FI912998A - Foerfarande foer framstaellning av aralifatiskt n-substituerade aminoalkanfosfinsyror. - Google Patents

Foerfarande foer framstaellning av aralifatiskt n-substituerade aminoalkanfosfinsyror. Download PDF

Info

Publication number
FI912998A
FI912998A FI912998A FI912998A FI912998A FI 912998 A FI912998 A FI 912998A FI 912998 A FI912998 A FI 912998A FI 912998 A FI912998 A FI 912998A FI 912998 A FI912998 A FI 912998A
Authority
FI
Finland
Prior art keywords
hydrogen
radical
aliphatic
araliphatic
cycloaliphatic
Prior art date
Application number
FI912998A
Other languages
English (en)
Other versions
FI101705B1 (fi
FI912998A0 (fi
FI101705B (fi
Inventor
Christian Marescaux
Raymond Bernasconi
Markus Schmutz
Wolfgang Froestl
Stuart J Mickel
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of FI912998A0 publication Critical patent/FI912998A0/fi
Publication of FI912998A publication Critical patent/FI912998A/fi
Application granted granted Critical
Publication of FI101705B1 publication Critical patent/FI101705B1/fi
Publication of FI101705B publication Critical patent/FI101705B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/36—Amides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Catalysts (AREA)
  • Treating Waste Gases (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Medicinal Preparation (AREA)
FI912998A 1990-06-22 1991-06-19 Menetelmä aralifaattisesti N-substituoitujen aminoalkaanifosfiinihappo jen valmistamiseksi FI101705B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
CH209290 1990-06-22
CH209290 1990-06-22
CH44091 1991-02-13
CH44091 1991-02-13
CH119991 1991-04-22
CH119991 1991-04-22

Publications (4)

Publication Number Publication Date
FI912998A0 FI912998A0 (fi) 1991-06-19
FI912998A true FI912998A (fi) 1991-12-23
FI101705B1 FI101705B1 (fi) 1998-08-14
FI101705B FI101705B (fi) 1998-08-14

Family

ID=27172107

Family Applications (1)

Application Number Title Priority Date Filing Date
FI912998A FI101705B (fi) 1990-06-22 1991-06-19 Menetelmä aralifaattisesti N-substituoitujen aminoalkaanifosfiinihappo jen valmistamiseksi

Country Status (21)

