WO2024135339A1 - クロマメノキエキスおよびコーンシルクエキスの組み合わせ - Google Patents

クロマメノキエキスおよびコーンシルクエキスの組み合わせ Download PDF

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Publication number
WO2024135339A1
WO2024135339A1 PCT/JP2023/043398 JP2023043398W WO2024135339A1 WO 2024135339 A1 WO2024135339 A1 WO 2024135339A1 JP 2023043398 W JP2023043398 W JP 2023043398W WO 2024135339 A1 WO2024135339 A1 WO 2024135339A1
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WO
WIPO (PCT)
Prior art keywords
extract
corn silk
composition
glycation
combination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2023/043398
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English (en)
French (fr)
Japanese (ja)
Inventor
辰也 金
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shiseido Co Ltd
Original Assignee
Shiseido Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shiseido Co Ltd filed Critical Shiseido Co Ltd
Priority to CN202380080181.0A priority Critical patent/CN120225212A/zh
Priority to JP2024565764A priority patent/JPWO2024135339A1/ja
Publication of WO2024135339A1 publication Critical patent/WO2024135339A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

Definitions

  • the present invention relates to a combination of black gram extract and corn silk extract.
  • a reaction known as the Maillard reaction or glycation occurs in the body, where proteins and amino acids in tissues are glycated. In some cases, these can become abnormal proteins and accumulate in the body. For example, if metabolic function declines with age or hyperglycemia continues due to diabetes, glycation reactions gradually progress in the body, impairing the normal function of proteins in each tissue. When glycation reactions occur, they ultimately form irreversible compounds known as advanced glycation end products (AGEs), which are deposited in various tissues or bind to AGE receptors localized in vascular endothelial cells, causing a variety of diseases.
  • AGEs advanced glycation end products
  • Protein glycation is also thought to be a contributing factor in skin aging.
  • Patent Document 1 discloses a glycation reaction inhibitor that contains one or more plants or processed products thereof selected from the group consisting of butterbur, chestnut, peanut, persimmon, rosehip, blueberry, pomegranate, rosemary, grape, apricot, shiso, sage, peppermint, savory, yerba mate, coffee plant, olive, and tea plant.
  • the inventors have discovered a new combination of black gram extract and corn silk extract.
  • the present invention is based on this discovery.
  • the present invention therefore provides a combination of black gram extract and corn silk extract.
  • a composition comprising an extract of Psathys nigra for use in combination with a composition comprising a corn silk extract.
  • a composition comprising corn silk extract for use in combination with a composition comprising black gram extract.
  • a composition comprising an extract of black gram and an extract of corn silk.
  • the composition according to any one of (1) to (3) for inhibiting glycation.
  • the composition according to any one of (1) to (4) for inhibiting glycation in the skin.
  • (21) A combination of Black Bean Extract and Corn Silk Extract to inhibit glycation in the skin.
  • (22) A combination of black gram extract and corn silk extract for preventing or improving one or more selected from the group consisting of firmness, wrinkles, and sagging.
  • (23) A combination of the corn silk extract and the umbellifera extract according to any one of (20) to (22), for use in such a way that the CA/CB ratio is 0.15 to 7.5, where CA is the dry weight of the corn silk extract and CB is the dry weight of the umbellifera extract.
  • a method for inhibiting glycation in a subject comprising administering an effective amount of a combination of black gram extract and corn silk extract.
  • a method for inhibiting glycation in the skin of a subject comprising administering an effective amount of a combination of black gram extract and corn silk extract.
  • the present invention provides a combination of black gram extract and corn silk extract. By using the combination of the present invention, it is possible to effectively inhibit glycation reactions.
  • FIG. 1 shows the results of evaluating the anti-glycation effect after 28 days of addition of either the black gram extract or the corn silk extract alone.
  • FIG. 2 shows the results of evaluating the anti-glycation effect after 35 days from the addition of either the black gram extract or the corn silk extract alone.
  • a thunbergia japonica extract for use in combination with corn silk extract may be a composition comprising a thunbergia japonica extract for use in combination with corn silk extract, or a thunbergia japonica extract for use in combination with a composition comprising corn silk extract, or a composition comprising a thunbergia japonica extract for use in combination with a composition comprising corn silk extract.
  • a corn silk extract for use in combination with a thunbergia japonica extract may be a composition comprising a corn silk extract for use in combination with a thunbergia japonica extract, or a composition comprising a corn silk extract for use in combination with a composition comprising a thunbergia japonica extract, or a composition comprising a corn silk extract for use in combination with a composition comprising a thunbergia japonica extract.
