WO2024150570A1 - 自動分析装置 - Google Patents

自動分析装置 Download PDF

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Publication number
WO2024150570A1
WO2024150570A1 PCT/JP2023/044116 JP2023044116W WO2024150570A1 WO 2024150570 A1 WO2024150570 A1 WO 2024150570A1 JP 2023044116 W JP2023044116 W JP 2023044116W WO 2024150570 A1 WO2024150570 A1 WO 2024150570A1
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WO
WIPO (PCT)
Prior art keywords
dispensing nozzle
reference position
coordinate
position block
contact
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2023/044116
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English (en)
French (fr)
Japanese (ja)
Inventor
皓輝 横田
拓也 高橋
慧 中島
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hitachi High Tech Corp
Original Assignee
Hitachi High Tech Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hitachi High Tech Corp filed Critical Hitachi High Tech Corp
Priority to CN202380084202.6A priority Critical patent/CN120322680A/zh
Priority to EP23916185.4A priority patent/EP4650784A1/en
Priority to JP2024570087A priority patent/JPWO2024150570A1/ja
Publication of WO2024150570A1 publication Critical patent/WO2024150570A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N35/1011—Control of the position or alignment of the transfer device
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00594—Quality control, including calibration or testing of components of the analyser
    • G01N35/00613—Quality control
    • G01N35/00623—Quality control of instruments
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0439—Rotary sample carriers, i.e. carousels
    • G01N2035/0443—Rotary sample carriers, i.e. carousels for reagents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0439—Rotary sample carriers, i.e. carousels
    • G01N2035/0444—Rotary sample carriers, i.e. carousels for cuvettes or reaction vessels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1081—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane
    • G01N35/109—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane with two horizontal degrees of freedom
    • G01N2035/1093—Cylindrical, e.g. variable radius and angle

