YU42628B - Process for obtaining 2-substituted 4-amino-6,7-dimethoxyquinoline - Google Patents

Process for obtaining 2-substituted 4-amino-6,7-dimethoxyquinoline

Info

Publication number
YU42628B
YU42628B YU1572/83A YU157283A YU42628B YU 42628 B YU42628 B YU 42628B YU 1572/83 A YU1572/83 A YU 1572/83A YU 157283 A YU157283 A YU 157283A YU 42628 B YU42628 B YU 42628B
Authority
YU
Yugoslavia
Prior art keywords
dimethoxyquinoline
amino
substituted
obtaining
Prior art date
Application number
YU1572/83A
Other languages
English (en)
Other versions
YU157283A (en
Inventor
S F Cmpbell
J D Hardstons
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of YU157283A publication Critical patent/YU157283A/xx
Publication of YU42628B publication Critical patent/YU42628B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/195—Radicals derived from nitrogen analogues of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
YU1572/83A 1982-07-24 1983-07-22 Process for obtaining 2-substituted 4-amino-6,7-dimethoxyquinoline YU42628B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8221457 1982-07-24

Publications (2)

Publication Number Publication Date
YU157283A YU157283A (en) 1986-02-28
YU42628B true YU42628B (en) 1988-10-31

Family

ID=10531886

Family Applications (1)

Application Number Title Priority Date Filing Date
YU1572/83A YU42628B (en) 1982-07-24 1983-07-22 Process for obtaining 2-substituted 4-amino-6,7-dimethoxyquinoline

Country Status (26)

Country Link
US (3) US4656174A (de)
EP (1) EP0100200B1 (de)
JP (1) JPS5933264A (de)
KR (1) KR880001315B1 (de)
AU (1) AU548036B2 (de)
CA (1) CA1255670A (de)
CS (1) CS247073B2 (de)
DD (1) DD211555A5 (de)
DE (1) DE3371336D1 (de)
DK (1) DK166821B1 (de)
ES (1) ES8504131A1 (de)
FI (1) FI78296C (de)
GR (1) GR79603B (de)
HK (1) HK32289A (de)
HU (1) HU190907B (de)
IE (1) IE55798B1 (de)
IL (1) IL69311A (de)
NO (1) NO171594C (de)
NZ (1) NZ204996A (de)
PH (1) PH19424A (de)
PL (1) PL139498B1 (de)
PT (1) PT77082B (de)
SG (1) SG6489G (de)
SU (2) SU1251801A3 (de)
YU (1) YU42628B (de)
ZA (1) ZA835355B (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT384218B (de) * 1985-12-04 1987-10-12 Gerot Pharmazeutika Verfahren zur herstellung von neuen chinazolin-derivaten
GB8716972D0 (en) * 1987-07-17 1987-08-26 Pfizer Ltd Treatment of cardiac arrhythmias
GB8719378D0 (en) * 1987-08-15 1987-09-23 Pfizer Ltd Antiarrythmic agents
US4882337A (en) * 1988-08-12 1989-11-21 Pfizer Inc. Tetrahydroisoquinoline antiarrhythmic agents
US5304554A (en) * 1990-04-27 1994-04-19 Emory University 4-[(alkyl or dialkyl)amino]quinolines and their method of preparation
US5270323A (en) * 1990-05-31 1993-12-14 Pfizer Inc. Method of treating impotence
PT100905A (pt) * 1991-09-30 1994-02-28 Eisai Co Ltd Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem
TW304945B (de) * 1992-06-27 1997-05-11 Hoechst Ag
RU2118322C1 (ru) * 1993-07-05 1998-08-27 Дюфар Интернэшнл Рисерч Б.В. 2,3-дигидро-1,4-бензодиокси-5-ил-пиперазиновые производные или их соли
US6143746A (en) * 1994-01-21 2000-11-07 Icos Corporation Tetracyclic cyclic GMP-specific phosphodiesterase inhibitors, process of preparation and use
GB9514465D0 (en) * 1995-07-14 1995-09-13 Glaxo Lab Sa Chemical compounds
GB9514464D0 (en) 1995-07-14 1995-09-13 Glaxo Lab Sa Medicaments
GB9514473D0 (en) * 1995-07-14 1995-09-13 Glaxo Lab Sa Chemical compounds
NZ325248A (en) 1995-12-23 1999-09-29 Pfizer Res & Dev Quinoline and quinazoline compounds useful in therapy
YU49898A (sh) 1996-05-10 2000-03-21 Icos Corporation Hemijska jedinjenja
GB9700504D0 (en) * 1997-01-11 1997-02-26 Pfizer Ltd Pharmaceutical compounds
GB9708917D0 (en) * 1997-05-01 1997-06-25 Pfizer Ltd Compounds useful in therapy
GB9711650D0 (en) * 1997-06-05 1997-07-30 Pfizer Ltd Compounds useful in therapy
MXPA03000458A (es) 2000-07-20 2004-06-02 Neurogen Corp Ligandos receptores de capsaicina.
DE10035928A1 (de) * 2000-07-21 2002-03-07 Asta Medica Ag Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel
EP1178036A1 (de) * 2000-08-04 2002-02-06 Aventis Cropscience S.A. Fungizide Phenylimidate-Derivate
US6900220B2 (en) 2001-01-02 2005-05-31 Syntex (U.S.A.) Llc Quinazolone derivatives as alpha 1A/B adrenergic receptor antagonists
KR100420663B1 (ko) * 2001-01-09 2004-03-02 주식회사 켐온 퀴놀린 유도체, 그의 제조방법 및 그를 포함하는 약학적조성물
US6734303B2 (en) 2001-05-18 2004-05-11 Pfizer Inc. Process for the production of quinazolines
US7084156B2 (en) * 2001-11-27 2006-08-01 Merck & Co., Inc. 2-Aminoquinoline compounds
CN102743382B (zh) * 2005-09-19 2016-12-07 诺伊罗纳森特公司 刺激神经形成和抑制神经元变性的方法和组合物
AU2013211455B2 (en) * 2005-09-19 2017-12-07 Neuronascent, Inc. Methods and compositions for stimulating neurogenesis and inhibiting neuronal degeneration
EP2101772B1 (de) * 2006-12-06 2012-04-25 Cornell Research Foundation, Inc. Neuromuskuläre blocker mit mittlerer dauer und antagonisten advon
WO2010107488A1 (en) 2009-03-17 2010-09-23 Cornell University Reversible nondepolarizing neuromuscular blockade agents and methods for their use
US9220700B2 (en) 2009-08-19 2015-12-29 Cornell University Cysteine for physiological injection
ES2584702T3 (es) 2012-06-20 2016-09-28 Novartis Ag Moduladores de ruta del complemento y usos de los mismos
TWI649308B (zh) * 2013-07-24 2019-02-01 小野藥品工業股份有限公司 喹啉衍生物