  • composition comprising thunbergia bilis extract and corn silk extract.
  • a glycation inhibitor comprising a linden extract for use in combination with a corn silk extract or a composition comprising a corn silk extract.
  • a glycation inhibitor comprising a linden extract may be a composition comprising a linden extract for inhibiting glycation.
  • a glycation inhibitor comprising corn silk extract for use in combination with bilberry extract or a composition comprising bilberry extract.
  • a glycation inhibitor comprising corn silk extract may be a composition comprising corn silk extract for inhibiting glycation.
  • a glycation inhibitor comprising thunbergia japonica extract and corn silk extract.
  • a glycation inhibitor comprising thunbergia japonica extract and corn silk extract may be a composition comprising thunbergia japonica extract and corn silk extract for inhibiting glycation.
  • inhibition of glycation may be performed either in vivo or in vitro.
  • the inhibition of glycation in the body may be the inhibition of glycation of components such as proteins and amino acids in tissues, and is preferably, but not limited to, the inhibition of glycation in the skin.
  • Subjects for which such inhibition of glycation is performed include, but are not limited to, humans, primates including chimpanzees, pet animals such as dogs and cats, livestock animals such as cows, horses, sheep, and goats, and mammals such as rodents such as mice and rats.
  • the inhibition of glycation outside of a living body may be, but is not limited to, the inhibition of glycation in a biological sample such as a tissue fragment or cell derived from a living body.
  • a biological sample such as a tissue fragment or cell derived from a living body.
  • a biological sample is preferably, but is not limited to, a sample derived from skin, and if a commercially available sample is available, it may be used.
  • a biological sample may also include, but is not limited to, a sample indirectly obtained from a living body, such as an established cell line.
  • the inhibition of glycation outside of a living body may be performed in a sample other than a biological sample, and may be, for example, the inhibition of glycation of components contained in food or beverages (e.g., amino acids, proteins (e.g., collagen, etc.), etc.).
  • components contained in food or beverages e.g., amino acids, proteins (e.g., collagen, etc.), etc.
  • an agent for preventing or improving one or more selected from the group consisting of firmness, wrinkles, and sagging comprising thunbergia umbellata extract, for use in combination with corn silk extract or a composition comprising corn silk extract.
  • Such an agent for preventing or improving one or more selected from the group consisting of firmness, wrinkles, and sagging may be a composition comprising thunbergia umbellata extract for preventing or improving one or more selected from the group consisting of firmness, wrinkles, and sagging.
  • Such prevention or improvement may also be achieved by, but is not limited to, the inhibition of glycation.
  • a preventive or improving agent for one or more selected from the group consisting of firmness, wrinkles, and sagging comprising corn silk extract, for use in combination with bilberry extract or a composition comprising bilberry extract.
  • a preventive or improving agent comprising corn silk extract may be a composition comprising corn silk extract for preventing or improving one or more selected from the group consisting of firmness, wrinkles, and sagging.
  • Such prevention or improvement may be achieved by, but is not limited to, inhibition of glycation.
  • a preventive or improving agent for one or more selected from the group consisting of firmness, wrinkles, and sagging comprising thunbergia japonica extract and corn silk extract.
  • a preventive or improving agent comprising thunbergia japonica extract and corn silk extract may be a composition comprising thunbergia japonica extract and corn silk extract for preventing or improving one or more selected from the group consisting of firmness, wrinkles, and sagging.
  • prevention or improvement may be achieved by, but is not limited to, the inhibition of glycation.
  • black bilberry in the present invention means "Vaccinium uliginosum", a plant of the genus Vaccinium in the family Ericaceae, and is also commonly called bog bilberry or great bilberry, and in Japan, it is also called Asama grape or Kozan (high mountain) grape.
  • the part to be used may be either the whole or a part of the plant, and is not limited thereto, and may be, for example, the fruit.
  • the juice derived from the fruit of this black bilberry may be written, for example, as Wild blueberry juice concentrate (Vaccinium uliginosum) in English, and is also written as "Wild blueberry juice concentrate (Vaccinium uliginosum)" in Chinese. It is sometimes written as:
  • the “corn silk” of the present invention refers to the dried style and stigma of the female flower of corn (Zea mays L.) of the Gramineae family, which is also known as the herbal medicine Nanban hair or Nanba hair. In China, it is sometimes called “corn stigma,” “corn stamen,” or “corn hair,” and in Japan, it is sometimes sold commercially as “Nanban hair” or “Nanban hair.”