Definitions

  • the present invention relates to an automatic analyzer having a dispensing mechanism.
  • Patent Document 1 discloses an automatic analyzer that can automatically correct positional deviations based on fluctuations in the relative positions of a dispensing mechanism and a first mechanism.
  • the first mechanism is a mechanism that is placed on the same mechanism base as the dispensing mechanism and has a stop position at which the dispensing nozzle stops, and the relative position changes due to distortion of the mechanism base.
  • the automatic analyzer provides a member indicating a predetermined first position and a member indicating a second position of the first mechanism on the first mechanism. Since the members are provided on the first mechanism, the positional relationship between the members and the stop position does not change due to distortion of the mechanism base.
  • a correction value that corrects the deviation in the stop position is calculated based on the positional deviation of the first position and the second position that indicates the deviation in the relative position between the dispensing mechanism and the first mechanism, which is obtained by detecting the member with the dispensing nozzle and detecting the first position and the second position.
  • Patent Document 1 gives an example of a cylindrical member, and discloses that the first position or the second position is identified by contacting the dispensing nozzle with the inner wall surface of the cylinder.
  • the first mechanism in Patent Document 1 is, for example, a mechanism such as a reagent disk, a reaction disk, or a washing tank.
  • the automatic analyzer cannot perform measurements, so it is necessary to complete the correction value calculation process as quickly as possible.
  • the control delay between when the dispensing mechanism detects that the dispensing nozzle has come into contact with the reference position block and when it stops the arm will cause the dispensing nozzle to come into contact with the reference position block in a deflected state. In this case, there will be a large error in the position of the identified reference position block, and the correction accuracy will decrease.
  • the dispensing nozzle is moved slowly enough that it does not deflect when it comes into contact with the reference position block, or if it is moved manually, the correction accuracy will improve, but the time required for the correction value calculation process will increase.
  • An automated analyzer has a dispensing mechanism equipped with a horizontal drive mechanism to which a dispensing nozzle is attached and which moves the dispensing nozzle horizontally, and a contact detector to detect when the tip of the dispensing nozzle comes into contact with a conductor; a reference position block which is a conductor; and a control unit which controls the dispensing mechanism.
  • the control unit horizontally moves the dispensing nozzle toward the side of the reference position block at a constant speed, and acquires a first coordinate which is the coordinate of the attachment part of the dispensing nozzle to the horizontal drive mechanism when the contact detector detects that the tip of the dispensing nozzle has come into contact with the reference position block and stops the horizontal drive mechanism, and a second coordinate which is the coordinate of the attachment part of the dispensing nozzle to the horizontal drive mechanism when the dispensing nozzle moves horizontally at a constant speed from the stop position of the horizontal drive mechanism in a direction away from the side of the reference position block and the contact detector detects that the tip of the dispensing nozzle has left the reference position block and stops the horizontal drive mechanism.
  • the control unit calculates the coordinate of the contact point where the tip of the dispensing nozzle comes into contact with the reference position block based on the first coordinate and the second coordinate.
  • FIG. 1 is an example of the overall configuration of an automatic analyzer. 1 shows an example of the configuration of a dispensing mechanism having two horizontal drive shafts.
  • 13 is a front view showing a state in which the dispensing nozzle is in contact with the reference position block.
  • FIG. 13 is a top view showing a state in which the dispensing nozzle is in contact with the reference position block.
  • FIG. 13 is a front view showing a state in which the dispensing nozzle has moved away from the reference position block and stopped.
  • FIG. 13 is a top view showing a state in which the dispensing nozzle has moved away from the reference position block and stopped.
  • FIG. 11 is a flowchart showing an outline of a method for correcting the stop position of the dispensing nozzle.
  • FIG. 11 is a flowchart showing an outline of a method for correcting the stop position of the dispensing nozzle.
  • 13 is a diagram showing the positional relationship between coordinate 1, coordinate 2, and contact point coordinates. 13 is an image of the motion trajectory of a dispensing nozzle for obtaining multiple contact point coordinates.
  • 11 is a diagram for explaining a method of converting from a two-dimensional coordinate system to a control value for the amount of rotation of the arm.
  • FIG. 11 is a diagram for explaining a method of converting from a two-dimensional coordinate system to a control value for the amount of rotation of the arm.
  • FIG. 1 shows an example of the overall configuration of an automatic analyzer.
  • the automatic analyzer is roughly composed of a sample transport mechanism 19, a reagent disk 11, a reaction disk 1, sample dispensing mechanisms 13, 14, reagent dispensing mechanisms 7, 8, 9, 10, stirring mechanisms 5, 6, a spectrophotometer 4, a cleaning mechanism 3, cleaning tanks 15, 16, 30, 31, 32, 33, a reagent pump 20, a sample pump 21, a cleaning pump 22, a control unit 41 that controls each part of the automatic analyzer, a data storage unit 42 that stores various data, an input unit 43 that inputs necessary data from the outside to the data storage unit 42, a measurement unit 44 that calculates absorbance from the amount of light obtained by the spectrophotometer 4, an analysis unit 45 that calculates the amount of components from the absorbance, and an output unit 46 that displays and outputs data to the outside.
