FI894350A - Method for the preparation of new organic nitrates - Google Patents

Method for the preparation of new organic nitrates Download PDF

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Publication number
FI894350A
FI894350A FI894350A FI894350A FI894350A FI 894350 A FI894350 A FI 894350A FI 894350 A FI894350 A FI 894350A FI 894350 A FI894350 A FI 894350A FI 894350 A FI894350 A FI 894350A
Authority
FI
Finland
Prior art keywords
organic nitrates
preparation
acids
tolerance
new organic
Prior art date
Application number
FI894350A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI894350A0 (en
FI95569B (en
FI95569C (en
Inventor
Joachim Huetter
Eike Noack
Klaus Sandrock
Original Assignee
Sanol Arznei Schwarz Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanol Arznei Schwarz Gmbh filed Critical Sanol Arznei Schwarz Gmbh
Publication of FI894350A0 publication Critical patent/FI894350A0/en
Publication of FI894350A publication Critical patent/FI894350A/en
Publication of FI95569B publication Critical patent/FI95569B/en
Application granted granted Critical
Publication of FI95569C publication Critical patent/FI95569C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C07C327/34—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups with amino groups bound to the same hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton

Abstract

Organic nitrates with a specific structure, consisting of nitrato fatty acids (nitratoalkanoic acids) and sulphur-containing amino acids or peptides, of the general formula <IMAGE> in which the symbols have the meanings specified in the claims. Because of the general structural principle - presence of sulphhydryl groups - they prevent nitrate tolerance or attenuate a tolerance which has already occurred. The compounds are used in medicaments for treating circulatory disorders, high blood pressure, heart failure and for dilating peripheral vessels.
FI894350A 1988-09-15 1989-09-14 Method for the preparation of new organic nitrates FI95569C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3831311 1988-09-15
DE3831311 1988-09-15

Publications (4)

Publication Number Publication Date
FI894350A0 FI894350A0 (en) 1989-09-14
FI894350A true FI894350A (en) 1990-03-16
FI95569B FI95569B (en) 1995-11-15
FI95569C FI95569C (en) 1996-02-26

Family

ID=6362967

Family Applications (1)

Application Number Title Priority Date Filing Date
FI894350A FI95569C (en) 1988-09-15 1989-09-14 Method for the preparation of new organic nitrates

Country Status (15)

Country Link
EP (1) EP0362575B1 (en)
JP (1) JP2628756B2 (en)
AT (1) ATE121077T1 (en)
CZ (1) CZ284586B6 (en)
DE (1) DE58909173D1 (en)
DK (1) DK452989A (en)
ES (1) ES2073418T3 (en)
FI (1) FI95569C (en)
HR (1) HRP920987A2 (en)
HU (1) HU209716B (en)
IE (1) IE65918B1 (en)
PL (1) PL163343B1 (en)
PT (1) PT91702B (en)
SK (1) SK530389A3 (en)
YU (1) YU48302B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5284872A (en) * 1989-09-12 1994-02-08 Schwarz Pharma Ag Nitrato alkanoic acid derivatives, methods for their production, pharmaceutical compositions containing the derivatives and medicinal uses thereof
DE4011505C2 (en) * 1990-04-10 1995-01-12 Sanol Arznei Schwarz Gmbh Nitratoalkanecarboxylic acid derivatives, processes for their preparation and medicaments containing them
NL9001955A (en) * 1990-09-05 1992-04-01 Cedona Pharm Bv NEW THIAZOLIDINE DERIVATIVES.
JP3361836B2 (en) * 1991-07-04 2003-01-07 三共株式会社 Amino acid derivatives
FR2680173A1 (en) * 1991-08-07 1993-02-12 Hoechst Lab Organic nitrates, processes for preparing them and their use in the treatment of cardiovascular diseases
DE4321306A1 (en) * 1993-06-26 1995-01-05 Sanol Arznei Schwarz Gmbh disulfide
US5807847A (en) * 1996-06-04 1998-09-15 Queen's University At Kingston Nitrate esters
ES2142773B1 (en) * 1998-10-07 2001-01-01 Lacer Sa ISOSORBIDA MONONITRATE DERIVATIVES AND THEIR EMPLOYMENT AS VASODILATATING AGENTS WITH DECREASED TOLERANCE.
ES2604562T3 (en) 2007-02-05 2017-03-07 Nicox Science Ireland Nitric Oxide Donor Compounds
EP2149576A1 (en) 2008-07-22 2010-02-03 Lacer, S.A. Isosorbide Nitrates having vasodilating activity
CN103687843B (en) 2011-10-24 2016-11-16 尼科斯科学爱尔兰公司 Quinonyl Nitric oxidedonating compounds
WO2014169976A1 (en) 2013-04-18 2014-10-23 Nicox Science Ireland Quinone based nitric oxide donating compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3512627A1 (en) * 1985-04-06 1986-10-09 Boehringer Mannheim Gmbh, 6800 Mannheim AMINO-PROPANOL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, USE OF THE SAME AND MEDICINAL PRODUCTS CONTAINING THE SAME

Also Published As

Publication number Publication date
JPH0291054A (en) 1990-03-30
EP0362575A1 (en) 1990-04-11
HRP920987A2 (en) 1994-04-30
HUT51229A (en) 1990-04-28
DK452989D0 (en) 1989-09-14
FI894350A0 (en) 1989-09-14
IE65918B1 (en) 1995-11-29
EP0362575B1 (en) 1995-04-12
CZ284586B6 (en) 1999-01-13
JP2628756B2 (en) 1997-07-09
DE58909173D1 (en) 1995-05-18
HU209716B (en) 1994-10-28
ES2073418T3 (en) 1995-08-16
PT91702A (en) 1990-03-30
IE892932L (en) 1990-03-15
YU176289A (en) 1992-02-20
FI95569B (en) 1995-11-15
DK452989A (en) 1990-03-16
PL163343B1 (en) 1994-03-31
FI95569C (en) 1996-02-26
SK280513B6 (en) 2000-03-13
CZ530389A3 (en) 1998-11-11
YU48302B (en) 1998-05-15
PT91702B (en) 1995-06-30
SK530389A3 (en) 2000-03-13
ATE121077T1 (en) 1995-04-15

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Legal Events

Date Code Title Description
FG Patent granted

Owner name: SCHWARZ PHARMA AG

BB Publication of examined application
MM Patent lapsed

Owner name: SCHWARZ PHARMA AG