Country Link
US (3) US5229379A (fi)
EP (1) EP0463560B1 (fi)
JP (1) JP3222487B2 (fi)
KR (1) KR100219315B1 (fi)
AT (1) ATE129500T1 (fi)
AU (1) AU641772B2 (fi)
CA (1) CA2045077C (fi)
DE (1) DE59106756D1 (fi)
DK (1) DK0463560T3 (fi)
ES (1) ES2079520T3 (fi)
FI (1) FI101705B (fi)
GR (1) GR3017895T3 (fi)
HR (1) HRP940512A2 (fi)
HU (1) HUT59148A (fi)
IE (1) IE69314B1 (fi)
IL (3) IL114631A (fi)
NO (1) NO302476B1 (fi)
NZ (2) NZ247934A (fi)
PT (1) PT98064B (fi)
SI (1) SI9111099B (fi)
YU (1) YU109991A (fi)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5457095A (en) * 1984-10-12 1995-10-10 Ciba-Geigy Corporation Substituted propane-phosponous acid compounds
US5567840A (en) * 1989-05-13 1996-10-22 Ciba-Geigy Corporation Substituted aminoalkylphosphinic acids
US5281747A (en) * 1989-05-13 1994-01-25 Ciba-Geigy Corporation Substituted aminoalkylphosphinic acids
EP0767174A1 (de) * 1991-11-21 1997-04-09 Ciba-Geigy Ag Neue Aminoalkanphosphinsäuren und ihre Salze
GB9125615D0 (en) * 1991-12-02 1992-01-29 Wyeth John & Brother Ltd Amines
AU662404B2 (en) * 1992-05-08 1995-08-31 Novartis Ag Novel N-aralkyl- and N-heteroaralkyl-aminoalkanephosphinic acids
DE4407197A1 (de) * 1994-03-04 1995-09-07 Hoechst Schering Agrevo Gmbh Verfahren zur Herstellung von /L/-Homoalanin-4-yl-(methyl)phosphinsäure und deren Salze durch Racematspaltung
WO1997011953A1 (en) * 1995-09-28 1997-04-03 Novartis Ag Novel hydroxylated and alkoxylated n- and/or p-aralkylphosphinic acid derivatives
DE19634706A1 (de) * 1996-08-28 1998-03-05 Hoechst Ag Verfahren zur Herstellung von 2-Cyanoethyl-phosphinsäureestern
AU744189B2 (en) * 1997-06-23 2002-02-14 Neuro Therapeutics Limited Neurologically-active compounds
JP3382159B2 (ja) * 1998-08-05 2003-03-04 株式会社東芝 情報記録媒体とその再生方法及び記録方法
US7319095B2 (en) * 1999-12-09 2008-01-15 Astrazeneca Ab Use of GABAB receptor agonists
SE9904508D0 (sv) * 1999-12-09 1999-12-09 Astra Ab New compounds
WO2004083855A1 (en) * 2003-03-19 2004-09-30 Solvo Biotechnology, Inc. Method for the identification of cells specifically modulating slow inhibition in the neocortex
AR045794A1 (es) * 2003-09-23 2005-11-16 Aventis Pharma Inc Procedimiento para preparar derivados de acido 3- amino-2- hidroxipropilfosfinico
JP2007509974A (ja) * 2003-10-31 2007-04-19 アルザ・コーポレーシヨン ３−アミノプロピル−ｎ−ブチルホスフィン酸の増大した吸収のための組成物および薬用量形態
GB0327186D0 (en) * 2003-11-21 2003-12-24 Novartis Ag Organic compounds
US7566738B2 (en) * 2004-11-03 2009-07-28 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of sulfinic acids, methods of synthesis, and use
US7494985B2 (en) * 2004-11-03 2009-02-24 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis, and use
WO2008033572A1 (en) * 2006-09-15 2008-03-20 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
WO2010051883A1 (de) 2008-11-05 2010-05-14 Clariant International Ltd Verfahren zur herstellung von dialkylphosphinsäuren, -estern und -salzen mittels allylalkoholen/acroleinen und ihre verwendung
DE102008055916A1 (de) 2008-11-05 2010-05-06 Clariant International Limited Verfahren zur Herstellung von mono-hydroxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Allylalkoholen und ihre Verwendung
DE102008055914A1 (de) 2008-11-05 2010-05-06 Clariant International Limited Verfahren zur Herstellung von mono-hydroxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Acroleinen und ihre Verwendung