  • a reference position block 61 for correcting the stop position of the dispensing nozzle is located within the movable range of the dispensing mechanism and on the mechanism where the stop position of the dispensing nozzle is provided.
  • Figure 1 shows an example in which the reference position block 61 is located on the reaction disk 1 and the reagent disk 11.
  • the sample transport mechanism 19 transports a rack (transport member) 18 carrying one or more sample containers 17 containing samples to be analyzed.
  • the reagent disk 11 has a plurality of reagent bottles 12 containing reagents used in sample analysis arranged in a circumferential direction.
  • the reaction disk 1 has a plurality of reaction containers 2 arranged in a circumferential direction, in which the sample and the reagent are mixed and reacted.
  • the sample dispensing mechanisms 13 and 14 dispense the sample from the sample container 17 transported to the sample dispensing position by the sample transport mechanism 19 to the reaction container 2.
  • the reagent dispensing mechanisms 7, 8, 9, and 10 dispense the reagent from the reagent bottle 12 to the reaction container 2.
  • the stirring mechanisms 5 and 6 stir the mixture (reaction liquid) of the sample and the reagent dispensed in the reaction container 2.
  • the spectrophotometer 4 receives transmitted light or scattered light obtained by irradiating the reaction liquid in the reaction container 2 with light from a light source (not shown).
  • the cleaning mechanism 3 cleans the reaction container 2 after use.
  • Sample nozzle washing tanks 15 and 16 are disposed within the movable ranges of sample dispensing mechanisms 13 and 14, respectively, and wash sample nozzles 13a and 14a with washing water.
  • Reagent nozzle washing tanks 30, 31, 32, and 33 are disposed within the movable ranges of reagent dispensing mechanisms 7, 8, 9, and 10, respectively, and wash reagent nozzles 7a, 8a, 9a, and 10a with washing water.
  • the analysis of the component amounts of a sample is performed in the following procedure.
  • the sample in the sample container 17 placed on the rack 18 transported near the reaction disk 1 by the sample transport mechanism 19 is dispensed into the reaction container 2 on the reaction disk 1 by the sample nozzle 13a (or 14a) of the sample dispensing mechanism 13 (or 14).
  • the reagent used for the analysis is dispensed from the reagent bottle 12 on the reagent disk 11 to the reaction container 2 to which the sample was previously dispensed by the reagent nozzle 7a (or 8a, 9a, 10a) of the reagent dispensing mechanism 7 (or 8, 9, 10).
  • the mixture of the sample and the reagent in the reaction container 2 is stirred by the stirring mechanism 5 (or 6).
  • the above is an example of the configuration when an automatic analyzer performs biochemical analysis, and the measurement mechanism differs depending on the analysis content performed by the automatic analyzer.
  • Known measurement methods used in automatic analyzers include an analysis method (colorimetric analysis) that uses a reagent that changes the color of the reaction solution by reacting with the analyte component in the sample, and an analysis method (immunoanalysis) that uses a reagent in which a label is added to a substance that specifically binds directly or indirectly to the analyte component in the sample, and counts the label.
  • an analysis method colorimetric analysis
  • immunoanalysis an analysis method that uses a reagent in which a label is added to a substance that specifically binds directly or indirectly to the analyte component in the sample, and counts the label.
  • Both include a process in which a sample contained in a sample container or a reagent contained in a reagent bottle is dispensed and mixed into a reaction container by a dispensing mechanism.
  • FIG. 2 shows an example of the configuration of the dispensing mechanism of this embodiment.
  • one end of the ⁇ 1 arm 52 is attached rotatably in the XY plane to the upper end position of the shaft 51 that can be driven up and down.
  • One end of the ⁇ 2 arm 53 is attached rotatably in the XY plane to the tip position, which is the free end of the ⁇ 1 arm 52.
  • a dispensing nozzle 54 is attached to the tip position, which is the free end of the ⁇ 2 arm 53, so as to extend downward in the Z-axis direction (vertical direction).
  • the dispensing nozzle 54 and the syringe 55 are connected via a tube 56.
  • the tube 56 runs from the base of the shaft 51 through the shaft 51, the ⁇ 1 arm 52, and the ⁇ 2 arm 53, and is connected to one end of the dispensing nozzle 54.
  • a plunger 57 for varying the internal volume of the syringe 55 is movably attached. Depending on the moving position of the plunger 57, a sample or a reagent is sucked or discharged from the tip of the dispensing nozzle 54.
  • a capacitance type contact detector 58 is connected to the dispensing nozzle 54, which can detect when the dispensing nozzle 54 comes into contact with a conductor such as a sample, a reagent, etc.
  • the ⁇ 1 arm 52 and the ⁇ 2 arm 53 are collectively referred to as a horizontal drive mechanism, since they move the dispensing nozzle 54 horizontally.
  • the main cause of change in the relative position between the dispensing mechanism and the reaction disk 1, reagent disk 11, or cleaning tank where the dispensing nozzle stop position is that the load balance of the entire automatic analyzer changes during transportation or aging, causing the mechanism base 35 (see Figure 1) to become distorted. Distortion of the mechanism base 35 causes a shift in the relative position between the dispensing mechanism and the mechanism where the dispensing nozzle stop position is located. By correcting the dispensing nozzle stop position by the amount of this relative position shift, it is possible to ensure that the dispensing mechanism can dispense and the dispensing nozzle can be cleaned appropriately.
  • the reference position block 61 is a cylinder and a circular recess is provided at the center of the cylinder.
  • the shape of the reference position block 61 is not limited to the illustrated shape.
  • the tip 54b of the dispensing nozzle 54 is brought into contact with the side surface 61a of the circular recess, and multiple contact point coordinates are fitted to the contour shape of the side surface 61a of the circular recess, thereby identifying the position of the reference position block 61. Therefore, the shape of the circular recess can be any shape, such as a rectangle, as long as the contour shape is a known shape that is defined so that it can be fitted.
