YU45086A - Process for producing 2-amino-3-nitro-6-(4-fluorine-benzylamino)pyridine and 2-amino-3-carbetoxi-amino 6-(4-fluorine-benzylamino)-pyridine - Google Patents
Process for producing 2-amino-3-nitro-6-(4-fluorine-benzylamino)pyridine and 2-amino-3-carbetoxi-amino 6-(4-fluorine-benzylamino)-pyridineInfo
- Publication number
- YU45086A YU45086A YU00450/86A YU45086A YU45086A YU 45086 A YU45086 A YU 45086A YU 00450/86 A YU00450/86 A YU 00450/86A YU 45086 A YU45086 A YU 45086A YU 45086 A YU45086 A YU 45086A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- amino
- pyridine
- benzylamino
- fluorine
- nitro
- Prior art date
Links
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title 3
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 title 1
- IIFVWLUQBAIPMJ-UHFFFAOYSA-N (4-fluorophenyl)methanamine Chemical compound NCC1=CC=C(F)C=C1 IIFVWLUQBAIPMJ-UHFFFAOYSA-N 0.000 abstract 1
- RDJILYVRVOTMTQ-UHFFFAOYSA-N 6-methoxy-3-nitropyridin-2-amine Chemical compound COC1=CC=C([N+]([O-])=O)C(N)=N1 RDJILYVRVOTMTQ-UHFFFAOYSA-N 0.000 abstract 1
- ZVCIIRBNNSUNCH-UHFFFAOYSA-N 6-n-[(4-fluorophenyl)methyl]-3-nitropyridine-2,6-diamine Chemical compound C1=C([N+]([O-])=O)C(N)=NC(NCC=2C=CC(F)=CC=2)=C1 ZVCIIRBNNSUNCH-UHFFFAOYSA-N 0.000 abstract 1
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3510623 | 1985-03-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU45086A true YU45086A (en) | 1988-02-29 |
Family
ID=6266157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU00450/86A YU45086A (en) | 1985-03-23 | 1986-03-21 | Process for producing 2-amino-3-nitro-6-(4-fluorine-benzylamino)pyridine and 2-amino-3-carbetoxi-amino 6-(4-fluorine-benzylamino)-pyridine |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US4785110A (enExample) |
| EP (1) | EP0199951B1 (enExample) |
| JP (1) | JPS61221172A (enExample) |
| KR (1) | KR860007214A (enExample) |
| AT (1) | ATE60322T1 (enExample) |
| AU (1) | AU579922B2 (enExample) |
| BR (1) | BR8601283A (enExample) |
| CA (1) | CA1273343A (enExample) |
| CS (1) | CS259887B2 (enExample) |
| DD (1) | DD246761A5 (enExample) |
| DE (1) | DE3677042D1 (enExample) |
| DK (1) | DK162215C (enExample) |
| ES (1) | ES8702893A1 (enExample) |
| FI (1) | FI84819C (enExample) |
| GR (1) | GR860745B (enExample) |
| HU (1) | HU206679B (enExample) |
| IE (1) | IE58560B1 (enExample) |
| IL (1) | IL78218A (enExample) |
| NO (1) | NO860825L (enExample) |
| PL (1) | PL146631B1 (enExample) |
| PT (1) | PT82235B (enExample) |
| TR (1) | TR22924A (enExample) |
| YU (1) | YU45086A (enExample) |
| ZA (1) | ZA862138B (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI855016L (fi) * | 1985-06-28 | 1986-12-29 | Degussa | Synergistisk kombination av flupirtin och 4-acetamido-fenol. |
| DE4327516A1 (de) * | 1993-08-17 | 1995-02-23 | Asta Medica Ag | Primäre und sekundäre neuroprotektive Wirkung bei neurodegenerativen Erkrankungen von Flupirtin |
| WO2004069802A1 (ja) * | 2003-02-06 | 2004-08-19 | Shionogi & Co., Ltd. | ２－アミノ－３－置換ピリジンの製造方法 |
| US20080279930A1 (en) * | 2007-05-07 | 2008-11-13 | Bernd Terhaag | Controlled-Release Flupirtine Compositions, Compacts, Kits and Methods of Making and Use Thereof |
| EP2206699A1 (en) | 2008-12-24 | 2010-07-14 | AWD.pharma GmbH & Co.KG | Crystalline form of flupirtine ((2-amino-6-(4-fluoro-benzylamino)-pyridin-3-yl)-carbamic acid ethyl ester) |