DE102008056228A1 (de) * 2008-11-06 2010-05-12 Clariant International Limited Verfahren zur Herstellung von monoaminofunktionalisierten Dialkylphosphinsäuren, deren Salze und Ester und ihre Verwendung
DE102008056234A1 (de) * 2008-11-06 2010-05-12 Clariant International Ltd. Verfahren zur Herstellung von momo-carboxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Vinylen/Nitrilen und ihre Verwendung
DE102008056339A1 (de) * 2008-11-07 2010-05-12 Clariant International Limited Verfahren zur Herstellung von mono-aminofunktionalisierten Dialkylphosphinsäuren, -estern und -salzen und ihre Verwendung
WO2010051893A1 (de) 2008-11-07 2010-05-14 Clariant International Ltd Verfahren zur herstellung von dialkylphosphinsäuren, -estern und -salzen mittels acrylsäurederivaten und ihre verwendung
DE102008056341A1 (de) * 2008-11-07 2010-05-12 Clariant International Limited Verfahren zur Herstellung von monoaminofunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Acrylnitrilen und ihre Verwendung
DE102008056342A1 (de) 2008-11-07 2010-05-12 Clariant International Limited Verfahren zur Herstellung von Dialkylphosphinsäuren, -estern und -salzen mittels Acrylnitrilen und ihre Verwendung
EP2367835B1 (de) 2008-11-11 2013-12-11 Clariant Finance (BVI) Limited Verfahren zur herstellung von mono-allylfunktionalisierten dialkylphosphinsäuren, deren salze und ester mit allylischen verbindungen und ihre verwendung
DE102008060036A1 (de) 2008-12-02 2010-06-10 Clariant International Limited Verfahren zur Herstellung von mono-carboxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Vinylester einer Carbonsäure und ihre Verwendung
DE102008060035A1 (de) 2008-12-02 2010-06-10 Clariant International Limited Verfahren zur Herstellung von mono-hydroxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Vinylester einer Carbonsäure und ihre Verwendung
DE102008060535A1 (de) 2008-12-04 2010-06-10 Clariant International Limited Verfahren zur Herstellung von mono-carboxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Vinylether und ihre Verwendung
DE102008063627A1 (de) 2008-12-18 2010-06-24 Clariant International Limited Verfahren zur Herstellung von monohydroxyfunktionalisierten Dialkylphosphinsäuren,-estern und -salzen mittels Ethylenoxid und ihre Verwendung
DE102008063642A1 (de) 2008-12-18 2010-06-24 Clariant International Limited Verfahren zur Herstellung von monocarboxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Alkylenoxiden und ihre Verwendung
DE102008063668A1 (de) 2008-12-18 2010-07-01 Clariant International Limited Verfahren zur Herstellung von Alkylphosponsäuren, -estern und -salzen mittels Oxidation von Alkylphosphonigsäuren und ihre Verwendung
US9181487B2 (en) 2008-12-18 2015-11-10 Clariant Finance (Bvi) Limited Process for preparing ethylenedialkylphosphinic acids, esters and salts by means of acetylene and use thereof
DE102008063640A1 (de) * 2008-12-18 2010-06-24 Clariant International Limited Verfahren zur Herstellung von gemischtsubstituierten Dialkylphosphinsäuren, -estern und -salzen und ihre Verwendung
DE102008064012A1 (de) 2008-12-19 2010-06-24 Clariant International Limited Halogenfreie Addukte von Alkylphosphonigsäurederivaten und diesterbildenden Olefinen, halogenfreie Verfahren zu deren Herstellung und ihre Verwendung
DE102008064003A1 (de) 2008-12-19 2010-06-24 Clariant International Limited Verfahren zur Herstellung von mono-funktionalisierten Dialkylphosphinsäuren, -estern und -salzen und ihre Verwendung

