WO2024124812A1 - 一种高纯度阿拉伯糖晶体的制备方法 - Google Patents

一种高纯度阿拉伯糖晶体的制备方法 Download PDF

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WO2024124812A1
WO2024124812A1 PCT/CN2023/096370 CN2023096370W WO2024124812A1 WO 2024124812 A1 WO2024124812 A1 WO 2024124812A1 CN 2023096370 W CN2023096370 W CN 2023096370W WO 2024124812 A1 WO2024124812 A1 WO 2024124812A1
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arabinose
sugar solution
temperature
controlled
purity
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PCT/CN2023/096370
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English (en)
French (fr)
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韩新峰
李东旭
杨铭乾
廖承军
秦淑芳
罗家星
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浙江华康药业股份有限公司
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Publication of WO2024124812A1 publication Critical patent/WO2024124812A1/zh

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  • the invention belongs to the technical field of sugar alcohol preparation, and particularly relates to a method for preparing high-purity arabinose crystals.
  • Arabinose is widely used in the fields of medicine and health food. Low-purity arabinose crystal products are cheap because they cannot meet customer needs. High-purity arabinose crystal products are sold at a higher price due to complex processes and difficulty in production, but they can meet the process formula requirements of some special customers and have a large market space.
  • L-arabinose is often affected by high temperature and low pH conditions due to its characteristics and then reacts to convert into other substances, such as isomerization reaction to convert into xylose; decomposition reaction to decompose into small molecules with less than five carbon atoms; polymerization reaction to generate maltotriose, which leads to a continuous decrease in the content of arabinose during the production process, especially during decolorization, evaporation, and chromatographic separation, and the purity of the produced crystalline arabinose is difficult to reach above 99.5%.
  • Patent publication number CN112079886A discloses a method for improving the purity of xylose and arabinose by chromatographic separation, but also fails to consider the problem that higher temperatures and lower pH values in production processes such as decolorization and chromatographic separation may lead to low arabinose conversion.
  • the technical problem to be solved by the present invention is to provide a method for preparing high-purity arabinose crystals, by controlling the pH value and temperature during the preparation process to prevent isomerization reaction, decomposition reaction and polymerization reaction, thereby improving the purity of the arabinose crystals.
  • the present invention is achieved by providing a method for preparing high-purity arabinose crystals, comprising the following steps:
  • Step 1 dissolution: dissolving the low-content arabinose crystals to obtain a dissolved sugar solution.
  • the dissolution tank system is provided with a temperature sensor and an automatic regulating valve.
  • the temperature of the material dissolution process is monitored by the Siemens DCS automatic temperature control system to ensure that the temperature of the dissolved solution is 55-60° C. during the dissolution process.
  • the arabinose content in the low-purity arabinose crystals is 96-97%.
  • Step 2 blending: The dissolved sugar solution is piped into the blending tank through an electromagnetic flowmeter, an automatic regulating valve and a Siemens intelligent control system, and the arabinose centrifuged mother liquor of step 8 is added to the blending tank for blending to obtain a blended sugar solution, wherein the pH value after blending is within the range of 4.3 to 5.0, the dry basis concentration is 50 to 60%, and the arabinose content after blending is 94 ⁇ 0.5%. Ensure the stability of the liquid.
  • Step 3 Ion exchange: The blended sugar solution is subjected to ion exchange treatment to obtain ion-exchange sugar solution.
  • the material temperature is controlled at 45-50°C through an ion-exchange feed heat exchanger, and the pH of the ion-exchange sugar solution is stabilized at 5.5-6.5.
  • Step 4 decolorization and filtration:
  • the ionized sugar solution enters the decolorization tank through a pipeline for decolorization and filtration to obtain a decolorized sugar solution.
  • the decolorization temperature is controlled at 60-65°C and the pH is 5.5-7.5.
  • Step 5 fine filtration: The decolorized sugar solution is finely filtered using a fine filtration membrane with a pore size of 0.45 ⁇ m to obtain a finely filtered sugar solution. During the fine filtration process, the temperature is controlled at 50-65° C. and the pH value is 5.0-7.5.
  • Step 6 Evaporation and concentration: The refined filtered sugar solution enters the MVR evaporator for evaporation and concentration to obtain concentrated sugar solution, with the temperature controlled at 65-70°C and the pH value at 5.0-7.5.
  • Step 7 Crystallization: The concentrated sugar solution is put into the vacuum sugar boiling system for crystallization treatment. The temperature is controlled at 63-65°C and the vacuum degree is 70-90mbar.
  • Step 8 centrifugation: the material treated in step 7 is centrifuged in a centrifuge to separate solid arabinose and arabinose centrifuge mother liquor, and the arabinose centrifuge mother liquor is passed into a blending tank through a pipeline to perform the operation of step 2.
  • the arabinose content in the arabinose centrifuge mother liquor is 89-91%.
  • Step 9 drying: using 80° C. hot air to dry the solid arabinose to obtain high-purity arabinose crystals, wherein the arabinose content is more than 99.8%.
  • the temperature of the liquid material processing stage is strictly controlled not to exceed 70°C to avoid the high temperature accelerating the conversion of arabinose into miscellaneous sugars and reducing its purity.
  • the method for preparing high-purity arabinose crystals of the present invention has the following characteristics:
  • the pH of the ion exchange output is stably controlled to be 5.5-6.5, thereby avoiding the problem of local over-alkalinity of the feed liquid during the operation of adjusting the pH of the feed liquid by adding alkali, causing the isomerization problem of the feed liquid and affecting the production efficiency and product quality of the subsequent production process.
  • FIG1 is a schematic flow chart of the steps of the method for preparing high-purity arabinose crystals of the present invention.
  • FIG1 Please refer to FIG1 for a preferred embodiment of the method for preparing high-purity arabinose crystals of the present invention.
  • the direction indicated by the arrow in the figure is a schematic diagram of the flow direction of the material or the moving direction of the process.
  • the preparation method comprises the following steps:
  • Step 1 Dissolution: Dissolve the low-content arabinose crystals to obtain dissolved sugar solution.
  • the dissolution tank system is equipped with a temperature sensor and an automatic regulating valve.
  • the temperature of the material dissolution process is monitored through the Siemens DCS automatic temperature control system to ensure The temperature of the dissolving liquid during the dissolving process is 55-60° C., and the arabinose content in the low-purity arabinose crystals is 96-97%, thereby ensuring the stability of the liquid.
  • Step 2 blending: the dissolved sugar solution is passed through an electromagnetic flowmeter, an automatic regulating valve and a Siemens intelligent control system through a pipeline into a blending tank, the arabinose centrifuged mother liquor of step 8 is added into the blending tank for blending to obtain a blended sugar solution, the pH value after blending is in the range of 4.3 to 5.0, the dry basis concentration is 50 to 60%, and the arabinose content after blending is 94 ⁇ 0.5%.
