YU48323B - Postupak za dobijanje askorbinske kiseline - Google Patents
Postupak za dobijanje askorbinske kiselineInfo
- Publication number
- YU48323B YU48323B YU113690A YU113690A YU48323B YU 48323 B YU48323 B YU 48323B YU 113690 A YU113690 A YU 113690A YU 113690 A YU113690 A YU 113690A YU 48323 B YU48323 B YU 48323B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- procedure
- obtaining
- acid
- sodium
- separation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/62—Three oxygen atoms, e.g. ascorbic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Furan Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cosmetics (AREA)
Abstract
POSTUPAK ZA DOBIJANJE ASKORBINSKE KISELINE polazeći od vodenog,metanolnog ili vodeno-metanolnog rastvora askorbinske kiseline dobivenog nakon a) esterifikovanja L-2-ketogulonske kiseline, u datom slučaju u obliku natrijumove soli, u prisustvu jake kiseline odabrane između sumporne, hlorovodonične ili sulfonske kiseline, b) transformisanja, u datom slučaju in situ, estra L-2-ketogulonske kiseline u natrijumaskorbinat pomoću mineralne baze ili organske baze u alkoholnom rastvoru, c) u datom slučaju odvajanja istaloženog natrijumaskorbinata, d) odvajanja askorbinske kiseline od njene soli pomoću jake kiseline radeći u metanolu ili vodeno-metanolnom rastvoru u kojem je so natrijuma jake kiseline slabo rastvorna, e) odvajanja soli jake kiseline, naznačen time, što se za odvajanje - ili koncentruje metanolni ili vodeno-metanolni rastvor, odvoji sirova askorbinska kiselina koja se rastvori u vodi, potom propusti vodeni rastvor kroz smole kiselog i baznog tipa, - ili koncentruje metanolni ili vodeno-metanolni rastvor, odvoji sirova askorbinska kiselina koja se rastvori u metanolu, potom propusti kroz smole kiselog i baznog tipa, - ili propusti metanolni rastvor kroz smole kiselog i baznog tipa, potom kristalizuje čista askorbinska kiselina iz obezbojenog metanolnog rastvora i odvoji filtriranjem, - ili propusti vodeno-metanolni rastvor kroz smole kiselog i baznog tipa, potom kristalizuje askorbinska kiselina i odvoji filtriranjem.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR898907716A FR2648136B1 (fr) | 1989-06-12 | 1989-06-12 | Procede de preparation de l'acide ascorbique |
Publications (2)
Publication Number | Publication Date |
---|---|
YU113690A YU113690A (sh) | 1992-09-07 |
YU48323B true YU48323B (sh) | 1998-05-15 |
Family
ID=9382598
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU113690A YU48323B (sh) | 1989-06-12 | 1990-06-11 | Postupak za dobijanje askorbinske kiseline |
Country Status (16)
Country | Link |
---|---|
US (1) | US5391770A (sh) |
EP (1) | EP0403351B2 (sh) |
JP (1) | JP2921927B2 (sh) |
KR (1) | KR100210636B1 (sh) |
AT (1) | ATE126223T1 (sh) |
CA (1) | CA2018692C (sh) |
DE (1) | DE69021455T3 (sh) |
DK (1) | DK0403351T4 (sh) |
ES (1) | ES2075887T5 (sh) |
FR (1) | FR2648136B1 (sh) |
GR (2) | GR3017085T3 (sh) |
HU (1) | HU205754B (sh) |
IE (1) | IE69381B1 (sh) |
PT (1) | PT94354B (sh) |
RU (1) | RU1833383C (sh) |
YU (1) | YU48323B (sh) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1036457C (zh) * | 1991-10-01 | 1997-11-19 | 武田药品工业株式会社 | 2-酮基-l-古洛糖酸低级烷基脂的制备方法 |
EP0671405A1 (de) * | 1994-01-18 | 1995-09-13 | F. Hoffmann-La Roche Ag | Herstellung von 2-Keto-L-gulonsäureestern |
JPH08176133A (ja) * | 1994-12-26 | 1996-07-09 | Takeda Chem Ind Ltd | L−アスコルビン酸の精製法 |