  • the contour shape is one that can be fitted with high accuracy even if the number of contact points is small.
  • the material of the reference position block 61 is a conductive material that can be detected by the contact detector 58, such as a metal.
  • FIG. 3 and 4 show a state where the dispensing nozzle 54 is stopped by contacting the side surface of the circular recess of the reference position block 61.
  • Figs. 5 and 6 show a state where the dispensing nozzle 54 is stopped away from the circular recess of the reference position block 61.
  • Figs. 3 and 5 are views of the reference position block 61 viewed from the horizontal direction
  • Figs. 4 and 6 are views of the reference position block 61 viewed from the vertical direction.
  • Figs. 3 and 4 show a state where the ⁇ 2 arm 53 is stopped by a contact detection signal from the contact detector 58, but the dispensing nozzle 54 is deflected due to a control delay from receiving the contact detection signal to stopping the ⁇ 2 arm 53.
  • the deflection of the dispensing nozzle 54 caused by such a control delay reduces the accuracy of identifying the position of the reference position block 61 and reduces the accuracy of correcting the stop position of the dispensing nozzle.
  • FIG. 7 is a flowchart showing an overview of the dispensing nozzle stop position correction method in this embodiment. This operation is automatically performed when the user performs maintenance via the input unit 43 at any time, or after a reset operation is performed during the analysis preparation operation. This makes it possible to avoid continuing analysis with a positional deviation in the stop position of the dispensing nozzle.
  • the control unit 41 reads out the position information data (position adjustment value) of the reference position block 61 stored in the data storage unit 42, moves the dispensing nozzle 54 horizontally to the center of the reference position block 61, and then drives the shaft 51 so that the height of the tip 54b of the dispensing nozzle 54 moves to a position lower than the top surface of the reference position block 61 (step S01).
  • the position adjustment value refers to the position information data obtained on the actual machine for each stop position of the dispensing nozzle 54 when the automatic analyzer is installed in order to absorb errors during manufacture and assembly, and is stored in the data storage unit 42.
  • the reference position block 61 is also included as a stop position for the dispensing nozzle 54.
  • the dispensing mechanism drives the ⁇ 2 arm 53 at a constant speed so that the dispensing nozzle 54 contacts the circular recessed portion side surface 61a of the reference position block 61.
  • the contact detector 58 detects that the dispensing nozzle 54 contacts the circular recessed portion side surface 61a and outputs a contact detection signal.
  • the dispensing mechanism receives the contact detection signal from the contact detector 58 and stops driving the ⁇ 2 arm 53.
  • the time required for correcting the stop position of the dispensing nozzle can be shortened by setting the driving speed of the ⁇ 2 arm 53 to a high speed.
  • the maximum movement amount at this time is set to a movement amount that does not cause plastic deformation of the dispensing nozzle 54 due to the driving of the ⁇ 2 arm 53 after the tip 54b of the dispensing nozzle 54 contacts the circular recessed portion side surface 61a.
  • the position coordinate (coordinate 1) of the base (attachment part) 54a of the dispensing nozzle 54 when the ⁇ 2 arm 53 stops due to the contact detection signal is obtained and stored in the data storage unit 42 (S02).
  • Figures 3 and 4 show the state of the dispensing nozzle in step S02, where the dispensing nozzle 54 has elastically deformed, and the position coordinates of the base 54a and tip 54b of the dispensing nozzle 54 are different.
  • the dispensing mechanism drives the ⁇ 2 arm 53 in the opposite direction to step S02 at the same constant speed as step S02 so that the dispensing nozzle 54 moves away from the circular recess side surface 61a of the reference position block 61.
  • the contact detector 58 detects that the dispensing nozzle 54 has moved away from the circular recess side surface 61a and outputs a separation detection signal.
  • the dispensing mechanism receives the separation detection signal from the contact detector 58 and stops driving the ⁇ 2 arm 53.
  • the contact/separation of the dispensing nozzle 54 with the circular recess side surface 61a may be determined by the ON/OFF of the contact detection signal.
  • the maximum movement amount of the ⁇ 2 arm 53 in preparation for a case where the drive of the ⁇ 2 arm 53 does not stop due to the OFF of the separation detection signal or contact detection signal for some reason.
  • the maximum movement amount at this time may be greater than the maximum movement amount in step S01 because the dispensing nozzle 54 moves in a direction away from the circular recess side surface 61a.
  • the position coordinate (coordinate 2) of the base 54a of the dispensing nozzle 54 when the ⁇ 2 arm 53 stops due to the separation detection signal (or the contact detection signal turning OFF) is obtained and stored in the data storage unit 42 (S03).
  • FIG. 8 shows the positional relationship between the position 71 of the coordinates 1, the position 72 of the coordinates 2, and the coordinates of the contact point 73.
  • the position 71 of the coordinates 1 is located outside the circular recess side surface 61a by the amount of movement from when the contact detector 58 detects that the dispensing nozzle 54 contacts the circular recess side surface 61a at the contact point 73 until the ⁇ 2 arm 53 stops due to a control delay.
  • the position 72 of the coordinates 2 is located inside the circular recess side surface 61a by the amount of movement from when the contact detector 58 detects that the dispensing nozzle 54 leaves the circular recess side surface 61a at the contact point 73 until the ⁇ 2 arm 53 stops due to a control delay.
  • the ⁇ 2 arm 53 is moved at the same constant speed, so the contact point coordinates can be calculated as the midpoint of the line segment connecting the coordinates 1 and 2.
  • the control unit 41 stores the calculated contact point coordinates in the data storage unit 42 .
