YU48302B - Postupak za dobijanje novih organskih nitrata kao i za dobijanje njihovih farmaceutski prihvatljivih soli - Google Patents

Postupak za dobijanje novih organskih nitrata kao i za dobijanje njihovih farmaceutski prihvatljivih soli

Info

Publication number
YU48302B
YU48302B YU176289A YU176289A YU48302B YU 48302 B YU48302 B YU 48302B YU 176289 A YU176289 A YU 176289A YU 176289 A YU176289 A YU 176289A YU 48302 B YU48302 B YU 48302B
Authority
YU
Yugoslavia
Prior art keywords
obtaining
organic nitrates
pharmaceuticalally
procedure
acceptable salts
Prior art date
Application number
YU176289A
Other languages
English (en)
Other versions
YU176289A (en
Inventor
J. Hutter
E. Noack
K. Sandrock
Original Assignee
Schwarz Pharma Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schwarz Pharma Ag. filed Critical Schwarz Pharma Ag.
Priority to SI8911762A priority Critical patent/SI8911762B/sl
Publication of YU176289A publication Critical patent/YU176289A/xx
Publication of YU48302B publication Critical patent/YU48302B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C07C327/34—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups with amino groups bound to the same hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Peptides Or Proteins (AREA)

Abstract

POSTUPAK ZA DOBIJANJE NOVIH ORGANSKIH NITRATA KAO I ZA DOBIJANJE NJIHOVIH FARMACEUTSKI PRIHVATLJIVIH SOLI naznačen time, što se jedno jedinjenje odgovarajućih nitromasnih kiselina opšte formule (A) u obliku njihovih slobodnih kiselina, njihovih reaktivnih halogenida kiselina, azida, estara i/ili anhidrida, kondenzuje sa amino grupom jednog jedinjenja opšte formule (B) da bi se obrazovalo jedno jedinjenje opšte formule (I) koje se, eventualno, na bočnom nizu alkiluje sa jednom C1-C3-grupom, pri čemu u opštim formulama (A), (B) i (I) označava R hidroksi, C1-C3-alkoksi, amino; R1 vodonik, alkil sa 1 do 8 ugljenikovih atoma; R2 vodonik ili metil; R3 vodonik; R4 vodonik, fenil ili metoksifenil; R5 merkaptometil, merkaptoetil, metiltioetil, njegovi S-acilderivati, naročito S-acetil, S-propionil, S-buturil, S-kapronil, S-kapril, S-izobuturil, S-pivaloil, S-benzoil; R i R5 mogu biti međusobno vezani uz obrazovanje jednog tiolaktona; R i R4 mogu biti međusobno vezani uz obrazovanje jednog estra ili amida; R3 i R4 mogu biti međusobno vezani uz obrazovanje jednog alkilen mosta sa 2 do 4 ugljenikova atoma, jednog alkilen mosta sa 2 do 3 ugljenikova atoma, i jednim atomom sumpora, jednog alkilen mosta sa 3 do 4 ugljenikova atoma, koji sadrži jednu dvostruku vezu ili jednog alkilen mosta kao napred, supstituisanog sa hidroksi; m, n i o su celi brojevi od 0 do 10. Prijava sadrži još 1 nezavisan i 7 zavisnih zahteva.
YU176289A 1988-09-15 1989-09-12 Postupak za dobijanje novih organskih nitrata kao i za dobijanje njihovih farmaceutski prihvatljivih soli YU48302B (sh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SI8911762A SI8911762B (sl) 1988-09-15 1989-09-12 Novi organski nitrati in postopki za njihovo pripravo

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3831311 1988-09-15

Publications (2)

Publication Number Publication Date
YU176289A YU176289A (en) 1992-02-20
YU48302B true YU48302B (sh) 1998-05-15

Family

ID=6362967

Family Applications (1)

Application Number Title Priority Date Filing Date
YU176289A YU48302B (sh) 1988-09-15 1989-09-12 Postupak za dobijanje novih organskih nitrata kao i za dobijanje njihovih farmaceutski prihvatljivih soli