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB890533A (en) * 1959-11-09 1962-03-07 Allen & Hanburys Ltd Improvements in or relating to heterocyclic quaternary ammonium salts
CH414637A (de) * 1962-08-31 1966-06-15 Geigy Ag J R Verfahren zur Herstellung von Carbostyrilderivaten
US3272824A (en) * 1962-12-06 1966-09-13 Norwich Pharma Co 4-amino-6, 7-di(lower) alkoxyquinolines
US3542785A (en) * 1967-05-15 1970-11-24 Ciba Geigy Corp 2-hydroxy-4-aryl-quinolines
US3517005A (en) * 1967-10-26 1970-06-23 Pfizer & Co C Certain 2- and 4-substituted quinazolines
US3511836A (en) * 1967-12-13 1970-05-12 Pfizer & Co C 2,4,6,7-tetra substituted quinazolines
US3629418A (en) * 1969-02-14 1971-12-21 Miles Lab Process for producing an anti-depressant effect with piperazine quinolines
GB1383409A (en) * 1972-09-09 1974-02-12 Pfizer Ltd Derivatives of 2-amino- and 4-amino-quinazoline and pharmaceutical compositions containing them
US4035367A (en) * 1974-09-09 1977-07-12 Sandoz, Inc. Hydroxyalkyl-substituted-amino-quinolines
US4188390A (en) * 1977-11-05 1980-02-12 Pfizer Inc. Antihypertensive 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl) piperazin-1-yl or homopiperazin-1-yl]quinazolines
JPS54125688A (en) * 1978-02-27 1979-09-29 Mitsubishi Yuka Yakuhin Kk Novel quinazoline derivative*its manufacture and antihypertensive drug
JPS5480372A (en) * 1977-12-12 1979-06-27 Toray Ind Inc Production of fishing rod made of carbon fiber-reinforced resin
JPS54122283A (en) * 1978-03-13 1979-09-21 Sumitomo Chem Co Ltd Novel quinazoline derivative and its preparation
JPS54128588A (en) * 1978-03-29 1979-10-05 Dainippon Pharmaceut Co Ltd Antidepressive drugs consisting mainly of 2-(1-piperazinyl)- 4-phenylquinoline
JPS54128582A (en) * 1978-03-30 1979-10-05 Sumitomo Chem Co Ltd Novel quinazoline derivative and its preparation
US4287341A (en) * 1979-11-01 1981-09-01 Pfizer Inc. Alkoxy-substituted-6-chloro-quinazoline-2,4-diones
DE3034001A1 (de) * 1980-09-10 1982-04-22 Hoechst Ag, 6000 Frankfurt Isochinolinderivate, verfahren zu ihrer hersellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung