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2535175A (en) * 1949-05-11 1950-12-26 Us Rubber Co Nitroalkanephosphonates
US3184496A (en) * 1961-02-27 1965-05-18 Hooker Chemical Corp Process for the preparation and recovery of triethyl phosphite and derivatives thereof
US3374288A (en) * 1965-09-03 1968-03-19 Du Pont Polycarbonamide filaments containing polyalkylene oxide, sodium phenyl phosphinate and sodium aminoalkylphosphinate
US3493639A (en) * 1965-10-27 1970-02-03 Shell Oil Co Process for producing pentavalent phosphorus derivatives
US3385822A (en) * 1967-07-03 1968-05-28 Gen Electric Moisture curable polysiloxane phosphate composition
US3637763A (en) * 1969-01-02 1972-01-25 Merck & Co Inc Preparation of (cis-1 2-epoxypropyl) phosphonates from substituted imino compounds
US3784590A (en) * 1969-01-02 1974-01-08 Merck & Co Inc Hydroxy and imino containing phosphonic acid diesters
DE2032712C3 (de) * 1970-07-02 1978-10-19 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von w-Amino-alkanphosphonsäure bzw.- phosphinsäurederivaten
SU463675A1 (ru) * 1973-12-04 1975-03-15 Казанский Химико-Технологический Институт Им.С.М.Кирова Способ получени -фосфорилированных нитроалканолов
DE2424243A1 (de) * 1974-05-18 1975-11-27 Bayer Ag Perfluoralkansulfonamidoalkanphosphonsaeure- bzw. -phosphinsaeurederivate
DE2440239A1 (de) * 1974-08-22 1976-03-04 Hoechst Ag Innere ammoniumsalze von phosphinsaeuren
US4064163A (en) * 1976-12-30 1977-12-20 Amchem Products, Inc. Process for the manufacture of aliphatic phosphonic acids
US4339443A (en) * 1978-09-22 1982-07-13 Fbc Limited Compounds and compositions
US4322375A (en) * 1979-02-06 1982-03-30 Ciba-Geigy Corporation 2-Substituted 5-phenoxyphenylphosphonic acid derivatives
US4390690A (en) * 1979-07-24 1983-06-28 Occidental Research Corp. Layered organophosphorous inorganic polymers containing oxygen bonded to carbon
DE3070229D1 (en) * 1979-12-08 1985-03-28 Fbc Ltd Derivatives of 4-(methylphosphinyl)-2-oxobutanoic acid, herbicidal compositions containing them, and intermediates and methods for their production
US4466913A (en) * 1981-06-30 1984-08-21 Maiji Seika Kaisha Ltd. Phosphorus-containing compounds and process for producing the same
EP0093081B1 (de) * 1982-04-23 1986-03-19 Ciba-Geigy Ag Herbizide und pflanzenwuchsregulierende Mittel
US4536355A (en) * 1982-10-08 1985-08-20 Zoecon Corporation Phenoxyphenylaminoalkylphosphinates useful in weed control
SU1174438A1 (ru) * 1984-05-21 1985-08-23 МГУ им.М.В.Ломоносова Способ получени алкокси-(триметилсилокси)фосфинов
GB8425872D0 (en) * 1984-10-12 1984-11-21 Ciba Geigy Ag Chemical compounds
US5243062A (en) * 1984-10-12 1993-09-07 Ciba-Geigy Corporation Substituted propane-phosphonous acid compounds
US4740322A (en) * 1985-07-29 1988-04-26 The Lubrizol Corporation Sulfur-containing compositions, and additive concentrates, lubricating oils, metal working lubricants and asphalt compositions containing same
US4657899A (en) * 1986-04-09 1987-04-14 Nova Pharmaceutical Corporation Antagonists of specific excitatory amino acid neurotransmitter receptors
US4740332A (en) * 1986-05-12 1988-04-26 E. R. Squibb & Sons, Inc. Process for preparing phosphonous acids
GB8728483D0 (en) * 1987-12-04 1988-01-13 Ciba Geigy Ag Chemical compounds
US5300679A (en) * 1987-12-04 1994-04-05 Ciba-Geigy Corporation Substituted propane-phosphinic acid compounds
JPH0651709B2 (ja) * 1987-12-09 1994-07-06 明治製菓株式会社 新規ホスフィン酸誘導体およびそれを有効成分とする脳循環代謝改善剤
GB8820266D0 (en) * 1988-08-26 1988-09-28 Smith Kline French Lab Compounds
EP0767174A1 (de) * 1991-11-21 1997-04-09 Ciba-Geigy Ag Neue Aminoalkanphosphinsäuren und ihre Salze
AU662404B2 (en) * 1992-05-08 1995-08-31 Novartis Ag Novel N-aralkyl- and N-heteroaralkyl-aminoalkanephosphinic acids

