YU109991A - Aralifatske n-substituisane aminoalkanfosfinske kiseline i postupak za njihovo pripremanje - Google Patents

Aralifatske n-substituisane aminoalkanfosfinske kiseline i postupak za njihovo pripremanje

Info

Publication number
YU109991A
YU109991A YU109991A YU109991A YU109991A YU 109991 A YU109991 A YU 109991A YU 109991 A YU109991 A YU 109991A YU 109991 A YU109991 A YU 109991A YU 109991 A YU109991 A YU 109991A
Authority
YU
Yugoslavia
Prior art keywords
hydrogen
radical
aliphatic
araliphatic
cycloaliphatic
Prior art date
Application number
YU109991A
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English (en)
Serbian (sr)
Original Assignee
Ciba-Geigy Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba-Geigy Ag. filed Critical Ciba-Geigy Ag.
Priority to SI9111099A priority Critical patent/SI9111099B/sl
Publication of YU109991A publication Critical patent/YU109991A/sh
Priority to HR940512A priority patent/HRP940512A2/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/36—Amides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Treating Waste Gases (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Catalysts (AREA)
  • Medicinal Preparation (AREA)

Abstract

ARALIFATSKE N-SUBSTITUISANE AMINOALKANFOSFINSKE KISELINE I POSTUPAK ZA NJIHOVO PRIPREMANJE, aralifatske N-supstituisane aminoalkanfosfinske kiseline formule I u kojoj R1, R1', R2', i R3 označavaju vodonik, R2 predstavlja vodonik ili hidroksi grupu, R4 označava aralifatski ostatak, različiti nesupstituisani 1-fenilnižialkil, ili hetero arilalifatski ostatak, R5 predstavlja vodonik, nižu alkil-grupu ili grupu R4, a R označava alifatski, cikloalifatski, cikloalifatsko-alifatski ili aralifatski ostatak sa najmanje 2 atoma ugljenika, i njihove soli lako upotrebljive za lečenje oblika epilepsije koji spadaju u bolesti poznate kao "petit mal", kao i za sprečavanje stanja sličnih "petit mal-u", koja se lako javljaju pri lečenju sa poznatim antiepilepticima. Sintetizuju se tako što se u jedinjenju formule II u kojoj R1, R1', R2' i R3 označavaju vodonik R6 stoji kao zaštitna grupa hidroksi-grupe, R8 za grupu R5, ili kao zaštitna grupa za amino grupu, a R10 za vodonik ili za zaštićenu hidroksi grupu, pri čemu R, R1, R4 i R5 imaju navedena značenja, ili u njegovoj soli, zamenjuju zaštitne grupe, R6 za hidroksi grupu, sa vodonikom, kako bi se oslobodila hidroksi grupa, a u datom primeru, odcepljuje se zaštitna grupa R8 za amino grupu, a hidroksi grupa R2 se oslobadja iz zaštićene hidroksi grupe R10.
YU109991A 1990-06-22 1991-06-21 Aralifatske n-substituisane aminoalkanfosfinske kiseline i postupak za njihovo pripremanje YU109991A (sh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SI9111099A SI9111099B (en) 1990-06-22 1991-06-21 Process for preparation of araliphatically n-substituted aminoalkanephosphinic acids
HR940512A HRP940512A2 (en) 1990-06-22 1994-09-08 Process for the preparation of aliphactic n-substituted amyloalkansulphonic acids

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH209290 1990-06-22
CH44091 1991-02-13
CH119991 1991-04-22

Publications (1)

Publication Number Publication Date
YU109991A true YU109991A (sh) 1994-06-24

Family

ID=27172107

Family Applications (1)

Application Number Title Priority Date Filing Date
YU109991A YU109991A (sh) 1990-06-22 1991-06-21 Aralifatske n-substituisane aminoalkanfosfinske kiseline i postupak za njihovo pripremanje

Country Status (21)

Country Link
US (3) US5229379A (sh)
EP (1) EP0463560B1 (sh)
JP (1) JP3222487B2 (sh)
KR (1) KR100219315B1 (sh)
AT (1) ATE129500T1 (sh)
AU (1) AU641772B2 (sh)
CA (1) CA2045077C (sh)
DE (1) DE59106756D1 (sh)
DK (1) DK0463560T3 (sh)
ES (1) ES2079520T3 (sh)
FI (1) FI101705B (sh)
GR (1) GR3017895T3 (sh)
HR (1) HRP940512A2 (sh)
HU (1) HUT59148A (sh)
IE (1) IE69314B1 (sh)
IL (3) IL98502A (sh)
NO (1) NO302476B1 (sh)
NZ (2) NZ238636A (sh)
PT (1) PT98064B (sh)
SI (1) SI9111099B (sh)
YU (1) YU109991A (sh)

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Also Published As

Publication number Publication date
HRP940512A2 (en) 1996-04-30
ATE129500T1 (de) 1995-11-15
SI9111099B (en) 2001-06-30
JPH04243829A (ja) 1992-08-31
PT98064B (pt) 1998-10-30
HU912064D0 (en) 1991-12-30
NO912429D0 (no) 1991-06-21
CA2045077A1 (en) 1991-12-23
EP0463560B1 (de) 1995-10-25
IE69314B1 (en) 1996-09-04
KR100219315B1 (ko) 1999-10-01
IL114631A0 (en) 1995-11-27
EP0463560A1 (de) 1992-01-02
IL98502A0 (en) 1992-07-15
HUT59148A (en) 1992-04-28
IE912158A1 (en) 1992-01-01
NZ247934A (en) 1997-07-27
US5407922A (en) 1995-04-18
US5545631A (en) 1996-08-13
JP3222487B2 (ja) 2001-10-29
AU641772B2 (en) 1993-09-30
DE59106756D1 (de) 1995-11-30
SI9111099A (sl) 1998-02-28
AU7922091A (en) 1992-01-02
CA2045077C (en) 2002-08-20
IL114631A (en) 1998-12-06
US5229379A (en) 1993-07-20
GR3017895T3 (en) 1996-01-31
FI912998A0 (fi) 1991-06-19
NO302476B1 (no) 1998-03-09
NZ238636A (en) 1994-12-22
DK0463560T3 (da) 1995-12-04
PT98064A (pt) 1992-04-30
FI912998A (fi) 1991-12-23
FI101705B1 (fi) 1998-08-14
NO912429L (no) 1991-12-23
ES2079520T3 (es) 1996-01-16
KR920000774A (ko) 1992-01-29
FI101705B (fi) 1998-08-14
IL98502A (en) 1998-04-05

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