| EP2206700A1 (en) | 2008-12-24 | 2010-07-14 | AWD.pharma GmbH & Co.KG | Crystalline form of flupirtine ((2-amino-6-(4-fluoro-benzylamino)-pyridin-3-yl)-carbamic acid ethyl ester) |
| EP2206701A1 (en) | 2008-12-24 | 2010-07-14 | AWD.pharma GmbH & Co.KG | Crystalline form of flupirtine ((2-amino-6-(4-fluoro-benzylamino)-pyridin-3-yl)-carbamic acid ethyl ester) |
| DE102009023162B4 (de) * | 2009-05-29 | 2011-07-07 | Corden PharmaChem GmbH, 68305 | Verfahren zur Herstellung von Flupirtin |
| CN102140077A (zh) * | 2010-01-28 | 2011-08-03 | 范扶民 | 氟吡汀a晶型及其制备方法 |
| WO2013080215A1 (en) | 2011-11-30 | 2013-06-06 | Arch Pharmalabs Limited | An improved process for the preparation of flupirtine and pharmaceutically acceptable salts thereof |
| CN104083335B (zh) * | 2013-07-31 | 2015-11-11 | 成都苑东药业有限公司 | 一种马来酸氟吡汀胶囊组合物及其制备方法 |
| DE102017007385A1 (de) | 2017-08-02 | 2019-02-07 | Christoph Hoock | Maleatfreie feste Arzneimittelformen |
| CN121021385A (zh) * | 2025-10-28 | 2025-11-28 | 山东道可化学有限公司 | 一种2-氨基-3-氯-5-三氟甲基吡啶的合成方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE764362R (en) * | 1966-05-12 | 1971-09-16 | Degussa | Subst amino pyridienes production |
| DE1670522C3 (de) * | 1966-05-12 | 1978-08-31 | Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt | Neue Benzylaminopyridine |
| US4481205A (en) * | 1980-09-13 | 1984-11-06 | Degussa Aktiengesellschaft | 2-Amino-3-carbethoxyamino-6-(p-fluoro-benzylamino)-pyridine-maleate |
| ATE25078T1 (de) * | 1982-10-27 | 1987-02-15 | Degussa | 2-amino-3-acylamino-6-benzylamino-pyridinderivate mit anti-epileptischer wirkung. |
-
1986
- 1986-03-05 NO NO860825A patent/NO860825L/no unknown
- 1986-03-15 EP EP86103517A patent/EP0199951B1/de not_active Expired - Lifetime
- 1986-03-15 AT AT86103517T patent/ATE60322T1/de not_active IP Right Cessation
- 1986-03-15 DE DE8686103517T patent/DE3677042D1/de not_active Expired - Lifetime
- 1986-03-19 DK DK126886A patent/DK162215C/da not_active IP Right Cessation
- 1986-03-20 FI FI861183A patent/FI84819C/fi not_active IP Right Cessation
- 1986-03-20 GR GR860745A patent/GR860745B/el unknown
- 1986-03-21 IL IL78218A patent/IL78218A/xx unknown
- 1986-03-21 ZA ZA862138A patent/ZA862138B/xx unknown
- 1986-03-21 ES ES553222A patent/ES8702893A1/es not_active Expired
- 1986-03-21 IE IE74686A patent/IE58560B1/en not_active IP Right Cessation
- 1986-03-21 DD DD86288169A patent/DD246761A5/de unknown
- 1986-03-21 AU AU54997/86A patent/AU579922B2/en not_active Expired
- 1986-03-21 CS CS861986A patent/CS259887B2/cs unknown
- 1986-03-21 BR BR8601283A patent/BR8601283A/pt not_active IP Right Cessation
- 1986-03-21 PL PL1986258543A patent/PL146631B1/pl unknown
- 1986-03-21 PT PT82235A patent/PT82235B/pt unknown
- 1986-03-21 CA CA000504732A patent/CA1273343A/en not_active Expired - Lifetime
- 1986-03-21 YU YU00450/86A patent/YU45086A/xx unknown
- 1986-03-22 KR KR1019860002142A patent/KR860007214A/ko not_active Withdrawn
- 1986-03-22 TR TR163/86A patent/TR22924A/xx unknown
- 1986-03-24 HU HU861216A patent/HU206679B/hu unknown
- 1986-03-24 JP JP61064292A patent/JPS61221172A/ja active Granted
- 1986-03-24 US US06/843,253 patent/US4785110A/en not_active Expired - Lifetime
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