IL115564A (en) * | 1995-10-11 | 1999-06-20 | Yissum Res Dev Co | Process for the recovery of ascorbic acid from an aqueous feed solution |
DE19547073C1 (de) * | 1995-12-16 | 1996-11-14 | Merck Patent Gmbh | Verfahren zur Herstellung von Ascorbinsäure |
JP3976832B2 (ja) * | 1996-04-30 | 2007-09-19 | ディーエスエム アイピー アセッツ ビー.ブイ. | 2−ケト−l−グロン酸の単離方法 |
IL119731A0 (en) * | 1996-12-01 | 1997-03-18 | Yissum Res Dev Co | A process for the production of erythorbic acid |
US5998634A (en) * | 1999-03-15 | 1999-12-07 | The United States Of America As Represented By The Secretary Of The Interior | One-step synthesis of vitamin-C (L-ascorbic acid) |
DE19919203A1 (de) | 1999-04-28 | 2000-11-02 | Basf Ag | Verfahren zur Herstellung von L-Ascorbinsäure |
US6153791A (en) * | 1999-08-02 | 2000-11-28 | Archer-Daniels-Midland Company | Process for purifying 2-keto-L-gulonic acid |
US6902917B1 (en) * | 1999-08-03 | 2005-06-07 | Archer-Daniels-Midland Company | Process for recovery of organic acids from fermentration broths |
DE19938980A1 (de) * | 1999-08-19 | 2001-02-22 | Basf Ag | Verfahren zur Herstellung von 2-Keto-L-gulonsäureestern |
DE19954511A1 (de) | 1999-11-12 | 2001-05-17 | Basf Ag | Verfahren zur Herstellung von Alkalisalzen der L-Ascorbinsäure |
US6670505B1 (en) | 2000-03-07 | 2003-12-30 | Eastman Chemical Company | Process for the recovery of organic acids from aqueous solutions |
DE10022518A1 (de) | 2000-05-10 | 2001-11-15 | Basf Ag | Verfahren zur Herstellung von L-Ascorbinsäure durch Lactonisierung von 2-Keto-L-gulonsäure oder 2-Keto-L-gulonsäureestern |
US6320061B1 (en) | 2000-06-05 | 2001-11-20 | Eastman Chemical Company | Solvent exchange process |
US6610863B2 (en) | 2000-12-22 | 2003-08-26 | Eastman Chemical Company | Continuous process for producing L-ascorbic acid |
EP1368329B1 (en) * | 2000-12-22 | 2005-08-31 | Eastman Chemical Company | Process for producing ascorbic acid in the presence of a sulfit |
US6740762B2 (en) | 2001-08-24 | 2004-05-25 | Eastman Chemical Company | Process for ascorbic acids using alkaline earth silicate catalysts |
US6716997B1 (en) | 2001-10-09 | 2004-04-06 | Eastman Chemical Company | Systems and methods for generation of ascorbic acid with reduced color |
WO2003031427A1 (en) * | 2001-10-09 | 2003-04-17 | Eastman Chemical Company | Systems and methods for generation of ascorbic acid with reduced color |
DE10149869A1 (de) * | 2001-10-10 | 2003-04-24 | Basf Ag | Verfahren zur Isolierung von Salzen von organischen Säuren aus einer Fermentationsbrühe und zur Freisetzung der organischen Säure |
US6518454B1 (en) | 2001-10-12 | 2003-02-11 | Eastman Chemical Company | Preparation of esters of carboxylic acids |
US6476239B1 (en) | 2002-02-12 | 2002-11-05 | Eastman Chemical Company | Process for the preparation of ascorbic acid |
DE50302916D1 (de) | 2002-11-11 | 2006-05-18 | Basf Ag | VERFAHREN ZUR HERSTELLUNG VON 2-KETO-L-GULONSÄURE-C-4 C-10 /sb -ALKYLESTERN |
US6872314B2 (en) * | 2003-08-29 | 2005-03-29 | Eastman Chemical Company | Dewatering process |
US7799942B2 (en) * | 2005-08-12 | 2010-09-21 | Eastman Chemical Company | Production of terephthalic acid di-esters |
US7276621B2 (en) * | 2005-08-12 | 2007-10-02 | Eastman Chemical Company | Production of di-(2-ethylhexyl) terephthalate |
US7741509B2 (en) * | 2007-01-30 | 2010-06-22 | Eastman Chemical Company | Conversion of terephthalic acid to Di-n-butyl terephthalate |
CN100545156C (zh) * | 2007-04-10 | 2009-09-30 | 三达膜科技(厦门)有限公司 | 维生素c母液中回收维生素c和古龙酸的生产方法 |
