YU46436B - Postupak za dobijanje 6-beta (supstituisanih)-s- hidroksimetil-penicilanskih kiselina i njihovih derivata - Google Patents
Postupak za dobijanje 6-beta (supstituisanih)-s- hidroksimetil-penicilanskih kiselina i njihovih derivataInfo
- Publication number
- YU46436B YU46436B YU14488A YU14488A YU46436B YU 46436 B YU46436 B YU 46436B YU 14488 A YU14488 A YU 14488A YU 14488 A YU14488 A YU 14488A YU 46436 B YU46436 B YU 46436B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- penicylic
- hydroxymethyl
- beta
- derivatives
- acids
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/86—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
POSTUPAK ZA DOBIJANJE 6-BETA (SUPSTITUISANIH)-S- HIDROKSIMETIL-PENICILANSKIH KISELINA I NJIHOVIH DERIVATA formule: ili njihovih farmaceutski primenljivih kiselinskih adicionih soli, u kojoj se R1 bira iz grupe koju cine: gde je R2 izabrano iz grupe koju cine propargil, fenil, vinil, alil, ciklopropil, fluoretil, 2-fluormetil, 2-hidroksietil, metoksi, metoksimetil, 2-metoksietil, metiltiometil i 2-tionilmetil, R4 je izabrano iz grupe koju cine vinil, alil i alkil sa 1-3 atoma ugljenika, X je izabrano iz grupe koju cine vodonik, metil, metoksi i fluor i Rb je ostatak estarske grupe koja lako moze hidrolizovati in vivo, izabrana izmedju 3-ftaladil, 4-krotonlaktonil, gama-butirolakton-4-il, gde su R5 i R6 svaki vodonik, metil ili etil, n je 1-5 i R7 je alkil sa 1-6 atoma utljenika, naznacen time, Sto se u prvoj fazi uklanja benzil ili alil grupa iz jedinjenja formule (II): gde je R1 kao Sto je prethodno definisano, R je alil ili benzil, i to alil grupa pomoCu tetrakis (tri fenilfosfin) paladijuma (O) i trifenilfosfina na sobnoj temperaturi i u reakciono inertnom rastvaracu, kao Sto je etilacetat, a benzil grupa hidrogenovanjem u prisustvu paladijuma u reakciono inertnom rastvaracu, kao Sto je tetrahidrofuran, na sobnoj temperaturi, da bi se dobilo jedinjenje formule (I): u kojoj je R1 kao Sto je prethodno definisano, Sto se po Zelji formira njegova farmaceutski prihvatljiva so, kao Sto je so sa alkalnim metalom, i Sto u narednoj fazi reaguje bazna so jedinjenja formule (I): u kojoj je R1 prethodno definisano sa jedinjenjem formule RbQ, gde je Rb prethodno definisano, a Q je halogenid u reakciono inertnom rastvaracu, kao Sto je dimetilformamid, na temperaturi od 0 stepeni C do 100 stepeni C, najpozeljnije na oko 25 stepeni C.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US731987A | 1987-01-27 | 1987-01-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU14488A YU14488A (en) | 1990-02-28 |
| YU46436B true YU46436B (sh) | 1993-10-20 |
Family
ID=21725481
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU14488A YU46436B (sh) | 1987-01-27 | 1988-01-26 | Postupak za dobijanje 6-beta (supstituisanih)-s- hidroksimetil-penicilanskih kiselina i njihovih derivata |
| YU124389A YU47020B (sh) | 1987-01-27 | 1989-06-19 | Postupak za dobijanje 6-beta(supstituisanih)-(s)-hidroksimetil-penicilan skih kiselina i njihovih derivata |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU124389A YU47020B (sh) | 1987-01-27 | 1989-06-19 | Postupak za dobijanje 6-beta(supstituisanih)-(s)-hidroksimetil-penicilan skih kiselina i njihovih derivata |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP0276942B1 (sh) |
| JP (1) | JPS63246384A (sh) |
| KR (1) | KR900005050B1 (sh) |
| CN (1) | CN1014710B (sh) |
| AT (1) | ATE74359T1 (sh) |
| AU (2) | AU590142B2 (sh) |
| CA (1) | CA1288091C (sh) |
| DD (1) | DD279882A5 (sh) |
| DE (1) | DE3869630D1 (sh) |
| DK (1) | DK36788A (sh) |
| ES (1) | ES2031589T3 (sh) |
| FI (1) | FI880334A (sh) |
| GR (1) | GR3004460T3 (sh) |
| HU (1) | HU205765B (sh) |
| IE (1) | IE60348B1 (sh) |
| IL (1) | IL85167A (sh) |
| MY (1) | MY102312A (sh) |
| NO (1) | NO172493C (sh) |
| NZ (1) | NZ223296A (sh) |
| PH (1) | PH24478A (sh) |
| PL (2) | PL159842B1 (sh) |