  • Step 3 Ion exchange: The blended sugar solution is subjected to ion exchange treatment to obtain an ion exchange sugar solution, and the material temperature is controlled at 45-50°C by the ion exchange feed heat exchanger, and the pH of the ion exchange sugar solution is stabilized at 5.5-6.5.
  • the ion exchange treatment uses an ion exchange column, in which the ratio of cationic resin to anionic resin is 7:10. By adjusting the ratio of cations and anions in the ion exchange resin to 7:10, the pH of the ion exchange output is stably regulated to 5.5-6.5, avoiding the subsequent conversion of arabinose into other miscellaneous sugars under conditions of too low pH.
  • Step 4 decolorization and filtration:
  • the ionized sugar solution enters the decolorization tank through the pipeline for decolorization and filtration to obtain decolorized sugar solution, and the decolorization temperature is controlled at 60-65°C and the pH is 5.5-7.5.
  • the decolorization and filtration treatment method includes: adding activated carbon to the decolorization tank at 1.2-1.4 kg/ton dry basis for decolorization, stirring and decolorizing at 110 rpm for 30-45 minutes, and then filtering and removing the activated carbon using a plate and frame filter press.
  • Step 5 fine filtration: The decolorized sugar solution is finely filtered using a fine filtration membrane with a pore size of 0.45 ⁇ m to obtain a finely filtered sugar solution. During the fine filtration process, the temperature is controlled at 50-65° C. and the pH value is 5.0-7.5.
  • Step 6 Evaporation and concentration: The refined filtered sugar solution enters the MVR evaporator for evaporation and concentration to obtain concentrated sugar solution, with the temperature controlled at 65-70°C and the pH value at 5.0-7.5.
  • Step 7 crystallization: the concentrated sugar solution is put into the vacuum sugar boiling system for crystallization treatment, the temperature is controlled at 63-65°C, and the vacuum degree is 70-90 mbar.
  • the crystallization treatment includes: when the supersaturation of the concentrated sugar solution reaches between 1.01 and 1.02, 300-400 mesh arabinose seeds are added at a dry basis ratio of 0.02% for vacuum evaporation crystallization, the crystallization cycle is controlled at 8 hours, and the stirring speed is controlled at 80 rpm.
  • Step 8 centrifugation: The material after step 7 is centrifuged and separated by centrifugation to separate solid arabinose and arabinose centrifuge mother liquor, and the arabinose centrifuge mother liquor is passed into the blending tank through a pipeline to perform the operation of step 2, and the arabinose content in the arabinose centrifuge mother liquor is 89-91%.
  • the centrifugation treatment also includes controlling the washing time at 10s and the water temperature at 55-60°C.
  • Step 9 drying: using 80°C hot air to dry the solid arabinose to obtain high-purity arabinose crystals, wherein the arabinose content is more than 99.8%.
  • the drying treatment method also includes: controlling the moisture content at 0.15-0.3%, and then cooling the product to 20-24°C with 12-15°C clean cold air after the moisture content is qualified.
  • Step 11 dissolution: dissolve the purchased low-purity arabinose crystals.
  • the dissolution tank system is equipped with a temperature sensor and an automatic regulating valve.
  • the temperature of the material dissolution process is monitored through the Siemens DCS automatic temperature control system to ensure that the dissolution liquid is stable during the dissolution process.
  • the temperature is 55-60° C., and the arabinose content in the low-purity arabinose crystals is 96%.
  • Step 12 blending: the sugar solution of step 11 is passed through an electromagnetic flowmeter, an automatic regulating valve and a Siemens intelligent control system through a pipeline into a blending tank, and the arabinose centrifuged mother liquor of step 18 is added into the blending tank for blending.
  • the pH value after blending is 5.0, the dry basis concentration is 50%, and the arabinose content is 93.84%.
  • Step 13 Deionization: The blended sugar solution obtained in step 12 enters the deionization process, and the temperature of the sugar solution is controlled at 45-50°C through the deionization feed heat exchanger, and the ratio of the cation and anion resins in the deionization system is adjusted to 7:10, and the pH of the deionized liquid is stabilized at 6.5.
  • Step 14 decolorization and filtration: the sugar solution after separation enters the decolorization tank through the pipeline, activated carbon is added into the decolorization tank at a rate of 1.2 kg/ton dry basis for decolorization, the decolorization is carried out at 110 rpm with stirring for 30 minutes, and then the activated carbon is filtered out using a plate and frame filter press, and the decolorization temperature is controlled at 60°C and the pH is 5.0-7.5.
  • Step 15 fine filtration: Use a fine filtration membrane with a pore size of 0.45 ⁇ m to finely filter the sugar solution decolorized in step 14. During the fine filtration process, the temperature is controlled at 50-65° C. and the pH value is 5.0-7.5.
  • Step 16 evaporation concentration: the sugar solution treated in step 15 enters the MVR evaporator for concentration, and the temperature is controlled at 68°C and the pH value is 5.0-7.5.
  • Step 17 crystallization: the sugar solution treated in step 16 enters the vacuum sugar boiling system, the temperature is controlled at 63-65°C, the vacuum degree is 70-90 mbar, and when the supersaturation of the sugar solution reaches between 1.01 and 1.02, 300-400 mesh seed crystals are added at a dry basis ratio of 0.02 to carry out vacuum evaporation crystallization.
  • the crystallization cycle is controlled at 8 hours, and the stirring speed is controlled at 80 rpm.
  • Step 18 centrifugation: the material treated in step 17 is centrifuged in a centrifuge, the washing time is controlled at 10s, the water temperature is 55-60°C, solid arabinose and arabinose centrifuge mother liquor are separated, the solid arabinose is subjected to the operation of step 19, and the arabinose centrifuge mother liquor is passed into a blending tank through a pipeline to perform the operation of step 12.
  • the arabinose content in the arabinose centrifuge mother liquor is 89%.
  • Step 19 drying and packaging:
  • the solid arabinose treated in step 18 is dried with 80°C hot air, and the moisture is controlled at 0.15-0.3%. After the moisture is qualified, the product is cooled to 20-24°C with 12-15°C clean cold air to obtain high-purity arabinose crystals, wherein the arabinose content is more than 99.8%.
  • the treated arabinose crystals are packaged using a packaging machine.
  • Step 21 dissolving: dissolving the purchased low-purity arabinose crystals, the dissolving tank system is provided with a temperature sensor and an automatic regulating valve, and the temperature monitoring of the material dissolving process is realized through the Siemens DCS automatic temperature control system to ensure that the temperature of the dissolving liquid during the dissolving process is 55-60° C., and the arabinose content in the low-purity arabinose crystals is 97%.