  • the style and stigma of the female flower of corn may be plucked and dried. This drying method is not limited to, but examples include hot air drying, vacuum freeze drying, far-infrared drying, microwave heating drying, and sun drying.
  • the above-mentioned corn (Zea mays L.) of the Gramineae family may be a closely related species or a cultivated variety.
  • the method for producing the extract of the above-mentioned components is not particularly limited, and extraction can be performed according to a method commonly used in the technical field.
  • the extraction method include, but are not limited to, hot water extraction, ultrasonic extraction, filtration, reflux extraction, and solvent (e.g., ethanol) extraction. These may be performed alone, or two or more methods may be used in combination.
  • the extract may be further extracted one or more times in the same manner to obtain an extract of high purity.
  • a raw material production method that does not involve extraction includes squeezing and concentrating the fruit juice, and the product can be produced by any method.
  • the type of extraction solvent used to produce the black gram extract or corn silk extract of the present invention is not particularly limited, and any solvent known in the art may be used as long as it produces an extract having the desired effect of the present invention.
  • solvents include, but are not limited to, water, alcohols having 1 to 4 carbon atoms, ethyl acetate, acetone, chloroform, etc., and two or more of these may be used in combination.
  • corn silk extract for example, corn silk dry extract (manufactured by Fukuda Ryu Co., Ltd.) can be used. This is produced by extracting corn silk with hot water, removing water, powdering, etc.
  • the amounts of the black gram extract and the corn silk extract used in the composition of the present invention can be appropriately determined depending on the application, but preferably, when the dry weight of the corn silk extract is CA and the dry weight of the black gram extract is CB, the CA/CB is 0.15 to 7.5, more preferably 0.3 to 3.2.
  • the value of the dry weight in the present invention is not limited, but may be obtained, for example, by directly measuring the extract that has been thoroughly dried, or by converting the Brix (soluble solid weight per 100 g of extract) of the extract.
  • the conversion from Brix to dry weight can be performed using the following formula 1.
  • composition of the present invention may be, but is not limited to, a pharmaceutical composition, a cosmetic composition, or a food composition.
  • composition of the present invention may be either an oral composition or a topical composition. It is believed that the black gram extract and corn silk extract of the present invention are preferably absorbed from the digestive tract by oral ingestion, and the active ingredients act in the body. Therefore, according to one preferred embodiment of the present invention, the composition of the present invention is an oral composition.
  • composition of the present invention may further contain known components (additives) that are used in oral compositions.
  • additives include, but are not limited to, emulsifiers, hydrating agents, solvents, emollients, stabilizers, thickeners, preservatives, lubricants, chelating agents, fillers, excipients, powders, fragrances, flavorings, absorbents, dyes, opacifiers, antioxidants, preservatives, vitamins, amino acids, nutrients, minerals (electrolytes), flavorings such as synthetic flavorings and natural flavorings, pectinic acid and its salts, alginic acid and its salts, organic acids, pH regulators, glycerin, alcohol, carbonation agents used in carbonated drinks, etc.
  • the oral composition of the present invention may be liquid, semi-solid, or solid, and is preferably, but not limited to, a drink.
  • composition of the present invention when used as a topical composition, it may further contain known ingredients (additives) that are incorporated into topical compositions.
  • ingredients include, but are not limited to, emulsifiers, hydrating agents, solvents, emollients, stabilizers, thickeners, preservatives, lubricants, chelating agents, fillers, excipients, powders, fragrances, flavorings, absorbents, dyes, opacifiers, antioxidants, vitamins, amino acids, etc.
  • the topical composition of the present invention may be a liquid, semi-solid, or solid.
  • Figure 1 shows the results of the evaluation of the anti-glycation effect after 28 days when black laurel extract or corn silk extract was added alone
  • Figure 2 shows the results of the evaluation of the anti-glycation effect after 35 days.
  • a concentration-dependent anti-glycation effect was observed for both black laurel extract and corn silk extract.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
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  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Medical Informatics (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Medicines Containing Plant Substances (AREA)
PCT/JP2023/043398 2022-12-19 2023-12-05 クロマメノキエキスおよびコーンシルクエキスの組み合わせ Ceased WO2024135339A1 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202380080181.0A CN120225212A (zh) 2022-12-19 2023-12-05 笃斯越桔提取物和玉米须提取物的组合
JP2024565764A JPWO2024135339A1 (https=) 2022-12-19 2023-12-05