| PT (1) | PT86613B (sh) |
| SU (2) | SU1591812A3 (sh) |
| YU (2) | YU46436B (sh) |
| ZA (1) | ZA88514B (sh) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE74359T1 (de) * | 1987-01-27 | 1992-04-15 | Pfizer | 6-beta(substituierte)-(s)hydroxymethylpenicillans|ure und deren derivate. |
| WO1998029114A1 (en) * | 1996-12-30 | 1998-07-09 | Bar-Ilan University | Tricarboxylic acid-containing oxyalkyl esters and uses thereof |
| GB0128052D0 (en) * | 2001-11-22 | 2002-01-16 | Drug Discovery Lab As | Compounds |
| US8187727B2 (en) | 2005-07-22 | 2012-05-29 | Lg Chem, Ltd. | Imidazole derivatives, preparation method thereof and organic electronic device using the same |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4272439A (en) * | 1978-06-02 | 1981-06-09 | Schering Corporation | 6-(Substituted-hydroxymethylene penams) |
| US4304779A (en) * | 1979-05-09 | 1981-12-08 | Schering Corporation | 6-(Nitrogen-containing heterocyclic)hydroxymethylpenicillanic acids, compounds related thereto and processes for their preparation |
| US4287181A (en) * | 1979-10-22 | 1981-09-01 | Pfizer Inc. | Derivatives of 6β-hydroxyalkylpenicillanic acids as β-lactamase inhibitors |
| EP0083977A1 (en) * | 1982-01-11 | 1983-07-20 | Pfizer Inc. | 6-Alpha-hydroxymethylpenicillanic acid sulfone as a beta-lactamase inhibitor |
| PT79893B (en) * | 1984-01-30 | 1987-02-03 | Pfizer | Process for preparing 6-(substituted)methylenepenicillanic and 6-(substituted)hydroxymethylpenicilanic and derivatives thereof |
| DE3584015D1 (de) * | 1984-01-30 | 1991-10-17 | Pfizer | 6-(substituierte) methylen-penicillansaeure und 6-(substituierte) hydroxymethyl-penicillansaeure und deren derivate. |
| ATE74359T1 (de) * | 1987-01-27 | 1992-04-15 | Pfizer | 6-beta(substituierte)-(s)hydroxymethylpenicillans|ure und deren derivate. |
-
1988
- 1988-01-20 AT AT88300425T patent/ATE74359T1/de not_active IP Right Cessation
- 1988-01-20 EP EP88300425A patent/EP0276942B1/en not_active Expired - Lifetime
- 1988-01-20 DE DE8888300425T patent/DE3869630D1/de not_active Expired - Fee Related
- 1988-01-20 ES ES198888300425T patent/ES2031589T3/es not_active Expired - Lifetime
- 1988-01-20 MY MYPI88000048A patent/MY102312A/en unknown
- 1988-01-21 IL IL8516788A patent/IL85167A/en not_active IP Right Cessation
- 1988-01-22 AU AU10743/88A patent/AU590142B2/en not_active Ceased
- 1988-01-25 NO NO880297A patent/NO172493C/no unknown
- 1988-01-25 CA CA000557293A patent/CA1288091C/en not_active Expired - Fee Related
- 1988-01-25 PT PT86613A patent/PT86613B/pt not_active IP Right Cessation
- 1988-01-26 YU YU14488A patent/YU46436B/sh unknown
- 1988-01-26 NZ NZ223296A patent/NZ223296A/xx unknown
- 1988-01-26 CN CN88100588A patent/CN1014710B/zh not_active Expired
- 1988-01-26 IE IE19788A patent/IE60348B1/en not_active IP Right Cessation
- 1988-01-26 SU SU884355157A patent/SU1591812A3/ru active
- 1988-01-26 HU HU88293A patent/HU205765B/hu not_active IP Right Cessation
- 1988-01-26 ZA ZA88514A patent/ZA88514B/xx unknown
- 1988-01-26 PL PL1988270301A patent/PL159842B1/pl unknown
- 1988-01-26 FI FI880334A patent/FI880334A/fi not_active IP Right Cessation
- 1988-01-26 PL PL88292979A patent/PL161601B1/pl unknown
- 1988-01-26 DK DK036788A patent/DK36788A/da not_active Application Discontinuation
- 1988-01-26 PH PH36405A patent/PH24478A/en unknown
- 1988-01-26 KR KR8800565A patent/KR900005050B1/ko not_active IP Right Cessation
- 1988-01-27 JP JP63016775A patent/JPS63246384A/ja active Pending
- 1988-01-27 DD DD88312469A patent/DD279882A5/de not_active IP Right Cessation
- 1988-11-25 SU SU884356907A patent/SU1681730A3/ru active
-
1989
- 1989-06-19 YU YU124389A patent/YU47020B/sh unknown
-
1990
- 1990-01-25 AU AU48832/90A patent/AU613821B2/en not_active Ceased
-
1992
- 1992-04-29 GR GR920400826T patent/GR3004460T3/el unknown
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