  • FIG. 9 shows an image of the movement trajectory of the dispensing nozzle 54 for acquiring the contact point coordinates.
  • an example of the movement trajectory for successively acquiring the contact point coordinates (x 1 , y 1 ) to (x 12 , y 12 ) is shown.
  • the ⁇ 1 arm 52 is slightly moved (step S06), and the processing of steps S02 to S04 is executed again. This allows a large number of contact point coordinates to be acquired. If a predetermined contact point coordinate (for example, the coordinates of the 12 contact points in the example of FIG.
  • the position coordinates of the reference position block 61 are calculated from the acquired contact point coordinates (S07). If the position of the reference position block 61 is defined as its center position, the center of the reference position block 61 is the center of the circular recess in this example, so that a circle that best fits the acquired 12 contact point coordinates can be calculated, and the coordinates of the center of the obtained circle can be calculated as the position coordinates of the reference position block 61.
  • control unit 41 continues acquiring the position coordinates of other reference position blocks 61, and if the position coordinates of the reference position block 61 required for correction have been acquired (Yes in S08), it corrects the stop position of the dispensing nozzle (S09). Note that the process may proceed to step S09 after acquiring the position coordinates of all reference position blocks 61 arranged in the automated analyzer has been completed.
  • step S09 the control unit 41 first checks whether there is a deviation in the position coordinates of the reference position block 61 used for correction for each stop position of the dispensing nozzle 54. If the deviation in the position coordinates of the reference position block 61 is within the allowable range, the process ends without making correction. If the deviation in the position coordinates of the reference position block 61 exceeds the allowable range, a correction value is calculated. Since the positional relationship between the position of the first reference position block, the position of the second reference position block, and the stop position of the dispensing nozzle 54 on the same mechanism does not change, the correction amount for the stop position of the dispensing nozzle 54 can be calculated from the position deviation of the first reference position block and the position deviation of the second reference position block.
  • the control unit 41 stores the calculated correction amount in the data storage unit 42.
  • the dispensing mechanism is able to stop the dispensing nozzle at an appropriate position regardless of the state of the mechanism base 35.
  • the horizontal movement of the dispensing nozzle 54 has been described using a two-dimensional coordinate system with the X-axis and Y-axis directions. Meanwhile, the dispensing mechanism moves the dispensing nozzle to the desired position by rotating the arm as shown in Figure 2.
  • the two-dimensional coordinate system (x, y) can be replaced with the amount of rotation of the arm as follows:
  • Figure 10 shows the correspondence between a two-dimensional coordinate system and the horizontal drive mechanism in the dispensing mechanism shown in Figure 2.
  • the two-dimensional coordinate system has the origin at the connection position between the shaft 51 and the ⁇ 1 arm 52.
  • the arm length of the ⁇ 1 arm 52 is l1
  • the arm length of the ⁇ 2 arm 53 is l2 .
  • the ⁇ 1 arm 52 and the ⁇ 2 arm 53 are driven by stepping motors.
  • the angle of each arm can be calculated from the initial angle of the ⁇ 1 arm 52 and the ⁇ 2 arm 53 before driving, the number of movement pulses that give the amount of movement (amount of rotation) relative to the initial angle, and the movement angle resolution that indicates the angle by which the arm rotates with one pulse.
  • the above-mentioned configurations, functions, and processing units may be realized in whole or in part as, for example, an integrated circuit or other hardware. Furthermore, the above-mentioned configurations, functions, etc. may be realized by a processor interpreting and executing a program that realizes each function. In other words, they may be realized as software. Information such as the programs, tables, and files that realize each function can be stored in storage devices such as memory, hard disks, and SSDs (Solid State Drives), as well as storage media such as IC cards, SD cards, and DVDs.
  • storage devices such as memory, hard disks, and SSDs (Solid State Drives), as well as storage media such as IC cards, SD cards, and DVDs.
  • control lines and information lines are those considered necessary for the explanation, and do not represent all the control lines and information lines required for the product. In reality, it is safe to assume that almost all components are interconnected.
  • the present invention is not limited to the above-described embodiment, and includes various modified examples.
  • this embodiment an example of detecting the position of the reference position block to correct the stop position of the dispensing nozzle is shown, but the method disclosed in this embodiment can be applied when detecting the position of the reference position block for a different purpose.
  • the above-described embodiment has been described in detail to clearly explain the present invention, and is not necessarily limited to having all of the configurations described.
  • it is possible to replace part of the configuration of one embodiment with the configuration of another embodiment and it is also possible to add the configuration of another embodiment to the configuration of one embodiment.
  • reaction disk 1... reaction disk, 2... reaction container, 3... cleaning mechanism, 4... spectrophotometer, 5, 6... stirring mechanism, 7, 8, 9, 10... reagent dispensing mechanism, 7a, 8a, 9a, 10a... reagent nozzle, 11... reagent disk, 12... reagent bottle, 13, 14... sample dispensing mechanism, 13a, 14a... sample nozzle, 15, 16... sample nozzle cleaning tank, 17... sample container, 18... rack (transport member), 19... sample transport mechanism, 20... reagent pump, 21... sample pump, 22... cleaning pump, 30, 31, 32, 33... reagent nozzle cleaning tank, 35... mechanism base, 41... control unit, 42... data storage unit, 43... input unit, 44... measurement unit, 45... analysis unit, 46... output unit, 51...