  • Step 22 blending: the sugar solution of step 21 is passed through a pipeline into a blending tank by means of an electromagnetic flowmeter, an automatic regulating valve and a Siemens intelligent control system, and the arabinose centrifuged mother liquor of step 28 is added into the blending tank for blending.
  • the pH value after blending is in the range of 4.3 to 5.0, the dry basis concentration is 60%, and the arabinose content is 94.57%.
  • Step 23 Deionization: The blended sugar solution obtained in step 22 enters the deionization process, and the temperature of the sugar solution is controlled at 45-50°C through the deionization feed heat exchanger, and the ratio of the cation and anion resins in the deionization system is adjusted to 7:10, and the pH of the liquid after deionization is stabilized at 6.0.
  • Step 24 decolorization and filtration: the sugar solution after separation enters the decolorization tank through the pipeline, activated carbon is added into the decolorization tank at a rate of 1.4 kg/ton dry basis for decolorization, the decolorization is carried out at 110 rpm with stirring for 35 minutes, and then the activated carbon is filtered out using a plate and frame filter press, and the decolorization temperature is controlled at 62°C and pH 5.5-7.5.
  • Step 25 fine filtration: Use a fine filtration membrane with a pore size of 0.45 ⁇ m to finely filter the sugar solution decolorized in step 24. During the fine filtration process, the temperature is controlled at 50-65° C. and the pH value is 5.0-7.5.
  • Step 26 evaporation concentration: the sugar solution treated in step 25 enters the MVR evaporator for concentration, and the temperature is controlled at 68°C and the pH value is 5.0-7.5.
  • Step 27 crystallization: the sugar solution treated in step 26 enters the vacuum sugar boiling system, the temperature is controlled at 63-65°C, the vacuum degree is 70-90 mbar, and when the supersaturation of the sugar solution reaches between 1.01 and 1.02, 300-400 mesh seed crystals are added at a dry basis ratio of 0.02 to carry out vacuum evaporation crystallization.
  • the crystallization cycle is controlled at 8 hours, and the stirring speed is controlled at 80 rpm.
  • Step 28 centrifugation: the material treated in step 27 is centrifuged in a centrifuge, the washing time is controlled at 10s, the water temperature is 55-60°C, solid arabinose and arabinose centrifuge mother liquor are separated, the solid arabinose is subjected to the operation of step 29, and the arabinose centrifuge mother liquor is passed into a blending tank through a pipeline to perform the operation of step 22.
  • the arabinose content in the arabinose centrifuge mother liquor is 91%.
  • Step 29 drying and packaging:
  • the solid arabinose treated in step 28 is dried with 80°C hot air, and the moisture is controlled at 0.15-0.3%. After the moisture is qualified, the product is cooled to 20-24°C with 12-15°C clean cold air to obtain high-purity arabinose crystals, wherein the arabinose content is more than 99.8%.
  • the treated arabinose crystals are packaged using a packaging machine.
  • Step 31 dissolving: dissolving the purchased low-purity arabinose crystals, the dissolving tank system is provided with a temperature sensor and an automatic regulating valve, and the temperature monitoring of the material dissolution process is realized by the Siemens DCS automatic temperature control system to ensure that the temperature of the dissolving liquid during the dissolution process is 55-60° C., and the arabinose content in the low-purity arabinose crystals is 96.5%.
  • Step 32 blending: the sugar solution of step 31 is passed through an electromagnetic flowmeter, an automatic regulating valve and a Siemens intelligent control system through a pipeline into a blending tank, and the arabinose centrifuged mother liquor of step 38 is added into the blending tank for blending.
  • the pH value after blending is in the range of 4.3 to 5.0, the dry basis concentration is 55%, and the arabinose content is 94.50%.
  • Step 33 Deionization: The blended sugar solution obtained in step 32 enters the deionization process, and the temperature of the sugar solution is controlled at 45-50°C through the deionization feed heat exchanger, and the ratio of the cation and anion resins in the deionization system is adjusted to 7:10, and the pH of the liquid after deionization is stabilized at 5.5.
  • Step 34 decolorization and filtration:
  • the sugar solution after separation enters the decolorization tank through a pipeline, and activated carbon is added to the decolorization tank at a rate of 1.25 kg/ton dry basis for decolorization.
  • the decolorization is stirred at 110 rpm for 45 minutes, and then the activated carbon is removed by filtering using a plate and frame filter press.
  • the decolorization temperature is controlled at 65°C and the pH is 5.5-7.5.
  • Step 35 fine filtration: Use a fine filtration membrane with a pore size of 0.45 ⁇ m to finely filter the sugar solution decolorized in step 34. During the fine filtration process, the temperature is controlled at 50-65° C. and the pH value is 5.0-7.5.
  • Step 36 evaporation concentration: the sugar solution treated in step 35 enters the MVR evaporator for concentration, and the temperature is controlled at 70°C and the pH value is 5.0-7.5.
  • Step 37 crystallization: the sugar solution treated in step 36 enters a vacuum sugar boiling system, the temperature is controlled at 63-65°C, the vacuum degree is 70-90 mbar, and when the supersaturation of the sugar solution reaches between 1.01 and 1.02, 300-400 mesh seed crystals are added at a dry basis ratio of 0.02 to carry out vacuum evaporation crystallization.
  • the crystallization cycle is controlled at 8 hours, and the stirring speed is controlled at 80 rpm.
  • Step 38 centrifugation: the material treated in step 37 is centrifuged in a centrifuge, the washing time is controlled at 10s, the water temperature is 55-60°C, solid arabinose and arabinose centrifuge mother liquor are separated, the solid arabinose is subjected to the operation of step 39, and the arabinose centrifuge mother liquor is passed into a blending tank through a pipeline to perform the operation of step 32.
  • the arabinose content in the arabinose centrifuge mother liquor is 90.3%.
  • Step 39 drying and packaging:
  • the solid arabinose treated in step 38 is dried with 80°C hot air, and the moisture is controlled at 0.15-0.3%. After the moisture is qualified, the product is cooled to 20-24°C with 12-15°C clean cold air to obtain high-purity arabinose crystals, wherein the arabinose content is more than 99.8%.
  • the treated arabinose crystals are packaged using a packaging machine.
  • Step 41 dissolving: dissolving the purchased low-purity arabinose crystals, the dissolving tank system is provided with a temperature sensor and an automatic regulating valve, and the temperature monitoring of the material dissolving process is realized through the Siemens DCS automatic temperature control system to ensure that the temperature of the dissolving liquid during the dissolving process is 55-60° C., and the arabinose content in the low-purity arabinose crystals is 96.9%.
