YU176289A - New organic nitrates and process for obtaining thereof - Google Patents

New organic nitrates and process for obtaining thereof

Info

Publication number
YU176289A
YU176289A YU01762/89A YU176289A YU176289A YU 176289 A YU176289 A YU 176289A YU 01762/89 A YU01762/89 A YU 01762/89A YU 176289 A YU176289 A YU 176289A YU 176289 A YU176289 A YU 176289A
Authority
YU
Yugoslavia
Prior art keywords
organic nitrates
obtaining
acids
tolerance
new organic
Prior art date
Application number
YU01762/89A
Other versions
YU48302B (en
Inventor
J Hutter
E Noack
S Klaus
Original Assignee
Sanol Arznei Schwarz Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanol Arznei Schwarz Gmbh filed Critical Sanol Arznei Schwarz Gmbh
Priority to SI8911762A priority Critical patent/SI8911762B/en
Publication of YU176289A publication Critical patent/YU176289A/en
Publication of YU48302B publication Critical patent/YU48302B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C07C327/34—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups with amino groups bound to the same hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Organic nitrates with a specific structure, consisting of nitrato fatty acids (nitratoalkanoic acids) and sulphur-containing amino acids or peptides, of the general formula <IMAGE> in which the symbols have the meanings specified in the claims. Because of the general structural principle - presence of sulphhydryl groups - they prevent nitrate tolerance or attenuate a tolerance which has already occurred. The compounds are used in medicaments for treating circulatory disorders, high blood pressure, heart failure and for dilating peripheral vessels.
YU176289A 1988-09-15 1989-09-12 PROCEDURE FOR OBTAINING NEW ORGANIC NITRATES AS FOR OBTAINING THEIR PHARMACEUTICALALLY ACCEPTABLE SALTS YU48302B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SI8911762A SI8911762B (en) 1988-09-15 1989-09-12 Novel organic nitrates and a process for their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3831311 1988-09-15

Publications (2)

Publication Number Publication Date
YU176289A true YU176289A (en) 1992-02-20
YU48302B YU48302B (en) 1998-05-15

Family

ID=6362967

Family Applications (1)

Application Number Title Priority Date Filing Date
YU176289A YU48302B (en) 1988-09-15 1989-09-12 PROCEDURE FOR OBTAINING NEW ORGANIC NITRATES AS FOR OBTAINING THEIR PHARMACEUTICALALLY ACCEPTABLE SALTS

Country Status (15)

Country Link
EP (1) EP0362575B1 (en)
JP (1) JP2628756B2 (en)
AT (1) ATE121077T1 (en)
CZ (1) CZ284586B6 (en)
DE (1) DE58909173D1 (en)
DK (1) DK452989A (en)
ES (1) ES2073418T3 (en)
FI (1) FI95569C (en)
HR (1) HRP920987A2 (en)
HU (1) HU209716B (en)
IE (1) IE65918B1 (en)
PL (1) PL163343B1 (en)
PT (1) PT91702B (en)
SK (1) SK530389A3 (en)
YU (1) YU48302B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5284872A (en) * 1989-09-12 1994-02-08 Schwarz Pharma Ag Nitrato alkanoic acid derivatives, methods for their production, pharmaceutical compositions containing the derivatives and medicinal uses thereof
DE4011505C2 (en) * 1990-04-10 1995-01-12 Sanol Arznei Schwarz Gmbh Nitratoalkanecarboxylic acid derivatives, processes for their preparation and medicaments containing them
NL9001955A (en) * 1990-09-05 1992-04-01 Cedona Pharm Bv NEW THIAZOLIDINE DERIVATIVES.
JP3361836B2 (en) * 1991-07-04 2003-01-07 三共株式会社 Amino acid derivatives
FR2680173A1 (en) * 1991-08-07 1993-02-12 Hoechst Lab Organic nitrates, processes for preparing them and their use in the treatment of cardiovascular diseases
DE4321306A1 (en) * 1993-06-26 1995-01-05 Sanol Arznei Schwarz Gmbh disulfide
US5807847A (en) * 1996-06-04 1998-09-15 Queen's University At Kingston Nitrate esters
ES2142773B1 (en) * 1998-10-07 2001-01-01 Lacer Sa ISOSORBIDA MONONITRATE DERIVATIVES AND THEIR EMPLOYMENT AS VASODILATATING AGENTS WITH DECREASED TOLERANCE.
EP2125695B1 (en) 2007-02-05 2016-10-26 Nicox Science Ireland Nitric oxide donor compounds
EP2149576A1 (en) 2008-07-22 2010-02-03 Lacer, S.A. Isosorbide Nitrates having vasodilating activity
CA2839390C (en) 2011-10-24 2015-09-15 Nicox S.A. Quinone based nitric oxide donating compounds
WO2014169976A1 (en) 2013-04-18 2014-10-23 Nicox Science Ireland Quinone based nitric oxide donating compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3512627A1 (en) * 1985-04-06 1986-10-09 Boehringer Mannheim Gmbh, 6800 Mannheim AMINO-PROPANOL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, USE OF THE SAME AND MEDICINAL PRODUCTS CONTAINING THE SAME

Also Published As

Publication number Publication date
HUT51229A (en) 1990-04-28
PT91702A (en) 1990-03-30
FI894350A0 (en) 1989-09-14
PT91702B (en) 1995-06-30
JP2628756B2 (en) 1997-07-09
DK452989D0 (en) 1989-09-14
DK452989A (en) 1990-03-16
FI894350A (en) 1990-03-16
CZ530389A3 (en) 1998-11-11
HU209716B (en) 1994-10-28
SK280513B6 (en) 2000-03-13
CZ284586B6 (en) 1999-01-13
ES2073418T3 (en) 1995-08-16
IE65918B1 (en) 1995-11-29
PL163343B1 (en) 1994-03-31
YU48302B (en) 1998-05-15
SK530389A3 (en) 2000-03-13
JPH0291054A (en) 1990-03-30
EP0362575A1 (en) 1990-04-11
IE892932L (en) 1990-03-15
HRP920987A2 (en) 1994-04-30
FI95569B (en) 1995-11-15
FI95569C (en) 1996-02-26
ATE121077T1 (en) 1995-04-15
EP0362575B1 (en) 1995-04-12
DE58909173D1 (en) 1995-05-18

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