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PCT/JP2023/044116 2023-01-13 2023-12-08 自動分析装置 Ceased WO2024150570A1 (ja)

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Application Number Priority Date Filing Date Title
CN202380084202.6A CN120322680A (zh) 2023-01-13 2023-12-08 自动分析装置
EP23916185.4A EP4650784A1 (en) 2023-01-13 2023-12-08 Automatic analysis device
JP2024570087A JPWO2024150570A1 (https=) 2023-01-13 2023-12-08

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JP2023-003866 2023-01-13

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11160327A (ja) * 1997-11-27 1999-06-18 Aloka Co Ltd 分注装置
JP2008281365A (ja) * 2007-05-08 2008-11-20 Shimadzu Corp マイクロチップ電気泳動装置
JP2012242106A (ja) * 2011-05-16 2012-12-10 Hitachi High-Technologies Corp 自動分析装置及び方法
JP2021139825A (ja) * 2020-03-09 2021-09-16 株式会社日立ハイテク 自動分析装置
WO2022196272A1 (ja) * 2021-03-16 2022-09-22 株式会社日立ハイテク 自動分析装置

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11160327A (ja) * 1997-11-27 1999-06-18 Aloka Co Ltd 分注装置
JP2008281365A (ja) * 2007-05-08 2008-11-20 Shimadzu Corp マイクロチップ電気泳動装置
JP2012242106A (ja) * 2011-05-16 2012-12-10 Hitachi High-Technologies Corp 自動分析装置及び方法
JP2021139825A (ja) * 2020-03-09 2021-09-16 株式会社日立ハイテク 自動分析装置
WO2022196272A1 (ja) * 2021-03-16 2022-09-22 株式会社日立ハイテク 自動分析装置

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP4650784A1 *

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