  • Step 42 blending: the sugar solution of step 41 is passed through a pipeline into a blending tank by means of an electromagnetic flowmeter, an automatic regulating valve and a Siemens intelligent control system, and the arabinose centrifuged mother liquor of step 48 is added into the blending tank for blending.
  • the pH value after blending is in the range of 4.3 to 5.0, the dry basis concentration is 60%, and the arabinose content is 94.43%.
  • Step 43 Deionization: The blended sugar solution obtained in step 42 enters the deionization process, and the temperature of the sugar solution is controlled at 45-50°C through the deionization feed heat exchanger, and the ratio of the cation and anion resins in the deionization system is adjusted to 7:10, and the pH of the liquid after deionization is stabilized at 6.2.
  • Step 44 decolorization and filtration: the sugar solution after separation enters the decolorization tank through a pipeline, activated carbon is added into the decolorization tank at a rate of 1.38 kg/ton dry basis for decolorization, the decolorization is carried out by stirring at 110 rpm for 40 minutes, and then the activated carbon is removed by filtering using a plate and frame filter press, and the decolorization temperature is controlled at 60°C and the pH is 5.5-7.5.
  • Step 45 fine filtration: Use a fine filtration membrane with a pore size of 0.45 ⁇ m to finely filter the sugar solution decolorized in step 44. During the fine filtration process, the temperature is controlled at 50-65° C. and the pH value is 5.0-7.5.
  • Step 46 evaporation concentration: The sugar solution treated in step 45 enters the MVR evaporator for concentration, and the temperature is controlled at 65°C. pH value: 5.0 ⁇ 7.5.
  • Step 47 crystallization: the sugar solution treated in step 46 enters a vacuum sugar boiling system, the temperature is controlled at 63-65°C, the vacuum degree is 70-90 mbar, and when the supersaturation of the sugar solution reaches between 1.01 and 1.02, 300-400 mesh seed crystals are added at a dry basis ratio of 0.02 to carry out vacuum evaporation crystallization.
  • the crystallization cycle is controlled at 8 hours, and the stirring speed is controlled at 80 rpm.
  • Step 48 centrifugation: the material treated in step 47 is centrifuged in a centrifuge, the washing time is controlled at 10s, the water temperature is 55-60°C, solid arabinose and arabinose centrifuge mother liquor are separated, the solid arabinose is subjected to the operation of step 49, and the arabinose centrifuge mother liquor is passed into a blending tank through a pipeline to perform the operation of step 42.
  • the arabinose content in the arabinose centrifuge mother liquor is 89.8%.
  • Step 49 drying and packaging:
  • the solid arabinose treated in step 48 is dried with 80°C hot air, and the moisture is controlled at 0.15-0.3%. After the moisture is qualified, the product is cooled to 20-24°C with 12-15°C clean cold air to obtain high-purity arabinose crystals, wherein the arabinose content is more than 99.8%.
  • the treated arabinose crystals are packaged using a packaging machine.
  • the conventional preparation process is adopted, and the ratio of anion resin to cation resin in the ion exchange stage is 1:1.
  • Step 51 dissolving: dissolving the purchased low-purity arabinose crystals, the dissolving tank system is provided with a temperature sensor and an automatic regulating valve, and the temperature monitoring of the material dissolution process is realized through the Siemens DCS automatic temperature control system to ensure that the temperature of the dissolving liquid during the dissolution process is 55-60° C., the arabinose content in the low-purity arabinose crystals is 97%, the dry basis concentration is 55%, and the pH value is in the range of 3.5-5.0.
  • Step 52 Deionization: The sugar solution obtained in step 51 enters the deionization process, and the temperature of the sugar solution is controlled at 45-50°C through the deionization feed heat exchanger, and the ratio of the cation and anion resins in the deionization system is adjusted to 1:1. The pH of the liquid after deionization is stabilized at 3.5-4.0.
  • Step 53 decolorization and filtration: the sugar solution after separation enters the decolorization tank through the pipeline, activated carbon is added into the decolorization tank at a rate of 1.4 kg/ton dry basis for decolorization, the decolorization is carried out at 110 rpm with stirring for 45 minutes, and then the activated carbon is filtered out using a plate and frame filter press, and the decolorization temperature is controlled at 75-80°C and pH 3.5-4.5.
  • Step 54 fine filtration: Use a fine filtration membrane with a pore size of 0.45 ⁇ m to finely filter the sugar solution decolorized in step 53. During the fine filtration process, the temperature is controlled at 50-65° C. and the pH value is 3.5-4.5.
  • Step 55 evaporation concentration: the sugar solution treated in step 54 enters the falling film evaporator for concentration, and the temperature is controlled at 65-98°C and the pH value is 3.5-4.5.
  • Step 56 crystallization: the sugar solution treated in step 55 enters a vacuum sugar boiling system, the temperature is controlled at 63-65°C, the vacuum degree is 70-90 mbar, and when the supersaturation of the sugar solution reaches between 1.01 and 1.02, 300-400 mesh seed crystals are added at a dry basis ratio of 0.02 to carry out vacuum evaporation crystallization.
  • the crystallization cycle is controlled at 8 hours, and the stirring speed is controlled at 80 rpm.
  • Step 57 centrifugation: The material treated in step 56 is centrifuged in a centrifuge, the washing time is controlled at 10s and the water temperature is controlled at 55-60°C. Solid arabinose and arabinose centrifugal mother liquor are separated, solid arabinose is subjected to the operation of step 58, and arabinose centrifugal mother liquor is returned to step 51 through a pipeline.
  • Step 58 drying and packaging: the solid arabinose treated in step 57 is dried with 80°C hot air, and the moisture content is controlled at 0.15-0.3%. After the moisture content is qualified, the product is cooled to 20-24°C with 12-15°C clean cold air to obtain arabinose crystals, and the treated arabinose crystals are packaged using a packaging machine.

