YU111390A - Supstituisani derivati aminoalkilbenzola - Google Patents

Supstituisani derivati aminoalkilbenzola

Info

Publication number
YU111390A
YU111390A YU111390A YU111390A YU111390A YU 111390 A YU111390 A YU 111390A YU 111390 A YU111390 A YU 111390A YU 111390 A YU111390 A YU 111390A YU 111390 A YU111390 A YU 111390A
Authority
YU
Yugoslavia
Prior art keywords
carbon atoms
lower alkyl
denotes
denote
halogen
Prior art date
Application number
YU111390A
Other languages
English (en)
Other versions
YU48452B (sh
Inventor
P. Guerry
S. Jolidon
R. Zurflueh
Original Assignee
F. Hoffmann-La Roche Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag. filed Critical F. Hoffmann-La Roche Ag.
Publication of YU111390A publication Critical patent/YU111390A/sh
Priority to HR930493A priority Critical patent/HRP930493A2/xx
Publication of YU48452B publication Critical patent/YU48452B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/04—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated
    • C07C225/08—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and containing rings
    • C07C225/12—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and containing rings with doubly-bound oxygen atoms bound to carbon atoms being part of rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
    • C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Lubricants (AREA)
  • Fats And Perfumes (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Saccharide Compounds (AREA)

Abstract

SUPSTITUISANI DERIVATI AMINOALKILBENZOLA. Jedinjenja opšte formule u kojoj R1 i R2 označavaju svaki posebno vodnik, niži alki ili niži alkenil ili zajedno označavaju pravolančani alkilen sa 2 do 4 atoma ugljenika, R3 označava vodonik, halogen ili niži alkil, Q označava alkilen sa 2 do 11 atoma ugljenika i najmanje dva atoma ugljenika izmedju dve slobodne valence ili alkenilen sa 4 do 11 atoma ugljenika i najmanje 4 atoma ugljenika izmedju dve slobodne valence i Y i Y označavaju svaki posebno jednu direktnu vezu ili grupu -CH2-,-CH2CH2-, -CH=CH- ili -C=C-, pri čemu je grupa R1R2N-Q-CN2-vezana u položaju 3 4 prstena koji je obeležen simbolom A, i simbol R znači da je dotični prsten nesupstituisan ili supstituisan helogenom, trifluormetilom, cijan-grupom, nitrogrupom, nižim alkilom ili nižom alkoksi-grupom, i njihove farmaceutski prihvatljive kiselinske adicione soli imaju dragocene farmakološke osobine. Ona poseduju naročito jako izraženo antifungalno dejstvo i pokazuju sinergetske efekte u kombinaciji sa poznatim, antifungalno delujućim supstancama, koje sprečavaju sterolni biosintezu, kao što su ketokonazol i terbinafin. Ova jedinjenja formule I prema tome se mogu primeniti kao lekovi, naročito za suzbijanje ili sprečavanje topičkih ili sistemskih infekcija, koje su prouzrokovane patogenim gljivama.
YU111390A 1989-06-08 1990-06-07 Supstituisani derivati aminoalkil benzola i postupak za njihovo spravljanje YU48452B (sh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
HR930493A HRP930493A2 (en) 1989-06-08 1993-03-24 Substituted aminoalkylbenzene derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH215989 1989-06-08
CH89090 1990-03-19

Publications (2)

Publication Number Publication Date
YU111390A true YU111390A (sh) 1992-09-07
YU48452B YU48452B (sh) 1998-08-14

Family

ID=25686023

Family Applications (1)

Application Number Title Priority Date Filing Date
YU111390A YU48452B (sh) 1989-06-08 1990-06-07 Supstituisani derivati aminoalkil benzola i postupak za njihovo spravljanje

Country Status (24)

Country Link
US (1) US5137920A (sh)
EP (1) EP0401798B1 (sh)
JP (1) JPH0742257B2 (sh)
KR (1) KR100195648B1 (sh)
AT (1) ATE116963T1 (sh)
AU (1) AU633923B2 (sh)
CA (1) CA2016738A1 (sh)
CS (1) CS276440B6 (sh)
DE (1) DE59008219D1 (sh)
DK (1) DK0401798T3 (sh)
DZ (1) DZ1424A1 (sh)
ES (1) ES2066907T3 (sh)
FI (1) FI102167B (sh)
GR (1) GR3015715T3 (sh)
HU (1) HUT58278A (sh)
IE (1) IE65830B1 (sh)
IL (1) IL94605A (sh)
MC (1) MC2130A1 (sh)
MY (1) MY106220A (sh)
NO (1) NO173136C (sh)
NZ (1) NZ233901A (sh)
PH (1) PH27360A (sh)
PT (1) PT94310B (sh)
YU (1) YU48452B (sh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1250436B (it) * 1991-07-01 1995-04-07 Mini Ricerca Scient Tecnolog Benzofenoni ad azione antifungina
TW438774B (en) * 1993-07-14 2001-06-07 Hoffmann La Roche Pharmaceutical composition for lowering cholesterol containing phenalkylamines and certain novel phenalkylamines
GB9509631D0 (en) * 1995-05-12 1995-07-05 Sandoz Ltd Antifungal combination
CA2190699A1 (en) 1995-12-08 1997-06-09 Johannes Aebi Tertiary amines
EP1456171B1 (en) * 2001-12-12 2006-12-20 F. Hoffmann-La Roche Ag Substituted cyclohexane derivatives

