B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MXPA03006893A (es) | 6,7,8,9-tetrahidro-5h-benzocicloheptenil aminas aciladas y su uso como farmacos. | |
IL157210A0 (en) | Acylated 1,2,3,4-tetrahydronaphthyl amines and their use as pharmaceuticals | |
MXPA03006974A (es) | Indanil aminas aciladas y su uso como farmacos. | |
MY135778A (en) | 4-fluoro-n-indan-2-yl benzamide and its use as pharmaceutical | |
JP2005538123A5 (sh) | ||
JP2005538124A5 (sh) | ||
WO2005082863A3 (en) | 1,4 diaryl-dihydropyrimidin-2 ones and their use as a human neutrophil elastase inhibitors | |
RU2005106292A (ru) | Ацилированные гетероарилконденсированные циклоалкениламины и их применение в качестве фармацевтических средств | |
IL166493A0 (en) | Acylamino-substituted heteroaromatic compounds andtheir use as pharmaceuticals | |
AU2002253010A1 (en) | Acylated indanyl amines and their use as pharmaceuticals | |
CY1112800T1 (el) | Η χρηση υποκαθιστουμενων κυανοπυρρολιδινων για τη θεραπεια της υπερλιπιδαιμιας | |
ATE311380T1 (de) | Durch säuregruppen disubstitierte heteroaryl- derivate und ihre verwendung als matrix metalloproteinas inhibitoren | |
CA2494628A1 (en) | Acylated arylcycloalkylamines and their use as pharmaceuticals | |
JP2005534706A5 (sh) | ||
JP4972266B2 (ja) | 増殖性疾患を処置するためのα,β−不飽和スルホン | |
AU778965B2 (en) | Tryptase inhibitors | |
CA2523196A1 (en) | Triaza- and tetraaza-anthracenedione derivatives, their preparation and their use as pharmaceuticals | |
JPH02233677A (ja) | 新規な1―〔3―(2―ヒドロキシ―3―アルキルアミノプロポキシ)―2―チエニル〕―3―フェニル―1―プロパノン類及びその製造方法 | |
AR035538A1 (es) | 4-fluoro-n-indan-2-il-benzamida para la fabricacion de un medicamento y composiciones farmaceuticas que la comprenden | |
PA8552001A1 (es) | 1,2,3,4-tetrahidronaftil aminas aciladas y su uso como farmacos |