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Abstract

本发明涉及一种高纯度阿拉伯糖晶体的制备方法，包括将低含量阿拉伯糖晶体依次进行溶解、勾兑、离子交换、脱色过滤、精滤、蒸发浓缩、结晶、离心分离、干燥等处理工序，在阿拉伯糖晶体的制备过程中控制物料的pH4.3～7.5和温度不超过70℃，避免阿拉伯糖高温加速转化为杂糖而降低纯度，提高所制备的阿拉伯糖晶体的纯度。

Description

一种高纯度阿拉伯糖晶体的制备方法 技术领域
本发明属于糖醇制备技术领域，特别涉及一种高纯度阿拉伯糖晶体的制备方法。
背景技术
阿拉伯糖在医药和保健食品等领域有着广泛应用，低纯度的阿拉伯糖晶体产品因不能满足客户的需求而价格便宜，高纯度阿拉伯糖晶体产品由于工艺复杂、生产难度大，售价较高，但能满足一些特殊客户工艺配方需求，存在较大市场空间。
在现有技术在生产工艺中，L-阿拉伯糖因其特性往往会受高温和低pH条件的影响进而发生反应转化为其他物质，如发生异构反应，转化成木糖；发生分解反应，分解成五碳以下的小分子；发生聚合反应，生成麦芽三糖，从而导致阿拉伯糖在生产过程中，尤其是脱色、蒸发、色谱分离过程中含量不断下降，生产所得结晶阿拉伯糖纯度都较难达到99.5％以上。
公开号CN112079886A的专利公开了一种经色谱分离提高木糖和阿拉伯糖纯度的方法，同样也没有考虑生产过程如脱色、色谱分离等工序中较高的温度和较低的pH值会导致阿拉伯糖转化低的问题。
发明内容
本发明所要解决的技术问题在于，提供一种高纯度阿拉伯糖晶体的制备方法，通过控制制备过程中的pH值和温度，防止发生异构反应、分解反应和聚合反应，提高阿拉伯糖晶体的纯度。
本发明是这样实现的，提供一种高纯度阿拉伯糖晶体的制备方法，包括如下步骤：
步骤一、溶解：将低含量阿拉伯糖晶体进行溶解处理得到溶解糖液，溶解罐系统设置温度传感器、自动调节阀，通过西门子DCS自动温控系统实现物料溶解过程的温度监控，确保溶解过程溶解液温度55～60℃，所述低纯度阿拉伯糖晶体中阿拉伯糖含量为96～97％。
步骤二、勾兑：通过电磁流量计、自动调节阀和西门子智能化控制系统将溶解糖液经管道进入勾兑罐，向勾兑罐内加入步骤八的阿拉伯糖离心母液进行勾兑处理得到勾兑糖液，勾兑后的pH值在4.3～5.0的范围内，干基浓度为50～60％，勾兑后阿拉伯糖含量94±0.5％。确保料液的稳定性。
步骤三：离子交换：将勾兑糖液进行离子交换处理得到离交糖液，通过离交进料换热器把物料温度控制在45～50℃，离交糖液的pH稳定在5.5～6.5。
步骤四、脱色过滤：离交糖液经管道进入脱色罐进行脱色过滤处理得到脱色糖液，脱色温度控制在60～65℃，pH5.5～7.5。
步骤五、精滤：将脱色糖液使用孔径为0.45μm的精滤膜进行精滤处理得到精滤糖液，精滤过程中温度控制50～65℃，pH值5.0～7.5。
步骤六、蒸发浓缩：将精滤糖液进入MVR蒸发器进行蒸发浓缩处理得到浓缩糖液，控制温度为65～70℃，pH值5.0～7.5。
步骤七、结晶：将浓缩糖液进入真空煮糖系统进行结晶处理，温度控制在63～65℃，真空度在70～90mbar。
步骤八、离心：将步骤七处理后的物料经离心机进行离心分离处理，分离出固体阿拉伯糖和阿拉伯糖离心母液，阿拉伯糖离心母液通过管道通入勾兑罐进行步骤二的操作，阿拉伯糖离心母液中阿拉伯糖含量为89～91％。
步骤九、干燥：用80℃热风对固体阿拉伯糖进行干燥处理，得到高纯度阿拉伯糖晶体，其中阿拉伯糖含量为99.8％以上。
严格控制液体物料处理阶段温度不超过70℃，避免阿拉伯糖高温加速转化为杂糖而降低纯度。
与现有技术相比，本发明的高纯度阿拉伯糖晶体的制备方法具有以下特点：
(1)精制前设置勾兑工序，确保料液的稳定性；
(2)通过调节离子交换树脂的阳、阴离子比例为7:10，进而稳定调控离交出料pH5.5～6.5，避免了加碱方式调节料液pH操作中料液局部过碱化，造成料液的异构问题，影响后续生产工艺的生产效率及产品质量。
(3)使用杂糖含量较高的阿拉伯糖晶体，对其进行溶解、提纯浓缩得到纯度为99.8％以上的阿拉伯糖晶体，并相对常规生产工艺可提高产品结晶收率3.5％以上。
附图说明
图1为本发明高纯度阿拉伯糖晶体的制备方法的步骤流程示意图。
具体实施方式
为了使本发明所要解决的技术问题、技术方案及有益效果更加清楚明白，以下结合实施例和附图，对本发明进行进一步详细说明。应当理解，此处所描述的具体实施例仅仅用以解释本发明，并不用于限定本发明。
请参照图1所示，本发明高纯度阿拉伯糖晶体的制备方法的较佳实施例。图中的箭头所示方向为物料的流动方向或流程移动方向示意。所述制备方法包括如下步骤：
步骤一、溶解：将低含量阿拉伯糖晶体进行溶解处理得到溶解糖液，溶解罐系统设置温度传感器、自动调节阀，通过西门子DCS自动温控系统实现物料溶解过程的温度监控，确保 溶解过程溶解液温度55～60℃，所述低纯度阿拉伯糖晶体中阿拉伯糖含量为96～97％。确保料液的稳定性。
步骤二、勾兑：通过电磁流量计、自动调节阀和西门子智能化控制系统将溶解糖液经管道进入勾兑罐，向勾兑罐内加入步骤八的阿拉伯糖离心母液进行勾兑处理得到勾兑糖液，勾兑后的pH值在4.3～5.0的范围内，干基浓度为50～60％，勾兑后阿拉伯糖含量94±0.5％。
步骤三：离子交换：将勾兑糖液进行离子交换处理得到离交糖液，通过离交进料换热器把物料温度控制在45～50℃，离交糖液的pH稳定在5.5～6.5。所述离子交换处理使用离子交换柱，在离子交换柱中，阳离子树脂与阴离子树脂的比例为7：10。通过调节离交树脂阳、阴离子比例为7:10，进而稳定调控离交出料pH5.5～6.5，避免后续出现pH过低条件下阿拉伯糖转化为其他杂糖。