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3123643A (en) * 1964-03-03 Basic - substituted x a alkyl triphenyl-
US1894865A (en) * 1930-08-28 1933-01-17 Soc Of Chemical Ind Basic ether of aromatic ketones
US2668850A (en) * 1952-04-24 1954-02-09 Hoffmann La Roche Phenyl-phenethyl ketones
US2668813A (en) * 1952-07-21 1954-02-09 Hoffmann La Roche Basic ketones and salts thereof
US2796435A (en) * 1955-02-16 1957-06-18 Hoffmann La Roche Derivatives of 4(diethylaminoethoxy)-diphenylpropane
GB923727A (en) * 1960-02-04 1963-04-18 Wellcome Found Benzoylphenalkyl quaternary ammonium compounds and their preparation
US3312696A (en) * 1964-02-20 1967-04-04 Turbanti Luigi 2-tertiary amino alkoxy-betaphenyl-propiophenones
US3494961A (en) * 1965-03-12 1970-02-10 Hoffmann La Roche 1,4-bis-(p-(dialkylaminoalkoxy)aryl)-1,4-bis-(aryl)-2-b-1,4-diols
US3553332A (en) * 1967-06-27 1971-01-05 Hoffmann La Roche Anti-tubercular benzophenone derivatives
US3864501A (en) * 1973-10-10 1975-02-04 Us Agriculture Method of enhancing coloration of fruits and vegetables with a dialhylamino-alkoxybenzene
US4216326A (en) * 1975-01-20 1980-08-05 Sterling Drug Inc. Intermediates for preparing anti-inflammatory phenyl-lower-alkylamines
DD158237A1 (de) * 1981-04-21 1983-01-05 Helmut Roehnert Verfahren zur herstellung von substituierten[2-(aminomethyl)-phenyl]-phenylmethanonen
HU187208B (en) * 1982-12-28 1985-11-28 Richter Gedeon Vegyeszet Process for production of new dialcil-amino-alcoxi-benzoalcohole derivates, their acid additional and quaterner soils and medical preparates consisting of them
HU187204B (en) * 1982-12-28 1985-11-28 Richter Gedeon Vegyeszet Process for producing new diethyl-amino-alkoxy-benzhydrol derivatives, acid additional salts, and quaternary salts and pharmaceutical compositions contatining them
US4568695A (en) * 1983-12-07 1986-02-04 A. H. Robins Company, Incorporated 2-Amino-3-benzoyl-phenethylalcohols and intermediates therefor
DE3512179A1 (de) * 1985-04-03 1986-12-04 Merck Patent Gmbh, 6100 Darmstadt Fotoinitiatoren fuer die fotopolymerisation in waessrigen systemen

Also Published As

Publication number Publication date
YU48452B (sh) 1998-08-14
DE59008219D1 (de) 1995-02-23
AU633923B2 (en) 1993-02-11
IE65830B1 (en) 1995-11-15
IL94605A0 (en) 1991-04-15
IL94605A (en) 1997-04-15
JPH0324043A (ja) 1991-02-01
EP0401798A2 (de) 1990-12-12
US5137920A (en) 1992-08-11
MC2130A1 (fr) 1992-01-03
MY106220A (en) 1995-04-29
CS276440B6 (en) 1992-05-13
JPH0742257B2 (ja) 1995-05-10
ES2066907T3 (es) 1995-03-16
PH27360A (en) 1993-06-21
FI902769A0 (fi) 1990-06-04
FI102167B1 (fi) 1998-10-30
PT94310A (pt) 1991-02-08
NZ233901A (en) 1993-03-26
PT94310B (pt) 1997-01-31
DZ1424A1 (fr) 2004-09-13
KR910000618A (ko) 1991-01-29
NO902528L (no) 1990-12-10
NO173136B (no) 1993-07-26
DK0401798T3 (da) 1995-05-01
FI102167B (fi) 1998-10-30
AU5626190A (en) 1990-12-13
KR100195648B1 (ko) 1999-06-15
CA2016738A1 (en) 1990-12-08
NO902528D0 (no) 1990-06-07
GR3015715T3 (en) 1995-07-31
ATE116963T1 (de) 1995-01-15
NO173136C (no) 1993-11-03
CS283190A3 (en) 1992-01-15
EP0401798B1 (de) 1995-01-11
IE902041L (en) 1990-12-08
HU903315D0 (en) 1990-10-28
HUT58278A (en) 1992-02-28
EP0401798A3 (de) 1992-03-11

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