CN101914079B (zh) * | 2010-08-20 | 2012-06-06 | 安徽丰原发酵技术工程研究有限公司 | 一种维生素c的生产方法 |
CN102424695A (zh) * | 2011-10-28 | 2012-04-25 | 安徽泰格生物技术股份有限公司 | 一种古龙酸甲酯钠及其制备方法 |
CN111018814B (zh) * | 2019-12-06 | 2022-11-08 | 石药集团维生药业(石家庄)有限公司 | 一种维生素c二母液回收利用的方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR779883A (fr) * | 1933-10-25 | 1935-04-13 | Hoffmann La Roche | Procédé de préparation de l'acide 1-ascorbique |
US2265121A (en) * | 1933-10-25 | 1941-12-02 | Hoffmann La Roche | Process for the manufacture of levoascorbic acid |
US2443583A (en) * | 1944-07-12 | 1948-06-15 | Hugh H Mottern | Manufacture of ascorbic acid |
FR922949A (fr) * | 1946-02-26 | 1947-06-23 | Bataafsche Petroleum | Procédé pour préparer l'acide ascorbique à partir d'esters de l'acide cetogulonique |
JPS6019285B2 (ja) * | 1977-02-07 | 1985-05-15 | 武田薬品工業株式会社 | 分別方法 |
PL130761B1 (en) * | 1980-07-18 | 1984-09-29 | Krakowskie Zaklady Pharma | Process for preparing 1-ascorbic acid from its salts |
JPS58177986A (ja) * | 1982-04-09 | 1983-10-18 | Shionogi & Co Ltd | L−アスコルビン酸の製造方法 |
JP3433820B2 (ja) * | 1993-05-07 | 2003-08-04 | 関西電力株式会社 | ガス燃焼装置及びガス燃焼システム |
-
1989
- 1989-06-12 FR FR898907716A patent/FR2648136B1/fr not_active Expired - Lifetime
-
1990
- 1990-06-08 RU SU904830021A patent/RU1833383C/ru active
- 1990-06-11 IE IE209590A patent/IE69381B1/en not_active IP Right Cessation
- 1990-06-11 JP JP2150081A patent/JP2921927B2/ja not_active Expired - Lifetime
- 1990-06-11 ES ES90401592T patent/ES2075887T5/es not_active Expired - Lifetime
- 1990-06-11 DK DK90401592T patent/DK0403351T4/da active
- 1990-06-11 KR KR1019900008530A patent/KR100210636B1/ko not_active IP Right Cessation
- 1990-06-11 EP EP90401592A patent/EP0403351B2/fr not_active Expired - Lifetime
- 1990-06-11 YU YU113690A patent/YU48323B/sh unknown
- 1990-06-11 HU HU903799A patent/HU205754B/hu unknown
- 1990-06-11 CA CA002018692A patent/CA2018692C/fr not_active Expired - Lifetime
- 1990-06-11 AT AT90401592T patent/ATE126223T1/de not_active IP Right Cessation
- 1990-06-11 DE DE69021455T patent/DE69021455T3/de not_active Expired - Lifetime
- 1990-06-12 PT PT94354A patent/PT94354B/pt not_active IP Right Cessation
-
1993
- 1993-12-23 US US08/171,988 patent/US5391770A/en not_active Expired - Lifetime
-
1995
- 1995-08-10 GR GR950400344T patent/GR3017085T3/el unknown
-
2000
- 2000-08-03 GR GR20000401816T patent/GR3034121T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
GR3034121T3 (en) | 2000-11-30 |
DE69021455T3 (de) | 2001-02-22 |
KR910000692A (ko) | 1991-01-30 |
ES2075887T5 (es) | 2000-12-16 |
IE902095L (en) | 1990-12-12 |
JPH0324068A (ja) | 1991-02-01 |
ES2075887T3 (es) | 1995-10-16 |
DE69021455D1 (de) | 1995-09-14 |
CA2018692A1 (fr) | 1990-12-12 |
EP0403351B1 (fr) | 1995-08-09 |
HU903799D0 (en) | 1990-11-28 |
YU113690A (sh) | 1992-09-07 |
DK0403351T4 (da) | 2000-09-25 |
FR2648136B1 (fr) | 1994-06-17 |
RU1833383C (ru) | 1993-08-07 |
US5391770A (en) | 1995-02-21 |
CA2018692C (fr) | 2001-05-08 |
DK0403351T3 (da) | 1995-09-18 |
PT94354A (pt) | 1991-02-08 |
HU205754B (en) | 1992-06-29 |
FR2648136A1 (fr) | 1990-12-14 |
IE69381B1 (en) | 1996-09-04 |
GR3017085T3 (en) | 1995-11-30 |
PT94354B (pt) | 2001-06-29 |
KR100210636B1 (ko) | 1999-07-15 |
JP2921927B2 (ja) | 1999-07-19 |
EP0403351B2 (fr) | 2000-08-23 |
DE69021455T2 (de) | 1996-02-01 |
HUT54131A (en) | 1991-01-28 |
ATE126223T1 (de) | 1995-08-15 |
EP0403351A1 (fr) | 1990-12-19 |
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