步骤四、脱色过滤：离交糖液经管道进入脱色罐进行脱色过滤处理得到脱色糖液，脱色温度控制在60～65℃，pH5.5～7.5。所述脱色过滤处理方式包括：向脱色罐内按照1.2～1.4Kg/吨干基加入活性炭进行脱色，在110rpm搅拌脱色30～45min，然后使用板框压滤机过滤去除掉活性炭。
步骤五、精滤：将脱色糖液使用孔径为0.45μm的精滤膜进行精滤处理得到精滤糖液，精滤过程中温度控制50～65℃，pH值5.0～7.5。
步骤六、蒸发浓缩：将精滤糖液进入MVR蒸发器进行蒸发浓缩处理得到浓缩糖液，控制温度为65～70℃，pH值5.0～7.5。
步骤七、结晶：将浓缩糖液进入真空煮糖系统进行结晶处理，温度控制在63～65℃，真空度在70～90mbar。所述结晶处理包括：在浓缩糖液过饱和度达到1.01～1.02之间按照万分之二的干基比例加入300～400目阿拉伯糖晶种进行真空蒸发结晶，结晶周期控制在8小时，搅拌转速控制在80rpm。
步骤八、离心：将步骤七处理后的物料经离心机进行离心分离处理，分离出固体阿拉伯糖和阿拉伯糖离心母液，阿拉伯糖离心母液通过管道通入勾兑罐进行步骤二的操作，阿拉伯糖离心母液中阿拉伯糖含量为89～91％。所述离心分离处理还包括洗水时间控制在10s、水温控制在55～60℃。
步骤九、干燥：用80℃热风对固体阿拉伯糖进行干燥处理，得到高纯度阿拉伯糖晶体，其中阿拉伯糖含量为99.8％以上。所述干燥处理方式还包括：水分控制在0.15～0.3％，水分合格后再用12～15℃洁净冷风把产品冷却至20～24℃。
严格控制液体物料处理阶段温度不超过70℃，避免阿拉伯糖高温加速转化为杂糖而降低 纯度。
下面通过具体实施例进一步说明本发明的高纯度阿拉伯糖晶体的制备方法。
实施例1：确定温度和pH对阿拉伯糖含量的影响
本实施例包括如下步骤：
取L-阿拉伯糖样品100g加水配成折光60％的溶液，分别调pH2.7和4.3，再依次于60℃、65℃、70℃下加热48h，并分别在24h和48h取样检测，结果如下表1所示：
表1不同温度和pH条件下阿拉伯糖溶液的组分测定
对比可知，阿拉伯糖生产过程中pH越低、加热温度越高，随着时间的延长阿拉伯糖含量下降越快。对比不同条件下阿拉伯糖的变化趋势，pH是造成阿拉伯糖含量下降的主要因素，pH在4.3以上时，物料在75℃加热48小时，含量仅下降2.31％；而pH2.7的条件下，物料75℃加热48小时，含量下降8.9％，是pH4.3条件下的3倍多。
由此可见，有效调节阿拉伯糖糖液pH至4.3以上，可以减少高温对阿拉伯糖含量的影响，避免为控制物料含量而降低加工温度，进而使生产效率降低。
实施例2
本发明的高纯度阿拉伯糖晶体的制备方法的第一个实施例，包括如下步骤：
步骤11、溶解：将购买的低纯度阿拉伯糖晶体溶解，溶解罐系统设置温度传感器、自动调节阀，通过西门子DCS自动温控系统实现物料溶解过程的温度监控，确保溶解过程溶解液 温度55～60℃，所述低纯度阿拉伯糖晶体中阿拉伯糖含量为96％。
步骤12、勾兑：通过电磁流量计、自动调节阀和西门子智能化控制系统将步骤11的糖液经管道进入勾兑罐，向勾兑罐内加入步骤18的阿拉伯糖离心母液进行勾兑，勾兑后的pH值5.0，干基浓度为50％，阿拉伯糖含量为93.84％。
步骤13：离交：将步骤12所得勾兑后糖液进入离交工序，通过离交进料换热器把糖液温度控制在45～50℃，调节离交系统阳、阴树脂比例为7：10，离交后液pH稳定在6.5。
步骤14、脱色过滤：离交后的糖液经管道进入脱色罐，向脱色罐内按照1.2Kg/吨干基加入活性炭进行脱色，在110rpm搅拌脱色30min，然后使用板框压滤机过滤去除掉活性炭，脱色温度控制在60℃，pH5.0～7.5。
步骤15、精滤：使用孔径为0.45μm的精滤膜精滤步骤14脱色后的糖液，精滤过程中温度控制50～65℃，pH值5.0～7.5。
步骤16、蒸发浓缩：步骤15处理后的糖液进入MVR蒸发器进行浓缩，控制温度为68℃，pH值5.0～7.5。
步骤17、结晶：步骤16处理后的糖液进入真空煮糖系统，温度控制在63～65℃，真空度在70～90mbar，在糖液过饱和度达到1.01～1.02之间按照万分之二的干基比例加入300～400目晶种进行真空蒸发结晶，结晶周期控制在8小时，搅拌转速控制在80rpm。
步骤18、离心：步骤17处理后的物料经离心机离心，洗水时间控制在10s、水温在55～60℃，分离出固体阿拉伯糖和阿拉伯糖离心母液，固体阿拉伯糖进行步骤19的操作，阿拉伯糖离心母液通过管道通入勾兑罐进行步骤12的操作，阿拉伯糖离心母液中阿拉伯糖含量为89％。
步骤19、干燥、包装：用80℃热风对步骤18处理后的固体阿拉伯糖进行干燥，水分控制在0.15～0.3％，水分合格后再用12～15℃洁净冷风把产品冷却至20～24度℃，得到高纯度阿拉伯糖晶体，其中阿拉伯糖含量为99.8％以上。使用包装机将处理后的阿拉伯糖晶体包装。
实施例3
本发明的高纯度阿拉伯糖晶体的制备方法的第二个实施例，包括如下步骤：
步骤21、溶解：将购买的低纯度阿拉伯糖晶体溶解，溶解罐系统设置温度传感器、自动调节阀，通过西门子DCS自动温控系统实现物料溶解过程的温度监控，确保溶解过程溶解液温度55～60℃，所述低纯度阿拉伯糖晶体中阿拉伯糖含量为97％。
步骤22、勾兑：通过电磁流量计、自动调节阀和西门子智能化控制系统将步骤21的糖液经管道进入勾兑罐，向勾兑罐内加入步骤28的阿拉伯糖离心母液进行勾兑，勾兑后的pH值在4.3～5.0的范围内，干基浓度为60％，阿拉伯糖含量94.57％。
步骤23：离交：将步骤22所得勾兑后糖液进入离交工序，通过离交进料换热器把糖液温度控制在45～50℃，调节离交系统阳、阴树脂比例为7：10，离交后液PH稳定在6.0。
