ES2066907T3 - Derivados sustituidos de aminoalquilbenceno. - Google Patents

Derivados sustituidos de aminoalquilbenceno.

Info

Publication number
ES2066907T3
ES2066907T3 ES90110724T ES90110724T ES2066907T3 ES 2066907 T3 ES2066907 T3 ES 2066907T3 ES 90110724 T ES90110724 T ES 90110724T ES 90110724 T ES90110724 T ES 90110724T ES 2066907 T3 ES2066907 T3 ES 2066907T3
Authority
ES
Spain
Prior art keywords
carbon atoms
lower alkyl
denotes
denote
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90110724T
Other languages
English (en)
Inventor
Philippe Dr Guerry
Synese Dr Jolidon
Rene Dr Zurfluh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2066907T3 publication Critical patent/ES2066907T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/04—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated
    • C07C225/08—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and containing rings
    • C07C225/12—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and containing rings with doubly-bound oxygen atoms bound to carbon atoms being part of rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
    • C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Lubricants (AREA)
  • Fats And Perfumes (AREA)
  • Saccharide Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

Abstract

LOS COMPUESTOS DE FORMULA GENERAL (FORMULA) - EN DONDE R1 Y R2 SIGNIFICAN CADA UNO HIDROGENO, UN ALQUILO O ALQUENILO INFERIOR, O FORMAN JUNTOS UN ALQUILENO LINEAL DE 2-4 ATOMOS DE C; R3 SIGNIFICA HIDROGENO, HALOGENO O UN ALQUILO INFERIOR; Q UN ALQUILENO CON 2 A 11 ATOMOS DE C Y AL MENOS 2 ATOMOS DE C ENTRE LAS DOS VALENCIAS LIBRES, O BIEN ALQUENILOS CON 4 A 11 ATOMOS DE C Y AL MENOS 4 ATOMOS DE C ENTRE LAS DOS VALENCIAS LIBRES; Y E Y'' CADA UNA UN ENLACE DIRECTO O UN GRUPO -CH2-, -CH2CH2-, -CH=CH- O -C(TRIPLE ENLACE)C-, ESTANDO UNIDO EL GRUPO R1R2N-Q-CH2- A LA 3 O 4 POSICION DEL ANILLO DESIGNADO POR A Y SIGNIFICANDO EL SIMBOLO R QUE EL ANILLO NO ESTA SUSTITUIDO O ESTA SUSTITUIDO POR HALOGENO, TRIFLUOROMETILO, CIANO, NITRO, ALQUILO INFERIOR O ALCOXI INFERIOR - Y SUS SALES DE ADICION CON ACIDOS, TOLERABLES FISIOLOGICAMENTE, POSEEN VALIOSAS PROPIEDADES FARMACOLOGICAS. POSEEN ESPECIALMENTE UNA ACUSADA ACCION ANTIFUNGICA Y PRESENTAN EFECTOS SINERGISTICOS EN COMBINACION CON SUSTANCIAS ANTIFUNGICAS YA CONOCIDAS, QUE INHIBEN LA BIOSINTESIS DE LOS ESTEROLES, TALES COMO KETOCONAZOL Y TERBINAFINA. POR TANTO, LOS COMPUESTOS DE FORMULA I PUEDEN UTILIZARSE ESPECIALMENTE COMO FARMACOS PARA COMBATIR O PREVENIR INFECCIONES TOPICAS O SISTEMICAS, OCASIONADAS POR HONGOS PATOGENOS.
ES90110724T 1989-06-08 1990-06-06 Derivados sustituidos de aminoalquilbenceno. Expired - Lifetime ES2066907T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH215989 1989-06-08
CH89090 1990-03-19

Publications (1)

Publication Number Publication Date
ES2066907T3 true ES2066907T3 (es) 1995-03-16

Family

ID=25686023

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90110724T Expired - Lifetime ES2066907T3 (es) 1989-06-08 1990-06-06 Derivados sustituidos de aminoalquilbenceno.

Country Status (24)

Country Link
US (1) US5137920A (es)
EP (1) EP0401798B1 (es)
JP (1) JPH0742257B2 (es)
KR (1) KR100195648B1 (es)
AT (1) ATE116963T1 (es)
AU (1) AU633923B2 (es)
CA (1) CA2016738A1 (es)
CS (1) CS276440B6 (es)
DE (1) DE59008219D1 (es)
DK (1) DK0401798T3 (es)
DZ (1) DZ1424A1 (es)
ES (1) ES2066907T3 (es)
FI (1) FI102167B1 (es)
GR (1) GR3015715T3 (es)
HU (1) HUT58278A (es)
IE (1) IE65830B1 (es)
IL (1) IL94605A (es)
MC (1) MC2130A1 (es)
MY (1) MY106220A (es)
NO (1) NO173136C (es)
NZ (1) NZ233901A (es)
PH (1) PH27360A (es)
PT (1) PT94310B (es)
YU (1) YU48452B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1250436B (it) * 1991-07-01 1995-04-07 Mini Ricerca Scient Tecnolog Benzofenoni ad azione antifungina
TW438774B (en) * 1993-07-14 2001-06-07 Hoffmann La Roche Pharmaceutical composition for lowering cholesterol containing phenalkylamines and certain novel phenalkylamines
GB9509631D0 (en) * 1995-05-12 1995-07-05 Sandoz Ltd Antifungal combination
CA2190699A1 (en) * 1995-12-08 1997-06-09 Johannes Aebi Tertiary amines
CN100503560C (zh) * 2001-12-12 2009-06-24 霍夫曼-拉罗奇有限公司 取代的环己烷衍生物

