YU58093A - 1,3,4-benzotriazepin-5(4h)-on derivati i postupak za njihovo dobijanje - Google Patents

1,3,4-benzotriazepin-5(4h)-on derivati i postupak za njihovo dobijanje

Info

Publication number
YU58093A
YU58093A YU58093A YU58093A YU58093A YU 58093 A YU58093 A YU 58093A YU 58093 A YU58093 A YU 58093A YU 58093 A YU58093 A YU 58093A YU 58093 A YU58093 A YU 58093A
Authority
YU
Yugoslavia
Prior art keywords
normal
branched chain
hydrogen
4alkyl
alkyl
Prior art date
Application number
YU58093A
Other languages
English (en)
Inventor
I. Bodi
E. Gal
M. Gal
L. Jaszlitz
A. Jednakovits
A. Kiss
A.M. Kovacs
G. Mathe
I. Pallagi
G. Rabloczky
A. Simai
E. Tihanyi
Original Assignee
Egis Gyogyszergyar Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egis Gyogyszergyar Rt. filed Critical Egis Gyogyszergyar Rt.
Publication of YU58093A publication Critical patent/YU58093A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
    • C07D255/04—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1,3,4-BENZOTRIAZEPIN-5(4H)-ON DERIVATI I POSTUPAK ZA NJIHOVO DOBIJANJE, pronalazak se odnosi na racemske ili optički aktivne 1,3,4-benzotriazepin-5(4H)-on derivate, postupak za njihovo dobivanje, farmaceutske preparate koji obuhvataju iste, korišćenje pomenutih jedinjenja za tretiranje obolenja i za dobivanje farmaceutskih preparata koja sadrže pomenuta jedinjenja kao aktivni sastojak. Nova jedinjenja prema pronalasku odgovaraju opštoj formuli I, gde R1 je vodonik ili C1-4alkil normalnog ili račvastog lanca koji po izboru nosi piridil ili fenil supstituent; R2 je cijanoimino; R3 je vodonik ili C1-4alkil normalnog ili račvastog lanca; R4 je C1-4alkil; i isprekidana linija predstavlja valentnu vezu; ili R2 je grupa formule R9R10N, gde R9 i R10 su nezavisno vodonik ili C1-10alkil normalnog ili račvastog lanca, ili R9R10N gradi 5- do 7-članu heterocikličnu grupu; ili R9R10N gradi grupu formule N=C(NR12R13)NH2, gde R12 i R13 su nezavisno vodonik ili C1-10alkil normalnog ili račvastog lanca; ili NR12R13 gradi 5 do 7-članu heterocikličnu grupu; R4 je C1-4alkil; i isprekidana linija je valentna veza usled čega nema supstituenta R1; uz predpostavku da kada su R9 i R10 isti onda nisu vodonik.
YU58093A 1992-09-04 1993-09-03 1,3,4-benzotriazepin-5(4h)-on derivati i postupak za njihovo dobijanje YU58093A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9202833A HU212266B (en) 1992-09-04 1992-09-04 Process for producing novel 1,3,4-benzotriazepin-5(4h)-one derivatives and pharmaceutical preparations containing them

Publications (1)

Publication Number Publication Date
YU58093A true YU58093A (sh) 1996-02-19

Family

ID=10982296

Family Applications (1)

Application Number Title Priority Date Filing Date
YU58093A YU58093A (sh) 1992-09-04 1993-09-03 1,3,4-benzotriazepin-5(4h)-on derivati i postupak za njihovo dobijanje

Country Status (14)

Country Link
US (1) US5441948A (sh)
JP (1) JPH06157483A (sh)
KR (1) KR940007008A (sh)
CN (1) CN1087632A (sh)
CH (1) CH686081A5 (sh)
CZ (1) CZ182493A3 (sh)
DE (1) DE4329874A1 (sh)
FI (1) FI933872A (sh)
FR (1) FR2695388B1 (sh)
GB (1) GB2270313B (sh)
HU (1) HU212266B (sh)
IT (1) IT1273981B (sh)
NL (1) NL9301524A (sh)
YU (1) YU58093A (sh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104961747B (zh) * 2015-06-02 2017-10-24 大连理工大学 一种四氢苯并[d][1,2,6]氧杂二氮*类化合物及其制备方法
CN104945403B (zh) * 2015-06-02 2017-07-21 大连理工大学 一种四氢苯并[e][1,2,4]三氮杂*类化合物及其制备方法
CN105037386B (zh) * 2015-06-02 2017-10-24 大连理工大学 一种四氢苯并[c][1,2,5]噁二嗪类化合物及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57109772A (en) * 1980-12-27 1982-07-08 Otsuka Pharmaceut Co Ltd Benzotriazepine derivative
US4482547A (en) * 1982-08-26 1984-11-13 Hoechst-Roussel Pharmaceuticals Inc. Substituted-1,3,4-benzotriazepines

Also Published As

Publication number Publication date
FI933872A0 (fi) 1993-09-03
HU212266B (en) 1996-04-29
GB2270313B (en) 1995-07-12
CZ182493A3 (en) 1994-04-13
US5441948A (en) 1995-08-15
ITMI931897A0 (it) 1993-09-03
CN1087632A (zh) 1994-06-08
HU9202833D0 (en) 1992-11-30
IT1273981B (it) 1997-07-14
KR940007008A (ko) 1994-04-26
FR2695388A1 (fr) 1994-03-11
GB2270313A (en) 1994-03-09
CH686081A5 (de) 1995-12-29
NL9301524A (nl) 1994-04-05
DE4329874A1 (de) 1994-03-10
JPH06157483A (ja) 1994-06-03
FI933872A (fi) 1994-03-05
ITMI931897A1 (it) 1995-03-03
FR2695388B1 (fr) 1995-05-24
HUT67062A (en) 1995-01-30
GB9318254D0 (en) 1993-10-20

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