步骤24、脱色过滤：离交后的糖液经管道进入脱色罐，向脱色罐内按照1.4Kg/吨干基加入活性炭进行脱色，在110rpm搅拌脱色35min，然后使用板框压滤机过滤去除掉活性炭，脱色温度控制在62℃、pH5.5～7.5。
步骤25、精滤：使用孔径为0.45μm的精滤膜精滤步骤24脱色后的糖液，精滤过程中温度控制50～65℃，pH值5.0～7.5。
步骤26、蒸发浓缩：步骤25处理后的糖液进入MVR蒸发器进行浓缩，控制温度为68℃，pH值5.0～7.5。
步骤27、结晶：步骤26处理后的糖液进入真空煮糖系统，温度控制在63～65℃，真空度在70～90mbar，在糖液过饱和度达到1.01～1.02之间按照万分之二的干基比例加入300～400目晶种进行真空蒸发结晶，结晶周期控制在8小时，搅拌转速控制在80rpm。
步骤28、离心：步骤27处理后的物料经离心机离心，洗水时间控制在10s、水温在55～60℃，分离出固体阿拉伯糖和阿拉伯糖离心母液，固体阿拉伯糖进行步骤29的操作，阿拉伯糖离心母液通过管道通入勾兑罐进行步骤22的操作，阿拉伯糖离心母液中阿拉伯糖含量为91％。
步骤29、干燥、包装：用80℃热风对步骤28处理后的固体阿拉伯糖进行干燥，水分控制在0.15～0.3％，水分合格后再用12～15℃洁净冷风把产品冷却至20～24度℃，得到高纯度阿拉伯糖晶体，其中阿拉伯糖含量为99.8％以上。使用包装机将处理后的阿拉伯糖晶体包装。
实施例4
本发明的高纯度阿拉伯糖晶体的制备方法的第三个实施例，包括如下步骤：
步骤31、溶解：将购买的低纯度阿拉伯糖晶体溶解，溶解罐系统设置温度传感器、自动调节阀，通过西门子DCS自动温控系统实现物料溶解过程的温度监控，确保溶解过程溶解液温度55～60℃，所述低纯度阿拉伯糖晶体中阿拉伯糖含量为96.5％。
步骤32、勾兑：通过电磁流量计、自动调节阀和西门子智能化控制系统将步骤31的糖液经管道进入勾兑罐，向勾兑罐内加入步骤38的阿拉伯糖离心母液进行勾兑，勾兑后的pH值在4.3～5.0的范围内，干基浓度为55％，阿拉伯糖含量94.50％。
步骤33：离交：将步骤32所得勾兑后糖液进入离交工序，通过离交进料换热器把糖液温度控制在45～50℃，调节离交系统阳、阴树脂比例为7：10，离交后液PH稳定在5.5。
步骤34、脱色过滤：离交后的糖液经管道进入脱色罐，向脱色罐内按照1.25Kg/吨干基加入活性炭进行脱色，在110rpm搅拌脱色45min，然后使用板框压滤机过滤去除掉活性炭， 脱色温度控制在65℃，pH5.5～7.5。
步骤35、精滤：使用孔径为0.45μm的精滤膜精滤步骤34脱色后的糖液，精滤过程中温度控制50～65℃，pH值5.0～7.5。
步骤36、蒸发浓缩：步骤35处理后的糖液进入MVR蒸发器进行浓缩，控制温度为70℃，pH值5.0～7.5。
步骤37、结晶：步骤36处理后的糖液进入真空煮糖系统，温度控制在63～65℃，真空度在70～90mbar，在糖液过饱和度达到1.01～1.02之间按照万分之二的干基比例加入300～400目晶种进行真空蒸发结晶，结晶周期控制在8小时，搅拌转速控制在80rpm。
步骤38、离心：步骤37处理后的物料经离心机离心，洗水时间控制在10s、水温在55～60℃，分离出固体阿拉伯糖和阿拉伯糖离心母液，固体阿拉伯糖进行步骤39的操作，阿拉伯糖离心母液通过管道通入勾兑罐进行步骤32的操作，阿拉伯糖离心母液中阿拉伯糖含量为90.3％。
步骤39、干燥、包装：用80℃热风对步骤38处理后的固体阿拉伯糖进行干燥，水分控制在0.15～0.3％，水分合格后再用12～15℃洁净冷风把产品冷却至20～24度℃，得到高纯度阿拉伯糖晶体，其中阿拉伯糖含量为99.8％以上。使用包装机将处理后的阿拉伯糖晶体包装。
实施例5
本发明的高纯度阿拉伯糖晶体的制备方法的第四个实施例，包括如下步骤：
步骤41、溶解：将购买的低纯度阿拉伯糖晶体溶解，溶解罐系统设置温度传感器、自动调节阀，通过西门子DCS自动温控系统实现物料溶解过程的温度监控，确保溶解过程溶解液温度55～60℃，所述低纯度阿拉伯糖晶体中阿拉伯糖含量为96.9％。
步骤42、勾兑：通过电磁流量计、自动调节阀和西门子智能化控制系统将步骤41的糖液经管道进入勾兑罐，向勾兑罐内加入步骤48的阿拉伯糖离心母液进行勾兑，勾兑后的pH值在4.3～5.0的范围内，干基浓度为60％，阿拉伯糖含量94..43％。
步骤43：离交：将步骤42所得勾兑后糖液进入离交工序，通过离交进料换热器把糖液温度控制在45～50℃，调节离交系统阳、阴树脂比例为7：10，离交后液PH稳定在6.2。
步骤44、脱色过滤：离交后的糖液经管道进入脱色罐，向脱色罐内按照1.38Kg/吨干基加入活性炭进行脱色，在110rpm搅拌脱色40min，然后使用板框压滤机过滤去除掉活性炭，脱色温度控制在60℃，pH5.5～7.5。
步骤45、精滤：使用孔径为0.45μm的精滤膜精滤步骤44脱色后的糖液，精滤过程中温度控制50～65℃，pH值5.0～7.5。
步骤46、蒸发浓缩：步骤45处理后的糖液进入MVR蒸发器进行浓缩，控制温度为65℃， pH值5.0～7.5。
步骤47、结晶：步骤46处理后的糖液进入真空煮糖系统，温度控制在63～65℃，真空度在70～90mbar，在糖液过饱和度达到1.01～1.02之间按照万分之二的干基比例加入300～400目晶种进行真空蒸发结晶，结晶周期控制在8小时，搅拌转速控制在80rpm。
步骤48、离心：步骤47处理后的物料经离心机离心，洗水时间控制在10s、水温在55～60℃，分离出固体阿拉伯糖和阿拉伯糖离心母液，固体阿拉伯糖进行步骤49的操作，阿拉伯糖离心母液通过管道通入勾兑罐进行步骤42的操作，阿拉伯糖离心母液中阿拉伯糖含量为89.8％。
步骤49、干燥、包装：用80℃热风对步骤48处理后的固体阿拉伯糖进行干燥，水分控制在0.15～0.3％，水分合格后再用12～15℃洁净冷风把产品冷却至20～24度℃，得到高纯度阿拉伯糖晶体，其中阿拉伯糖含量为99.8％以上。使用包装机将处理后的阿拉伯糖晶体包装。