Country Status (15)

Country Link
EP (1) EP0362575B1 (sh)
JP (1) JP2628756B2 (sh)
AT (1) ATE121077T1 (sh)
CZ (1) CZ284586B6 (sh)
DE (1) DE58909173D1 (sh)
DK (1) DK452989A (sh)
ES (1) ES2073418T3 (sh)
FI (1) FI95569C (sh)
HR (1) HRP920987A2 (sh)
HU (1) HU209716B (sh)
IE (1) IE65918B1 (sh)
PL (1) PL163343B1 (sh)
PT (1) PT91702B (sh)
SK (1) SK280513B6 (sh)
YU (1) YU48302B (sh)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4011505C2 (de) * 1990-04-10 1995-01-12 Sanol Arznei Schwarz Gmbh Nitratoalkancarbonsäure-Derivate, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
US5284872A (en) * 1989-09-12 1994-02-08 Schwarz Pharma Ag Nitrato alkanoic acid derivatives, methods for their production, pharmaceutical compositions containing the derivatives and medicinal uses thereof
NL9001955A (nl) * 1990-09-05 1992-04-01 Cedona Pharm Bv Nieuwe thiazolidinederivaten.
JP3361836B2 (ja) * 1991-07-04 2003-01-07 三共株式会社 アミノ酸誘導体
FR2680173A1 (fr) * 1991-08-07 1993-02-12 Hoechst Lab Nitrates organiques, leurs procedes de preparation et leur utilisation dans le traitement de maladies cardiovasculaires .
DE4321306A1 (de) * 1993-06-26 1995-01-05 Sanol Arznei Schwarz Gmbh Disulfide
US5807847A (en) * 1996-06-04 1998-09-15 Queen's University At Kingston Nitrate esters
ES2142773B1 (es) * 1998-10-07 2001-01-01 Lacer Sa Derivados de mononitrato de isosorbida y su empleo como agentes vasodilatadores con tolerancia desminuida.
ES2604562T3 (es) 2007-02-05 2017-03-07 Nicox Science Ireland Compuestos donantes de óxido nítrico
EP2149576A1 (en) 2008-07-22 2010-02-03 Lacer, S.A. Isosorbide Nitrates having vasodilating activity
CN103739499B (zh) 2011-10-24 2016-09-07 尼科斯科学爱尔兰公司 醌基一氧化氮供体化合物
WO2014169976A1 (en) 2013-04-18 2014-10-23 Nicox Science Ireland Quinone based nitric oxide donating compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3512627A1 (de) * 1985-04-06 1986-10-09 Boehringer Mannheim Gmbh, 6800 Mannheim Amino-propanol-derivate, verfahren zu deren herstellung, verwendung derselben und diese enthaltende arzneimittel

Also Published As

Publication number Publication date
CZ530389A3 (cs) 1998-11-11
DK452989A (da) 1990-03-16
EP0362575B1 (de) 1995-04-12
PT91702B (pt) 1995-06-30
PT91702A (pt) 1990-03-30
HUT51229A (en) 1990-04-28
DE58909173D1 (de) 1995-05-18
HU209716B (en) 1994-10-28
DK452989D0 (da) 1989-09-14
CZ284586B6 (cs) 1999-01-13
IE892932L (en) 1990-03-15
ES2073418T3 (es) 1995-08-16
YU176289A (en) 1992-02-20
SK530389A3 (en) 2000-03-13
IE65918B1 (en) 1995-11-29
PL163343B1 (pl) 1994-03-31
FI894350A0 (fi) 1989-09-14
HRP920987A2 (hr) 1994-04-30
FI95569B (fi) 1995-11-15
JPH0291054A (ja) 1990-03-30
FI95569C (fi) 1996-02-26
FI894350A (fi) 1990-03-16
JP2628756B2 (ja) 1997-07-09
ATE121077T1 (de) 1995-04-15
SK280513B6 (sk) 2000-03-13
EP0362575A1 (de) 1990-04-11

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