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JP2022202400 2022-12-19

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986001713A1 (en) * 1984-09-21 1986-03-27 Innofinance Általános Innovációs Pénzintézet Skin regenerating and hydrating cosmetic compositions and process for the preparation of the active ingredient
WO1999053936A1 (fr) * 1998-04-17 1999-10-28 Shanghai Meiji Health Pharmaceutical Corp., Ltd. Agents hypoglycemiques
JP2004505007A (ja) * 1999-12-21 2004-02-19 ロレアル 抗グリケーション剤としての少なくとも１つのスノキ属植物の抽出物の使用
KR20060066866A (ko) * 2004-12-14 2006-06-19 학교법인 한림대학교 들쭉나무 추출물을 포함하는 당뇨병 합병증 저해제
KR20210156441A (ko) * 2020-06-18 2021-12-27 종근당건강 주식회사 들쭉나무 열매 분말을 함유하는 피부노화 개선용 조성물

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986001713A1 (en) * 1984-09-21 1986-03-27 Innofinance Általános Innovációs Pénzintézet Skin regenerating and hydrating cosmetic compositions and process for the preparation of the active ingredient
WO1999053936A1 (fr) * 1998-04-17 1999-10-28 Shanghai Meiji Health Pharmaceutical Corp., Ltd. Agents hypoglycemiques
JP2004505007A (ja) * 1999-12-21 2004-02-19 ロレアル 抗グリケーション剤としての少なくとも１つのスノキ属植物の抽出物の使用
KR20060066866A (ko) * 2004-12-14 2006-06-19 학교법인 한림대학교 들쭉나무 추출물을 포함하는 당뇨병 합병증 저해제
KR20210156441A (ko) * 2020-06-18 2021-12-27 종근당건강 주식회사 들쭉나무 열매 분말을 함유하는 피부노화 개선용 조성물

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HARRIS CORY S.; CUERRIER ALAIN; LAMONT ERIN; HADDAD PIERRE S.; ARNASON JOHN T.; BENNETT STEFFANY A.; JOHNS TIMOTHY: "Investigating Wild Berries as a Dietary Approach to Reducing the Formation of Advanced Glycation Endproducts: Chemical Correlates ofIn VitroAntiglycation Activity", PLANTS FOODS FOR HUMAN NUTRITION., KLUWER ACADEMIC PUBLISHERS., NL, vol. 69, no. 1, 22 January 2014 (2014-01-22), NL , pages 71 - 77, XP035364143, ISSN: 0921-9668, DOI: 10.1007/s11130-014-0403-3 *
MATSUURA PHARMACEUTICAL CO., LTD.: "Cornsilk EXPOWDER P: A powder that suppresses blood sugar rise! Improves urinary output in edema models!", IPROS PHARMACEUTICAL AND FOOD TECHNOLOGY, XP009558893, Retrieved from the Internet <URL:https://ls.ipros.jp/product/detail/print/?objectId=1650234&hub=45+google> [retrieved on 20240213] *
SUZUKI RYUICHIRO, IIJIMA MIKI, OKADA YOSHIHITO, OKUYAMA TORU: "Chemical Constituents of the Style of Zea mays L. with Glycation Inhibitory Activity", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, JP, vol. 55, no. 1, 1 January 2007 (2007-01-01), JP , pages 153 - 155, XP093186685, ISSN: 0009-2363, DOI: 10.1248/cpb.55.153 *
WANG KAI-JIN; ZHAO JIN-LIANG: "Corn silk (Zea maysL.), a source of natural antioxidants with α-amylase, α-glucosidase, advanced glycation and diabetic nephropathy inhibitory activities", BIOMEDICINE & PHARMACOTHERAPY, ELSEVIER, FR, vol. 110, 1 January 1900 (1900-01-01), FR , pages 510 - 517, XP085573712, ISSN: 0753-3322, DOI: 10.1016/j.biopha.2018.11.126 *

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CN120225212A (zh) 2025-06-27

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