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3123643A (en) * 1964-03-03 Basic - substituted x a alkyl triphenyl-
US1894865A (en) * 1930-08-28 1933-01-17 Soc Of Chemical Ind Basic ether of aromatic ketones
US2668813A (en) * 1952-07-21 1954-02-09 Hoffmann La Roche Basic ketones and salts thereof
US2668850A (en) * 1952-04-24 1954-02-09 Hoffmann La Roche Phenyl-phenethyl ketones
US2796435A (en) * 1955-02-16 1957-06-18 Hoffmann La Roche Derivatives of 4(diethylaminoethoxy)-diphenylpropane
GB923727A (en) * 1960-02-04 1963-04-18 Wellcome Found Benzoylphenalkyl quaternary ammonium compounds and their preparation
US3312696A (en) * 1964-02-20 1967-04-04 Turbanti Luigi 2-tertiary amino alkoxy-betaphenyl-propiophenones
US3494961A (en) * 1965-03-12 1970-02-10 Hoffmann La Roche 1,4-bis-(p-(dialkylaminoalkoxy)aryl)-1,4-bis-(aryl)-2-b-1,4-diols
US3553332A (en) * 1967-06-27 1971-01-05 Hoffmann La Roche Anti-tubercular benzophenone derivatives
US3864501A (en) * 1973-10-10 1975-02-04 Us Agriculture Method of enhancing coloration of fruits and vegetables with a dialhylamino-alkoxybenzene
US4216326A (en) * 1975-01-20 1980-08-05 Sterling Drug Inc. Intermediates for preparing anti-inflammatory phenyl-lower-alkylamines
DD158237A1 (de) * 1981-04-21 1983-01-05 Helmut Roehnert Verfahren zur herstellung von substituierten[2-(aminomethyl)-phenyl]-phenylmethanonen
HU187208B (en) * 1982-12-28 1985-11-28 Richter Gedeon Vegyeszet Process for production of new dialcil-amino-alcoxi-benzoalcohole derivates, their acid additional and quaterner soils and medical preparates consisting of them
HU187204B (en) * 1982-12-28 1985-11-28 Richter Gedeon Vegyeszet Process for producing new diethyl-amino-alkoxy-benzhydrol derivatives, acid additional salts, and quaternary salts and pharmaceutical compositions contatining them
US4568695A (en) * 1983-12-07 1986-02-04 A. H. Robins Company, Incorporated 2-Amino-3-benzoyl-phenethylalcohols and intermediates therefor
DE3512179A1 (de) * 1985-04-03 1986-12-04 Merck Patent Gmbh, 6100 Darmstadt Fotoinitiatoren fuer die fotopolymerisation in waessrigen systemen

Also Published As

Publication number Publication date
NO173136C (no) 1993-11-03
YU48452B (sh) 1998-08-14
IE902041L (en) 1990-12-08
DZ1424A1 (fr) 2004-09-13
IL94605A0 (en) 1991-04-15
CA2016738A1 (en) 1990-12-08
DE59008219D1 (de) 1995-02-23
EP0401798A2 (de) 1990-12-12
GR3015715T3 (en) 1995-07-31
HU903315D0 (en) 1990-10-28
AU5626190A (en) 1990-12-13
FI902769A0 (fi) 1990-06-04
JPH0742257B2 (ja) 1995-05-10
YU111390A (sh) 1992-09-07
CS283190A3 (en) 1992-01-15
HUT58278A (en) 1992-02-28
ATE116963T1 (de) 1995-01-15
PT94310A (pt) 1991-02-08
KR100195648B1 (ko) 1999-06-15
IE65830B1 (en) 1995-11-15
IL94605A (en) 1997-04-15
AU633923B2 (en) 1993-02-11
DK0401798T3 (da) 1995-05-01
MY106220A (en) 1995-04-29
PT94310B (pt) 1997-01-31
KR910000618A (ko) 1991-01-29
EP0401798A3 (de) 1992-03-11
NO902528L (no) 1990-12-10
FI102167B (fi) 1998-10-30
MC2130A1 (fr) 1992-01-03
NO902528D0 (no) 1990-06-07
EP0401798B1 (de) 1995-01-11
NO173136B (no) 1993-07-26
CS276440B6 (en) 1992-05-13
NZ233901A (en) 1993-03-26
FI102167B1 (fi) 1998-10-30
JPH0324043A (ja) 1991-02-01
US5137920A (en) 1992-08-11
PH27360A (en) 1993-06-21

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