Also Published As

Publication number Publication date
FI832658A0 (fi) 1983-07-21
IL69311A (en) 1987-01-30
ZA835355B (en) 1984-05-30
DD211555A5 (de) 1984-07-18
US4758568A (en) 1988-07-19
HU190907B (en) 1986-12-28
HK32289A (en) 1989-04-28
SU1251801A3 (ru) 1986-08-15
CA1255670A (en) 1989-06-13
GR79603B (de) 1984-10-31
YU157283A (en) 1986-02-28
SU1340589A3 (ru) 1987-09-23
AU548036B2 (en) 1985-11-21
IE55798B1 (en) 1991-01-16
PT77082B (en) 1986-04-11
NO832688L (no) 1984-01-25
FI78296C (fi) 1989-07-10
SG6489G (en) 1989-06-09
KR840005428A (ko) 1984-11-12
KR880001315B1 (ko) 1988-07-23
PT77082A (en) 1983-08-01
CS247073B2 (en) 1986-11-13
FI78296B (fi) 1989-03-31
DE3371336D1 (en) 1987-06-11
US4686228A (en) 1987-08-11
FI832658A (fi) 1984-01-25
EP0100200B1 (de) 1987-05-06
IE831730L (en) 1984-01-24
NO171594C (no) 1993-04-07
EP0100200A1 (de) 1984-02-08
JPS5933264A (ja) 1984-02-23
PH19424A (en) 1986-04-15
AU1722283A (en) 1984-01-26
DK166821B1 (da) 1993-07-19
IL69311A0 (en) 1983-11-30
ES524320A0 (es) 1985-04-16
JPH0219112B2 (de) 1990-04-27
DK337383A (da) 1984-01-25
US4656174A (en) 1987-04-07
PL139498B1 (en) 1987-01-31
PL243131A1 (en) 1984-12-17
NZ204996A (en) 1986-05-09
NO171594B (no) 1992-12-28
ES8504131A1 (es) 1985-04-16
DK337383D0 (da) 1983-07-22

Similar Documents

Publication Publication Date Title
YU157283A (en) Process for obtaining 2-substituted 4-amino-6,7-dimethoxyquinoline
YU312781A (en) Process for obtaining 4-amino-6,7-dimethoxy-2-piperazine quinazoline
YU42031B (en) Process for obtaining antitumoral quinazoline derivatives
ES510685A0 (es) Procedimiento para la obtencion de derivados de quinolinona.
YU123282A (en) Process for the manufacture od quinoline derivatives
ES522089A0 (es) Derivados de quinolina.
DK446483A (da) Fremgangsmaade til fremstilling af 6-substituerede quinolin-5,8-quinoner
GB2146993B (en) Octahydropyrimido4,5-g quinolines
ATE67766T1 (de) Oktahydro-oxazolo(4,5-g>chinoline.
GB2092130B (en) 4-oximino-1,2,3,4-tetrahydroquinoline derivatives
YU34181A (en) Process for obtaining substituted 2-piperidino-4-amino-6,7-dimethoxy-quinazolines
DE3273516D1 (en) Process for making benzimidazoles
ES502465A0 (es) Procedimiento de preparar nuevas triazoloquinoxalin-1,4-dio-nas antialergicas
KE3866A (en) 2-substituted 4-amino-6,7-dimethoxyquinolines
YU176683A (en) Process for obtaining 4-nitro-1,2-hydrocarbyl-pyrazolidine
YU218681A (en) Process for obtaining 2-hydroxymethyl-quinoxaline-1,4-dioxide derivatives
ES521720A0 (es) Procedimiento de obtencion de nuevas carboxamidoguanidinas.
ES503007A0 (es) Procedimiento para la obtencion de 6-aril-4,5-dihidro-3(2h)-piridazinonas
YU206686A (en) Process for preparing 2-substituted 5-nitrozo-4,6-diamino-pyridines
YU201984A (en) Process for obtaining pyrbuterol from n-oxide
AR231435A1 (es) Procedimiento de obtencion de-2-cloro-2,6-dietil-n-metoxi-metil-acetanilida
DE3263811D1 (en) Process for the preparation of 1-acylamino-3,4-phthaloyl-acridones
IL76998A0 (en) 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-chloro-quinoline-3-carboxylic acid
IL76998A (en) 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-chloro-quinoline-3-carboxylic acid
PL231991A1 (en) Method of manufacture of n,n-diethanol-n-alkylglycocoll from n,n-dipolyoxyethylen-n-alkylglycocoll