下面再通过对比例进一步说明本发明的高纯度阿拉伯糖晶体的制备方法的技术效果。
对比例
采用常规制备工艺，离子交换阶段阴、阳树脂比例1:1。
步骤51、溶解：将购买的低纯度阿拉伯糖晶体溶解，溶解罐系统设置温度传感器、自动调节阀，通过西门子DCS自动温控系统实现物料溶解过程的温度监控，确保溶解过程溶解液温度55～60℃，所述低纯度阿拉伯糖晶体中阿拉伯糖含量为97％，干基浓度为55％，pH值在3.5～5.0的范围内。
步骤52：离交：将步骤51所得糖液进入离交工序，通过离交进料换热器把糖液温度控制在45～50℃，调节离交系统阳、阴树脂比例为1：1，离交后液pH稳定在3.5～4.0。
步骤53、脱色过滤：离交后的糖液经管道进入脱色罐，向脱色罐内按照1.4Kg/吨干基加入活性炭进行脱色，在110rpm搅拌脱色45min，然后使用板框压滤机过滤去除掉活性炭，脱色温度控制在75～80℃、pH3.5～4.5。
步骤54、精滤：使用孔径为0.45μm的精滤膜精滤步骤53脱色后的糖液，精滤过程中温度控制50～65℃，pH值3.5～4.5。
步骤55、蒸发浓缩：步骤54处理后的糖液进入降膜蒸发器进行浓缩，控制温度为65～98℃，pH值3.5～4.5。
步骤56、结晶：步骤55处理后的糖液进入真空煮糖系统，温度控制在63～65℃，真空度在70～90mbar，在糖液过饱和度达到1.01～1.02之间按照万分之二的干基比例加入300～400目晶种进行真空蒸发结晶，结晶周期控制在8小时，搅拌转速控制在80rpm。
步骤57、离心：步骤56处理后的物料经离心机离心，洗水时间控制在10s、水温在55～60℃， 分离出固体阿拉伯糖和阿拉伯糖离心母液，固体阿拉伯糖进行步骤58的操作，阿拉伯糖离心母液通过管道回套至步骤51。
步骤58、干燥、包装：用80℃热风对步骤57处理后的固体阿拉伯糖进行干燥，水分控制在0.15～0.3％，水分合格后再用12～15℃洁净冷风把产品冷却至20～24度℃，得到阿拉伯糖晶体，使用包装机将处理后的阿拉伯糖晶体包装。
表2各实施例和对比例的加工主要参数及产品收率对比
通过表2可以看出，各实施例制备的阿拉伯糖晶体中阿拉伯糖含量均大于99.8％，产品收率也均高于96％，均好于对比例制备的阿拉伯糖晶体的，达到预期效果。
以上所述仅为本发明的较佳实施例而已，并不用以限制本发明，凡在本发明的精神和原则之内所作的任何修改、等同替换和改进等，均应包含在本发明的保护范围之内。

Claims (6)

  1. 一种高纯度阿拉伯糖晶体的制备方法，其特征在于，包括如下步骤：
    步骤一、溶解：将低含量阿拉伯糖晶体进行溶解处理得到溶解糖液，溶解罐系统设置温度传感器、自动调节阀，通过西门子DCS自动温控系统实现物料溶解过程的温度监控，确保溶解过程溶解液温度55～60℃，所述低纯度阿拉伯糖晶体中阿拉伯糖含量为96～97％；
    步骤二、勾兑：将溶解糖液经管道进入勾兑罐，向勾兑罐内加入步骤八的阿拉伯糖离心母液进行勾兑处理得到勾兑糖液，勾兑后的pH值在4.3～5.0的范围内，干基浓度为50～60％，勾兑后阿拉伯糖含量94±0.5％；
    步骤三：离子交换：将勾兑糖液进行离子交换处理得到离交糖液，通过离交进料换热器把物料温度控制在45～50℃，离交糖液的pH稳定在5.5～6.5；
    步骤四、脱色过滤：离交糖液经管道进入脱色罐进行脱色过滤处理得到脱色糖液，脱色温度控制在60～65℃，pH5.5～7.5；
    步骤五、精滤：将脱色糖液使用孔径为0.45μm的精滤膜进行精滤处理得到精滤糖液，精滤过程中温度控制50～65℃，pH值5.0～7.5；
    步骤六、蒸发浓缩：将精滤糖液进入MVR蒸发器进行蒸发浓缩处理得到浓缩糖液，控制温度为65～70℃，pH值5.0～7.5；
    步骤七、结晶：将浓缩糖液进入真空煮糖系统进行结晶处理，温度控制在63～65℃，真空度在70～90mbar；
    步骤八、离心：将步骤七处理后的物料经离心机进行离心分离处理，分离出固体阿拉伯糖和阿拉伯糖离心母液，阿拉伯糖离心母液通过管道通入勾兑罐进行步骤二的操作，阿拉伯糖离心母液中阿拉伯糖含量为89～91％；
    步骤九、干燥：用80℃热风对固体阿拉伯糖进行干燥处理，得到高纯度阿拉伯糖晶体，其中阿拉伯糖含量为99.8％以上。
  2. 如权利要求1所述的高纯度阿拉伯糖晶体的制备方法，其特征在于，在步骤三中，所述离子交换处理使用离子交换柱，在离子交换柱中，阳离子树脂与阴离子树脂的比例为7：10。
  3. 如权利要求1所述的高纯度阿拉伯糖晶体的制备方法，其特征在于，在步骤四中，所述脱色过滤处理方式包括：向脱色罐内按照1.2～1.4Kg/吨干基加入活性炭进行脱色，在110rpm搅拌脱色30～45min，然后使用板框压滤机过滤去除掉活性炭。
  4. 如权利要求1所述的高纯度阿拉伯糖晶体的制备方法，其特征在于，在步骤七中，所述结晶处理包括：在浓缩糖液过饱和度达到1.01～1.02之间按照万分之二的干基比例加入300～400目阿拉伯糖晶种进行真空蒸发结晶，结晶周期控制在8小时，搅拌转速控制在80rpm。
  5. 如权利要求1所述的高纯度阿拉伯糖晶体的制备方法，其特征在于，在步骤八中，所述离心分离处理还包括洗水时间控制在10s、水温控制在55～60℃。
  6. 如权利要求1所述的高纯度阿拉伯糖晶体的制备方法，其特征在于，在步骤九中，所述干燥处理方式还包括：水分控制在0.15～0.3％，水分合格后再用12～15℃洁净冷风把产品冷却至20～24℃。
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