Also Published As

Publication number Publication date
US5229379A (en) 1993-07-20
NO912429L (no) 1991-12-23
AU641772B2 (en) 1993-09-30
FI101705B1 (fi) 1998-08-14
JPH04243829A (ja) 1992-08-31
NZ238636A (en) 1994-12-22
HRP940512A2 (en) 1996-04-30
CA2045077C (en) 2002-08-20
DE59106756D1 (de) 1995-11-30
NO912429D0 (no) 1991-06-21
EP0463560A1 (de) 1992-01-02
KR920000774A (ko) 1992-01-29
PT98064A (pt) 1992-04-30
AU7922091A (en) 1992-01-02
KR100219315B1 (ko) 1999-10-01
SI9111099A (sl) 1998-02-28
GR3017895T3 (en) 1996-01-31
IL98502A (en) 1998-04-05
SI9111099B (en) 2001-06-30
IL114631A0 (en) 1995-11-27
IL114631A (en) 1998-12-06
ES2079520T3 (es) 1996-01-16
HUT59148A (en) 1992-04-28
FI912998A0 (fi) 1991-06-19
IL98502A0 (en) 1992-07-15
IE69314B1 (en) 1996-09-04
US5545631A (en) 1996-08-13
IE912158A1 (en) 1992-01-01
NO302476B1 (no) 1998-03-09
FI101705B (fi) 1998-08-14
YU109991A (sh) 1994-06-24
US5407922A (en) 1995-04-18
ATE129500T1 (de) 1995-11-15
JP3222487B2 (ja) 2001-10-29
NZ247934A (en) 1997-07-27
HU912064D0 (en) 1991-12-30
DK0463560T3 (da) 1995-12-04
CA2045077A1 (en) 1991-12-23
EP0463560B1 (de) 1995-10-25
PT98064B (pt) 1998-10-30

Similar Documents

Publication Publication Date Title
FI912998A0 (fi) Foerfarande foer framstaellning av aralifatiskt n-substituerade aminoalkanfosfinsyror.
FI960155A (fi) Terapeuttisia heterosyklisiä yhdisteitä
IL73893A (en) 11-aryl-13-estradiene derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
KR0141913B1 (en) Anti-virus agents
IT8449031A1 (it) Impiego in terapia di composti di trasferimento di metilolo relative composizioni farmaceutiche e procedimento per preparare queste
GB9418912D0 (en) Pharmaceutically active compounds
MY113427A (en) Anti-neurodegeneratively active 10-aminoaliphatyl- dibenz [b,f] oxepines
AU626743B2 (en) Therapeutic application of fluoroquinolone derivatives for pneumocystosis
ZA876740B (en) Derivatives of 4,5-dihydrooxazoles,a process for their preparation and their use
ES8105993A1 (es) Un procedimiento para la preparacion de fenil-quinolicidinas
ATE110568T1 (de) Pharmazeutisches präparat zur behandlung des katarakts.
EP0328913A3 (de) Neue basisch substituierte 5-Halogen-Thienoisothiazol-3(2H)-on-1,1-dioxide, ein Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Präparate
ATE155791T1 (de) Etoposid-derivate, ihre herstellung, ihre verwendung als medikament und ihre verwendung zur herstellung eines antikrebsmittels
ES8307778A1 (es) Procedimiento para preparar difenilbutil-1-piperazinocarboxilatos.
DE59305351D1 (de) Neue acyclische amidingruppen-haltige diphosphonsäurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
SE8104393L (sv) Llalfa-amino-androstaner
ES8202811A1 (es) Un procedimiento para la preparacion de derivados de benzo (1,4) dioxina
ES8307798A1 (es) Un procedimiento para la preparacion de derivados de piperazilmetil-4-dibenzofuranona, o, dibenzofuranol.
ZA842505B (en) Iminosulphonamides and processes for the manufacture thereof,pharmaceutical preparations containing such compounds,and their use

Legal Events

Date Code Title Description
GB Transfer or assigment of application

Owner name: NOVARTIS AG